Assuntos
Segmento Anterior do Olho/anormalidades , Infecções Oculares Virais/diagnóstico , Microftalmia/diagnóstico , Complicações Infecciosas na Gravidez , Infecção por Zika virus/congênito , Segmento Anterior do Olho/virologia , Catarata/congênito , Coloboma/diagnóstico , Coloboma/virologia , DNA Viral/genética , Infecções Oculares Virais/virologia , Feminino , Humanos , Lactente , Recém-Nascido , Iris/anormalidades , Masculino , Microftalmia/virologia , Gravidez , Reação em Cadeia da Polimerase em Tempo Real , Zika virus/genética , Zika virus/imunologia , Infecção por Zika virus/diagnóstico , Infecção por Zika virus/virologiaRESUMO
UNLABELLED: Abstract PURPOSE: We present the clinical, paraclinical and therapeutic features in a patient with secondary congenital aphakia. METHODS: A 2-year-old patient, diagnosed with congenital rubella syndrome including sensorineural deafness, congenital heart disease, intellectual disability, microcephaly, microphthalmia, and congenital cataract, presented to our clinic for the surgical treatment of cataract. RESULTS: During the surgery, the absence of the lens' cortex was observed, hence, the final diagnose was of secondary congenital aphakia. Surgery was then continued with a posterior capsulorhexis and an anterior vitrectomy, deciding to postpone the implantation of the posterior chamber intraocular lens.
Assuntos
Capsulorrexe , Catarata/congênito , Síndrome da Rubéola Congênita/complicações , Vitrectomia , Afacia/congênito , Pré-Escolar , Perda Auditiva Neurossensorial/congênito , Cardiopatias Congênitas/virologia , Humanos , Deficiência Intelectual/virologia , Masculino , Microcefalia/virologia , Microftalmia/virologia , Resultado do TratamentoRESUMO
INTRODUCTION: Eye anomalies, including anophthalmos and microphthalmos (absent eye and small eye), are common features in congenital infection syndromes such as rubella. Influenza, Coxsackie virus, and Parvovirus are less well-established teratogens. We report an ecologic analysis of anophthalmia/microphthalmia prevalence in England in relation to temporal variation in these infections using routine infection data. METHODS: The national (England) anophthalmos/microphthalmos register holds details of 406 babies (excluding chromosomal anomalies) born 1988-1994. Weekly infection data were obtained from the U.K. Public Health Laboratory Service and Royal College of General Practitioners Weekly Returns Service. We assigned cases and births an estimated exposure based on the population infection counts in the gestational weeks known to be critical for ocular development. We calculated the rate ratio of anophthalmos/microphthalmos prevalence for infection in the 90th percentile compared with the 10th percentile by Poisson regression. RESULTS: There was a positive association between severe anophthalmos/microphthalmos prevalence and Parvovirus B19 (rate ratio = 1.26; 95% confidence interval = 1.00-1.58) and for influenza (1.41; 1.08-1.84). Coxsackie virus showed a negative association with any anophthalmos/microphthalmos (0.75; 0.58-0.98) and with severe cases (0.66; 0.46-0.95). CONCLUSIONS: This analysis provides suggestive evidence for a teratogenic role of influenza and Parvovirus in anophthalmos/microphthalmos. The role of maternal infections in congenital anomaly etiology is worthy of further investigation.
Assuntos
Anoftalmia/etiologia , Enterovirus Humano B/patogenicidade , Infecções por Enterovirus/complicações , Influenza Humana/complicações , Microftalmia/etiologia , Infecções por Parvoviridae/complicações , Parvovirus B19 Humano/patogenicidade , Anoftalmia/virologia , Inglaterra/epidemiologia , Feminino , Humanos , Recém-Nascido , Transmissão Vertical de Doenças Infecciosas , Microftalmia/virologia , Distribuição de Poisson , Gravidez , Prevalência , Sistema de Registros , Estações do AnoRESUMO
The authors report the clinical case of a newborn affected by congenital varicella syndrome, occurred about the 12th gestational week, with ophthalmic involvement. The ocular anomalies consisted in right microphthalmia, with lens opacities and atrophic chorioretinitis, without any involvement of other pathologies. The ophthalmic lesions and the sierological data confirmed that the infection occurred during the first weeks of gestation. Although the manifestation limited to the eyes is extremely rare, the authors point out the necessity of an appropriate prevention to avoid irreversible involvements of important organs.
