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2.
J Comp Pathol ; 123(1): 59-63, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10906257

RESUMO

This report describes an uncommon case of a cutaneous epitheliotropic T-cell lymphosarcoma with central nervous system (CNS) manifestations in a 9-year-old mixed breed German shepherd dog. The animal had a history of sudden blindness, pyrexia and multifocal areas of hyperaemia in the oral mucosa. A biopsy from the muco-cutaneous junction of the lips led to the diagnosis of an epitheliotropic lymphosarcoma and the animal was humanely destroyed. At necropsy, hyperaemia in the oral mucosa was no longer detectable. In the brain, a mass effacing the optic chiasm and invading the hypothalamic area was found; histological examination revealed lymphoid tumour cell infiltration. In the epithelium of the oral mucosa, intra-epithelial lymphoid tumour cells, sometimes arranged in small clusters (Pautrier's microabscesses), in combination with a mild inflammation in the superficial dermis were observed. Skin and brain tumour cells expressed CD3 antigen, indicating their T-cell origin. This is, to our knowledge, the first report of a cutaneous epitheliotropic lymphosarcoma with CNS metastasis in a dog.


Assuntos
Doenças do Cão/patologia , Neoplasias Hipotalâmicas/veterinária , Micose Fungoide/veterinária , Neoplasias Cutâneas/veterinária , Animais , Complexo CD3/química , Cães , Evolução Fatal , Neoplasias Hipotalâmicas/química , Neoplasias Hipotalâmicas/secundário , Técnicas Imunoenzimáticas/veterinária , Micose Fungoide/química , Micose Fungoide/patologia , Neoplasias Cutâneas/química , Neoplasias Cutâneas/patologia , Linfócitos T/química , Linfócitos T/patologia
3.
Childs Nerv Syst ; 9(2): 100-3, 1993 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-7686451

RESUMO

Insulin-like growth factor (IGF)-I, -II and IGF-binding proteins (IGFBPs) were demonstrated in the cyst fluid of a patient with a hypothalamic astrocytoma. The astrocytoma cyst fluid was subjected to gel chromatography at low pH and the IGF-I and IGF-II levels were measured by specific radioimmunoassays. Immunoreactive IGF-I and IGF-II levels were 19 ng/ml and 78 ng/ml respectively. Several-fold higher IGF-II values were obtained when cyst fluid was not extracted or was extracted with acid ethanol before radioimmunoassay analysis. The immunoreactive IGFBP-1 concentration was 26 ng/ml. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and subsequent Western ligand blotting with [125I]IGF-II revealed bands at approximately 200, 34.5, 29.5, 24 and 21 kD as visualized by autoradiography. Binding studies demonstrated that these binding proteins bind specifically [125I]IGF-I and [125I]IGF-II. These observations suggest that IGFs as well as IGF-binding proteins are produced by astrocytoma cells and may act in a paracrine or autocrine fashion capable of modulating the growth of astrocytoma tumours.


Assuntos
Proteínas de Transporte/análise , Glioblastoma/química , Inibidores do Crescimento/análise , Neoplasias Hipotalâmicas/química , Fator de Crescimento Insulin-Like II/análise , Fator de Crescimento Insulin-Like I/análise , Western Blotting , Pré-Escolar , Cromatografia em Gel , Glioblastoma/cirurgia , Humanos , Neoplasias Hipotalâmicas/cirurgia , Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina , Masculino , Radioimunoensaio
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