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1.
J Cancer Res Ther ; 19(7): 2079-2081, 2023 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-38376325

RESUMO

ABSTRACT: A 57-year-old male had abdominal pain and distension for 6-7 months with a palpable swelling in the right lumbar region. Contrast-enhanced computed tomography abdomen showed a large heterogeneous lesion with fat density measuring 22 cm ´ 16.5 cm in the right suprarenal region. Laparotomy was done which showed an encapsulated mass measuring 21 cm ´ 14 cm ´ 5 cm. Cut section revealed yellowish areas admixed with hemorrhage and large areas of necrosis. Microscopy revealed adrenal myelolipoma. The patient was found to have sickling positive. High-performance liquid chromatography showed double heterozygous for HbS and beta-thalassemia trait. The association of giant adrenal myelolipoma with double heterozygous for HbS and beta-thalassemia trait is rare, and as clinically it simulates retroperitoneal sarcoma, awareness of this rare entity is critical for its accurate diagnosis and proper management.


Assuntos
Neoplasias das Glândulas Suprarrenais , Lipoma , Mielolipoma , Neoplasias Retroperitoneais , Sarcoma , Neoplasias de Tecidos Moles , Talassemia beta , Masculino , Humanos , Pessoa de Meia-Idade , Talassemia beta/diagnóstico , Talassemia beta/genética , Mielolipoma/diagnóstico , Mielolipoma/genética , Mielolipoma/cirurgia , Neoplasias das Glândulas Suprarrenais/diagnóstico , Neoplasias das Glândulas Suprarrenais/genética , Neoplasias das Glândulas Suprarrenais/cirurgia
2.
Virchows Arch ; 480(3): 707-712, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34231054

RESUMO

A mediastinal mass was incidentally detected by chest X-ray in a 44-year-old man. Computed tomography findings revealed that the mass was a possible malignancy in the right and middle mediastinum and was removed by surgical resection. Macroscopically, the resected specimen was a well-demarcated yellowish, brownish, and whitish mass. Microscopically, a solid lesion with cords of epithelioid cells in the extra-adrenal myelolipoma-like lesion was observed. Immunohistochemically, the solid lesion was positive for typical vascular markers and CAMTA1, the expression of which is highly specific for epithelioid hemangioendothelioma (EHE). The endothelial cells and bone marrow elements of myelolipoma-like lesion were also positive for CAMTA1. Fluorescence in situ hybridization examination detected the CAMTA1-WWTR1 fusion gene not only in the solid lesion but also in the endothelial cells and bone marrow elements of myelolipoma-like lesion. To our knowledge, this is the first report suggesting common genetic abnormality, CAMTA1-WWTR1 fusion, in cases of EHE and extra-adrenal myelolipoma.


Assuntos
Neoplasias das Glândulas Suprarrenais , Hemangioendotelioma Epitelioide , Lipoma , Mielolipoma , Neoplasias das Glândulas Suprarrenais/genética , Adulto , Proteínas de Ligação ao Cálcio/genética , Células Endoteliais/patologia , Hemangioendotelioma Epitelioide/patologia , Humanos , Hibridização in Situ Fluorescente , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Masculino , Mielolipoma/genética , Transativadores/genética , Fatores de Transcrição/genética , Proteínas com Motivo de Ligação a PDZ com Coativador Transcricional
3.
Int J Surg Pathol ; 27(6): 664-668, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30942102

RESUMO

In this article, we describe a case of conventional epithelioid hemangioendothelioma (EHE) arising within an extra-adrenal myelolipoma. This composite neoplasm arose in the mediastinum of a 51-year-old female. The tumor was composed of a large myelolipoma that contained nodules of EHE consisting of CD31-positive epithelioid endothelial cells that grew in solid cords and were enmeshed in a basophilic hyalinized stroma. Both EHE and myelolipoma are characterized genetically by alterations of WWTR1. We demonstrated the expression of CAMTA-1 chimeric protein by immunohistochemistry both in the neoplastic endothelial cells of EHE and some of the endothelial cells lining the blood vessels in the myelolipoma. To the best of our knowledge, this is the first report of a malignant vascular neoplasm arising in association with myelolipoma.


