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1.
PLoS One ; 15(7): e0228309, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32722668

RESUMO

Caesarean section (CS) rates throughout Europe have risen significantly over the last two decades. As well as being an important clinical issue, these changes in mode of birth may have substantial resource implications. Policy initiatives to curb this rise have had to contend with the multiplier effect of women who had a CS for their first birth having a greater likelihood of requiring one during subsequent births, thus making it difficult to decrease CS rates in the short term. Our study examines the long-term resource implications of reducing CS rates among first-time mothers, as well as improving rates of vaginal birth after caesarean section (VBAC), among an annual cohort of women over the course of their most active childbearing years (18 to 44 years) in two public health systems in Europe. We found that the economic benefit of improvements in these two outcomes is considerable, with the net present value of the savings associated with a five-percentage-point change in nulliparous CS rates and VBAC rates being €1.1million and £9.8million per annual cohort of 18-year-olds in Ireland and England/Wales, respectively. Reductions in CS rates among first-time mothers are associated with a greater payoff than comparable increases in VBAC rates. The net present value of achieving CS rates comparable to those currently observed in the best performing Scandinavian countries was €3.5M and £23.0M per annual cohort in Ireland and England/Wales, respectively.


Assuntos
Cesárea/economia , Cesárea/estatística & dados numéricos , Atenção à Saúde/economia , Adolescente , Adulto , Atenção à Saúde/estatística & dados numéricos , Inglaterra/epidemiologia , Feminino , Custos de Cuidados de Saúde , Custos Hospitalares , Humanos , Irlanda/epidemiologia , Gravidez , Processos Estocásticos , Nascimento Vaginal Após Cesárea/economia , Nascimento Vaginal Após Cesárea/estatística & dados numéricos , País de Gales/epidemiologia , Adulto Jovem
2.
BJOG ; 126(8): 1043-1051, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-30957402

RESUMO

OBJECTIVE: To perform a health economic analysis of an intervention designed to increase rates of vaginal birth after caesarean, compared with usual care. DESIGN: Economic analysis alongside the cluster-randomised OptiBIRTH trial (Optimising childbirth by increasing vaginal birth after caesarean section (VBAC) through enhanced women-centred care). SETTING: Fifteen maternity units in three European countries - Germany (five), Ireland (five), and Italy (five) - with relatively low VBAC rates. POPULATION: Pregnant women with a history of one previous lower-segment caesarean section; sites were randomised (3:2) to intervention or control. METHODS: A cost-utility analysis from both societal and health-services perspectives, using a decision tree. MAIN OUTCOME MEASURES: Costs and resource use per woman and infant were compared between the control and intervention group by country, from pregnancy recognition until 3 months postpartum. Based on the caesarean section rates, and maternal and neonatal morbidities and mortality, the incremental cost-utility ratios were calculated per country. RESULTS: The mean difference in costs per quality-adjusted life years (QALYs) gained from a societal perspective between the intervention and the control group, using a probabilistic sensitivity analysis, was: €263 (95% CI €258-268) and 0.008 QALYs (95% CI 0.008-0.009 QALYs) for Germany, €456 (95% CI €448-464) and 0.052 QALYs (95% CI 0.051-0.053 QALYs) for Ireland, and €1174 (95% CI €1170-1178) and 0.006 QALYs (95% CI 0.005-0.007 QALYs) for Italy. The incremental cost-utility ratios were €33,741/QALY for Germany, €8785/QALY for Ireland, and €214,318/QALY for Italy, with a 51% probability of being cost-effective for Germany, 92% for Ireland, and 15% for Italy. CONCLUSION: The OptiBIRTH intervention was likely to be cost-effective in Ireland and Germany. TWEETABLE ABSTRACT: The OptiBIRTH intervention (to increase VBAC rates) is likely to be cost-effective in Germany and Ireland.


Assuntos
Análise Custo-Benefício , Serviços de Saúde Materno-Infantil/economia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Ensaios Clínicos Controlados Aleatórios como Assunto/economia , Nascimento Vaginal Após Cesárea/economia , Adulto , Análise por Conglomerados , Feminino , Alemanha , Humanos , Irlanda , Itália , Gravidez , Anos de Vida Ajustados por Qualidade de Vida
3.
BMC Pregnancy Childbirth ; 18(1): 92, 2018 04 11.
Artigo em Inglês | MEDLINE | ID: mdl-29642858

