Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 111
Filtrar
1.
Eur Rev Med Pharmacol Sci ; 25(5): 2291-2298, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33755966

RESUMO

OBJECTIVE: Epicardial fat thickness (EFT) and chlamydia infection are independent cardiovascular risk factors in coronary artery disease (CAD). We aimed to evaluate the effect of coexistence of EFT and chlamydia infection on the presence and severity of CAD in patients with stable angina pectoris (SAP). PATIENTS AND METHODS: The study included 208 patients with SAP, divided into a CAD group (n=112) and a control group (n=96). The presence of Chlamydia pneumoniae-IgG (CP-IgG), EFT, and left ventricular ejection fraction (LVEF) were compared between groups. RESULTS: CP-IgG, LVEF, and EFT were found to be independent predictors of CAD (CP-IgG, OR=1.559, p=0.021; LVEF, OR=0.798, p<0.001; EFT, OR=3.175, p=0.026). Moreover, a statistically significant interaction was detected between CP-IgG and EFT for predicting the presence of CAD (p<0.001). A good positive correlation was found between EFT and Gensini score (r=0.684, p<0.001). CONCLUSIONS: We found that there was an interaction between CP-Ig and EFT for CAD development. This finding suggests that the interaction of CP-IgG and EFT plays a prominent role in the inflammatory process.


Assuntos
Angina Estável/diagnóstico por imagem , Infecções por Chlamydia/diagnóstico por imagem , Chlamydophila pneumoniae/isolamento & purificação , Doença da Artéria Coronariana/diagnóstico por imagem , Pericárdio/diagnóstico por imagem , Angina Estável/microbiologia , Infecções por Chlamydia/microbiologia , Doença da Artéria Coronariana/microbiologia , Ecocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pericárdio/microbiologia
2.
Ann Thorac Surg ; 111(4): e259-e261, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-32882194

RESUMO

The bacterial purulent pericarditis is rapidly progressive and represents a highly fatal infection, with mortality rates reaching up to 100% if untreated. Approximately 40% to 50% of all cases are caused by Gram-positive bacteria, especially Streptococcus pneumoniae. We describe an extremely rare case of S. pneumoniae purulent pericarditis as a delayed complication of a blunt thoracic trauma. The patient was successfully treated with urgent pericardiocentesis, thoracoscopic pericardial fenestration, and broad-spectrum antibiotics. Owing to the high mortality rate of a purulent pericarditis, a high index of suspicion is needed in order to instaurate an appropriate therapy with drainage and antibiotics.


Assuntos
Pericardite/etiologia , Pericárdio/diagnóstico por imagem , Infecções Pneumocócicas/etiologia , Traumatismos Torácicos/complicações , Ferimentos não Penetrantes/complicações , Idoso de 80 Anos ou mais , Ecocardiografia , Feminino , Humanos , Pericardite/diagnóstico , Pericardite/microbiologia , Pericárdio/microbiologia , Infecções Pneumocócicas/diagnóstico , Infecções Pneumocócicas/microbiologia , Radiografia Torácica , Doenças Raras , Streptococcus pneumoniae/isolamento & purificação , Traumatismos Torácicos/diagnóstico , Tomografia Computadorizada por Raios X , Ferimentos não Penetrantes/diagnóstico
3.
Indian J Med Microbiol ; 38(3 & 4): 492-495, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33154273

RESUMO

Post-operative Aspergillus mediastinitis is regarded to be a devastating infection, usually affecting patients undergoing cardiothoracic surgery with specific predisposing factors characterised by a high mortality and chronic morbidity. Patient outcome after such a complication is extremely poor despite antifungal therapy and surgery. We describe the case of an immunocompetent 2-month-old child with obstructed supracardiac total anomalous pulmonary venous circulation (TAPVC) and severe pulmonary artery hypertension, who underwent TAPVC repair through median sternotomy and developed post-operative mediastinitis due to Aspergillus flavus.


