RESUMO
The influence of anesthesia on long-term changes in in vivo antibody levels after antigen challenge was examined. Rats experienced a surgical plane of various anesthetics alone (anesthesia/intact) or in combination with laparatomy (anesthesia/laparatomy) and were given 1 or 3 wk to recover. Antigen, keyhole limpet hemocyanin, was then administered, and antibody levels specific to the antigen were measured during the next 14 days. Comparisons were made between anesthesia-treated animals and home cage controls. Pentobarbital and chloral hydrate produced decreases in in vivo antibody levels even 3 wk after exposure, whereas halothane, methoxyflurane, and ketamine/xylazine did not. Ketamine/xylazine produced moderate but not significant decreases in antibody levels when 1 wk intervened between exposure and antigen administration, but not when 3 wk intervened. Surgery did not produce larger changes in antibody levels than did anesthesia itself. These data suggest the possibility that some anesthetics, per se, may contribute to infection that may occur postoperatively.
Assuntos
Anestésicos/imunologia , Formação de Anticorpos/efeitos dos fármacos , Animais , Hidrato de Cloral/imunologia , Halotano/imunologia , Ketamina/imunologia , Laparotomia , Masculino , Metoxiflurano/imunologia , Pentobarbital/imunologia , Ratos , Ratos Sprague-Dawley , Xilazina/imunologiaRESUMO
Two surgeons, in whom liver damage developed after occupational exposure to sub-anaesthetic doses of halothane, were found to have a circulating antibody which reacted specifically with halothane-altered hepatocyte membrane components. This antibody had been found previously only in those patients in whom severe hepatic necrosis developed after exposure to halothane and in no other form of liver injury. It may provide a specific diagnostic marker in patients in whom there are other possible causes of liver damage and could, therefore, remove the need for a challenge exposure and its attendant risks.
Assuntos
Doença Hepática Induzida por Substâncias e Drogas/etiologia , Cirurgia Geral , Halotano/efeitos adversos , Doenças Profissionais/induzido quimicamente , Adulto , Anticorpos/análise , Doença Hepática Induzida por Substâncias e Drogas/imunologia , Testes Imunológicos de Citotoxicidade , Halotano/imunologia , Humanos , Masculino , Metoxiflurano/imunologiaRESUMO
Methyoxyflurane, a halogenated general anaesthetic, showed a net sensibilizing effect in the guinea-pig when tested experimentally by the Magnusson and Klingman technique. According to these authors classification it may be classed as of "moderate allergenicity". In addition, the sensibilisation reaction obtained is prolonged. It remains at a similar level for 2 to 7 weeks after the end of the sensibilisation phase.
