RESUMO
Los linfangiomas orbitarios son malformaciones vasculares benignas, de crecimiento lento, abortivas y no funcionales, que se presentan principalmente en la primera década de la vida. Las opciones terapéuticas en estos casos presentan una resolutividad limitada, algunos tratamientos suelen ser agresivos y provocar daños del aparato visual. Se presenta un caso de una paciente femenina de 6 años de edad atendida por proptosis del ojo izquierdo a la que se le realizó el diagnóstico clínico-imagenológico de linfangioma de la órbita, con el objetivo de mostrar el resultado alcanzado en el manejo de la misma mediante el uso del sildenafilo por vía oral, modalidad terapéutica en estudio a nivel mundial en el tratamiento de estas afecciones. El tratamiento con sildenafilo en el linfangioma orbitario demostró ser eficaz en la mejoría del cuadro clínico y por imágenes. Durante el tratamiento no se reportaron reacciones adversas(AU)
Orbital lymphatic malformations are benign, slow-growing, abortive, nonfunctional vascular malformations that occur mainly in the first decade of life. Therapeutic options in these cases present limited resolution, some treatments are usually aggressive and cause damage to the visual apparatus. We present a case of a 6-year-old female patient treated for proptosis of the left eye. The clinical-imaging diagnosis of lymphangioma of the orbit was made to show the results achieved in its treatment through the use of oral sildenafil, a therapeutic modality under study worldwide in the treatment of these conditions. The treatment with sildenafil in orbital lymphangioma proved to be effective in the improvement of the clinical and imaging picture. No adverse reactions were reported during treatment(AU)
Assuntos
Humanos , Feminino , Criança , Malformações Vasculares/terapia , Linfangioma/etiologiaAssuntos
Biópsia/métodos , Clobetasol/administração & dosagem , Doença de Crohn/complicações , Linfangioma , Pele/patologia , Neoplasias Vulvares , Doença de Crohn/diagnóstico , Fármacos Dermatológicos/administração & dosagem , Feminino , Glucocorticoides/administração & dosagem , Humanos , Linfangioma/diagnóstico , Linfangioma/tratamento farmacológico , Linfangioma/etiologia , Pessoa de Meia-Idade , Resultado do Tratamento , Neoplasias Vulvares/diagnóstico , Neoplasias Vulvares/tratamento farmacológico , Neoplasias Vulvares/etiologiaAssuntos
Antibióticos Antineoplásicos/uso terapêutico , Neoplasias da Mama/radioterapia , Neoplasias do Endométrio/radioterapia , Linfangioma/tratamento farmacológico , Sirolimo/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Vulvares/tratamento farmacológico , Administração Cutânea , Idoso , Antibióticos Antineoplásicos/administração & dosagem , Feminino , Humanos , Linfangioma/etiologia , Pessoa de Meia-Idade , Radioterapia/efeitos adversos , Sirolimo/administração & dosagem , Neoplasias Cutâneas/etiologia , Parede Torácica , Neoplasias Vulvares/etiologiaRESUMO
Lymphangioma circumscriptum is a benign lymphatic malformation that usually presents at birth or early childhood. Acquired oral lymphangioma has been reported secondary to radiation therapy and denture-induced trauma due to damage to previously normal lymphatics. To the best of our knowledge, this is the first report of acquired oral lymphangioma due to childhood tuberculous adenitis.
