RESUMO
The enteropooling activity of soya-peptone was studied in germfree piglets. The enteropooling activity was restricted to the proximal part of the jejunum and was found to be blocked by aspirin. The hypothesis that soya-peptone acts via an increased biosynthesis/release of prostanoids was further studied using guinea-pig lung parenchyma. In this tissue soya-peptone induces the release of TXB2, which was inhibited by indomethacin (3 microM). The involvement of cholinergic, histaminergic and serotonergic pathways in the soya-peptone-mediated response was excluded, using antagonists. The conclusion was reached that soya-peptone can stimulate/modulate the biosynthesis of cyclic eicosanoids and that it exerts its enteropooling activity via the same mechanism in the jejunum of piglets.
Assuntos
Diarreia/veterinária , Ácidos Graxos/biossíntese , Glycine max/efeitos adversos , Peptonas/efeitos adversos , Ácidos Prostanoicos/biossíntese , Doenças dos Suínos/etiologia , Ração Animal/efeitos adversos , Animais , Aspirina/farmacologia , Diarreia/etiologia , Ácidos Eicosanoicos/biossíntese , Cobaias , Jejuno/fisiopatologia , Pulmão/fisiopatologia , SuínosRESUMO
In experiments performed on anaesthetized dogs the effects of dye shock and peptone shock on changes in serum osmolality, haematocrit value, amino acid level in serum and erythrocytes, and serum total protein and protein fraction levels were determined. In further experid (0.1 mg/kg). It was found that Arfonad exerts an inhibitory effect on the shock-induced reduction in the serum osmolality, plasma volume and on the albumin level.