Assuntos
Aspergilose/complicações , Aspergillus flavus/isolamento & purificação , Mediastinite/microbiologia , Complicações Pós-Operatórias/microbiologia , Aspergilose/terapia , Evolução Fatal , Humanos , Imunocompetência , Lactente , Masculino , Pericárdio/microbiologia , Complicações Pós-Operatórias/terapia , Hipertensão Arterial Pulmonar/cirurgia , Veias Pulmonares/anormalidades
7.
BMJ Case Rep ; 20182018 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-30333198

RESUMO

Meningococcal pericarditis is a rare but severe form of acute purulent pericarditis. It is a classic complication of Neisseria meningitidis of serotype W135, usually occurring in pilgrims to Mecca and their household contacts. This severe form of meningococcaemia is difficult to diagnose and evolves frequently and gradually towards a tamponade, requiring emergency drainage. We report a case of meningococcal pericarditis caused by N. meningitidis W135 in an immunocompetent patient, without any other organ involvement especially meningeal, requiring pericardium drainage in emergency and then intrapericardial fibrinolysis.


Assuntos
Fibrinólise/fisiologia , Neisseria meningitidis/isolamento & purificação , Pericardite Constritiva/diagnóstico por imagem , Pericárdio/microbiologia , Drenagem/métodos , Ecocardiografia Transesofagiana/métodos , Humanos , Masculino , Infecções Meningocócicas/microbiologia , Pessoa de Meia-Idade , Pericardite Constritiva/tratamento farmacológico , Pericardite Constritiva/microbiologia , Pericardite Constritiva/cirurgia , Pericárdio/efeitos dos fármacos , Pericárdio/cirurgia , Resultado do Tratamento , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Ativador de Plasminogênio Tipo Uroquinase/uso terapêutico
8.
BMJ Case Rep ; 20182018 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-29592995

RESUMO

We report an extremely rare case of purulent pericarditis caused by the normally commensal oral flora, Streptococcus constellatus, a viridans Streptococcal species and member of the S. anginosus group (previously also known by the eponymous 'S. milleri', for American Willoughby Dayton Miller). This case is a previously healthy 71-year-old immunocompetent woman from Arizona who presented with a 5-day history of progressive shortness of breath and chest tightness, and subjective fever and chills, but without history of nausea, vomiting, night sweats, recent travel, autoimmune disease or sick contacts. Early recognition and intervention of purulent pericarditis allow patients like the one outlined in this case to achieve full recovery.


Assuntos
Pericardite/diagnóstico por imagem , Pericardite/microbiologia , Infecções Estreptocócicas/complicações , Streptococcus constellatus/isolamento & purificação , Idoso , Antibacterianos/uso terapêutico , Ceftriaxona/uso terapêutico , Diagnóstico Diferencial , Ecocardiografia , Feminino , Humanos , Derrame Pericárdico/diagnóstico por imagem , Derrame Pericárdico/tratamento farmacológico , Derrame Pericárdico/microbiologia , Pericardite/tratamento farmacológico , Pericárdio/diagnóstico por imagem , Pericárdio/microbiologia , Infecções Estreptocócicas/diagnóstico por imagem , Infecções Estreptocócicas/tratamento farmacológico , Tomografia Computadorizada por Raios X
9.
Vet Microbiol ; 214: 65-74, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29408034

RESUMO

Fowl adenovirus serotype 4 (FAdV-4), a member of the Aviadenovirus genus of the Adenoviridae family, causes hepatitis-hydropericardium syndrome (HHS) in chickens. It causes mortality of up to 80% in 3-6-week-old broilers, posing a substantial threat to the poultry industry. However, the specific host responses to the virus are not well understood. To better understand the interactions between the host and FAdV-4 and to explore the pathogenesis of this virus, a high-throughput RNA-seq technology was utilized with leghorn male hepatocellular (LMH) cells at 12, 24, and 48 h after FAdV-4 infection. We identified a total of 7000 differentially expressed genes (DEGs), which were enriched in a variety of biological processes and pathways using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Several immune related pathways, including Toll-like receptor (TLR) signaling pathway and cytokine-cytokine receptor interaction pathway, were activated after the FAdV-4 infection. The transcriptional data were validated by quantitative real-time PCR. The expression profiles of 10 genes involved in FAdV-4-infected chicken livers, including TLR2A, TLR3, TLR5, MyD88, IL12B, IL15, IL18, CCL20, TNFRSF21, and CD30, were consistent with RNA-seq profiles. By transfecting small interfering RNA into LMH cells, our results confirmed that MyD88 mediated FAdV-4-induced inflammation. To our knowledge, this was the first study to use transcriptome analysis to investigate host responses to FAdV-4 infection. These findings provide insights into the mechanisms of FAdV-4 pathogenesis and host-FAdV-4 interaction.