RESUMO

BACKGROUND: The OptiBIRTH study incorporates a multicentre cluster randomised trial in 15 hospital sites across three European countries. The trial was designed to test a complex intervention aimed at improving vaginal birth after caesarean section (VBAC) rates through increasing women's involvement in their care. Prior to developing a robust standardised model to conduct the health economic analysis, an analysis of a hypothetical cohort was performed to estimate the costs and health effects of VBAC compared to elective repeat caesarean delivery (ERCD) for low-risk women in four European countries. METHODS: A decision-analytic model was developed to estimate the costs and the health effects, measured using Quality Adjusted Life Years (QALYs), of VBAC compared with ERCD. A cost-effectiveness analysis for the period from confirmation of pregnancy to 6 weeks postpartum was performed for short-term consequences and during lifetime for long-term consequences, based on a hypothetical cohort of 100,000 pregnant women in each of four different countries; Belgium, Germany, Ireland and Italy. A societal perspective was adopted. Where possible, transition probabilities, costs and health effects were adapted from national data obtained from the respective countries. Country-specific thresholds were used to determine the cost-effectiveness of VBAC compared to ERCD. Deterministic and probabilistic sensitivity analyses were conducted to examine the uncertainty of model assumptions. RESULTS: Within a 6-week time horizon, VBAC resulted in a reduction in costs, ranging from €3,334,052 (Germany) to €66,162,379 (Ireland), and gains in QALYs ranging from 6399 (Italy) to 7561 (Germany) per 100,000 women birthing in each country. Compared to ERCD, VBAC is the dominant strategy in all four countries. Applying a lifetime horizon, VBAC is dominant compared to ERCD in all countries except for Germany (probabilistic analysis, ICER: €8609/QALY). In conclusion, compared to ERCD, VBAC remains cost-effective when using a lifetime time. CONCLUSIONS: In all four countries, VBAC was cost-effective compared to ERCD for low-risk women. This is important for health service managers, economists and policy makers concerned with maximising health benefits within limited and constrained resources.


Assuntos
Recesariana/economia , Procedimentos Cirúrgicos Eletivos/economia , Nascimento Vaginal Após Cesárea/economia , Adulto , Bélgica , Análise Custo-Benefício , Procedimentos Cirúrgicos Eletivos/métodos , Feminino , Alemanha , Humanos , Irlanda , Itália , Gravidez , Anos de Vida Ajustados por Qualidade de Vida
4.
Trials ; 18(1): 434, 2017 09 20.
Artigo em Inglês | MEDLINE | ID: mdl-28931404

RESUMO

BACKGROUND: Rates of cesarean delivery are continuously increasing in industrialized countries, with repeated cesarean accounting for about a third of all cesareans. Women who have undergone a first cesarean are facing a difficult choice for their next pregnancy, i.e.: (1) to plan for a second cesarean delivery, associated with higher risk of maternal complications than vaginal delivery; or (b) to have a trial of labor (TOL) with the aim to achieve a vaginal birth after cesarean (VBAC) and to accept a significant, but rare, risk of uterine rupture and its related maternal and neonatal complications. The objective of this trial is to assess whether a multifaceted intervention would reduce the rate of major perinatal morbidity among women with one prior cesarean. METHODS/DESIGN: The study is a stratified, non-blinded, cluster-randomized, parallel-group trial of a multifaceted intervention. Hospitals in Quebec are the units of randomization and women are the units of analysis. As depicted in Figure 1, the study includes a 1-year pre-intervention period (baseline), a 5-month implementation period, and a 2-year intervention period. At the end of the baseline period, 20 hospitals will be allocated to the intervention group and 20 to the control group, using a randomization stratified by level of care. Medical records will be used to collect data before and during the intervention period. Primary outcome is the rate of a composite of major perinatal morbidities measured during the intervention period. Secondary outcomes include major and minor maternal morbidity; minor perinatal morbidity; and TOL and VBAC rate. The effect of the intervention will be assessed using the multivariable generalized-estimating-equations extension of logistic regression. The evaluation will include subgroup analyses for preterm and term birth, and a cost-effectiveness analysis. DISCUSSION: The intervention is designed to facilitate: (1) women's decision-making process, using a decision analysis tool (DAT), (2) an estimate of uterine rupture risk during TOL using ultrasound evaluation of low-uterine segment thickness, (3) an estimate of chance of TOL success, using a validated prediction tool, and (4) the implementation of best practices for intrapartum management. TRIAL REGISTRATION: Current Controlled Trials, ID: ISRCTN15346559 . Registered on 20 August 2015.


