Is apical periodontitis in root filled teeth associated with the type of restoration?

OBJECTIVE: To study the association between type of restoration and apical periodontitis (AP) in root filled teeth. MATERIALS AND METHODS: The present study used data from surveys conducted in 1983, 1993 and 2003. In 1983, 130 randomly selected subjects aged 3-80 years in the city of Jönköping, Sweden, were invited for a clinical and radiological examination. The study was repeated in 1993 and 2003. New participants were, thus, recruited with the same sampling criteria and sample size in the same geographical area in 1993 and 2003, respectively. In the present study, only dentate individuals aged 20-70 years with ≥1 root filled tooth were included, yielding a sample of 788 subjects with 2634 root filled teeth. Apical periodontitis on the tooth level was the dependent variable. Periapical status was assessed according to Periapical Index (PAI). Independent variables were root filling quality, recurrent caries, type of restoration, number of teeth with apical periodontitis, age and gender. Root fillings appearing homogenous and ending within 2 mm from radiographic apex were regarded as adequate, otherwise inadequate. All radiographs were re-studied by one observer regarding periapical status and root filling quality. Risk was analyzed by means of a GEE model. RESULTS: Type of restoration, root filling quality, number of teeth with apical periodontitis within the individual and age were found to be predictors of AP in root filled teeth. Presence of recurrent caries and gender were not found to be associated with AP. CONCLUSIONS: According to the present study, root filling quality and type of restoration may be predictive of AP in root filled teeth.

Periapical status of root-filled teeth in Norwegian children and adolescents.

OBJECTIVE: To study the periapical status of root-filled permanent teeth of 9-17-year-olds in Møre & Romsdal county, Norway. MATERIALS AND METHODS: All permanent teeth with endodontic treatment in patients born in 1994-2001 were identified in the dental records of the Public Dental Service. The data collected consisted of chart entries and radiographs. Of 1182 teeth, 174 teeth in 155 patients met further inclusion criteria, i.e. completed endodontic treatment and a follow-up with a readable radiograph of at least 1 year. Periapical status was assessed with the Periapical Index (PAI) and the technical quality of the root fillings was also quantified on a 4-grade visual scale. RESULTS: Apical periodontitis was found on follow-up radiographs in 25% of all teeth and in 48% of the teeth with pre-operative apical periodontitis. Forty-two per cent of root fillings were of adequate technical quality. Adequate technical quality of the root filling was significantly correlated with radiographic success. CONCLUSIONS: About one fourth of all root-filled teeth and almost half of the teeth with pre-operative apical periodontitis showed clear signs of the disease at recall.

Periapical inflammation subsequent to coronal inoculation of dog teeth root filled with resilon/epiphany in 1 or 2 treatment sessions with chlorhexidine medication.

INTRODUCTION: Therapeutic methods that inhibit microbial ingress into filled root canals are desirable. This in vivo study assessed the inhibition of periapical inflammation subsequent to coronal inoculation in canals medicated with 2% chlorhexidine gel and filled with Resilon/Epiphany (Pentron Clinical Technologies, Wallingford, CT). METHODS: Six Beagle dogs each had 10 two-rooted premolars treated. In group 1 (n = 36 roots), 1 root/tooth had the canal conditioned with Primer Epiphany, filled with Epiphany sealer and Resilon core in 1 session, and coronally sealed with PhotacFil. In group 2 (n = 36 roots), the second root/tooth had the canal medicated with 2% chlorhexidine gel for 1 week and then filled and coronally sealed as in group 1. After 3 weeks, canals were exposed to the oral environment for 7 days, inoculated with isologous plaque, and coronally sealed. Negative controls treated as groups 1 and 2 remained sealed. Positive controls had canals unfilled and exposed. Seven months after inoculation, dogs were euthanized; jaw blocks processed for histologic examination; and periapical inflammation (PI) recorded as none, mild, or severe. RESULTS: In groups 1 and 2, severe PI occurred in 5 of 65 roots (8%) and mild PI in 18 of 65 roots (28%) with a significantly higher (P = .031) PI incidence in group 2 than in group 1. Negative controls had only mild PI in 9 of 29 roots (31%). Roots medicated with 2% chlorhexidine gel had mild PI significantly more (P = .009) than roots filled in 1 session (more than 2-fold). CONCLUSIONS: Intracanal medication with 2% chlorhexidine gel and root filling with Resilon/Epiphany did not effectively inhibit apical periodontitis subsequent to coronal inoculation.

Periapical status related to the quality of coronal restorations and root fillings in a Korean population.

