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1.
Sci Rep ; 10(1): 19612, 2020 11 12.
Artigo em Inglês | MEDLINE | ID: mdl-33184342

RESUMO

Massive hepatic necrosis after therapeutic embolization has been reported. We employed a 320-detector CT scanner to compare liver perfusion differences between blunt liver trauma patients treated with embolization and observation. This prospective study with informed consent was approved by institution review board. From January 2013 to December 2016, we enrolled 16 major liver trauma patients (6 women, 10 men; mean age 34.9 ± 12.8 years) who fulfilled inclusion criteria. Liver CT perfusion parameters were calculated by a two-input maximum slope model. Of 16 patients, 9 received embolization and 7 received observation. Among 9 patients of embolization group, their arterial perfusion (78.1 ± 69.3 versus 163.1 ± 134.3 mL/min/100 mL, p = 0.011) and portal venous perfusion (74.4 ± 53.0 versus 160.9 ± 140.8 mL/min/100 mL, p = 0.008) were significantly lower at traumatic parenchyma than at non-traumatic parenchyma. Among 7 patients of observation group, only portal venous perfusion was significantly lower at traumatic parenchyma than non-traumatic parenchyma (132.1 ± 127.1 vs. 231.1 ± 174.4 mL/min/100 mL, p = 0.018). The perfusion index between groups did not differ. None had massive hepatic necrosis. They were not different in age, injury severity score and injury grades. Therefore, reduction of both arterial and portal venous perfusion can occur when therapeutic embolization was performed in preexisting major liver trauma, but hepatic perfusion index may not be compromised.


Assuntos
Embolização Terapêutica/métodos , Fígado/diagnóstico por imagem , Fígado/lesões , Imagem de Perfusão/métodos , Ferimentos não Penetrantes/diagnóstico por imagem , Ferimentos não Penetrantes/terapia , Adulto , Embolização Terapêutica/efeitos adversos , Feminino , Artéria Hepática , Humanos , Masculino , Necrose Hepática Massiva/diagnóstico por imagem , Necrose Hepática Massiva/etiologia , Pessoa de Meia-Idade , Perfusão , Veia Porta , Estudos Prospectivos , Tomografia Computadorizada por Raios X , Adulto Jovem
4.
Acta Cardiol ; 64(1): 95-7, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19317305

RESUMO

A 60-year-old man without any history of cardiac disease was admitted for fulminant hepatic failure (FHF) with coma which revealed severe dilated cardiomyopathy. The patient improved with an adapted medical treatment and was finally discharged from the hospital. Congestive heart failure is a rare cause of FHF, but an important differential diagnosis because it has a specific and potentially efficient treatment.


Assuntos
Cardiomiopatia Dilatada/complicações , Coma/etiologia , Necrose Hepática Massiva/etiologia , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Aspirina/uso terapêutico , Cardiomiopatia Dilatada/diagnóstico por imagem , Diagnóstico Diferencial , Diuréticos/uso terapêutico , Humanos , Masculino , Necrose Hepática Massiva/diagnóstico por imagem , Pessoa de Meia-Idade , Inibidores da Agregação Plaquetária/uso terapêutico , Fatores de Risco , Ultrassonografia
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