Assuntos
Recesariana , Técnicas de Apoio para a Decisão , Saúde Materna , Resultado da Gravidez , Nascimento Vaginal Após Cesárea , Recesariana/efeitos adversos , Recesariana/economia , Comportamento de Escolha , Tomada de Decisão Clínica , Protocolos Clínicos , Análise Custo-Benefício , Feminino , Custos de Cuidados de Saúde , Humanos , Modelos Logísticos , Análise Multivariada , Nomogramas , Participação do Paciente , Valor Preditivo dos Testes , Gravidez , Nascimento Prematuro/etiologia , Quebeque , Projetos de Pesquisa , Fatores de Risco , Nascimento a Termo , Fatores de Tempo , Prova de Trabalho de Parto , Ultrassonografia , Ruptura Uterina/diagnóstico por imagem , Ruptura Uterina/etiologia , Nascimento Vaginal Após Cesárea/efeitos adversos , Nascimento Vaginal Após Cesárea/economia
5.
Taiwan J Obstet Gynecol ; 56(3): 286-290, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28600035

RESUMO

OBJECTIVE: We aimed to predict the perinatal outcomes and costs of health services following labour induction for late-term pregnancies. MATERIALS AND METHODS: We conducted a cohort study of 245 women who underwent labour induction during their 41st week of gestation. The cervical condition was assessed upon admission using the Bishop score and ultrasound cervical length measurements. We estimated the direct costs of labour induction, and a predictive model for perinatal outcomes was constructed using the decision tree analysis algorithm and a logit model. RESULTS: A very unfavourable Bishop score at admission (Bishop score <2) (OR, 3.43 [95% CI, 1.77-6.59]), and a history of previous caesarean section (OR, 7.72 [95% CI, 2.43-24.43]) or previous vaginal delivery (OR, 0.24 [95% CI, 0.09-0.58]) were the only variables with predictive capacity for caesarean section in our model. The mean cost of labour induction was €3465.56 (95% confidence interval [CI], 3339.53-3591.58). Unfavourable Bishop scores upon admission and no history of previous deliveries significantly increased the cost of labour induction. Both of these criteria significantly predicted the likelihood of a caesarean section in the decision tree analysis. CONCLUSION: The cost of labour induction mostly depends on the likelihood of successful trial of labour. Combined use of the Bishop score and previous vaginal or caesarean deliveries improves the ability to predict the likelihood of a caesarean section and the economic costs associated with labour induction for late-term pregnancies. This information is useful for patient counselling.


Assuntos
Cesárea/economia , Idade Gestacional , Trabalho de Parto Induzido/economia , Prova de Trabalho de Parto , Adulto , Algoritmos , Medida do Comprimento Cervical , Colo do Útero/diagnóstico por imagem , Cesárea/estatística & dados numéricos , Estudos de Coortes , Parto Obstétrico/economia , Parto Obstétrico/estatística & dados numéricos , Feminino , Hospitalização/economia , Humanos , Recém-Nascido , Masculino , Gravidez , Resultado da Gravidez , Terceiro Trimestre da Gravidez , Estudos Prospectivos , Fatores de Risco , Nascimento Vaginal Após Cesárea/economia
6.
Value Health ; 20(1): 163-173, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-28212958

RESUMO

BACKGROUND: For women who have had a previous low transverse cesarean delivery, the decision to undergo a trial of labor after cesarean (TOLAC) or an elective repeat cesarean delivery (ERCD) has important clinical and economic ramifications. OBJECTIVES: To evaluate the cost-effectiveness of the alternative choices of a TOLAC and an ERCD for women with low-risk, singleton gestation pregnancies. METHODS: We searched EMBASE, MEDLINE, CINAHL, Cochrane Library, EconLit, and the Cost-Effectiveness Analysis Registry with no language, publication, or date restrictions up until October 2015. Studies were included if they were primary research, compared a TOLAC with an ERCD, and provided information on the relative cost of the alternatives. Abstracts and partial economic evaluations were excluded. RESULTS: Of 310 studies initially reviewed, 7 studies were included in the systematic review. In the base-case analyses, 4 studies concluded that TOLAC was dominant over ERCD, 1 study found ERCD to be dominant, and 2 studies found that although TOLAC was more costly, it offered more benefits and was thus cost-effective from a population perspective when considering societal willingness to pay for better outcomes. In sensitivity analyses, cost-effectiveness was found to be dependent on a high likelihood of TOLAC success, low risk of uterine rupture, and low relative cost of TOLAC compared with ERCD. CONCLUSIONS: For women who are likely to have a successful vaginal delivery, routine ERCD may result in excess morbidity and cost from a population perspective.


