RESUMO
Concerns regarding resource expenditures have been expressed about the 2012 NIA-AA Sponsored Guidelines for neuropathologic assessment of Alzheimer disease (AD) and related dementias. Here, we investigated a cost-reducing Condensed Protocol and its effectiveness in maintaining the diagnostic performance of Guidelines in assessing AD, Lewy body disease (LBD), microvascular brain injury, hippocampal sclerosis (HS), and congophilic amyloid angiopathy (CAA). The Condensed Protocol consolidates the same 20 regions into 5 tissue cassettes at â¼75% lower cost. A 28 autopsy brain-retrospective cohort was selected for varying levels of neuropathologic features in the Guidelines (Original Protocol), as well as an 18 consecutive autopsy brain prospective cohort. Three neuropathologists at 2 sites performed blinded evaluations of these cases. Lesion specificity was similar between Original and Condensed Protocols. Sensitivities for AD neuropathologic change, LBD, HS, and CAA were not substantially impacted by the Condensed Protocol, whereas sensitivity for microvascular lesions (MVLs) was decreased. Specificity for CAA was decreased using the Condensed Protocol when compared with the Original Protocol. Our results show that the Condensed Protocol is a viable alternative to the NIA-AA guidelines for AD neuropathologic change, LBD, and HS, but not MVLs or CAA, and may be a practical alternative in some practice settings.
Assuntos
Doença de Alzheimer/economia , Doença de Alzheimer/patologia , Redução de Custos/normas , National Institute on Aging (U.S.)/economia , National Institute on Aging (U.S.)/normas , Guias de Prática Clínica como Assunto/normas , Encéfalo/patologia , Estudos de Coortes , Redução de Custos/métodos , Humanos , Estudos Prospectivos , Estudos Retrospectivos , Método Simples-Cego , Estados UnidosRESUMO
Identifying knowledge gaps and research opportunities in cancer and aging research was the focus of a three-part conference series led by the Cancer and Aging Research Group from 2010 to 2015. The third meeting, featured representatives from the NIA, NCI, ACS and PCORI each of whom discussed research priorities and funding opportunities in cancer and aging at their respective agencies. This manuscript reports on the proceedings of that conference with a specific focus on funding priorities for interventions to improve the quality of life and survivorship of older adults with cancer. Helpful tips from each funder regarding writing a scientifically strong research proposal are presented.
Assuntos
Envelhecimento , Sobreviventes de Câncer , Neoplasias , Qualidade de Vida , Apoio à Pesquisa como Assunto/organização & administração , Sobrevivência , Idoso , American Cancer Society/economia , Pesquisa Biomédica , Sobreviventes de Câncer/psicologia , Humanos , National Cancer Institute (U.S.)/economia , National Institute on Aging (U.S.)/economia , National Institutes of Health (U.S.)/economia , Neoplasias/psicologia , Neoplasias/terapia , Avaliação de Resultados da Assistência ao Paciente , Assistência Centrada no Paciente , Estados UnidosAssuntos
Envelhecimento/fisiologia , Geriatria/tendências , Serviços de Saúde para Idosos/tendências , Dinâmica Populacional/tendências , Idoso , Envelhecimento/efeitos dos fármacos , Envelhecimento/genética , Senescência Celular/efeitos dos fármacos , Senescência Celular/genética , Senescência Celular/fisiologia , Controle de Custos/métodos , Geriatria/economia , Custos de Cuidados de Saúde/tendências , Gastos em Saúde/tendências , Serviços de Saúde para Idosos/economia , Humanos , Expectativa de Vida/tendências , National Institute on Aging (U.S.)/economia , Medicina Preventiva/economia , Medicina Preventiva/tendências , Apoio à Pesquisa como Assunto , Estados UnidosRESUMO
PURPOSE OF THE STUDY: The present study examined the characteristics of health disparities grants funded by National Institute on Aging (NIA) from 2000 to 2010. Objectives were (a) to examine longitudinal trends in health disparities-related grants funded by NIA and (b) to identify moderators of these trends. DESIGN AND METHODS: Our primary data source was the National Institutes of Health Research Portfolio Online Reporting Tools Expenditures and Results (RePORTER) system. The RePORTER data were merged with data from the Carnegie Classification of Institutions of Higher Education. General linear models were used to examine the longitudinal trends and how these trends were associated with type of grant and institutional characteristics. RESULTS: NIA funded 825 grants on health disparities between 2000 and 2010, expending approximately 330 million dollars. There was an overall linear increase over time in both the total number of grants and amount of funding, with an outlying spike during 2009. These trends were significantly influenced by several moderators including funding mechanism and type of institution. IMPLICATIONS: The findings highlight NIA's current efforts to fund health disparities grants to reduce disparities among older adults. Gerontology researchers may find this information very useful for their future grant submissions.
