Pólipo endometrial metastásico de adenocarcinoma de colon tratado con análogos de la LHRH / Endometrial polyp with metastases from an adenocarcinoma of the colon, treated with LHRH analogs

Se presenta el caso de una paciente diagnosticada de metástasis peritoneales múltiples por adenocarcinoma de colon intervenido 2 años antes, y un pólipo endometrial metastatizado por el mismo tumor. Después de realizarle laparotomía exploradora y legrado diagnóstico, y debido a que el pólipo le provocaba metrorragias anemizantes, se inició tratamiento paliativo con análogos de la LHRH y quimioterapia, con lo que cedió la hemorragia. Casi 3 años después, la paciente continúa con buena calidad de vida. Se destaca la buena respuesta al tratamiento con análogos de la LHRH y a propósito del caso se revisa la bibliografía existente (AU)

Hepatocellular carcinoma metastatic to the oral mucosa: report of a case with multiple gingival localizations.

BACKGROUND: Metastases to the oral mucosa are rare, representing less than 1% of the tumors at this site. Most of these metastatic neoplasms originate in the lungs, kidneys, and liver. METHODS: The clinicopathologic features of an occult hepatocellular carcinoma, metastatic to the oral mucosa, are reported. The patient, a 70-year-old male, complained of 3 distinct polypoid, reddish lesions of the antero-inferior alveolar crest and both the right and left postero-superior attached gingiva, without bone involvement. The lesions were excised, with the clinical diagnosis of multiple vascular tumors, formalin-fixed, paraffin-embedded, cut and stained with hematoxylin and eosin. Consecutive sections were immunostained for alpha-1-antichymotrypsin, CEA, cytokeratins, EMA, hepatocyte antigen, PSA, S-100 protein, and thyroglobulin, using the alkaline phosphatase/anti-alkaline phosphatase technique. RESULTS: The morphologic features of the lesions were consistent with the diagnosis of carcinoma with trabecular and glandular patterns and bile secretion; furthermore, immunohistochemical reactivity for alpha-1-antichymotrypsin, cytokeratins, CEA, EMA, and hepatocyte antigen was demonstrated and the hepatic origin of the tumor was postulated. Ultrasonography demonstrated a liver mass, which was biopsied and treated by chemoembolization. While no further complications occurred in the oral mucosa, the patient died 8 months after the diagnosis for widespread diffusion of the tumor to the lungs and brain. CONCLUSIONS: This case emphasizes the need to include metastatic tumors in the differential diagnosis of atypical neoplasms of the oral mucosa and to evaluate the opportunity of surgical treatment in order to preserve the functions of the mouth, even if the prognosis of the primary tumors remains unfavorable.

Polypoid tumour of the pericardium--a previously unrecognised macroscopic appearance of metastatic bladder carcinoma.

We report a case in which a metastasis to the pericardium from a bladder carcinoma had a polypoid appearance similar to that of the primary tumour. We suggest that the local environment of a metastatic deposit may influence its macroscopic appearance. The case described emphasises the importance of thorough exploration of the pericardial sac at surgery.