The isolation and identification of precursors and reaction products in the clandestine manufacture of methaqualone and mecloqualone.

Abuse of the hypnotic quinazolinone is well recognized and increasing. Clandestine laboratories producing methaqualone (2-methyl-3-ortho-tolyl-4(3H) quinazolinone) and mecloqualone (2-methyl-3-ortho-chlorophenyl-4(3H) quinazolinone) have been discovered throughout the United States. These laboratories utilize one of many synthesis routes to produce the illicit quinazolinone. Frequently, the clandestine chemist has little, if any, formal education in chemistry; does not keep notes; and does not label flasks and beakers containing solutions. The forensic chemist may be asked to analyze unmarked reaction mixtures that were seized in a clandestine laboratory raid. As a result, a rapid method of isolation and identification of the precursors and products of such a mixture is presented.

A simple procedure for separating drugs from interfering lipids on special thin layer chromatographic media.

A method is reported for separating drugs from serum lipids on special thin layer chromatographic media with insertable sample application discs, using a double-development, single dimensional technique. Drugs whose detection normally was precluded by lipid were detected at therapeutic levels using the new procedure.