Assuntos
Hemangioendotelioma Epitelioide/diagnóstico , Neoplasias do Mediastino/diagnóstico , Mielolipoma/diagnóstico , Neoplasias Complexas Mistas/diagnóstico , Proteínas de Fusão Oncogênica/genética , Proteínas de Ligação ao Cálcio/genética , Proteínas de Ligação ao Cálcio/metabolismo , Feminino , Hemangioendotelioma Epitelioide/genética , Hemangioendotelioma Epitelioide/patologia , Humanos , Neoplasias do Mediastino/genética , Neoplasias do Mediastino/patologia , Mediastino/patologia , Pessoa de Meia-Idade , Mielolipoma/genética , Mielolipoma/patologia , Neoplasias Complexas Mistas/genética , Neoplasias Complexas Mistas/patologia , Proteínas de Fusão Oncogênica/metabolismo , Transativadores/genética , Transativadores/metabolismo , Proteínas com Motivo de Ligação a PDZ com Coativador Transcricional
4.
Gynecol Endocrinol ; 35(5): 385-389, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30614301

RESUMO

17α-Hydroxylase/17,20-lyase deficiency (17-OHD) is a rare disease caused by mutations of the CYP17A1 gene. Slipped capital femoral epiphysis (SCFE) rarely occurs in adults. There are occasional reports of adrenal myelolipoma (AML) in 17-OHD. A 27-year-old Chinese female (46, XX) visited the hospital for SCFE and presented with continuous hypokalemia, absent spontaneous puberty, and hypertension. Hypergonadotropic hypogonadism was detected. The laboratory tests were consistent with 17-OHD. AML was considered based on the imaging examinations. A mutation analysis of the CYP17A1 gene identified the following compound heterozygous mutation: a frame-shift mutation, i.e. c.985_987delTACinsAA (p.Tyr329fs), that had been reported to be a common mutation in the Chinese population was found in exon 6. Another new nonsense mutation, i.e. c.1270C > T (p.Gln424*), that causes a premature termination codon was found in exon 8. Treatment with prednisone had poor efficacy. The administration of 0.75 mg dexamethasone and estradiol/dydrogesterone cyclic treatment significantly improved the patient's symptoms. For the first time, we report a 17-OHD case accompanied by SCFE, AML, and a novel mutation site in the CYP17A1 gene. We provide insight into the clinical manifestations, genetic analysis, and treatment options of 17-OHD.


Assuntos
Neoplasias das Glândulas Suprarrenais/genética , Hiperplasia Suprarrenal Congênita/genética , Mutação , Mielolipoma/genética , Escorregamento das Epífises Proximais do Fêmur/genética , Esteroide 17-alfa-Hidroxilase/genética , Adulto , Feminino , Humanos
5.
J Clin Endocrinol Metab ; 103(9): 3522-3530, 2018 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-29982598

RESUMO

Introduction: Adrenal myelolipoma (AML) is the second most common and invariably benign primary adrenal neoplasm. Due to the variable proportion of fat and hematopoietic elements and its often large size, it can cause differential diagnostic problems. Several reports confirmed the utility of miRNAs in the diagnosis of tumors, but miRNA expression in AML has not yet been investigated. Materials and Methods: Next-generation sequencing (NGS) was performed on 30 formalin-fixed, paraffin-embedded (FFPE) archived tissue samples [10 each of AML, adrenocortical adenoma (ACA), and adrenocortical carcinoma (ACC)]. Validation was performed by real-time quantitative reverse transcription polymerase chain reaction on a cohort containing 41 further FFPE samples (15 AML, 14 ACA, and 12 ACC samples). Circulating miRNA counterparts of significantly differentially expressed tissue miRNAs were studied in 33 plasma samples (11 each of ACA, ACC, and AML). Results: By NGS, 256 significantly differentially expressed miRNAs were discovered, and 8 of these were chosen for validation. Significant overexpression of hsa-miR-451a, hsa-miR-486-5p, hsa-miR-363-3p, and hsa-miR-150-5p was confirmed in AML relative to ACA and ACC. hsa-miR-184, hsa-miR-483-5p, and hsa-miR-183-5p were significantly overexpressed in ACC relative to ACA but not to AML. Circulating hsa-miR-451a and hsa-miR-363-3p were significantly overexpressed in AML, whereas circulating hsa-miR-483-5p and hsa-miR-483-3p were only significantly overexpressed in ACC vs ACA. Conclusions: We have found significantly differentially expressed miRNAs in AML and adrenocortical tumors. Circulating hsa-miR-451a might be a promising minimally invasive biomarker of AML. The lack of significantly different expression of hsa-miR-483-3p and hsa-miR-483-5p between AML and ACC might limit their applicability as diagnostic miRNA markers for ACC.


