RESUMO
Herpes zoster oticus (Ramsay Hunt Syndrome) is characterized by facial nerve paralysis, ear pain and auricular skin rash. It occurs as a result of reactivation oflatent varicella zoster virus infection in the geniculate ganglion of the facial nerve. Major clinical symptoms include 7th nerve paralysis or cranial nerve paralysis and vesicles along the nerve with cocomitant ear pain. Other cranial nerve involvement although uncommon, can be found in some cases. In this study, a 74-year-old female patient had ipsilateral 8th, 9th and 10th cranial nerves injury. Cranial nerve paralysis accompanied with injury has been repor ted in R amsay Hunt Syndrome.
Assuntos
Nervos Cranianos , Difenidramina/administração & dosagem , Herpes Zoster da Orelha Externa , Herpesvirus Humano 3/patogenicidade , Metilprednisolona/administração & dosagem , Valaciclovir/administração & dosagem , Idoso , Antieméticos/administração & dosagem , Antivirais/administração & dosagem , Nervos Cranianos/fisiopatologia , Nervos Cranianos/virologia , Transtornos de Deglutição/diagnóstico , Transtornos de Deglutição/etiologia , Pavilhão Auricular/fisiopatologia , Pavilhão Auricular/virologia , Paralisia Facial/diagnóstico , Paralisia Facial/fisiopatologia , Paralisia Facial/virologia , Feminino , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/virologia , Herpes Zoster da Orelha Externa/diagnóstico , Herpes Zoster da Orelha Externa/tratamento farmacológico , Herpes Zoster da Orelha Externa/fisiopatologia , Humanos , Exame Neurológico/métodos , Exame Físico/métodos , Resultado do TratamentoAssuntos
Fármacos Dermatológicos/administração & dosagem , Diterpenos/administração & dosagem , Pavilhão Auricular/efeitos dos fármacos , Otopatias/tratamento farmacológico , Verrugas/tratamento farmacológico , Administração Cutânea , Biópsia , Pavilhão Auricular/patologia , Pavilhão Auricular/virologia , Otopatias/diagnóstico , Otopatias/virologia , Humanos , Masculino , Pessoa de Meia-Idade , Indução de Remissão , Resultado do Tratamento , Verrugas/diagnóstico , Verrugas/virologiaRESUMO
Intradermal injection of vaccinia virus in the ear pinnae of mice provides a model of dermal infection and vaccination. The key features of this model are the appearance of a lesion on the surface of the ear that can be measured as a clinical sign of disease and substantial growth of virus in the infected skin in the absence of systemic spread. In addition, infected ears can be easily removed to allow virological, histological, and cellular analyses. Finally, evaluation of the roles of virus (and presumably also host) genes in vaccinia virus pathogenesis in the intradermal model can yield different results than similar experiments using other routes and may reveal otherwise unknown functions.
