Papiloma de plexo coroide em uma cadela / Choroid plexus papilloma in a bitch

Background: Choroid plexus papilloma is a benign neoplasm derived from the neuroepithelium of the choroid plexus of the ventricular cavity, commonly located in the fourth ventricle, affecting dogs of different age groups and without predilection for sex. There is a range of therapeutic options, and the treatment to be chosen will be defined based on tumor localization and development. Due to the difficulties in accessing treatments, tutors opt for euthanasia or death occurs with the worsening of the clinical condition. This case report aims to present the symptomatology, treatment and evolution of the case until the death of the animal, as well as the pathological findings. Case: A 12-year-old bitch, mixed breed, was treated presenting behavior alteration, with unusual aggressiveness, perceived by the tutor four weeks ago. Neurological examination revealed changes in behavior, compulsive walking and focal epileptic seizures. After the presumptive diagnosis of brain neoplasia, the dog underwent symptomatic treatment with prednisolone (1 mg/kg, orally, every 24 h, for 15 days, with subsequent reduction to 0.5 mg/kg for another 15 days) and phenobarbital (3 mg/kg, every 12 h, orally), until death. After the beginning of the treatment, no more epileptic seizures and aggressive behavior were observed. After 5 months of consultation, the dog returned with aggressive and anorexic behavior. Due to the worsening of clinical signs, with the possibility of brain neoplasia, the tutor opted for euthanasia. Necropsy was performed and macroscopic examination was observed in the telecephalus, occlusion of the third ventricle by grayish mass, soft, 1.2 cm in diameter with slight dilation of lateral ventricles. On histological examination, it was observed that the third ventricle was occluded, epithelial proliferation of arboriform aspect, composed of cuboidal cells to columnares sustained by moderate fibrovascular stroma. Based on macroscopic and histopathological findings of the telecephalus, the alterations determined the diagnosis of choroid plexus papilloma. Discussion: The diagnosis of choroid plexus papilloma was confirmed by observing the neurological signs and pathological findings that characterize this neoplasm. Choroid plexus tumors are less common, in the third ventricle, only in 36% of all reports are of tumors in that area. The search for care is mainly due to clinical signs that include behavioral, and locomotor changes and sometimes epileptic seizures, such clinical signs were found in the dog. Choroid plexus papilloma affects dogs of all ages, but more in adults and increasing the occurrence as they age. The tumor is still correlated in a higher occurrence in large animals, the evaluated dog was of age, but small in size. During anamnesis, in addition to the clinical history, neurological examinations provide a good basis for the presumptive diagnosis that can be complemented by an imaging diagnosis. Sometimes such technologies are not available for use, therefore, more comprehensive knowledge about clinical signs and anamnesis are indispensable for a correct diagnosis. Palliative drug therapies are an excellent option for most cases presented in the literature and clinical routine, since they provide better quality of life by decreasing or eliminating clinical signs, besides being easily administered by tutors. The therapy proved to be of great value for the improvement of the clinical signs of the evaluated dog, confirming the importance of knowledge of the appropriate prescriptions for each case and reinforcing that consultation with one was important in defining the diagnosis and symptomatic treatment.

Papiloma de plexo coróide em cão adulto - relato de caso / Choroid plexus papilloma in an adult dog - case report / Papiloma del plexo coroideo en un canino adulto - reporte de caso

O artigo descreve um caso de papiloma de plexo coróide (PPC) em cão da raça chow-chow, macho, com quatro anos de idade, o qual apresentou quadro crônico e progressivo de dificuldade de deambulação e dor cervical durante cerca de sete semanas. O paciente teve manifestações vestibulares e cerebelares progressivas. Exames pós-morte revelaram massa hemorrágica, assimétrica, não encapsulada em plexo coróide do quarto ventrículo, com extensão para ângulo cerebelo pontinomedular e segmentos cervicais craniais, caracterizada como PPC por avaliação histopatológica. O objetivo do presente relato é descrever a ocorrência de PPC, uma afecção raramente diagnosticada, bem como reafirmar a importância de incluir neoplasias intracranianas no diagnóstico diferencial de pacientes jovens com alterações neurológicas.(AU)

This article describes a case of choroid plexus papilloma in a four-year-old male chow-chow that presented a seven-week-Iong history of chronic and progressive incoordination and neck pain. Neurologic examination disclosed progressive cerebellar and vestibular manifestations. Postmortem examination revealed a non-encapsulated asymmetric hemorrhagic mass situated within the fourth ventricle, which expanded towards the cerebellum and cranial spinal cord segments. The neoplasm was diagnosed as choroid plexus papilloma (CPP) by histopathological evaluation. The present report aims to describe the occurrence of CPP, which is uncommonly diagnosed, and to reaffirm the importance of including intracranial neoplasms in the differential diagnosis of young patients with neurological disorders. (AU)