Assuntos
Neoplasias das Glândulas Suprarrenais/genética , MicroRNAs/metabolismo , Mielolipoma/genética , Adolescente , Neoplasias das Glândulas Suprarrenais/sangue , Neoplasias das Glândulas Suprarrenais/patologia , Adenoma Adrenocortical/sangue , Adenoma Adrenocortical/genética , Adenoma Adrenocortical/patologia , Carcinoma Adrenocortical/sangue , Carcinoma Adrenocortical/genética , Carcinoma Adrenocortical/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/metabolismo , Estudos de Coortes , Feminino , Perfilação da Expressão Gênica , Humanos , Masculino , Pessoa de Meia-Idade , Mielolipoma/sangue , Mielolipoma/patologia , Reação em Cadeia da Polimerase em Tempo Real , Adulto Jovem
6.
Arkh Patol ; 78(1): 36-41, 2016.
Artigo em Russo | MEDLINE | ID: mdl-26978235

RESUMO

The paper describes a case of von Hippel--Lindau-related pancreatic neuroendocrine tumor and adrenal myelolipoma in a 44-year-old woman. The pancreatic tumor and a left retroperitoneal mass were removed in the women in July 2014 and May 2015. Histological examination of the pancreatic tumor revealed that the latter consisted of clear cells forming tubular and tubercular structures showing the expression of chromogranin A, synaptophysin, and cytokeratins 18 and 19 and a negative response to CD10 and RCC. The adrenal medullary mass presented as clear-cell alveolar structures with inclusions of adipose tissue mixed with erythroid, myeloid, and lymphoid cells. The clear-cell component of the adrenal gland expressed neuroendocrine markers with a negative response to cytokeratins, CD10, and RCC. Molecular genetic examination yielded a signal corresponding to two copies of the VHL gene. No deletions or amplifications of the gene were detected. Cases of von Hippel--Lindau disease concurrent with adrenal pheochromocytoma and myelolipoma and simultaneous pancreatic involvement were not found in the literature.


Assuntos
Neoplasias das Glândulas Suprarrenais/patologia , Mielolipoma/patologia , Tumores Neuroendócrinos/patologia , Doença de von Hippel-Lindau/patologia , Neoplasias das Glândulas Suprarrenais/complicações , Neoplasias das Glândulas Suprarrenais/diagnóstico , Neoplasias das Glândulas Suprarrenais/genética , Adulto , Aberrações Cromossômicas , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Mielolipoma/complicações , Mielolipoma/diagnóstico , Mielolipoma/genética , Proteínas de Neoplasias/biossíntese , Proteínas de Neoplasias/genética , Tumores Neuroendócrinos/complicações , Tumores Neuroendócrinos/diagnóstico , Tumores Neuroendócrinos/genética , Neoplasias Pancreáticas/complicações , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/genética , Neoplasias Pancreáticas/patologia , Patologia Molecular , Feocromocitoma/complicações , Feocromocitoma/diagnóstico , Feocromocitoma/genética , Feocromocitoma/patologia , Doença de von Hippel-Lindau/complicações , Doença de von Hippel-Lindau/diagnóstico , Doença de von Hippel-Lindau/genética
7.
Crit Rev Oncog ; 18(1-2): 75-95, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23237553

