Age, education and intellectual quotient influences: structural equation modeling on the study of Benton Visual Retention Test (BVRT)

This study searched for sociodemographic influences on visual memory and visuoconstructive ability in healthy and clinical samples evaluated with Benton Visual Retention Test (BVRT) in two studies. In Study 1, we searched for changes related to age in children, adolescents, adults and elderly on the performance of the BVRT. In Study 2, we investigated the relations among age, years of education and intellectual quotient (IQ) on the performance of the BVRT using Structural Equation Modeling (SEM). Participants were 624 individuals aged between six and 89 years old (M = 25.40; SD = 22.34) from the normatization and evidence validity studies at Brazil. We used a sociodemographic questionnaire, BVRT and IQ measure was estimated. Study 1 has shown a performance similar to the developmental graphics with a U-inverted pattern in relation to age: An increase of the visual memory ability in the children and adolescent groups as age increases, a tendency of a decrease in the performance in the adult group that intensifies in the elderly group. Study 2 found that the model for the BVRT performance tested by SEM denoted satisfactory goodness-of-fit indexes, χ2/gl = 2.67, p < .001; CFI = .92; TLI = .93; RMSEA = .004, 90% CI = [.03, .05];WLSMV = 1.79, and corroborated the theoretical assumption. The SEM model confirmed in this study highlight the strong role of years of education in the prediction of BVRT scores

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Does item difficulty affect the magnitude of the retrieval practice effect? An evaluation of the retrieval effort hypothesis

Retrieving information by testing improves subsequent retention more than restudy, a phenomenon known as the retrieval practice effect. According to the retrieval effort hypothesis (REH), difficult items require more retrieval effort than easier items and, consequently, should benefit more from retrieval practice. In two experiments, we tested this prediction. Participants learned sets of easy and difficult Swahili-Portuguese word pairs (study phase) and repeatedly restudied half of these items and repeatedly retrieval practiced the other half (practice phase). Forty-eight hours later, they took a cued-recall test (final test phase). In both experiments, we replicated both the retrieval practice and the item difficulty effects. In Experiment 1 (N = 51), we found a greater retrieval practice effect for easy items, MDifference = .26, SD = .17, than for difficult items, MDifference = .19, SD = .19, t(50) = 2.01, p = .05, d = 0.28. In Experiment 2 (N = 28), we found a nonsignificant trend-F(1, 27) = 2.86, p = .10, = .10-toward a greater retrieval practice effect for difficult items, MDifference = .28, SD = .22, than for easy items, MDifference = .18, SD = .21. This was especially true for individuals who benefit from retrieval practice (difficult: MDifference = .32, SD = .18; easy: MDifference = .20, SD = .20), t(24) = -2.08, p = .05, d = -0.42. The results provide no clear evidence for the REH and are discussed in relation to current accounts of the retrieval practice effect

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Global functioning among middle-aged patients with chronic schizophrenia: the role of medication, working memory and verbal comprehension / Funcionamiento global entre pacientes de mediana edad con esquizofrenia crónica: el papel de la medicación, la memoria de trabajo y la comprensión verbal

The chronic phase of schizophrenia is characterized by illness progression and patients encountering difficulties to return to premorbid level of functioning. The objective of this study was to describe the characteristics of a sample of patients with chronic schizophrenia, as well to assess differences between patients under and over 45 years of age. In a clinical sample of 77 chronic schizophrenia patients, we assessed basic symptoms, cognitive performance, social functioning and quality of life. All participants obtained very high scores in residual symptoms, and no differences in sociodemographic or clinical characteristics between the age groups were found. Younger patients had better cognitive performance and older patients obtained better scores for social functioning and quality of life. Number of psychotropic drugs, verbal learning delayed of SCIP, errors in WCST, Similarities and Digit Symbol Coding of WAIS were the most important variables to predict global functioning of patients over 45 years old. Increasing our understanding of differences in characteristics of the chronic phase of the illness and the profile of functioning at different ages, may help us design intervention strategies to improve adaptation in young and middle-aged patients with chronic schizophrenia