Assuntos
Linfangioma , Úlceras Orais , Tuberculose dos Linfonodos , Pré-Escolar , Humanos , Recém-Nascido , Linfangioma/diagnóstico , Linfangioma/etiologia , Tuberculose dos Linfonodos/diagnóstico , Tuberculose dos Linfonodos/tratamento farmacológicoRESUMO
INTRODUCTION: The Breast cancer is the most common malignancy in middle-aged women and that causes skin metastasis. Skin metastasis in internal cancer cases is a very rare condition and may be difficult to diagnose and have poor prognostic marker. Cutaneous metastasis of breast carcinoma is mostly seen as direct invasion and/or local infiltration. However, in addition to the well-known types, cutaneous metastases may mimic many benign skin lesions and therefore may be difficult to diagnose. CASE REPORT: In this article we present a 36-year-old woman with telangiectatic carcinoma-like lymphangioma circumscriptum, a rare form of cutaneous metastasis skin metastases. It can be the first sign of internal malignancies, so early diagnosis is very important at this stage. CONCLUSION: Therefore, solitary lesions or benign dermatoses seen in the skin and not associated with specific disease should be considered as tumor metastasis especially in female patients with a history of breast cancer and differential diagnosis must be made.
Assuntos
Neoplasias da Mama/complicações , Neoplasias da Mama/fisiopatologia , Linfangioma/diagnóstico , Metástase Neoplásica/diagnóstico , Metástase Neoplásica/fisiopatologia , Neoplasias Cutâneas/diagnóstico , Telangiectasia/diagnóstico , Adulto , Detecção Precoce de Câncer/métodos , Feminino , Humanos , Linfangioma/etiologia , Linfangioma/fisiopatologia , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/fisiopatologia , Neoplasias Cutâneas/terapia , Telangiectasia/etiologia , Telangiectasia/fisiopatologiaAssuntos
Herpes Simples/complicações , Linfangioma/etiologia , Linfangioma/patologia , Neoplasias Vulvares/etiologia , Neoplasias Vulvares/patologia , Aciclovir/administração & dosagem , Adulto , Antivirais/administração & dosagem , Biópsia , Drenagem , Feminino , Histocitoquímica , Humanos , Linfangioma/terapia , Neoplasias Vulvares/terapiaRESUMO
A 34-year-old man presented with a painless lesion of the glans present for more than 4 years. The patient became HIV-positive in 2011, and he has been treated with tenofovir, emtricitabine, and efavirenz. A CD4 count performed 4 months prior was 570 cells/mL3; syphilis, hepatitis B, and hepatitis C serologies performed on the same date were non-reactive.
Assuntos
Linfangioma/etiologia , Linfangite/complicações , Vasos Linfáticos/patologia , Neoplasias Penianas/etiologia , Adulto , Soropositividade para HIV/complicações , Soropositividade para HIV/tratamento farmacológico , Humanos , Masculino , Esclerose/complicaçõesAssuntos
Linfangioma/etiologia , Neoplasias do Mediastino/etiologia , Osteólise Essencial/complicações , Adulto , Humanos , Linfangioma/diagnóstico por imagem , Linfangioma/patologia , Masculino , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/patologia , Osteólise Essencial/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Lymphangioma circumscriptum (LC) is a rare, benign condition, predominantly characterized by the malformation of lymphatic skin vessels. Its onset may be congenital or due to secondary causes such as radiotherapy, infections, or surgical procedures. We present the case of a 55-year-old patient with a pathologic history of squamous cell carcinoma of the penis followed by radical penectomy. Due to metastasis to the locoregional lymph nodes, the entire affected area was subsequently treated with radiation therapy, receiving a total dose of 55.8 Gray. Eight years after this treatment, translucent vesicles filled with a clear liquid appeared on the scrotum. Histopathology confirmed the diagnosis of LC and therapy with CO2 laser was applied, resulting in a favorable outcome. LC of the scrotum may present a long-term radiotherapy-induced complication of this site. Our clinical experience showed that the CO2 laser was the therapy of choice as the vesicles entirely disappeared and healed as white scar-like lesions.