El presente artículo describe un caso de papiloma de plexo coroideo (PPC) en un perro Chow Chow macho de cuatro años, que se presentó con un cuadro crónico y progresivo de dificultad para deambular y dolor cervical de aproximadamente siete semanas de evolución. El paciente presentó signos vestibulares y cerebelares progresivos. Los exámenes post mortem mostraron la presencia de una masa hemorrágica, asimétrica y no capsulada en el plexo coroideo del cuarto ventrículo, que se extendía hasta el ángulo cerebelo-ponte-medular y segmentos cervicales craneales, que fue caracterizado como un papiloma de plexo coroideo en el examen histopatológico. El objetivo del presente trabajo es describir este tipo de neoplasia, de diagnóstico inusual, así como también reafirmar la importancia de incluir a las masas intracraneanas en el diagnóstico diferencial de pacientes jóvenes con alteraciones neurológicas.(AU)

Papiloma de plexo coróide em cão adulto - relato de caso / Choroid plexus papilloma in an adult dog - case report / Papiloma del plexo coroideo en un canino adulto - reporte de caso

O artigo descreve um caso de papiloma de plexo coróide (PPC) em cão da raça chow-chow, macho, com quatro anos de idade, o qual apresentou quadro crônico e progressivo de dificuldade de deambulação e dor cervical durante cerca de sete semanas. O paciente teve manifestações vestibulares e cerebelares progressivas. Exames pós-morte revelaram massa hemorrágica, assimétrica, não encapsulada em plexo coróide do quarto ventrículo, com extensão para ângulo cerebelo pontinomedular e segmentos cervicais craniais, caracterizada como PPC por avaliação histopatológica. O objetivo do presente relato é descrever a ocorrência de PPC, uma afecção raramente diagnosticada, bem como reafirmar a importância de incluir neoplasias intracranianas no diagnóstico diferencial de pacientes jovens com alterações neurológicas.

This article describes a case of choroid plexus papilloma in a four-year-old male chow-chow that presented a seven-week-Iong history of chronic and progressive incoordination and neck pain. Neurologic examination disclosed progressive cerebellar and vestibular manifestations. Postmortem examination revealed a non-encapsulated asymmetric hemorrhagic mass situated within the fourth ventricle, which expanded towards the cerebellum and cranial spinal cord segments. The neoplasm was diagnosed as choroid plexus papilloma (CPP) by histopathological evaluation. The present report aims to describe the occurrence of CPP, which is uncommonly diagnosed, and to reaffirm the importance of including intracranial neoplasms in the differential diagnosis of young patients with neurological disorders.

El presente artículo describe un caso de papiloma de plexo coroideo (PPC) en un perro Chow Chow macho de cuatro años, que se presentó con un cuadro crónico y progresivo de dificultad para deambular y dolor cervical de aproximadamente siete semanas de evolución. El paciente presentó signos vestibulares y cerebelares progresivos. Los exámenes post mortem mostraron la presencia de una masa hemorrágica, asimétrica y no capsulada en el plexo coroideo del cuarto ventrículo, que se extendía hasta el ángulo cerebelo-ponte-medular y segmentos cervicales craneales, que fue caracterizado como un papiloma de plexo coroideo en el examen histopatológico. El objetivo del presente trabajo es describir este tipo de neoplasia, de diagnóstico inusual, así como también reafirmar la importancia de incluir a las masas intracraneanas en el diagnóstico diferencial de pacientes jóvenes con alteraciones neurológicas.

Papiloma de plexo coróide em Retriever do Labrador / Papilloma of the choroid plexus in a Retriever Labrador

Este relato refere-se à ocorrência de papiloma de plexo coróide em cão da raça Labrador, no qual as alterações neurológicas cursaram com sinais de otite média. A ausência de resposta à terapia instituída e a progressão dos sintomas, sugeriram tratar-se de alterações neurológicas de origem central. A evolução desfavorável do quadro associada à possibilidade da ocorrência de tumor em sistema nervoso central impeliram o proprietário à eutanásia do animal. A confirmação de papiloma de plexo coróide foi estabelecida com laudo histopatológico

This report refers to the occurrence of choroid plexus papilloma in a Labrador retriever, in which neurological signs presenting with signs of otitis media. The absence of response the therapy and the progression of symptoms, suggested that it was neurological disorders. The unfavorable evolution associated to the possibility of the tumor occurrence in the central nermous system prompted the owner to euthanasia of the animal. The confirmation of choroid plexus papilloma was established with the histopathological finding

Papiloma de plexo coróide em Retriever do Labrador / Papilloma of the choroid plexus in a Retriever Labrador

Este relato refere-se à ocorrência de papiloma de plexo coróide em cão da raça Labrador, no qual as alterações neurológicas cursaram com sinais de otite média. A ausência de resposta à terapia instituída e a progressão dos sintomas, sugeriram tratar-se de alterações neurológicas de origem central. A evolução desfavorável do quadro associada à possibilidade da ocorrência de tumor em sistema nervoso central impeliram o proprietário à eutanásia do animal. A confirmação de papiloma de plexo coróide foi estabelecida com laudo histopatológico(AU)

This report refers to the occurrence of choroid plexus papilloma in a Labrador retriever, in which neurological signs presenting with signs of otitis media. The absence of response the therapy and the progression of symptoms, suggested that it was neurological disorders. The unfavorable evolution associated to the possibility of the tumor occurrence in the central nermous system prompted the owner to euthanasia of the animal. The confirmation of choroid plexus papilloma was established with the histopathological finding(AU)