RESUMO

Multiple myeloma (MM) is a B cell malignancy characterized by uncontrolled expansion of malignant plasma cells within the bone marrow that contribute to formation of multiple osteolytic bone disease and severe skeletal devastation. Recently, direct and indirect observations suggest that fusion events between cells housed within the MM marrow microenvironment often occur and may play a role in tumor progression, including myeloma bone disease (MBD). A number of cells resident in the marrow, such as myeloid progenitors and dendritic cells, have inherited fusogenicity and osteoclastogenic potential due to the expression of a number of fusogenic proteins as well as a high sensitivity to fusogenic factors produced within the MM marrow milieu. Similarly, osteoclasts (OC), as bone-resorbing multinucleated cells resulting from the fusion of marrow monocyte/ macrophages, have been reported to improperly fuse with malignant plasma cells and drive transition of these cells into OC-like cells exerting bone-resorbing capacity. Further, based on indirect cytogenetic and molecular evidence, it has been proposed that MM cells may generate a hybrid progeny with high metastatic potential and drug resistance, ultimately pointing to uncontrolled homotypic fusions that accelerate MBD progression.


Assuntos
Fusão Celular , Transformação Celular Neoplásica/genética , Mielolipoma , Microambiente Tumoral , Linfócitos B/citologia , Linfócitos B/metabolismo , Medula Óssea/metabolismo , Medula Óssea/patologia , Reabsorção Óssea/metabolismo , Reabsorção Óssea/patologia , Comunicação Celular/fisiologia , Humanos , Mielolipoma/genética , Mielolipoma/metabolismo , Mielolipoma/patologia , Osteoblastos/metabolismo , Osteoblastos/patologia , Osteoclastos/metabolismo , Osteoclastos/patologia
8.
Am J Surg Pathol ; 30(7): 838-43, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16819325

RESUMO

Myelolipomas are defined as mature fat associated with hematopoietic elements, often found in the adrenal gland. The question of whether the hematopoietic cells are truly "normal" has not been evaluated extensively. In this study, we evaluated histologic, immunohistochemical features and comparisons of X-chromosome inactivation patterns in 19 myelolipomas. Formalin-fixed, paraffin-embedded tissue from 19 myelolipomas was stained with hematoxylin and eosin and immunostained with monoclonal antibodies against CD138, CD34, CD117, CD42a, hemoglobin, myeloperoxidase, collagen IV, and nerve growth factor receptor. Histologic evaluation included estimates of overall cellularity of hematopoietic tissue, estimates of cellularity in the areas of highest concentration of hematopoietic tissue, myeloid to erythroid ratio, and numbers of megakaryocytes. X-chromosome inactivation analysis was performed on myelolipomas from 11 female patients by polymerase chain reaction. Myelolipomas showed wide variation in cellularity within the lesion (5% to 90%) with no correlation with the patient's age. All the myelolipomas demonstrated normal trilineage hematopoiesis and cellular morphology, with few early myeloid precursors, as evidenced by negativity for CD117 and only rare positivity for CD34 antibodies. Most of the myelolipomas (14/18) had markedly increased megakaryocytes compared with normal marrows. The majority of myelolipomas also had a stromal composition and vascular patterns that were different from those of normal bone marrow. X-chromosome inactivation studies demonstrated nonrandom X-chromosome inactivation in 8/11 myelolipomas from female patients. Myelolipomas are morphologically different from the normal bone marrow. The majority of myelolipomas also have nonrandom X-chromosome inactivation, suggesting a clonal origin for these tumors.


Assuntos
Neoplasias das Glândulas Suprarrenais/genética , Cromossomos Humanos X/genética , Inativação Gênica , Hematopoese Extramedular/genética , Mielolipoma/genética , Tecido Adiposo/química , Tecido Adiposo/patologia , Neoplasias das Glândulas Suprarrenais/química , Neoplasias das Glândulas Suprarrenais/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/análise , Células Clonais , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , Microdissecção , Pessoa de Meia-Idade , Mielolipoma/química , Mielolipoma/patologia , Reação em Cadeia da Polimerase
9.
Eur J Histochem ; 50(2): 131-2, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16864124

RESUMO

We report a case of a 64-year-old woman who underwent left adrenalectomy with removal of a 8,5 cm clinically non-functioning adrenocortical adenoma and a 4-cm myelolipoma. Molecular testing for viral infection demonstrated the presence of cytomegalovirus (CMV) DNA sequences in the adrenal adenoma, but not in the myelolipoma (confirmed by immunohistochemistry). Moreover, the adrenal adenoma was also positive for parvovirus B19, and both adrenal tumor samples were positive for polyomavirus BK (BKV) and adenovirus DNA sequences. This is the first report of co-infection of an adrenocortical adenoma by CMV and BKV. The role of these viruses in adrenal tumorigenesis was postulated.