La fase crónica de la esquizofrenia se caracteriza por la progresión de la enfermedad y por las dificultades que presentan los pacientes para volver al nivel de funcionamiento premórbido. El objetivo de este estudio fue describir las características de una muestra de pacientes con esquizofrenia crónica, y conocer las diferencias entre los pacientes menores y mayores de 45 años. En una muestra clínica de 77 pacientes con esquizofrenia crónica, se han evaluado síntomas básicos, el rendimiento cognitivo, el funcionamiento social y la calidad de vida. Todos los participantes obtuvieron puntuaciones muy altas en los síntomas residuales, y no se encontraron diferencias en las características sociodemográficas o clínicas entre los grupos de edad. Los resultados señalan que los pacientes más jóvenes tienen mejor rendimiento cognitivo, y los mayores, mejor funcionamiento social y calidad de vida. El número de fármacos utilizados, los valores en la escala de aprendizaje verbal diferido del SCIP, los errores en WCST, los subtests de Semejanzas y Dígitos del WAIS fueron las variables que mejor pronostican el funcionamiento global de los pacientes mayores de 45 años. Por lo tanto, aumentar nuestra comprensión de las características de la fase crónica de la enfermedad y el perfil de funcionamiento en función de la edad, puede ayudarnos a diseñar estrategias de intervención para mejorar la adaptación en pacientes jóvenes y de mediana edad con esquizofrenia crónica

Funciones ejecutivas y alta capacidad intelectual / Executive functions and high intellectual capacity

Introducción. La alta capacidad intelectual es un proceso en desarrollo en el que las funciones ejecutivas (inhibición, memoria de trabajo y flexibilidad) desempeñan un papel en la manifestación óptima de su potencial. Objetivo. Explorar la eficacia del funcionamiento ejecutivo entre los perfiles de alta capacidad de superdotación y talento (convergente o divergente). Sujetos y métodos. Se estudiaron 78 niños con alta capacidad intelectual de 8-15 años con perfiles de superdotación (n = 21), talento convergente (n = 39) o talento divergente (n = 18). Se administró la batería de aptitudes diferenciales y generales o el Differential Aptitude Test (según la edad) y el test de pensamiento creativo de Torrance, además del test de clasificación de tarjetas de Wisconsin, el test de Corsi y el test go-no go mediante la plataforma Psychology Experiment Building Language. Se realizó un análisis multivariado de la varianza para conocer la relación entre función ejecutiva y perfi l intelectual. Resultados. Se obtienen diferencias significativas entre los perfiles estudiados y las funciones ejecutivas de fl exibilidad e inhibición, pero no en la memoria de trabajo. Conclusión. La memoria de trabajo es similar entre los perfiles estudiados, pero el perfil complejo de superdotación muestra mejor funcionamiento ejecutivo, con mayor flexibilidad e inhibición que el talento, especialmente el convergente (AU)

Introduction. High intellectual capacity is a process in development in which the executive functions (inhibition, working memory and fl exibility) play a role in the optimal manifestation of their potential. Aim. To explore the eff ectiveness of executive functioning among the profi les of high capacity giftedness and (convergent or divergent) talent. Subjects and methods. The study examines 78 children with high intellectual capacity aged 8-15 years with profi les of giftedness (n = 21), convergent talent (n = 39) or divergent talent (n = 18). A series of tests were administered including the Battery of Diff erential and General Aptitudes or the Diff erential Aptitude Test (depending on the age) and the Torrance Test of Creative Thinking, as well as the Wisconsin Card Sorting Test, the Corsi Test and the Go-No Go Test by means of the Psychology Experiment Building Language platform. A multivariate analysis of variance was performed to determine the relationship between executive function and intellectual profi le. Results. Signifi cant diff erences are obtained between the profi les studied and the executive functions of fl exibility and inhibition, but not in working memory. Conclusion. Working memory is similar across the profi les studied, but the complex profi le of giftedness displays better executive functioning, with greater fl exibility and inhibition than talent, especially of the convergent type (AU)

Modelo integrador de la adaptación social de niños con trastorno por déficit de atención/hiperactividad / Integrating model of the social adaptation of children with attention deficit hyperactivity disorder

