RESUMO
L. J. Thénard and J. L. Gay-Lussac discovered hydrogen peroxide in 1818. Later, Thénard noticed that animal and plant tissues decompose hydrogen peroxide. The substance which is responsible for this reaction was named as catalase by O. Loew in 1900. The catalase enzyme was regarded as a diagnostic and a tumour marker in the late years of the 19th century and in the early years of the 20th century. Acatalasemia, an inherited deficiency of enzyme catalase, was studied in Japan, Switzerland and Hungary. The recent findings on catalase are focusing on the effects of reactive oxygen species and on the association of acatalasemia and diabetes mellitus. Orv Hetil. 2018; 159(24): 959-964.
Assuntos
Acatalasia/história , Pesquisa Biomédica/história , Catalase/história , Peróxido de Hidrogênio/história , Animais , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Hungria , Japão , SuíçaRESUMO
The concept of the germ theory of disease combined with the development of dentistry during the latter half of the 19th century had a direct effect on the practice of endodontics. The significance of root canal irrigation to endodontics strengthened in the period between 1859 when Taft recommended frequent syringing of the root canal to remove "irritants" until the mid-1940s when endodontics became a special field within dentistry and the American Endodontic Society was established. This paper reviews the role of irrigants and irrigation in root canal treatment during this period. A variety of recommendations on the use of solutions to clean root canals appeared in the dental literature, often innovative and at times entrepreneurial, but invariably empirically based. While it was widely assumed that by wiping the root canal with disinfectants sterilization would be achieved, many of the principles associated with cleaning the root canal published during this period, in particular by Willoughby Dayton Miller in the 1890s and Louis Grossman in the 1940s, remain equally relevant in the 21st century.
Assuntos
Irrigantes do Canal Radicular/história , Endodontia/história , História do Século XIX , Peróxido de Hidrogênio/história , Oxidantes/história , Peróxidos/história , Hipoclorito de Sódio/história , Irrigação Terapêutica/históriaAssuntos
Ácidos Graxos/história , Peróxido de Hidrogênio/história , Fenilpropionatos/história , Animais , Bioquímica/história , Cães , Ácidos Graxos/metabolismo , História do Século XX , Peróxido de Hidrogênio/metabolismo , Oxirredução , Fenilpropionatos/metabolismo , Sociedades Científicas/história , Estados UnidosAssuntos
Anti-Infecciosos Locais/intoxicação , Peróxido de Hidrogênio/intoxicação , Administração Oral , Anti-Infecciosos Locais/história , Anti-Infecciosos Locais/uso terapêutico , Eméticos/intoxicação , França , História do Século XIX , Humanos , Peróxido de Hidrogênio/história , Peróxido de Hidrogênio/uso terapêutico , SegurançaRESUMO
The discovery of hydrogen peroxide (H2O2) by Thénard in 1818, and the early phase of its development, are discussed. A brief description is given of the uses of this compound for purposes other than contact lens care. A detailed description of the first application of H2O2 to hydrophilic contact lenses is provided. A review of toxicologic and microbiologic issues and concerns follows, with specific emphasis on the decimal reduction rate (D-value) for H2O2 and the contribution of elements test as applied to any disinfection system. The role of pH and increasing concentrations of H2O2 in inducing ocular discomfort is described. After the introduction of the first H2O2 system, a number of competitive methods reached the marketplace. The unique qualities of one neutralization technique are noted. Hydrogen peroxide will continue for some time as a popular contact lens disinfection mechanism.