Assuntos
Infecções por Adenoviridae/veterinária , Aviadenovirus/genética , Perfilação da Expressão Gênica , Fígado/citologia , Doenças das Aves Domésticas/microbiologia , Infecções por Adenoviridae/imunologia , Infecções por Adenoviridae/microbiologia , Animais , Aviadenovirus/imunologia , Aviadenovirus/patogenicidade , Contagem de Células , Galinhas/virologia , Hepatite Animal/microbiologia , Interações Hospedeiro-Patógeno/genética , Interações Hospedeiro-Patógeno/imunologia , Fígado/imunologia , Fígado/microbiologia , Fígado/patologia , Masculino , Pericárdio/microbiologia , Pericárdio/patologia , Filogenia , Doenças das Aves Domésticas/imunologia , Análise de Sequência de DNA , Sorogrupo , Receptores Toll-Like/genética
10.
Int J Cardiol ; 250: 223-228, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-29107356

RESUMO

Pericardial effusion is the abnormal accumulation of fluid in the pericardial space. The complications of pericardial effusion can either be acute (e.g., cardiac tamponade) or chronic (e.g., constrictive pericarditis). We have conducted a systematic review of the scientific literature to evaluate the efficacy and safety of intrapericardial fibrinolysis in preventing complications of pericardial effusion. We searched for both published and unpublished studies. 29 studies, with a total of 109 patients were included in this review; 17 case reports, 11 case series, and one randomised controlled trial (RCT). All included studies had a high risk of bias. The most common causes of pericardial effusion were Staphylococcus aureus (12 studies with 23 cases) and Mycobacterium tuberculosis (2 studies with 19 cases). The most common fibrinolytic agents used were streptokinase (15 studies) and urokinase (5 studies). Intrapericardial fibrinolysis prevented complications in 94 (86.2%) patients. Non-fatal procedure-related complications were reported 21 (19.2%) patients. No patient died following intrapericardial fibrinolysis. There is very low certainty of the efficiency and safety of intrapericardial fibrinolysis in preventing the complications of pericardial effusion. High quality RCTs are required to address this question.


Assuntos
Fibrinólise/efeitos dos fármacos , Fibrinolíticos/administração & dosagem , Derrame Pericárdico/tratamento farmacológico , Pericárdio/efeitos dos fármacos , Fibrinólise/fisiologia , Fibrinolíticos/farmacologia , Humanos , Derrame Pericárdico/diagnóstico , Pericardite/diagnóstico , Pericardite/tratamento farmacológico , Pericárdio/microbiologia , Pericárdio/patologia , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Estreptoquinase/farmacologia , Estreptoquinase/uso terapêutico , Resultado do Tratamento
11.
J Cardiol ; 71(3): 291-298, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29055511

