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1.
J Dtsch Dermatol Ges ; 17(11): 1115-1128, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31765098

RESUMO

AIMS: Classifications of occluding vasculopathies (except vasculitis [1]) may exhibit some difficulties. Firstly, classifications may follow different principles, e.g. clinicopathologic findings, etiology or pathogenesis. Secondly, authors may not distinguish between vasculitis and occluding vasculopathies. Thirdly, occluding vasculopathies are systemic diseases. Organ-specific variations make morphologic findings difficult to compare. Moreover, subtle changes are recognized in the skin, but may be invisible in other organs. Our aim was to use the skin and subcutis as a tool and clinicopathological correlation as the basic process for classification. METHODS AND RESULTS: We first differentiate in the skin between small and medium vessel occluding vasculopathies. Here we focus on medium vessel-occluding vasculopathies. In the second step we differentiate the vessel subtypes. In the final step, we differentiate according to the time point of the coagulation/reorganization process and the involved inflammatory cells/stromal features. By applying the same procedure to the various entities and visualizing the findings in the style of bar codes, the overlaps and differences in the clinical picture as well as the histopathology become more apparent. CONCLUSIONS: Occluding vasculopathies are often not separate entities, but reaction patterns and epiphenomena. Distinguishing them from vasculitides is crucial because of the differences in pathogenesis, therapeutic approach and prognosis.


Assuntos
Algoritmos , Processamento Eletrônico de Dados , Dermatopatias Vasculares/patologia , Vasculite/patologia , Anticoagulantes/efeitos adversos , Constrição Patológica/patologia , Diagnóstico Diferencial , Humanos , Livedo Reticular/classificação , Microvasos/patologia , Necrose/induzido quimicamente , Dermatopatias Bacterianas/patologia
2.
J Dtsch Dermatol Ges ; 17(9): 895-904, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31487114

RESUMO

AIMS: The classifications of occluding vasculopathies may present some difficulties. Firstly, classifications may follow different principles, e.g. clinicopathological findings, etiology or pathomechanism. Secondly, authors sometimes do not distinguish between vasculitis and vasculopathy. Thirdly, vasculopathies are often systemic diseases. Organ-specific variations make morphologic findings difficult to compare. Moreover, subtle changes may be recognized in the skin, but be invisible in other organs. Our aim was to use the skin and subcutis as tools and clinicopathological correlation as the basic process for classification. METHODS AND RESULTS: In the first step, we differentiate between small and medium vessel occluding vasculopathies in the skin, and focus in this part on small vessel occluding vasculopathies. In the second step, we differentiate among subtypes of small vessels. In the final step, we differentiate according to the time point of the coagulation/reorganization process and the involved inflammatory cells/stromal features. Applying the same procedure to the various entities and visualizing the findings with bar codes makes the similarities and differences more apparent, both clinically and with histopathology. CONCLUSION: Occluding vasculopathies are often not separate entities, but reaction patterns and epiphenomena. Distinguishing them from vasculitides is crucial because of differences in pathogenesis, therapeutic approach and prognosis.


Assuntos
Algoritmos , Processamento Eletrônico de Dados , Dermatopatias Vasculares/patologia , Vasculite/patologia , Anticoagulantes/efeitos adversos , Constrição Patológica/patologia , Diagnóstico Diferencial , Humanos , Livedo Reticular/classificação , Microvasos/patologia , Necrose/induzido quimicamente , Dermatopatias Bacterianas/patologia
3.
Acta Reumatol Port ; 37(3): 218-25, 2012.
Artigo em Português | MEDLINE | ID: mdl-23348110

RESUMO

Livedo reticularis (LR) is a common finding and results from a physiological vasospastic response to cold or systemic disease, characterized by a pattern of cyanotic discoloration, or erythematous-cyanotic aspect. LR can be congenital or acquired. Among the acquired LR stand out from the physiological or cutis marmorata, the idiopathic, the induced vasospastic, those due to intravascular diseases or even in the wall of the vessels. This article reviews several clinical features, differential diagnosis and various causes of livedo.


Assuntos
Livedo Reticular , Diagnóstico Diferencial , Humanos , Livedo Reticular/classificação , Livedo Reticular/diagnóstico , Livedo Reticular/etiologia
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