Introducción. Los niños con trastorno por déficit de atención/hiperactividad (TDAH) experimentan dificultades sociales que afectan a su funcionamiento personal y académico. Objetivo. Revisar los estudios que han abordado la influencia de las habilidades cognitivas y afectivas implicadas en su adaptación social, desde la perspectiva de un modelo integrador que incluye el funcionamiento ejecutivo, las habilidades mentalistas y el lenguaje pragmático. Desarrollo. Las investigaciones revisadas constatan una asociación entre funcionamiento ejecutivo (memoria de trabajo, inhibición, planificación), habilidad pragmática y rendimiento en tareas mentalistas, con la problemática social que experimentan las personas con TDAH. Conclusiones. Aunque la bibliografía respalda una relación entre estos constructos, los déficits observados en la ejecución de tareas de teoría de la mente o en el uso del lenguaje parecen responder más bien a un déficit de carácter procedimental y no tanto a dificultades de índole conceptual (AU)

Introduction. Children with attention deficit hyperactivity disorder (ADHD) experience social difficulties affecting their personal and academic functioning. Aim. To review the research addressing the influence of cognitive/affective abilities involved in their social adaptation, from the perspective of an integrative model that includes executive functioning, theory of mind and pragmatic language. Development. Research shows an association between executive functioning (working memory, inhibition, planning), pragmatic abilities, performance in theory of mind tasks, and the social problems experienced by individuals with ADHD. Conclusions. Although literature supports a relationship between these constructs, deficits observed in theory of mind tasks or language use, seem rather to reflect a procedural deficit than a conceptual impairment (AU)

Moderna investigación educativa en el síndrome de Down / No disponible

Down Syndrome Education International ha publicado 21 breves artículos que describen los modernos avances realizados en la investigación educativa sobre el síndrome de Down, y las cuestiones que aún están por resolver. Ofrecemos los cinco primeros sobre lenguaje de signos, memoria operativa verbal, aprendizaje de la lectura, lenguaje y habla, y perfil de puntos fuertes y débiles

Down Syndrome Education International has edited short articles which describe modern advances in the field of educational research in Down syndrome, and face to the questions that remain unresolved. We offer the first five articles dealing on sign language, verbal working memory, reading as a tool to improve language, communication and speech, and the profile of strengths and weaknesses

Verbal forward digit span in Spanish population / Amplitud verbal de dígitos en orden directo en población española

BACKGROUND: Older people complain of difficulties in recalling telephone numbers and being able to dial them in the correct order. This study examined the developmental trend of verbal forward digit span across adulthood and aging in a Spanish population, as an index of one of the components of Baddeley's working memory model- the phonological loop-, which illustrates these two aspects. METHOD: A verbal digit span was administered to an incidental sample of 987 participants ranging from 35 to 90 years old. The maximum length was defined that participants could recall of at least two out of three series in the same order as presented with no errors. Demographic variables of gender and educational level were also examined. RESULTS: The ANOVA showed that the three main factors (age group, gender and educational level) were significant, but none of the interactions was. Verbal forward digit span decreases during the lifespan, but gender and educational level affect it slightly. CONCLUSION: Phonological loop is affected by age. The verbal forward digit span in this study is generally lower than the one reported in other studies

ANTECEDENTES: Las personas mayores se quejan con frecuencia de las dificultades que tienen para recordar números de teléfono o para marcarlos en el orden correcto. Este estudio investiga el desarrollo de la amplitud verbal de dígitos en orden directo en adultos y personas mayores en población española, como índice de uno de los componentes del modelo de memoria operativa de Baddeley: el lazo fonológico, que precisamente ilustra estos dos aspectos. MÉTODO: la tarea verbal de amplitud de dígitos en orden directo se administró a una muestra incidental de 987 participantes, entre 35 y 90 años. Se definió como la longitud mayor de series de dígitos repetidas correctamente en, al menos, dos de las tres series. Variables demográficas, género y nivel educativo también se examinaron. RESULTADOS: el ANOVA mostró que los tres factores principales (grupo de edad, género y nivel educativo) fueron significativos, pero ninguna de las interacciones alcanzó la significación. La amplitud verbal de dígitos en orden directo desciende durante el ciclo vital, pero tanto género como nivel educativo afectaron ligeramente. CONCLUSIONES: el lazo fonológico está afectado por la edad. La amplitud verbal de dígitos en orden directo fue, en general, menor que la encontrada en otros estudios

Improving reading comprehension in reading and listening settings: the effect of two training programmes focusing on metacognition and working memory.