RESUMO

BACKGROUND: The etiology of infective endocarditis (IE) is changing. More aggressive forms with multiple IE cardiac lesions have become more frequent. This study sought to explore the relationship between contemporary causative microorganisms and IE cardiac lesions and to analyze the impact of multiple lesions on treatment choice. METHODS: In 246 patients hospitalized for IE between 2008 and 2015, cardiac lesions caused by IE were analyzed by echocardiography, classified according to the 2015 European Society of Cardiology guidelines and correlated with microbiological data. We defined a new parameter, the Echo IE Sum, to summarize all IE cardiac lesions in a single patient, enabling comprehensive comparisons between different etiologies and treatment strategies. RESULTS: Staphylococcus aureus was associated with the development of large vegetation (OR 2.442; 95% CI 1.220-4.889; p=0.012), non-HACEK bacteria with large vegetation (OR 13.662; 95% CI 2.801-66.639; p=0.001), perivalvular abscess or perivalvular pseudoaneurysm (OR 5.283; 95% CI 1.069-26.096; p=0.041), and coagulase-negative staphylococci (CoNS) with leaflet abscess or aneurysm (OR 3.451; 95% CI 1.285-9.266, p=0.014), and perivalvular abscess or perivalvular pseudoaneurysm (OR 4.290; 95% CI 1.583-11.627; p=0.004). The Echo IE Sum significantly differed between different etiologies (p<0.001), with the highest value in non-HACEK and the lowest in streptococcal endocarditis. Patients operated for IE had a significantly higher Echo IE Sum vs those who were medically treated (p<0.001). CONCLUSION: None of the IE cardiac lesions is microorganism-specific. However, more severe lesions were caused by S. aureus, CoNS, and non-HACEK bacteria. The highest propensity to develop multiple lesions was shown by the non-HACEK group. Higher Echo IE Sum in patients sent to surgery emphasized the importance of multiple IE cardiac lesions on treatment choice and potential usage of Echo IE Sum in patient management.


Assuntos
Abscesso/microbiologia , Falso Aneurisma/microbiologia , Endocardite/microbiologia , Aneurisma Cardíaco/microbiologia , Pericárdio/microbiologia , Adulto , Idoso , Estudos de Coortes , Ecocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infecções Estafilocócicas/microbiologia , Staphylococcus aureus
13.
J Infect Chemother ; 23(12): 833-836, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28803866

RESUMO

Campylobacter fetus is an organism residing primarily in the gastrointestinal tracts of cattle and sheep and transmitting to humans through ingestion of contaminated food products or surface water. The organism has caused various extraintestinal infections but, to date, purulent pericarditis due to the organism has rarely been described. We report a case of purulent pericarditis due to C. fetus subsp. fetus, occurring in a patient having several predisposing conditions, including receiving hemodialysis therapy, recent surgery for cecal cancer, and administration of esomeprazole. The patient mentioned having eaten homemade raw beef liver two weeks before the onset, suggesting that the ingested food product was contaminated with C. fetus and the organism transmitted to the pericardium through the bloodstream although blood culture was negative. The causative organism, recovered from the pericardial effusion, was unidentifiable with commercial systems but determinable with molecular methods at the subspecies level. The patient fully improved with pericardiocentesis and subsequent administration of ciprofloxacin, to which the organism was considered susceptible, for a total of four weeks. This is the first case of C. fetus pericarditis in which a history of ingesting a raw food product was clearly mentioned.


Assuntos
Infecções por Campylobacter/microbiologia , Campylobacter fetus/isolamento & purificação , Pericardite/microbiologia , Alimentos Crus/microbiologia , Animais , Antibacterianos/administração & dosagem , Sequência de Bases/genética , Infecções por Campylobacter/tratamento farmacológico , Campylobacter fetus/genética , Bovinos , Ciprofloxacina/administração & dosagem , Trato Gastrointestinal/microbiologia , Humanos , Fígado/microbiologia , Masculino , Pessoa de Meia-Idade , Pericardite/tratamento farmacológico , Pericárdio/microbiologia , Ovinos
14.
Pan Afr Med J ; 26: 89, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28491220

RESUMO

Primary intestinal lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia (particularly T-cell). The diagnosis is based on viewing the duodenal lymphangiectasia. A 20 years old female patient, treated for a primary intestinal lymphangiectasia, has consulted for anasarca. Etiological work-up reveals pleural and pericardial tuberculosis. The clinical aggravation of an enteropathy, particularly in adulthood, requires a search for a secondary etiology. Tuberculosis should be sought systematically.