Assuntos
Carcinoma de Células Escamosas/radioterapia , Lasers de Gás , Terapia com Luz de Baixa Intensidade/métodos , Linfangioma/etiologia , Neoplasias Induzidas por Radiação/patologia , Neoplasias Cutâneas/radioterapia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Humanos , Linfangioma/patologia , Linfangioma/radioterapia , Masculino , Pessoa de Meia-Idade , Neoplasias Induzidas por Radiação/radioterapia , Pênis/patologia , Pênis/cirurgia , Prognóstico , Dosagem Radioterapêutica , Radioterapia Adjuvante , Medição de Risco , Escroto/patologia , Escroto/efeitos da radiação , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Resultado do TratamentoRESUMO
Lymphangiectasias, or acquired lymphangiomas, are rare in the oral cavity, more typically occurring on the skin or the genital area and, to our knowledge, have not been reported previously in association with Crohn's disease. Lymphangiectasias can occur at any age and develop secondary to chronic obstruction of the lymphatics. This differentiates them from congenital lymphangiomas, which are congenital malformations of the lymphatic system. We present 2 cases of oral lymphangiectasias associated with Crohn's disease, one of which was treated successfully with cryotherapy.
Assuntos
Doença de Crohn/complicações , Linfangioma/etiologia , Neoplasias Bucais/etiologia , Adolescente , Adulto , Biópsia , Doença de Crohn/terapia , Crioterapia , Feminino , Humanos , Linfangioma/terapia , Masculino , Neoplasias Bucais/terapiaRESUMO
Lymphangioma is a rare benign disease of the lymphatic vessels. Typically, they are primary conditions but may be acquired secondarily, such as those caused by irradiation during radiotherapy for the treatment of breast cancer. The local lymphatic obstruction provoked by irradiation causes the appearance of asymptomatic hyaline vesicles on the irradiated skin. The present report describes a 78-year-old female patient, who initially presented hyaline vesicles that progressed into multiple papules with serous exudation of a yellowish and odorless secretion on the area of chronic radiodermitis in right breast. Despite the rarity of the case, we emphasize the importance of knowledge regarding dermatological disease for early diagnosis and proper medical conduct.
Assuntos
Neoplasias da Mama/radioterapia , Linfangioma/diagnóstico , Neoplasias Induzidas por Radiação/diagnóstico , Idoso , Neoplasias da Mama/cirurgia , Feminino , Humanos , Linfangioma/etiologia , MastectomiaRESUMO
Abstract Lymphangioma is a rare benign disease of the lymphatic vessels. Typically, they are primary conditions but may be acquired secondarily, such as those caused by irradiation during radiotherapy for the treatment of breast cancer. The local lymphatic obstruction provoked by irradiation causes the appearance of asymptomatic hyaline vesicles on the irradiated skin. The present report describes a 78-year-old female patient, who initially presented hyaline vesicles that progressed into multiple papules with serous exudation of a yellowish and odorless secretion on the area of chronic radiodermitis in right breast. Despite the rarity of the case, we emphasize the importance of knowledge regarding dermatological disease for early diagnosis and proper medical conduct.
