RESUMO
Brooke-Spiegler syndrome is a rare genetic condition associated with adnexal and epidermal tumours. Facial trichoepitheliomas and cylindromas are particularly distressing to sufferers. Conventional treatment can be followed by recurrence. We report a case with disfiguring trichoepithelioma treated with erbium:Yag and CO2 laser, achieving a good cosmetic result without recurrence after 2 years. Brooke-Spiegler syndrome and its treatment are reviewed.
Assuntos
Neoplasias Faciais/radioterapia , Terapia a Laser , Síndromes Neoplásicas Hereditárias/radioterapia , Adulto , Feminino , Humanos , Neoplasia de Células Basais/radioterapia , Neoplasias Cutâneas/radioterapia , SíndromeRESUMO
BACKGROUND: Multiple trichoepitheliomas are transmitted in an autosomal dominant fashion and can be clinically disfiguring. As with other dermal tumors, destructive techniques such as cryotherapy, electrodesiccation, and radiation therapy can improve the cosmetic appearance, but each of these treatments carries a significant risk of side effects and recurrence. OBJECTIVE: We describe a patient with a severe case of recurrent multiple trichoepitheliomas following excision, cryotherapy, and electrodesiccation. RESULTS: Treatment with a high-energy, pulsed carbon dioxide laser produced an excellent clinical response with no recurrence noted in the treated area for 12 months. CONCLUSION: Laser vaporization of trichoepitheliomas using a pulsed carbon dioxide delivery system may provide superior clinical results without scanning and evidence of regrowth.
Assuntos
Neoplasias Faciais/cirurgia , Terapia a Laser , Neoplasia de Células Basais/cirurgia , Neoplasias Cutâneas/cirurgia , Dióxido de Carbono , Crioterapia/efeitos adversos , Eletrocirurgia/efeitos adversos , Neoplasias Faciais/genética , Neoplasias Faciais/radioterapia , Seguimentos , Genes Dominantes , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/cirurgia , Neoplasia de Células Basais/genética , Neoplasia de Células Basais/radioterapia , Fatores de Risco , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/radioterapiaRESUMO
Because of the location of skin tumors, afflicted dogs and cats are frequently presented to veterinarians for examination. The location also facilitates the use of radiation therapy for patients with skin tumors. Few animals treated with radiation therapy for skin tumors experience significant toxicity. Animals with a variety of skin tumors can benefit from treatment with radiation therapy. These tumors include mast cell tumors, squamous cell carcinoma, tumors of the digit, tumors of the ear canal, tumors of the cutaneous adnexa, mammary gland tumors, plasma cell tumors, cutaneous melanoma, cutaneous hemangiosarcoma, and transmissible venereal tumors. The prognosis for individual patients varies with the tumor type and, in some cases, with the stage of the disease.
Assuntos
Doenças do Gato/radioterapia , Doenças do Cão/radioterapia , Neoplasias Cutâneas/veterinária , Adenocarcinoma/patologia , Adenocarcinoma/radioterapia , Adenocarcinoma/veterinária , Adenoma/patologia , Adenoma/radioterapia , Adenoma/veterinária , Animais , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/radioterapia , Carcinoma de Células Escamosas/veterinária , Doenças do Gato/patologia , Gatos , Doenças do Cão/patologia , Cães , Hemangiossarcoma/patologia , Hemangiossarcoma/radioterapia , Hemangiossarcoma/veterinária , Sarcoma de Mastócitos/patologia , Sarcoma de Mastócitos/radioterapia , Sarcoma de Mastócitos/veterinária , Melanoma/patologia , Melanoma/radioterapia , Melanoma/veterinária , Neoplasia de Células Basais/patologia , Neoplasia de Células Basais/radioterapia , Neoplasia de Células Basais/veterinária , Plasmocitoma/patologia , Plasmocitoma/radioterapia , Plasmocitoma/veterinária , Radioterapia (Especialidade) , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/radioterapiaRESUMO
Trichoepitheliomas are rare skin tumors which can cause significant cosmetic and functional impairment when they occur in the head and neck area. Multiple methods of treatment including plastic surgery, dermabrasion, cryosurgery and laser surgery have been reported in the literature. A 32-year-old male with multiple coalesced lesions in his ear canals was treated with radiation therapy after he failed more conventional methods of treatment. He is free of tumor in the radiated area 17.5 months after treatment with significant functional improvement. Various aspects of this tumor were reviewed. More data are still needed to define the proper place for radiation in the management of this disease.