INTRODUCTION: The purpose of this study was to assess the prevalence of apical periodontitis in root canal-treated teeth from the Korean population and to evaluate the relationship between the quality of root canal fillings and coronal restorations and the periapical status of these teeth. METHODS: Full-mouth periapical radiographs at the Dental Hospital of Yonsei University, Seoul, South Korea, were examined. A total of 1030 endodontically treated teeth restored with full veneer crown-type restorations were evaluated by 2 independent examiners. Teeth were classified as healthy or diseased according to the periapical status. The quality of endodontic treatment and coronal restorations were also classified via radiographic and clinical evaluation. The data were analyzed using the chi-square test and logistic regression. RESULTS: Forty-one percent of all endodontically treated teeth were classified as diseased. Approximately 35.6% of the teeth had endodontic treatments that were rated as adequate. The diseased teeth rate for cases with adequate endodontic treatment was 24.5%, which was significantly lower when compared with teeth with inadequate endodontic treatment (49.9%). The number of teeth with adequate coronal restorations was 706 (68.5%). Teeth with adequate coronal restorations had a significantly decreased prevalence of diseased teeth (34.7%) compared with teeth with inadequate coronal restorations (54.3%). Teeth with both adequate root fillings and restorations showed a significantly better outcome (82.3%) than the others, and teeth with both inadequate root fillings and restorations showed a significantly worse outcome (41.2%) than the others. CONCLUSIONS: Data from this Korean population showed a relatively high prevalence of apical periodontitis. The quality of endodontic treatment and coronal restorations were of equal importance and were strong independent predictors of the periapical status.

Symptomatic and asymptomatic apical periodontitis associated with red complex bacteria: clinical and microbiological evaluation.

In this study, the association of red complex (RC) bacteria that include Treponema denticola, Tannerella forsythia and Porphyromonas gingivalis with acute, exacerbated or chronic apical periodontitis was evaluated. Seventy-one patients with periapical disease were evaluated by clinical examination and microbiological samples obtained from the root canals were analyzed by a polymerase chain reaction assay. Twenty-one (29.6%) samples were positive for RC bacteria, with T. denticola, T. forsythia and P. gingivalis being detected in 14 (19.7%), 10 (14.1%) and 6 (8.5%) samples, respectively. RC bacteria were mainly associated with acute apical periodontitis (29.2%) and phoenix abscess (63.2%), while they were only sporadically detected (7.1%) in patients with chronic apical periodontitis. Generally, RC bacteria were associated with pain and a higher frequency of intracanalar/intrasulcular pus drainage. Involvement of RC bacteria in symptomatic periapical disease should be suspected in the presence of particularly severe clinical pain and pus drainage.

Relationship between smoking and endodontic variables in hypertensive patients.

INTRODUCTION: The aim of this study was to investigate the relationship between smoking and the prevalence of apical periodontitis and root canal treatment in hypertensive patients. METHODS: In a cross-sectional study, the records of 100 hypertensive patients, 50 smokers and 50 nonsmokers, were examined. Periapical status of all teeth was assessed by using the periapical index score. RESULTS: Apical periodontitis in 1 or more teeth was found in 92% of smoker patients and in 44% of nonsmoker subjects (P=.000; odds ratio [OR], 16.8; 95% confidence interval [CI], 4.6-61.3). One or more root-filled teeth were found in 58% and 20% of smoker and nonsmoker subjects, respectively (P < .01; OR, 5.5; 95% CI, 2.3-13.5). Among smoker hypertensive patients, 6% of the teeth had apical periodontitis, whereas in the nonsmoker subjects, 2% of teeth were affected (P < .01; OR, 3.3; 95% CI, 2.0-5.4). The percentage of root-filled teeth in the smoker and nonsmoker groups was 3.6% and 1.2%, respectively (P < .01; OR, 2.9; 95% CI, 1.6-5.5). CONCLUSIONS: The prevalence of apical periodontitis and root canal treatment was significantly higher in smoker hypertensive patients compared with nonsmoker subjects.

The effect of the gap between the post restoration and the remaining root canal filling on the periradicular status in a Turkish subpopulation.