Assuntos
Humanos , Feminino , Idoso , Neoplasias da Mama/radioterapia , Linfangioma/diagnóstico , Neoplasias Induzidas por Radiação/diagnóstico , Neoplasias da Mama/cirurgia , Linfangioma/etiologia , MastectomiaAssuntos
Linfangioma/diagnóstico , Linfangioma/etiologia , Linfedema/complicações , Doenças da Vulva/diagnóstico , Doenças da Vulva/etiologia , Neoplasias Vulvares/diagnóstico , Neoplasias Vulvares/etiologia , Xantomatose/diagnóstico , Xantomatose/etiologia , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Linfedema/cirurgia , Pessoa de Meia-IdadeAssuntos
Linfangioma/etiologia , Neoplasias Induzidas por Radiação/etiologia , Radioterapia Adjuvante/efeitos adversos , Neoplasias Vulvares/etiologia , Biópsia , Terapia Combinada , Feminino , Humanos , Histerectomia , Terapia a Laser , Lasers de Gás/uso terapêutico , Linfangioma/patologia , Linfangioma/cirurgia , Pessoa de Meia-Idade , Neoplasias Induzidas por Radiação/patologia , Neoplasias Induzidas por Radiação/cirurgia , Neoplasias do Colo do Útero/radioterapia , Neoplasias do Colo do Útero/cirurgia , Neoplasias Vulvares/patologia , Neoplasias Vulvares/cirurgiaRESUMO
OBJECTIVE: To assess the clinical outcomes of surgical treatment for acquired vulvar lymphangioma circumscriptum in patients who received radical surgery and/or adjuvant radiation therapy for cervical cancer. METHODS: A retrospective chart review of eight patients was performed to assess the demographic information, chief complaints, treatment modality for cervical cancer, location, and primary treatment modality for vulvar LC, postoperative changes in symptoms, and/or signs, the development of local recurrence and the outcome of patients. RESULTS: All eight patients were previously diagnosed with cervical cancer FIGO clinical stage IA to IIA and received surgery, radiation therapy, or concurrent chemoradiation therapy. Microscopic examination revealed multiple, dilated, D2-40-positive dermal vascular channels containing eosinophilic proteinaceous material, consistent with LC. Most chief complaints showed considerable improvements on assessment at the outpatient clinic after the primary surgery. No patient showed aggravation of symptoms. Two patients developed local recurrences. One patient developed recurrence on the opposite side 13 months after local excision. We performed a second wide local excision. Another patient developed recurrence 47 months after the primary surgery. Since the lesion was very small and localized, we decided to manage it conservatively, but monitor it very closely. The remaining six patients remained free of recurrence. CONCLUSION: It is not easy for gynecologists to have an initial clinical diagnosis of LC, because there are a number of diseases that exhibit similar clinical manifestation to that of vulvar LC. Even if it is diagnosed correctly, local recurrence often occurs. Relevant symptoms associated with LC are not only distressing, but also affect patients' quality of life. Based on our data, we propose that surgical treatment could provide a more long-lasting answer compared to other treatment modalities, since it is beneficial in terms of clinical outcomes. In the future, a long-term follow-up investigation is required to assess the prognosis and to compare the efficacy and side effects of each modality.
Assuntos
Quimiorradioterapia , Linfangioma/etiologia , Linfangioma/cirurgia , Neoplasias Induzidas por Radiação/etiologia , Qualidade de Vida , Radioterapia/efeitos adversos , Neoplasias do Colo do Útero/terapia , Neoplasias Vulvares/etiologia , Neoplasias Vulvares/cirurgia , Adulto , Idoso , Terapia Combinada , Feminino , Humanos , Histerectomia , Linfangioma/patologia , Linfangioma/psicologia , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/terapia , Neoplasias Induzidas por Radiação/patologia , Neoplasias Induzidas por Radiação/cirurgia , Prognóstico , Estudos Retrospectivos , Neoplasias do Colo do Útero/radioterapia , Neoplasias do Colo do Útero/cirurgia , Vulva/patologia , Vulva/cirurgia , Doenças da Vulva/etiologia , Doenças da Vulva/patologia , Doenças da Vulva/cirurgia , Neoplasias Vulvares/patologia , Neoplasias Vulvares/psicologiaRESUMO
A 55-year-old Japanese man with a history of diverticulitis underwent colonoscopy for careful evaluation of progressive anemia. A 5-mm depressed lesion oozing spontaneously was observed at the hepatic flexure. On suspicion of depressed-type of cancer, right-sided hemicolectomy was performed. Histopathological examination indicated a collapsed lymphangioma exactly over a diverticulum, which had previously been complicated diverticulitis. The colonic mucosa and lymphangioma prolapsed beyond the subserosal layer via the muscularis propria defect, resulting in a depressed lesion and mucosal laceration with hemorrhage. This case suggests the contribution of a colonic diverticulum to the development and rupture of lymphangioma, which needed to be distinguished from depressed-type colon cancer.