Assuntos
Neoplasias das Glândulas Suprarrenais/complicações , Adenoma Adrenocortical/patologia , Vírus BK/genética , Infecções por Citomegalovirus/complicações , Citomegalovirus/genética , Infecções por Polyomavirus/complicações , Neoplasias das Glândulas Suprarrenais/cirurgia , Neoplasias das Glândulas Suprarrenais/virologia , Adrenalectomia , Adenoma Adrenocortical/virologia , Vírus BK/isolamento & purificação , Citomegalovirus/isolamento & purificação , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Mielolipoma/genética , Mielolipoma/patologia , Reação em Cadeia da Polimerase
10.
Int J Urol ; 13(6): 801-2, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16834664

RESUMO

Adrenal myelolipoma is a rare benign tumor, occasionally reported in association with endocrine disorders. We report herein a case of bilateral adrenal myelolipoma associated with adrenogenital syndrome caused by 21-hydroxylase deficiency. A diagnosis of 21-hydroxylase deficiency was confirmed by mutation analysis of the CYP21 gene. Our case represents only the second case of bilateral adrenal myelolipoma associated with adrenogenital syndrome caused by 21-hydroxylase deficiency.


Assuntos
Hiperplasia Suprarrenal Congênita/genética , Mutação , Mielolipoma/genética , Esteroide 21-Hidroxilase/genética , Hiperplasia Suprarrenal Congênita/complicações , Hiperplasia Suprarrenal Congênita/enzimologia , Hiperplasia Suprarrenal Congênita/patologia , Hiperplasia Suprarrenal Congênita/terapia , Adrenalectomia/métodos , Idoso , Feminino , Humanos , Laparoscopia/métodos , Mielolipoma/complicações , Mielolipoma/enzimologia , Mielolipoma/patologia , Mielolipoma/terapia
11.
Artigo em Inglês | MEDLINE | ID: mdl-15136974

RESUMO

Various pathological disorders have been associated with primary aldosteronism, including glucagonoma, phaeochromocytoma and primary hyperparathyroidism. In this report, a case of adrenal myelolipoma (a rare non-functioning tumour composed of mature adipose tissue and normal haematopoietic elements similar to bone marrow cells), aldosterone-producing adenoma and a pituitary microadenoma coexisting in a 62-year-old man with a 15-year history of arterial hypertension, previous ablation of an autonomously-functioning thyroid adenoma, multiple lipomas and an heterozygosity of the retinoblastoma (RB) susceptibility gene is reported. We believe that this case probably represents another variant of the multiple neoplasia syndrome and we speculate that structural alteration of the RB gene may play a role in the tumorogenesis.


Assuntos
Adenoma/genética , Adenoma/metabolismo , Neoplasias das Glândulas Suprarrenais/genética , Neoplasias das Glândulas Suprarrenais/metabolismo , Aldosterona/biossíntese , Genes do Retinoblastoma , Neoplasia Endócrina Múltipla/genética , Mielolipoma/genética , Adenoma/diagnóstico , Adenoma/patologia , Neoplasias das Glândulas Suprarrenais/diagnóstico , Neoplasias das Glândulas Suprarrenais/patologia , Variação Genética , Heterozigoto , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Mielolipoma/diagnóstico , Mielolipoma/patologia
12.
Endocr Pathol ; 14(1): 93-100, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12746567

RESUMO

Myelolipomas are benign tumors composed of both mature adipose and myeloid tissues. They typically present as an incidental mass in one of the adrenal glands proper. However, they can occur in ectopic adrenal tissue or, rarely, without associated adrenal tissue in various locations and can grow to weights of several kilograms. These tumors have been linked to endocrinopathies, such as Cushing disease and congenital adrenal hyperplasia, which involve overproduction of adrenocorticotropic hormone. We report a case of three giant adrenal myelolipomas arising in a persistently virilized female with congenital adrenal hyperplasia, supporting a role for hormonal stimuli in myelolipoma formation.


