RESUMO
COX-2 expression was studied using an immunohistochemical method in 75 patients with pseudomyxoma peritonei (PMP). Twenty-five patients presented with disseminated peritoneal adenomucinosis (DPAM) and 50 with peritoneal mucinous carcinomatosis (PMCA). COX-2 was expressed in neoplastic mucinous epithelium of 30 cases (40%): 20 in PMCA (40%), 10 in DPAM (40%). Weak COX-2 expression was also noted in four of five patients with appendiceal mucinous neoplasms without peritoneal dissemination. In addition, COX-2 was detected in stromal, endothelial, inflammatory cells and reactive mesothelium. This preliminary information indicates a potential for the use of COX-2 inhibitors in patients with PMP.
Assuntos
Ciclo-Oxigenase 2/metabolismo , Proteínas de Membrana/metabolismo , Neoplasias Peritoneais/enzimologia , Pseudomixoma Peritoneal/enzimologia , Adenocarcinoma Mucinoso/diagnóstico , Adenocarcinoma Mucinoso/enzimologia , Adenocarcinoma Mucinoso/secundário , Adulto , Idoso , Neoplasias do Apêndice/diagnóstico , Neoplasias do Apêndice/enzimologia , Neoplasias do Apêndice/secundário , Cistadenoma Mucinoso/diagnóstico , Cistadenoma Mucinoso/enzimologia , Cistadenoma Mucinoso/secundário , Células Endoteliais/enzimologia , Células Endoteliais/patologia , Epitélio/enzimologia , Epitélio/patologia , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Neoplasias Peritoneais/diagnóstico , Neoplasias Peritoneais/secundário , Prognóstico , Estudos Prospectivos , Pseudomixoma Peritoneal/complicações , Pseudomixoma Peritoneal/diagnóstico , Receptor ErbB-2/metabolismo , Células Estromais/enzimologia , Células Estromais/patologiaRESUMO
An unusual case of carcinoma of the prostate with metastases is described. the prostate and the metastases showed adenocarcinoma with carcinoid-like areas. A tumor with the same histologic features was found at the tip of the appendix and proved to be metastatic. The possibility of primary carcinoid of the prostate was considered; however, Fontana-Masson stain and electron microscopy failed to confirm this. Immunoperoxidase stain for prostatic acid phosphatase was done on the prostate and metastases. This stain is specific for tissues of prostatic origin. The stain was positive in the carcinoid-like areas, indicating that it was not a true carcinoid but rather prostatic carcinoma with a carcinoid-like pattern. Apparently, this is the first case of a metastatic prostatic carcinoma showing carcinoid-like areas that were positive for prostatic acid phosphatase.