Assuntos
Recesariana/economia , Prova de Trabalho de Parto , Nascimento Vaginal Após Cesárea/economia , Análise Custo-Benefício , Feminino , Humanos , Modelos Econométricos , Gravidez , Reprodutibilidade dos Testes
7.
J Matern Fetal Neonatal Med ; 29(19): 3084-8, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26566014

RESUMO

OBJECTIVE: To compare the costs between planned cesarean delivery (CD) and induction of labor (IOL) in women with class III obesity. METHODS: We conducted a cost-minimization analysis using data from a previous study of women with a BMI ≥40 kg/m(2) delivering term singletons via planned CD or after IOL. Decision trees were built with branches for two "treatments": planned CD and IOL (probabilities derived from parent study). Direct and total costs were obtained for each mother-infant pair. Sensitivity analyses for probability of successful IOL were performed. RESULTS: A total of 661 mother-infant pairs were included - 399 IOLs and 262 planned CDs. Of 399 IOLs, 236 (59%) delivered vaginally and 163 (41%) had a CD. IOL was slightly less costly. For IOL and planned CD, respectively, direct costs were $7416 versus $7474, and total costs were $11 545 versus $11 665. Sensitivity analyses indicated that IOL was the least costly strategy if the probability of vaginal delivery after IOL was >57% (0.575 for direct costs; 0.570 for total costs). There was, however, a slight cost advantage to planned CD in women with a prior cesarean. CONCLUSIONS: In women with class III obesity, IOL is less costly than planned CD if the probability of vaginal delivery after IOL in an individual patient is greater than 57%.


Assuntos
Cesárea/economia , Custos e Análise de Custo , Trabalho de Parto Induzido/economia , Obesidade Mórbida , Adulto , Cesárea/estatística & dados numéricos , Redução de Custos , Árvores de Decisões , Feminino , Humanos , Trabalho de Parto Induzido/estatística & dados numéricos , Gravidez , Complicações na Gravidez , Nascimento Vaginal Após Cesárea/economia , Adulto Jovem
8.
J Matern Fetal Neonatal Med ; 29(7): 1030-5, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-25865742

RESUMO

OBJECTIVE: Given that cesarean delivery is one of the most commonly performed surgical procedures in the United States and an important contributor to obstetric care costs, this analysis sought to examine maternal hospital costs associated with trial of labor after cesarean delivery (TOLAC) versus repeat cesarean delivery (RCD). METHODS: A national sample was used to identify women with singleton pregnancy who underwent either TOLAC or RCD from 2006 to 2012. Women with diagnoses that could confound cost via extended hospital length of stay prior to delivery were excluded. Other medical and obstetric covariates that could influence cost were included in an adjusted model. RESULTS: A total of 485,247 women were identified, including 365,596 (75.3%) cesarean deliveries without labor, 41,988 (8.6%) successful and 77,663 (16.0%) unsuccessful TOLAC deliveries. The inflation-adjusted median costs in this cohort were $5512 for cesarean without labor, $4175 for successful TOLAC, $5166 for all TOLAC attempts, and $5759 for failed TOLAC. In a multivariable model, hospital region was a major predictor of median cost as were demographic variables and medical comorbidities. CONCLUSION: TOLAC is associated with modest reductions of cost for maternal hospitalizations. However, other medical, demographic and hospital factors appear to be more important factors.


Assuntos
Complicações do Trabalho de Parto/economia , Prova de Trabalho de Parto , Nascimento Vaginal Após Cesárea/economia , Adolescente , Adulto , Recesariana/economia , Recesariana/estatística & dados numéricos , Análise Custo-Benefício , Feminino , Humanos , Recém-Nascido , Tempo de Internação/economia , Tempo de Internação/estatística & dados numéricos , Pessoa de Meia-Idade , Complicações do Trabalho de Parto/epidemiologia , Gravidez , Fatores de Risco , Estados Unidos/epidemiologia , Ruptura Uterina/economia , Ruptura Uterina/epidemiologia , Ruptura Uterina/etiologia , Ruptura Uterina/terapia , Nascimento Vaginal Após Cesárea/efeitos adversos , Nascimento Vaginal Após Cesárea/estatística & dados numéricos , Adulto Jovem
9.
Trials ; 16: 542, 2015 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-26620402

RESUMO

BACKGROUND: The proportion of pregnant women who have a caesarean section shows a wide variation across Europe, and concern exists that these proportions are increasing. Much of the increase in caesarean sections in recent years is due to a cascade effect in which a woman who has had one caesarean section is much more likely to have one again if she has another baby. In some places, it has become common practice for a woman who has had a caesarean section to have this procedure again as a matter of routine. The alternative, vaginal birth after caesarean (VBAC), which has been widely recommended, results in fewer undesired results or complications and is the preferred option for most women. However, VBAC rates in some countries are much lower than in other countries. METHODS/DESIGN: The OptiBIRTH trial uses a cluster randomised design to test a specially developed approach to try to improve the VBAC rate. It will attempt to increase VBAC rates from 25 % to 40 % through increased women-centred care and women's involvement in their care. Sixteen hospitals in Germany, Ireland and Italy agreed to join the study, and each hospital was randomly allocated to be either an intervention or a control site. DISCUSSION: If the OptiBIRTH intervention succeeds in increasing VBAC rates, its application across Europe might avoid the 160,000 unnecessary caesarean sections that occur every year at an extra direct annual cost of more than €150 million. TRIAL REGISTRATION: Current Controlled Trials ISRCTN10612254 , registered 3 April 2013.