Assuntos
Linfangiectasia Intestinal/diagnóstico , Linfedema/diagnóstico , Pericárdio/microbiologia , Tuberculose Pleural/diagnóstico , Tuberculose/diagnóstico , Feminino , Humanos , Linfangiectasia Intestinal/etiologia , Linfedema/etiologia , Tuberculose/complicações , Tuberculose/fisiopatologia , Tuberculose Pleural/complicações , Adulto Jovem
15.
Mycoses ; 60(9): 576-580, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28497621

RESUMO

Invasive aspergillosis(IA) is a potentially lethal complication of Aspergillus infection affecting mainly immunocompromised hosts; however, during the last two decades its incidence was increasingly observed in critically ill immunocompetent patients. The objective of this study is to describe the clinical characteristics of histologically proven endomyocardial and pericardial invasion, in the context of IA, in critically ill patients. Eight critically ill patients with histopathological confirmation of endomyocardial/pericardial aspergillosis were evaluated. Risk factors, clinical and laboratory characteristics, treatment, histopathological characteristics and mortality were recorded. Signs and symptoms of cardiac dysfunction were not observed in any of the patients. Therapy was administered to six of them shortly after the first positive culture. The observed histopathological lesions included haemorrhagic lesions, small vessels with central thrombosis and surrounding consolidated tissue with necrosis. Voriconazole, caspofungin, lipid amphotericin B and itraconazole were the used antifungals. The mortality rate was high (87.5%). Endomyocardial and pericardial aspergillosis are devastating complications of invasive aspergillosis. Clinical suspicion is low making the diagnosis difficult, therefore histopathological examination of tissues are required. The mortality is high.


Assuntos
Estado Terminal , Cardiopatias/microbiologia , Infecções Fúngicas Invasivas/epidemiologia , Infecções Fúngicas Invasivas/microbiologia , Pericárdio/microbiologia , Anfotericina B/uso terapêutico , Antifúngicos/uso terapêutico , Caspofungina , Equinocandinas/uso terapêutico , Feminino , Cardiopatias/tratamento farmacológico , Cardiopatias/epidemiologia , Humanos , Imunocompetência , Hospedeiro Imunocomprometido , Incidência , Infecções Fúngicas Invasivas/tratamento farmacológico , Lipopeptídeos/uso terapêutico , Masculino , Pessoa de Meia-Idade , Miocárdio/patologia , Fatores de Risco , Voriconazol/uso terapêutico
16.
Int J Cardiol ; 236: 95-99, 2017 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-28268083

RESUMO

BACKGROUND: Epicardial adipose tissue (EAT) has a close functional and anatomic relationship with epicardial coronary arteries. Accumulating evidence suggests that host microbiome alterations may play a role in several inflammatory/immune disorders, triggering a robust proinflammatory response also involving interleukin-1ß (IL-1ß) and the NALP3 inflammasome. In the current study, we explore the hypothesis that in patients with non-ST elevation acute coronary syndrome (ACS), EAT contains potentially pro-atherosclerotic bacteria that might elicit inflammasome activation. METHODS: EAT samples were obtained during coronary artery bypass grafting from ACS (n=18) and effort stable angina (SA; n=16) patients, and as controls, from patients with angiographically normal coronary arteries undergoing surgery for mitral insufficiency (MVD; n=13). In all patients, NALP3 and proIL-1ß mRNA expressions were evaluated with qRT-PCR. In 3 patients from each group, EAT microbiota composition was determined using next-generation sequencing technologies. RESULTS: In EAT, mRNA expression of both NALP3 and pro-IL1ß was significantly higher in ACS than in SA and MVD (P=0.028 and P=0.005, respectively). A broad range of bacterial species (n=76) was identified in both ACS and SA, with different predominant species. In contrast, microbial DNA was barely observed in MVD. CONCLUSIONS: Our study demonstrated the presence of bacterial DNA directly into EAT, surrounding diseased coronary arteries, of patients with ACS. Furthermore, ACS is associated with NALP3/inflammasome pathway activation in EAT. Our data suggest that the EAT environment is susceptible to microbial colonization that might stimulate a proinflammatory response. These findings add new elements to the pathogenesis of ACS and suggest novel therapeutic targets.


