The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as "an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern," based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5-267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6-1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as "Low CTE" or "High CTE" for use in future clinical, pathological, and molecular studies.

Clasificación internacional del funcionamiento, de la discapacidad y de la salud en Rehabilitación: de la teoría a la práctica / The international classification of functioning, disability and health in rehabilitation: from the theory to the practice

Objetivo: La Clasificación internacional del funcionamiento, de la discapacidad y de la salud fue creada en el 2001 con el fin de proporcionar un marco conceptualmente universal para clasificar y describir el funcionamiento, la discapacidad y la salud desde una perspectiva biopsicosocial. El uso de esta clasificación es enormemente útil en el campo de la Rehabilitación, ya que permite describir el estado de salud de un paciente de forma global, universal y, además, etiológicamente neutral. Resultados: No obstante, la gran cantidad de categorías de la Clasificación internacional del funcionamiento, de la discapacidad y de la salud la hacen poco práctica en la realidad diaria, por lo que el objetivo de este artículo es el de presentar las diferentes iniciativas que existen sobre el desarrollo de nuevas herramientas de trabajo basadas en ella que posibilitan su uso en las diferentes prácticas profesionales (AU)

Objetive: The International Classification of Functioning, Disability and Health was created in 2001 with the aim of promoting a universally accepted conceptual framework to classify and describe functioning, disability and health from a biopsycosocial perspective. This classification is very useful in the rehabilitation field because it provides a way of describing the health status of a patient based on an universally globally agreed perspective and moreover neutral. Results: Nevertheless, the great number of categories from the ICF, makes it unpractical for the daily reality, therefore the objetive of this article is to present the diferent initiatives that exist in the developing of different new tools to posibilitate the use of the ICF in different sectors (AU)