Assuntos
Atenção à Saúde , Serviços de Saúde Materna , Assistência Centrada no Paciente , Nascimento Vaginal Após Cesárea , Protocolos Clínicos , Redução de Custos , Análise Custo-Benefício , Atenção à Saúde/economia , Europa (Continente) , Feminino , Custos de Cuidados de Saúde , Humanos , Serviços de Saúde Materna/economia , Seleção de Pacientes , Assistência Centrada no Paciente/economia , Gravidez , Estudos Prospectivos , Projetos de Pesquisa , Resultado do Tratamento , Nascimento Vaginal Após Cesárea/efeitos adversos , Nascimento Vaginal Após Cesárea/economia
10.
Am J Obstet Gynecol ; 211(1): 56.e1-56.e12, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24487008

RESUMO

OBJECTIVE: The purpose of this study was to estimate costs and outcomes of subsequent trials of labor after cesarean delivery (TOLAC) compared with elective repeat cesarean deliveries (ERCD). STUDY DESIGN: To compare TOLAC and ERCD, maternal and neonatal decision analytic models were built for each hypothetic subsequent delivery. We assumed that only women without previa would undergo TOLAC for their second delivery, that women with successful TOLAC would desire future TOLAC, and that women who chose ERCD would undergo subsequent ERCD. Main outcome measures were maternal and neonatal mortality and morbidity rates, direct costs, and quality-adjusted life years. Values were derived from the literature. One-way and Monte-Carlo sensitivity analyses were performed. RESULTS: TOLAC was less costly and more effective for most models. A progression of decreasing incremental cost and increasing incremental effectiveness of TOLAC was found for maternal outcomes with increasing numbers of subsequent deliveries. This progression was also displayed among neonatal outcomes and was most prominent when neonatal and maternal outcomes were combined, with an incremental cost and effectiveness of -$4700.00 and .073, respectively, for the sixth delivery. Net-benefit analysis showed an increase in the benefit of TOLAC with successive deliveries for all outcomes. The maternal model of the second delivery was sensitive to cost of delivery and emergent cesarean delivery. Successive maternal models became more robust, with the models of the third-sixth deliveries sensitive only to cost of delivery. Neonatal models were not sensitive to any variables. CONCLUSION: Although nearly equally effective relative to ERCD for the second delivery, TOLAC becomes less costly and more effective with subsequent deliveries.


Assuntos
Recesariana/economia , Custos de Cuidados de Saúde/estatística & dados numéricos , Prova de Trabalho de Parto , Nascimento Vaginal Após Cesárea/economia , Análise Custo-Benefício , Árvores de Decisões , Feminino , Humanos , Mortalidade Infantil , Recém-Nascido , Doenças do Recém-Nascido/economia , Mortalidade Materna , Modelos Econômicos , Método de Monte Carlo , Complicações Pós-Operatórias/economia , Gravidez , Complicações na Gravidez/economia , Resultado da Gravidez/economia , Anos de Vida Ajustados por Qualidade de Vida , Estados Unidos
11.
Appl Health Econ Health Policy ; 11(6): 561-76, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24155076

RESUMO

The caesarean section rate has continued to increase in most industrialised countries, which raises a number of economic concerns. This review provides an overview of the health economic implications of elective caesarean section. It provides a succinct summary of the health consequences associated with elective caesarean section for both the infant and the mother over the perinatal period and beyond. It highlights factors that complicate our understanding of the health consequences of elective caesarean section, including inconsistencies in definitions and coding of the procedure, failure to adopt an intention-to-treat principle when drawing comparisons, and the widespread reliance on observational data. The paper then summarises the economic costs associated with elective caesarean section. Evidence is presented to suggest that planned caesarean section may be less costly than planned vaginal birth in some clinical contexts, for example where the singleton fetus lies in a breech position at term. In contrast, elective caesarean section (or caesarean section as a whole) appears to be more costly than vaginal delivery (either spontaneous or instrumented) in low-risk or unselected populations. The paper proceeds with an overview of economic evaluations associated with elective caesarean section. All are currently based on decision-analytic models. Evidence is presented to suggest that planned trial of labour (attempted vaginal birth) following a previous caesarean section appears to be a more cost-effective option than elective caesarean section, although its cost effectiveness is dependent upon the probability of successful vaginal delivery. There is conflicting evidence on the cost effectiveness of maternal request caesareans when compared with trial of labour. The paucity of evidence on the value pregnant women, clinicians and other groups in society place on the option of elective caesarean section is highlighted. Techniques that might be used to elicit preferences for elective caesarean section and its attributes are outlined. The review concludes with directions for future research in this area.