BACKGROUND: Metacognition and working memory (WM) have been found associated with success in reading comprehension, but no studies have examined their combined effect on the training of reading comprehension. Another open question concerns the role of listening comprehension: In particular, it is not clear whether training to improve reading comprehension must necessarily be based on processing written material or whether, as suggested in a recent study by Clarke et al. (2010, Psychol. Sci., 21, 1106), a programme based on verbal language could also be effective. AIMS: The study examined the feasibility of improving text comprehension in school children by comparing the efficacy of two training programmes, both involving metacognition and WM, but one based on listening comprehension, the other on reading comprehension. PARTICIPANTS: The study involved a sample of 159 pupils attending eight classes in the fourth and fifth grades (age range 9-11 years). METHOD: The listening and reading programmes focused on the same abilities/processes strictly related to text comprehension, and particularly metacognitive knowledge and control, WM (per se and in terms of integrating information in a text). The training programmes were implemented by school teachers as part of the class's normal school activities, under the supervision of experts. Their efficacy was compared with the results obtained in an active control group that completed standard text comprehension activities. RESULTS: Our results showed that both the training programmes focusing on specific text comprehension skills were effective in improving the children's achievement, but training in reading comprehension generated greater gains than the listening comprehension programme. CONCLUSIONS: Our study suggests that activities focusing specifically on metacognition and WM could foster text comprehension, but the potential benefit is influenced by the training modality, that is, the Reading group obtained greater and longer-lasting improvements than the Active control or Listening groups.

Latent profile analysis of working memory performance in a sample of children with ADHD.

The current study used latent profile analysis (LPA) to ascertain distinct groups of children with ADHD (N = 701) in terms of performance on working memory (WM) tasks that tapped visuospatial sketchpad, spatial central executive, and verbal central executive functions. It compared the WM performances of these classes with a clinical comparison group (N = 59). The participants' age ranged from 7 to 16 years (586 males, 71 females). The results of the LPA supported three classes. For all three WM tasks, class 1 (N = 196) had more difficulties than classes 2 (N = 394) and 3 (N = 111), and the clinical comparison group. Class 2 had more difficulties than class 3 and the clinical comparison group, and there was no difference between class 3 and the clinical comparison group. Class 1 had lower IQ and academic abilities, and relatively more individuals with depressive disorders. The implications of the findings for understanding ADHD and its treatment are discussed.

The effect of pressure on high- and low-working-memory students: an elaboration of the choking under pressure hypothesis.

SAMPLE: Fifty-three third and fourth graders from China participated in this study. METHOD: Participants' working memory (WM) was assessed by the Automated Operation Span task. Then, they solved mental addition problems of different types under low- and high-pressure conditions. Performance was analysed as a function of pressure condition, working memory capacity, and problem type. RESULTS: On 'no carry' mental addition problems, there was no difference between the two groups of children regardless the presence of pressure. For problems with carries, low WM (LWM) children performed worse on all tasks compared with high WM (HWM) children in the no-pressure condition, but pressure influenced the LWM and HWM differently depending on the nature of the carrying task. On 'hidden carry' mental addition trials (for which guessing strategies were minimally effective), LWM performance was much lower than HWM performance under pressure. By contrast, performance was similar between LWM and HWM groups under pressure on the 'normal carry' trials that allowed for non-resource-intensive heuristic strategies. CONCLUSION: Whether high- or low-working-memory elementary-school-aged children were more or less affected by pressure was dependent on task-difficulty and the types of strategies that could be used to solve the problems.

Neural recruitment after mild traumatic brain injury is task dependent: a meta-analysis.

