RESUMO
Unilateral maxillary sinusitis was experimentally induced in New Zealand White rabbits with Streptococcus pneumoniae serotype 3, Bacteroides fragilis NCTC 9343, and Staphylococcus aureus V8. In another group of rabbits, sinusitis was induced by blocking of the sinus ostium only. Bacteriologic and light microscopic analysis was performed after 5 days to 1 month. Granulation-like polyps developed after deep mucosal inflammatory trauma initiating fibroblast proliferation, angiogenesis, and epithelial migration to cover the polyp. In regions of a more superficial trauma-characterized by epithelial desquamation and fibroblast growth-proliferation and differentiation of basal cells resulted in the formation of microcavities dissecting off edematous polyps. Polyps could be found in all sinusitis groups, irrespective of inducing agent. The cellular events of polyp formation appear to be the result of a continuous inflammatory reaction and are not directly related to the presence of a certain microorganism. Instead, the potential of any microorganism to induce a deep mucosal trauma or epithelial desquamation seems essential for its ability to initiate polyp formation.
Assuntos
Neoplasias do Seio Maxilar/microbiologia , Pólipos Nasais/microbiologia , Pólipos/microbiologia , Animais , Bacteroides fragilis/patogenicidade , Seio Maxilar/patologia , Neoplasias do Seio Maxilar/patologia , Sinusite Maxilar/microbiologia , Mucosa Nasal/patologia , Pólipos Nasais/patologia , Pólipos/patologia , Coelhos , Staphylococcus aureus/patogenicidade , Streptococcus pneumoniae/patogenicidade , VirulênciaAssuntos
Herpesvirus Humano 4/isolamento & purificação , Transplante de Rim , Linfoma de Células T/diagnóstico , Linfoma de Células T/microbiologia , Neoplasias do Seio Maxilar/diagnóstico , Neoplasias do Seio Maxilar/microbiologia , Adulto , Antígenos Virais/análise , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ciclofosfamida/administração & dosagem , Proteínas de Ligação a DNA/análise , Doxorrubicina/administração & dosagem , Antígenos Nucleares do Vírus Epstein-Barr , Herpesvirus Humano 4/imunologia , Humanos , Transplante de Rim/imunologia , Linfoma de Células T/imunologia , Linfoma de Células T/terapia , Masculino , Neoplasias do Seio Maxilar/imunologia , Neoplasias do Seio Maxilar/terapia , Prednisona/administração & dosagem , Vincristina/administração & dosagemRESUMO
Eight sinonasal carcinomas (one adenocarcinoma, two undifferentiated nasopharyngeal carcinomas, and five squamous cell carcinomas) were investigated for evidence of human papillomavirus (HPV) infection using in situ hybridization and the polymerase chain reaction for HPV types 6, 11, 16, 18, and 33. All eight cases were negative for HPV infection by in situ hybridization, while a single HPV-6-positive case was identified by the polymerase chain reaction. The HPV-positive case was an invasive papillary squamous cell carcinoma of the maxillary sinus. Although HPV-6 is usually associated with benign anogenital condylomata, it has been identified in malignant lesions of the upper respiratory tract. This may reflect exposure of the upper aerodigestive tract to additional carcinogens, such as smoke and alcohol, superimposed on the background proliferative stimulus of the HPV infection.
Assuntos
Carcinoma Papilar/microbiologia , Neoplasias do Seio Maxilar/microbiologia , Papillomaviridae/isolamento & purificação , Infecções Tumorais por Vírus/diagnóstico , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Nasofaríngeas/microbiologia , Hibridização de Ácido Nucleico , Papillomaviridae/classificação , Reação em Cadeia da PolimeraseRESUMO
Two new papillomaviruses, HPV 40 and HPV 57, were isolated from a PIN lesion and an inverted papilloma of the maxillary sinus, respectively. HPV 40 showed a 13% homology to HPV 7 by reassociation kinetics and HPV 57 showed a 17% homology to HPV 2 and 25% homology to HPV 27. Hybridization of the DNA of these papillomaviruses to a wide variety of different tumor biopsies revealed that HPV 40 was present in a few genital condylomata acuminata as well as in bowenoid lesions. HPV 57 DNA was present in an oral wart, a genital condyloma acuminatum, and verrucae vulgares lesions from two immunosuppressed patients.