Assuntos
Cesárea/economia , Procedimentos Cirúrgicos Eletivos/economia , Codificação Clínica , Análise Custo-Benefício , Feminino , Humanos , Recém-Nascido , Análise de Intenção de Tratamento , Gravidez , Resultado da Gravidez , Nascimento Vaginal Após Cesárea/economia
12.
Value Health ; 16(6): 953-64, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24041345

RESUMO

OBJECTIVE: To estimate the cost-effectiveness of a trial of labor after one previous cesarean (TOLAC) when incorporating long-term events and outcomes. METHODS: A Markov model comparing TOLAC with elective repeat cesarean delivery (ERCD) was developed for a hypothetical cohort with no contraindication to a TOLAC. Women were selected from a prospective study to derive probability estimates for potential events through three subsequent pregnancies. Probabilities for cerebral palsy and stress urinary incontinence, cost data, and quality-adjusted life-years (QALYs) were obtained from the literature. The primary outcome was cost-effectiveness measured as the marginal cost per QALY gained, with a $50,000 threshold per QALY used to define cost-effectiveness. RESULTS: The TOLAC strategy dominated the ERCD strategy at baseline, with $164.2 million saved and 500 QALYs gained per 100,000 women. The model was sensitive to six variables: the probability of uterine rupture and successful TOLAC among women with no prior vaginal delivery, the frequency of stress urinary incontinence, and the costs of failed TOLAC, successful TOLAC, and ERCD. When the probability of TOLAC success was at the base value, 67.2%, TOLAC was preferred if the probability of uterine rupture was 3.1% or less. When the probability of uterine rupture was at the base value, 0.8%, the TOLAC strategy was preferred as long as the probability of success was 47.2% or more. Probabilistic sensitivity analysis confirmed the base-case analysis. CONCLUSIONS: Under baseline circumstances, TOLAC is less expensive and more effective than an ERCD when considering long-term consequences when the likelihood of success is 47.2% or more.


Assuntos
Complicações na Gravidez/economia , Anos de Vida Ajustados por Qualidade de Vida , Prova de Trabalho de Parto , Nascimento Vaginal Após Cesárea/economia , Adulto , Idoso , Comportamento de Escolha , Análise Custo-Benefício , Procedimentos Cirúrgicos Eletivos , Feminino , Humanos , Cadeias de Markov , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Gravidez , Complicações na Gravidez/epidemiologia , Probabilidade , Estados Unidos/epidemiologia
13.
PLoS One ; 8(3): e58577, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23484038

RESUMO

BACKGROUND: Elective repeat caesarean delivery (ERCD) rates have been increasing worldwide, thus prompting obstetric discourse on the risks and benefits for the mother and infant. Yet, these increasing rates also have major economic implications for the health care system. Given the dearth of information on the cost-effectiveness related to mode of delivery, the aim of this paper was to perform an economic evaluation on the costs and short-term maternal health consequences associated with a trial of labour after one previous caesarean delivery compared with ERCD for low risk women in Ireland. METHODS: Using a decision analytic model, a cost-effectiveness analysis (CEA) was performed where the measure of health gain was quality-adjusted life years (QALYs) over a six-week time horizon. A review of international literature was conducted to derive representative estimates of adverse maternal health outcomes following a trial of labour after caesarean (TOLAC) and ERCD. Delivery/procedure costs derived from primary data collection and combined both "bottom-up" and "top-down" costing estimations. RESULTS: Maternal morbidities emerged in twice as many cases in the TOLAC group than the ERCD group. However, a TOLAC was found to be the most-effective method of delivery because it was substantially less expensive than ERCD (€ 1,835.06 versus € 4,039.87 per women, respectively), and QALYs were modestly higher (0.84 versus 0.70). Our findings were supported by probabilistic sensitivity analysis. CONCLUSIONS: Clinicians need to be well informed of the benefits and risks of TOLAC among low risk women. Ideally, clinician-patient discourse would address differences in length of hospital stay and postpartum recovery time. While it is premature advocate a policy of TOLAC across maternity units, the results of the study prompt further analysis and repeat iterations, encouraging future studies to synthesis previous research and new and relevant evidence under a single comprehensive decision model.