Individuals with mild traumatic brain injury (TBI) often have deficits in processing speed and working memory (WM) and there is a growing literature using functional imaging studies to document these deficits. However, divergent results from these studies revealed both hypoactivation and hyperactivation of neural resources after injury. We hypothesized that at least part of this variance can be explained by distinct demands between WM tasks. Notably, in this literature some WM tasks use discrete periods of encoding, maintenance, and retrieval, whereas others place continuous demands on WM. The purpose of this meta-analysis is to examine the differences in neural recruitment after mTBI to determine if divergent findings can be explained as a function of task demand and cognitive load. A comprehensive literature review revealed 14 studies using functional magnetic resonance imaging to examine brain activity of individuals with mTBI during working memory tasks. Three of the fourteen studies included reported hypoactivity, five reported hyperactivity, and the remaining six reported both hypoactivity and hyperactivity. Studies were grouped according to task type and submitted to GingerALE maximum likelihood meta-analyses to determine the most consistent brain activation patterns. The primary findings from this meta-analysis suggest that the discrepancy in activation patterns is at least partially attributable to the classification of WM task, with hyperactivation being observed in continuous tasks and hypoactivation being observed during discrete tasks. We anticipate that differential task load expressed in continuous and discrete WM tasks contributes to these differences. Implications for the interpretation of fMRI signals in clinical samples are discussed.

Fragile visual short-term memory is an object-based and location-specific store.

Fragile visual short-term memory (FM) is a recently discovered form of visual short-term memory. Evidence suggests that it provides rich and high-capacity storage, like iconic memory, yet it exists, without interference, almost as long as visual working memory. In the present study, we sought to unveil the functional underpinnings of this memory storage. We found that FM is only completely erased when the new visual scene appears at the same location and consists of the same objects as the to-be-recalled information. This result has two important implications: First, it shows that FM is an object- and location-specific store, and second, it suggests that FM might be used in everyday life when the presentation of visual information is appropriately designed.

Bilingualism interacts with domain in a working memory task: evidence from aging.

Younger and older adults who were either monolingual or bilingual were tested with verbal and spatial working memory (WM) span tasks. Aging was associated with a greater decline in spatial WM than in verbal WM, but the age-related declines were equivalent in both language groups. The bilingual participants outperformed the monolinguals in spatial WM, but achieved lower levels of performance than monolinguals in verbal WM. This interaction between bilingualism and WM domain was also consistent across the adult life span. These results are discussed in terms of the interactions between a domain-general executive processing advantage for bilinguals and the domain-specific content of particular WM tasks.

Trastorno por déficit de atención e hiperactividad y nuevas tecnologías / Attention deficit hyperactivity disorder and new technologies

En los últimos años ha surgido un creciente interés por las nuevas tecnologías, por la rapidez con la que se han instaurado entre la población general, y entre la población infanto juvenil en particular. El trastorno por déficit de atención es el trastorno psiquiátrico más importante en la etapa infanto juvenil, por la gran comorbilidad que puede presentar con otros trastornos psiquiátricos. La mayoría de los estudios sugieren que los niños con trastorno por déficit de atención e hiperactividad, son especialmente vulnerables a desarrollar adicciones a nuevas tecnologías. El objetivo del presente artículo es realizar una revisión bibliográfica de los artículos realizados sobre nuevas tecnologías y TDAH, con la finalidad de conocer más datos sobre la incidencia de comorbilidades entre ambos, los riesgos y los posibles beneficios de las nuevas tecnologías, y profundizar en una adecuada orientación terapéutica acerca del uso de nuevas tecnologías en población infanto juvenil con TDAH. Se postulan hipótesis biológicas, ambientales y neuropsicológicas para explicar esta comorbilidad. A pesar de la comorbilidad existente, algunos estudios apuntan a que un uso racional y adecuado de las mismas, puede contribuir a mejorar algunos de sus síntomas cardinales. Existen estudios que demuestran que videojuegos diseñados específicamente para mejorar la atención, pueden mejorar el déficit de atención en niños con TDAH. Las áreas que mayor mejoría experimentan a través del uso de videojuegos son la memoria de trabajo visuoespacial y la psicomotricidad fina

In the last years, a great interest in research of technologies has been conducted. New technologies can cause problems in the general population and especially in the childhood and adolescent population. The attention deficit disorder (ADHD) is the most important psychiatric disorder in childhood and adolescent stage. An important co morbidity between ADHD and psychiatric disorders has been reported in previous research. Most studies suggest that children with ADHD are especially vulnerable to develop addictions to new technologies. The aim of this paper is to make a review about ADHD and new technologies papers, in order to study the co morbidity between this disorders, the risks and benefits of new technologies, and to know therapeutic guidance about the use of new technologies in child and adolescent population with ADHD

Working memory capacity and mental rotation: evidence for a domain-general view.