Assuntos
Síndrome Coronariana Aguda , Tecido Adiposo , Ponte de Artéria Coronária/métodos , Inflamassomos/fisiologia , Microbiota/fisiologia , Pericárdio , Síndrome Coronariana Aguda/diagnóstico , Síndrome Coronariana Aguda/imunologia , Síndrome Coronariana Aguda/cirurgia , Tecido Adiposo/imunologia , Tecido Adiposo/microbiologia , Tecido Adiposo/patologia , Idoso , Contagem de Colônia Microbiana/métodos , Vasos Coronários/patologia , DNA Bacteriano/isolamento & purificação , Feminino , Humanos , Interleucina-1beta/análise , Itália , Masculino , Pessoa de Meia-Idade , Proteína 3 que Contém Domínio de Pirina da Família NLR/análise , Pericárdio/imunologia , Pericárdio/microbiologia , Pericárdio/patologia , Estatística como Assunto
18.
BMJ Case Rep ; 20152015 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-26643184

RESUMO

We report a case of a 55-year-old woman with a history of type 2 diabetes mellitus, Charcot arthropathy and end-stage renal disease, who presented with a syncopal episode after undergoing haemodialysis. She had a history of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia from an unknown source 3 months earlier, which was treated with an 8-week course of intravenous antibiotics. At the time of presentation to the emergency room, she was found to be in refractory shock. Bedside echocardiogram was performed, which showed moderate pericardial effusion. The effusion was later found to be due to MRSA, which was identified in blood and in pericardial fluid cultures. The patient was successfully treated with intravenous daptomycin for 6 weeks. Acute osteomyelitis of her right foot was the source of the MRSA, for which a right below-knee amputation was ultimately performed.


Assuntos
Amputação Cirúrgica , Extremidade Inferior/cirurgia , Staphylococcus aureus Resistente à Meticilina/isolamento & purificação , Osteomielite/complicações , Pericardite/complicações , Pericárdio/microbiologia , Infecções Estafilocócicas/complicações , Síncope/etiologia , Antibacterianos/administração & dosagem , Comorbidade , Feminino , Humanos , Extremidade Inferior/patologia , Pessoa de Meia-Idade , Osteomielite/microbiologia , Pericardite/microbiologia , Infecções Estafilocócicas/microbiologia , Síncope/microbiologia , Resultado do Tratamento
20.
J Forensic Leg Med ; 28: 15-8, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25440141

RESUMO

The purpose of this study was to evaluate the postmortem distributions of procalcitonin (PCT), C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and soluble interleukin-2 receptor (sIL-2R) levels in postmortem serum from femoral blood, pericardial fluid and pleural fluid in a series of sepsis-related fatalities (12 subjects) and control cases (20 subjects) that underwent medico-legal investigations. Our aim was to assess the diagnostic potential of the results obtained from pericardial and pleural fluid analysis in identifying sepsis-related deaths. All sepsis-related cases had a documented, clinical diagnosis that was established in vivo during hospitalization. Pneumonia was the main infectious focus identified during autopsy and histology. Pseudomonas aeruginosa, Klebsiella pnemoniae and Escherichia coli were the most commonly identified bacteria in blood and lung tissue cultures. The preliminary results corroborate the usefulness of PCT, CRP, sTREM-1 and sIL-2R determination in postmortem serum for the identification of sepsis-related deaths. Moreover, the data suggest that, as far as PCT, CRP, sTREM-1 and sIL-2R measurements are concerned, pericardial and pleural fluids can be considered suitable alternatives to postmortem serum should femoral blood prove unavailable at autopsy.


Assuntos
Autopsia , Pericárdio/química , Pleura/química , Sepse/metabolismo , Sepse/mortalidade , Idoso , Biomarcadores , Proteína C-Reativa/análise , Calcitonina/análise , Peptídeo Relacionado com Gene de Calcitonina , Feminino , Humanos , Masculino , Glicoproteínas de Membrana/análise , Pessoa de Meia-Idade , Pericárdio/microbiologia , Pleura/microbiologia , Estudos Prospectivos , Precursores de Proteínas/análise , Receptores Imunológicos/análise , Receptores de Interleucina-2/análise , Sensibilidade e Especificidade , Sepse/sangue , Receptor Gatilho 1 Expresso em Células Mieloides
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...