Assuntos
Cesárea/efeitos adversos , Cesárea/economia , Prova de Trabalho de Parto , Nascimento Vaginal Após Cesárea/economia , Análise Custo-Benefício , Técnicas de Apoio para a Decisão , Feminino , Humanos , Irlanda , Gravidez , Anos de Vida Ajustados por Qualidade de Vida
14.
Am J Perinatol ; 30(1): 11-20, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23292916

RESUMO

OBJECTIVE: To estimate the cost-effectiveness of a trial of labor after one previous cesarean delivery (TOLAC). STUDY DESIGN: A model comparing TOLAC with elective repeat cesarean delivery (ERCD) was developed for a hypothetical cohort with no contraindication to a TOLAC. Probabilistic estimates were obtained from women matched on their baseline characteristics using propensity scores. Cost data, quality-adjusted life-years (QALYs), and data on cerebral palsy were incorporated from the literature. RESULTS: The TOLAC strategy dominated the ERCD strategy at baseline, with $138.6 million saved and 1703 QALYs gained per 100,000 women. The model was sensitive to five variables: the probability of uterine rupture, the probability of successful TOLAC, the QALY of failed TOLAC, the cost of ERCD, and the cost of successful TOLAC without complications. When the probability of TOLAC success was at the base value, 68.5%, TOLAC was preferred if the probability of uterine rupture was 4.2% or less. When the probability of uterine rupture was at the base value, 0.8%, the TOLAC strategy was preferred as long as the probability of success was 42.6% or more. CONCLUSION: A TOLAC is less expensive and more effective than an ERCD in a group of women with balanced baseline characteristics.


Assuntos
Recesariana/economia , Prova de Trabalho de Parto , Nascimento Vaginal Após Cesárea/economia , Paralisia Cerebral/economia , Análise Custo-Benefício , Árvores de Decisões , Procedimentos Cirúrgicos Eletivos/economia , Feminino , Humanos , Método de Monte Carlo , Gravidez , Probabilidade , Anos de Vida Ajustados por Qualidade de Vida , Ruptura Uterina/economia
15.
Biosci Trends ; 5(4): 139-50, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21914948

RESUMO

Cesarean sections sometimes save the lives of mothers and babies; however, they are excessively used compared to medical necessity, which is influenced by various factors that are explored in this article. Since, in most cases the risks of cesarean sections are greater than the benefits, particularly in cesareans that are not medically indicated, it is astonishing that cesarean surgery is the most common surgical procedure, taking away resources from medically necessary care. While economic incentive is counted among the reasons for the increasing cesarean trend, the situation is not so simple since many factors interact to cause the trend. Since reversal of the vaginal birth after cesarean (VBAC) trend downward is correlated with revised policy statements by e.g. American College of Obstetricians and Gynecologists (ACOG), which have since been partially moderated, it became much more difficult for medical institutions to provide VBACs due to concerns about liability. Although whether to give birth by cesarean delivery is a matter for informed consent, yet childbearing women are influenced significantly by their health service providers' opinions. Even though the World Health Organization (WHO) recommends the most peripheral level of maternity care for normal pregnancy and childbirth that is safe using midwives, yet the percentage of midwife deliveries is low. Among other things, it has been suggested that more childbirth by midwife delivery and in out-of-hospital settings can reduce medically unnecessary cesareans and the undue risks associated with them, and free up medical resources for those in need.


Assuntos
Cesárea/tendências , Cesárea/efeitos adversos , Cesárea/economia , Países Desenvolvidos/estatística & dados numéricos , Países em Desenvolvimento/estatística & dados numéricos , Feminino , Humanos , Tocologia/economia , Tocologia/tendências , Guias de Prática Clínica como Assunto , Gravidez , Medição de Risco , Nascimento Vaginal Após Cesárea/efeitos adversos , Nascimento Vaginal Após Cesárea/economia , Nascimento Vaginal Após Cesárea/tendências , Organização Mundial da Saúde
16.
Semin Perinatol ; 34(5): 311-3, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20869545

RESUMO

Hospital administrators are most concerned with the quality of medical care. With specific regard to vaginal birth after cesarean, it is essential that the surgical personnel and anesthesia be able to intervene in a timely manner for an obstetrical emergency. Other considerations are patient satisfaction, perception by the community, and cost. Budgets and balancing resources are important factors but pale in decision-making compared with the ill-publicity and medicolegal risk associated with an untoward outcome.