Despite the existence of numerous studies that examined the relationship between working memory capacity and performance in complex cognitive tasks, it remains unclear whether this capacity is domain specific or domain general. In addition, the available empirical evidence is somewhat contradictory. In this work we have studied the role of verbal working memory capacity in a non-verbal task--mental image rotation. If this capacity were domain specific it would be expected that high and low verbal span participants would obtain similar results in the mental rotation task. We have found that this is not the case as the high span participants performed better in terms of both speed and accuracy. Moreover, these differences depended on the processing component of the mental rotation task: the higher the processing requirements the higher the differences as a function of the working memory capacity. Therefore, the evidence presented here supports the domain general hypothesis.

Representations in mental imagery and working memory: evidence from different types of visual masks.

Although few studies have systematically investigated the relationship between visual mental imagery and visual working memory, work on the effects of passive visual interference has generally demonstrated a dissociation between the two functions. In four experiments, we investigated a possible commonality between the two functions: We asked whether both rely on depictive representations. Participants judged the visual properties of letters using visual mental images or pictures of unfamiliar letters stored in short-term memory. Participants performed both tasks with two different types of interference: sequences of unstructured visual masks (consisting of randomly changing white and black dots) or sequences of structured visual masks (consisting of fragments of letters). The structured visual noise contained elements of depictive representations (i.e., shape fragments arrayed in space), and hence should interfere with stored depictive representations; the unstructured visual noise did not contain such elements, and thus should not interfere as much with such stored representations. Participants did in fact make more errors in both tasks with sequences of structured visual masks. Various controls converged in demonstrating that in both tasks participants used representations that depicted the shapes of the letters. These findings not only constrain theories of visual mental imagery and visual working memory, but also have direct implications for why some studies have failed to find that dynamic visual noise interferes with visual working memory.

Classifying retrieval strategies as a function of working memory.

Strategy selection may help explain performance differences between individuals with high working memory capacity (HWMs) and low working memory capacity (LWMs) (Budd, Whitney, & Turley, (Memory & Cognition, 23, 735-748 1995); Cokely, Kelley, & Gilchrist, (Psychonomic Bulletin & Review, 13, 991-997 2006). We compared the independent and spontaneous strategy use of HWMs and LWMs during a category fluency (retrieval) task that required participants to retrieve animal names. HWMs were more successful at the fluency task under normal conditions, but under increased cognitive load, there were no WM-related performance differences. One strategy (i.e., retrieving animals according to their scientific classification) significantly aided performance, irrespective of cognitive load. Under normal conditions, HWMs were more likely to use the effective strategy; however, under load, WM did not predict strategy use. Use of the classification strategy was more strongly related to retrieval performance than was WM. These results suggest that retrieval strategy use is related to WM capacity, and that employing a successful strategy may make up for WM disadvantages during a demanding retrieval task.

The effects of acute administration of the hydroalcoholic extract of rosemary (Rosmarinus officinalis L. ) (Lamiaceae) in animal models of memory

Rosmarinus officinalis (Rosemary) demonstrates antioxidant, antidepressant, diuretic, antinociceptive and antiulcerogenic activities. The present study was designed to examine the effects of the hydroalcoholic extract of R. officinalis on the memory of male mice. The behavioral tasks employed were social recognition (SR), the Morris water maze (MWM) and an inhibitory avoidance task (IA). The treatment with 150 and 300 mg/kg of R. officinalis improved the acquisition phase of learning of a new social memory in the SR task because a decrease was observed in the duration of social investigation. In the Morris water maze, no significant effect was observed on spatial memory when the groups were compared for the time spent in the correct quadrant. In the inhibitory avoidance task, the decrease in the step-down latencies in the test session indicate that 150 mg/kg of R. officinalis improved long-term memory when administered in the consolidation phase of learning. In conclusion, the present study showed that, the hydroalcoholic extract of R. officinalis at 150 and 300 mg/kg modulated the short- and long-term memories of mice, in a social recognition and inhibitory avoidance task, respectively. This modulator effect was shown to improve learning and memory processes.