Assuntos
Neoplasias das Glândulas Suprarrenais/patologia , Mielolipoma/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Retroperitoneais/patologia , Virilismo/fisiopatologia , Neoplasias das Glândulas Suprarrenais/complicações , Neoplasias das Glândulas Suprarrenais/genética , Hiperplasia Suprarrenal Congênita/complicações , Adulto , Aberrações Cromossômicas , Feminino , Humanos , Mielolipoma/complicações , Mielolipoma/genética , Neoplasias Primárias Múltiplas/genética , Obesidade Mórbida/complicações , Neoplasias Retroperitoneais/complicações , Neoplasias Retroperitoneais/genética
13.
Cancer Genet Cytogenet ; 134(1): 77-80, 2002 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-11996801

RESUMO

Adrenal myelolipoma (ML) is a rare, benign, nonfunctioning tumor-like lesion composed of mature adipose tissue interspersed with bone marrow-like hematopoietic elements in various proportions. It occurs usually in adults and is frequently asymptomatic in about half of cases. The histogenesis of adrenal ML is not clear and this lesion has been found to be associated with endocrine disorders, other adrenal dysfunction and tumors, and hyperstimulation with adrenocorticotropic hormone. Specific chromosomal abnormalities, however, have not been observed in such cases. Herein, we report a typical case of adrenal ML found incidentally in a 26-year-old man. Conventional cytogenetic techniques demonstrated balanced translocation between bands 3q25 and 21p11 in 9 of 20 metaphases analyzed in cultured tumor cells. To the best of our knowledge, this is the first reported case of adrenal ML showing chromosomal abnormality. This finding would indicate that adrenal ML is a bona fide neoplasm and the possibility of derivation from misplaced hematopoietic cells may be alternatively taken into consideration in view of the similar genetic changes in hematopolietic neoplasms.


Assuntos
Neoplasias das Glândulas Suprarrenais/genética , Cromossomos Humanos Par 21/genética , Cromossomos Humanos Par 3/genética , Mielolipoma/genética , Translocação Genética , Neoplasias das Glândulas Suprarrenais/patologia , Adulto , Humanos , Cariotipagem , Masculino , Mielolipoma/patologia
14.
Horm Metab Res ; 32(5): 169-73, 2000 May.
Artigo em Inglês | MEDLINE | ID: mdl-10871156

RESUMO

The molecular pathogenesis of adrenal myelolipoma is unclear. Endocrine activity of these tumors and association with other endocrine tumors have stimulated the hypothesis that it may belong to the group of sporadic tumors caused by defects of the gene responsible for multiple endocrine neoplasia type I (MEN-I). DNA of blood and tumoral sections from two patients with adrenal myelolipoma were analyzed by examination of variable number of tandem repeats (VNTR) loci PYGM, D11S987, D11S480, and D11S449 on chromosome 11q13 and by complete direct DNA sequencing of all coding exons and splice junctions of the MEN-I gene. Menin expression was examined by RT-PCR. RT-PCR did not detect menin expression in one adrenal myelolipoma. No loss of heterozygozity on chromosome 11q13 was identified. Intragenic heterozygozity was retained in codon 418 of the menin gene in both patients. No mutation was identified in the coding exons of the menin gene. Complete DNA sequencing yielded no hint that defects of the MEN-I gene are responsible for the formation of adrenal myelolipomas. Adrenal myelolipomas do not share the loss of heterozygozity on chromosome 11q13 observed in some benign adenomatous and many malignant adrenocortical tumors.


Assuntos
Neoplasias das Glândulas Suprarrenais/genética , Neoplasia Endócrina Múltipla Tipo 1/genética , Mielolipoma/genética , Proteínas de Neoplasias/genética , Proteínas Proto-Oncogênicas , Análise Mutacional de DNA , Regulação Neoplásica da Expressão Gênica , Humanos , Perda de Heterozigosidade , RNA Mensageiro/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa
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