Assuntos
Atitude do Pessoal de Saúde , Recesariana , Administradores Hospitalares , Prova de Trabalho de Parto , Recesariana/efeitos adversos , Recesariana/economia , Feminino , Custos de Cuidados de Saúde , Humanos , Satisfação do Paciente , Gravidez , Opinião Pública , Resultado do Tratamento , Nascimento Vaginal Após Cesárea/efeitos adversos , Nascimento Vaginal Após Cesárea/economia
18.
J Perinatol ; 29(11): 721-5, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19861969

RESUMO

Respect for patient autonomy remains a foundational principle guiding the ethical practice of medicine-a mission first articulated by Hippocrates. Damocles, another figure from ancient Greece, provides a useful parable for describing performance under distress: Damocles loses his desire for opulence and power when he notices a sword dangling precariously above his head. Contemporary obstetricians deciding whether to forestall or impose major abdominal surgery on parturients entrusted to their care struggle valiantly in the chasm dividing Hippocratic idealism from the economic realism driven by the medicolegal sword of Damocles. Given the inherent risk of unforeseeable and unsalvageable fetal catastrophe during labor and vaginal delivery, and the often unsubstantiated, yet automatic, allegation of negligence that follows a labor-associated adversity, obstetricians-and their liability insurance carriers-have recalibrated obstetric practice in alignment with the increasingly risk-averse preferences of most patients. Indeed, less intrapartum risk for patients and less corresponding medicolegal exposure for obstetricians help explain the rising cesarean delivery rate and, more importantly, the steady disappearance of higher-risk interventions such as vaginal birth after cesarean (VBAC). Is this increasing reluctance to offer VBAC supervision ethically defensible? This paper argues that it is. Fiduciary professionalism mandates physician self-sacrifice, not self-destruction; a VBAC gone awry without negligence or substandard care may, nevertheless, render future affordable liability coverage unattainable. Yet, the unavailability of VBAC infringes on the autonomy of women who want to assume the intrapartum risks of a VBAC in lieu of a repeat cesarean delivery. The proposed solution is the regionalization of VBAC care provision in designated medical centers and/or the implementation of binding arbitration in an ethical trade-off to enhance patient autonomy regarding the preferred mode of delivery despite parallel constraint on legal options.


Assuntos
Cesárea/economia , Juramento Hipocrático , Imperícia/economia , Obstetrícia/economia , Autonomia Pessoal , Padrões de Prática Médica/economia , Cesárea/ética , Recesariana/economia , Recesariana/ética , Análise Custo-Benefício/ética , Medicina Defensiva/economia , Medicina Defensiva/ética , Ética Médica , Feminino , Humanos , Recém-Nascido , Seguro de Responsabilidade Civil/economia , Seguro de Responsabilidade Civil/ética , Obstetrícia/ética , Padrões de Prática Médica/ética , Gravidez , Fatores de Risco , Gestão de Riscos/economia , Gestão de Riscos/ética , Estados Unidos , Nascimento Vaginal Após Cesárea/economia , Nascimento Vaginal Após Cesárea/ética
19.
Matern Child Health J ; 12(2): 266-74, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17549614

RESUMO

OBJECTIVE: To assess the impact of the HealthChoice program in Maryland on cesarean section and vaginal birth after C-section deliveries. STUDY DESIGN: Pre-post design using a comparison group with Maryland State Inpatient Databases, part of the Healthcare Cost and Utilization Project, developed by the Agency for Healthcare Research and Quality. Although the combined 1995 and 2000 database contained over 1.2 million inpatient discharge records, the analysis included all hospital discharge abstracts for women in labor. To identify the delivery, Diagnoses-Related Groups (DRGs) 370-375 were used from the discharge data. Together, there were 128,743 births identified in both years. METHODS: Pregnant women enrolled in Medicaid managed care were compared pre-implementation and post implementation with pregnant women delivering babies under private insurance. The analysis computed difference-in-differences estimates using a logistic regression model that controlled for maternal characteristics, payment source, labor and delivery complications, and hospital characteristics. The outcome variables included Primary Cesarean, Repeat Cesarean, and Vaginal Birth after C-section. RESULTS: These results suggest that Medicaid managed care enrollees were less likely to undergo cesarean section deliveries relative to privately insured beneficiaries. Medicaid MCOs may have done a better job of limiting the growth in overused procedures than did MCOs and providers for privately insured women. CONCLUSION: This study has shown that there has been an overall increase in the use of primary and repeat cesarean sections in Maryland hospitals. However, HealthChoice limited this increase for Medicaid enrollees relative to privately insured women. On the other hand, vaginal births after C-section have declined in Maryland.


Assuntos
Cesárea/estatística & dados numéricos , Programas de Assistência Gerenciada/estatística & dados numéricos , Medicaid/estatística & dados numéricos , Setor Privado/estatística & dados numéricos , Nascimento Vaginal Após Cesárea/estatística & dados numéricos , Adolescente , Adulto , Cesárea/economia , Bases de Dados Factuais , Feminino , Humanos , Cobertura do Seguro , Seguro Saúde , Modelos Logísticos , Programas de Assistência Gerenciada/economia , Maryland , Medicaid/economia , Gravidez , Estudos Retrospectivos , Estados Unidos , Nascimento Vaginal Após Cesárea/economia
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