Rosmarinus officinalis L. (Alecrim) possui atividade antioxidante, antidepressiva, diurética, antinociceptiva e antiulcerogênica. O presente estudo foi delineado para investigar o efeito do extrato hidroalcoólico de R. officinallis na memória de camundongos machos. Os modelos comportamentais utilizados foram a tarefa de reconhecimento social (RS), labirinto aquático de Morris (MWM) e esquiva inibitória (EI). O tratamento com 150 e 300mg/kg de R. officinallis, mostrou ter efeito positivo na aquisição de uma nova memória social, na tarefa de reconhecimento social, mostrando redução significativa do tempo de investigação social. No labirinto aquático de Morris, não foi visto efeito significativo na memória espacial, ao comparar o tempo desprendido no quadrante correto entre os diferentes tratamentos. Na esquiva inibitória a latência de descida da plataforma, observada na sessão teste, sugere que o tratamento com a dose 150 mg/kg de R. officinallis tem um efeito positivo na memória de longo prazo, quando administrada na fase de consolidação. Conclui-se que o extrato de R. officinalis nas doses de 150 e 300 mg/kg foi capaz de modular as memórias de curto e longo prazo dos roedores nas tarefas de reconhecimento social e esquiva inibitoria, respectivamente, e esse efeito modulatório melhorou os processos de aprendizado e memória.

Pattern classification of working memory networks reveals differential effects of methylphenidate, atomoxetine, and placebo in healthy volunteers.

Stimulant and non-stimulant drugs can reduce symptoms of attention deficit/hyperactivity disorder (ADHD). The stimulant drug methylphenidate (MPH) and the non-stimulant drug atomoxetine (ATX) are both widely used for ADHD treatment, but their differential effects on human brain function remain unclear. We combined event-related fMRI with multivariate pattern recognition to characterize the effects of MPH and ATX in healthy volunteers performing a rewarded working memory (WM) task. The effects of MPH and ATX on WM were strongly dependent on their behavioral context. During non-rewarded trials, only MPH could be discriminated from placebo (PLC), with MPH producing a similar activation pattern to reward. During rewarded trials both drugs produced the opposite effect to reward, that is, attenuating WM networks and enhancing task-related deactivations (TRDs) in regions consistent with the default mode network (DMN). The drugs could be directly discriminated during the delay component of rewarded trials: MPH produced greater activity in WM networks and ATX produced greater activity in the DMN. Our data provide evidence that: (1) MPH and ATX have prominent effects during rewarded WM in task-activated and -deactivated networks; (2) during the delay component of rewarded trials, MPH and ATX have opposing effects on activated and deactivated networks: MPH enhances TRDs more than ATX, whereas ATX attenuates WM networks more than MPH; and (3) MPH mimics reward during encoding. Thus, interactions between drug effects and motivational state are crucial in defining the effects of MPH and ATX.

Manipulations of attention dissociate fragile visual short-term memory from visual working memory.

People often rely on information that is no longer in view, but maintained in visual short-term memory (VSTM). Traditionally, VSTM is thought to operate on either a short time-scale with high capacity - iconic memory - or a long time scale with small capacity - visual working memory. Recent research suggests that in addition, an intermediate stage of memory in between iconic memory and visual working memory exists. This intermediate stage has a large capacity and a lifetime of several seconds, but is easily overwritten by new stimulation. We therefore termed it fragile VSTM. In previous studies, fragile VSTM has been dissociated from iconic memory by the characteristics of the memory trace. In the present study, we dissociated fragile VSTM from visual working memory by showing a differentiation in their dependency on attention. A decrease in attention during presentation of the stimulus array greatly reduced the capacity of visual working memory, while this had only a small effect on the capacity of fragile VSTM. We conclude that fragile VSTM is a separate memory store from visual working memory. Thus, a tripartite division of VSTM appears to be in place, comprising iconic memory, fragile VSTM and visual working memory.