RESUMO
Chronic inflammation, which is caused by recurrent infections, is one of the factors contributing to the pathogenesis of cholesteatoma. If reimplantation of autologous ossicles after a surgical intervention is intended, inactivation of planktonic bacteria and biofilms is desirable. High hydrostatic pressure treatment is a procedure, which has been used to inactivate cholesteatoma cells on ossicles. Here we discuss the potential inactivating effect of high hydrostatic pressure on microbial pathogens including biofilms. Recent experimental data suggest an incomplete inactivation at a pressure level, which is tolerable for the bone substance of ossicles and results at least in a considerable reduction of pathogen load. Further studies are necessary to access how far this quantitative reduction of pathogens is sufficient to prevent ongoing chronic infections, for example, due to forming of biofilms.
Assuntos
Colesteatoma/terapia , Pressão Hidrostática , Inflamação/patologia , Inflamação/terapia , Bactérias/classificação , Bactérias/patogenicidade , Bactérias/efeitos da radiação , Biofilmes/crescimento & desenvolvimento , Biofilmes/efeitos da radiação , Colesteatoma/microbiologia , Colesteatoma/patologia , Ossículos da Orelha/microbiologia , Ossículos da Orelha/patologia , Ossículos da Orelha/efeitos da radiação , Fungos/classificação , Fungos/patogenicidade , Fungos/efeitos da radiação , Humanos , Inflamação/complicações , Inflamação/microbiologiaRESUMO
Popular current thought states that hearing loss and facial weakness after radiosurgery of vestibular schwannomas is a function of cranial nerve damage. Although this may be true in some cases, the middle and inner ear contain rich networks of other sensitive structures that are at risk after radiotherapy and that may contribute to toxicity afterward. We reviewed the limited reported data regarding radiation tolerance of external, middle, and inner ear structures, and perspectives for therapy with gamma knife stereotactic radiosurgery are addressed.
Assuntos
Otopatias/etiologia , Neoplasias da Orelha/radioterapia , Orelha/efeitos da radiação , Neuroma Acústico/radioterapia , Lesões por Radiação/etiologia , Tolerância a Radiação , Radiocirurgia/efeitos adversos , Relação Dose-Resposta à Radiação , Orelha/patologia , Otopatias/patologia , Ossículos da Orelha/patologia , Ossículos da Orelha/efeitos da radiação , Humanos , Lesões por Radiação/patologia , Radiocirurgia/métodos , Osso Temporal/patologia , Osso Temporal/efeitos da radiaçãoRESUMO
Osteoradionecrosis of the temporal bone is a well-known sequela of radiotherapy for neoplasms at the base of the skull. Presenting symptoms include otalgia, chronic aural drainage, and hearing loss, which can be conductive, sensorineural, or mixed. The conductive component has been hypothesized to be caused by radionecrosis of the ossicular chain. This case report documents the existence of osteoradionecrosis of the ossicular chain in a 10-year-old boy operated on for resection of extensive osteoradionecrosis of the temporal bone.