OBJECTIVE: The aim of this study was to evaluate whether the gap between the post restoration and the remaining root canal filling had an impact on the periapical health of endodontically treated teeth in a Turkish subpopulation. STUDY DESIGN: Digital panoramic radiographs, evaluated for this cross-sectional study, were randomly selected from files of patients who attended to Yeditepe University, Faculty of Dentistry, between June 2007 and December 2008. The total number of teeth with endodontic posts and crowns was 407. Two observers assessed the radiographs and evaluated the quality of root canal filling and the gap between the root canal filling and the post restoration. Periapical status of the teeth was assessed by the Periapical Index (PAI) scores. Only the teeth with a minimum of 5 mm apical root canal filling that was classified as "good endodontic treatment" were included in the study. Teeth that had no root canal filling, poor endodontic treatment, or less than 5 mm remaining root canal filling beyond post restoration were not assessed. Chi-square test was used for statistical analysis and significance level was established at 5%. RESULTS: In cases with good endodontic treatment, there were 207 teeth that had no gap between the remaining root canal filling and the post restoration. In this group, 135 (65%) teeth had healthy periapex and 72 (35%) teeth showed signs of apical periodontitis. There were 81 teeth that had a gap between the remaining root canal filling and the post restoration. Of these teeth, 69 (85%) had periapical pathosis; however, only 12 (15%) teeth had healthy periapex. CONCLUSION: Statistical analysis revealed that the success rate of good endodontic treatment was significantly affected by the gap between the post restoration and remaining root canal filling (P < .001).

Treatment outcome in endodontics: the Toronto study--phases 3 and 4: orthograde retreatment.

Outcome 4-6 years after retreatment was assessed for Phases 3 and 4 of the Toronto Study. Of 477 teeth retreated, 333 were lost to follow-up, 18 were extracted, and 126 (41% recall, excluding 124 discontinuers) were examined for outcome of healed (periapical index score, < or = 2; no signs or symptoms) or diseased. When pooled with Phases 1 and 2, 187 of 229 teeth (82%) were healed. Logistic regression identified significant (P < or = .05) preoperative outcome predictors: root filling quality (odds ratio [OR], 4.18; confidence interval [CI], 1.72-10.12; healed: inadequate, 88%; adequate, 66%), perforation (OR, 4.01; CI, 1.28-12.62; healed: absent, 87%; present, 56%), and radiolucency (OR, 3.33; CI, 1.19-9.36; healed: absent, 93%; present, 80%). In teeth with radiolucency, outcome predictors were number of treatment sessions (OR, 12.08; CI, 1.84-infinity; healed: one, 100%; > or = 2, 77%) and previous root filling quality (OR, 7.68; CI, 2.36-26.89; healed: inadequate, 86%; adequate, 50%). Outcome was better in teeth with inadequate previous root filling, without perforation and radiolucency. Suggested significance of number of treatment sessions in teeth with radiolucency requires validation from randomized controlled trials.

Technical quality of root fillings and periapical status in root filled teeth in Jönköping, Sweden.

AIM: To study changes in technical quality of root fillings and periapical status in root filled teeth in random samples of 20 to 70 year-olds between 1973 and 2003. METHODOLOGY: Data from dentate subjects aged 20-70 years from examinations conducted in 1973 (n = 498), 1983 (n = 530), 1993 (n = 547) and 2003 (n = 491) were used for the analysis. Length of root fillings were measured on radiographs to the nearest 0.1 mm. Adequate seal was defined as a root filling without lateral and/or apical voids. Periapical status was assessed according to the periapical index. All observations were made by one calibrated observer registered from full mouth radiographic examinations. Teeth with root fillings ending within the canal without lateral or apical voids were considered adequate. The association between root filling quality and periapical status was analysed by means of the Chi-squared test and a multilevel logistic regression analysis. RESULTS: Adequately root filled teeth had a significantly lower frequency of apical periodontitis than inadequately root filled teeth (11.8% vs. 22.8%). The frequency of technically adequate root fillings increased statistically significant from 1973 (23.7%) to 2003 (36.4%) without a concomitant improvement of the periapical status in root filled teeth over time (24.5% vs. 24.6%). CONCLUSIONS: This study reports on an improving technical quality of root fillings over time, without a concomitant improvement of the periapical status in root filled teeth. A larger proportion of treated molars over time may be of importance for the result.

Aetiology, classification and pathogenesis of pulp and periapical disease.

At present, the majority of the treatments that are performed in the clinic are due to disease entities involving the dental pulp and periapex. Dental pulp is a richly vascularized and innervated tissue, enclosed by surrounding tissues that are incapable of expanding, such as dentin. It has terminal blood flow and small-gauge circulatory access the periapex. All of these characteristics severely constrain the defensive capacity of the pulp tissue when faced with the different aggressions it may be subjected to. Pulp tissue can also be affected by a retrograde infection, arising from the secondary canaliculi, from the periodontal ligament or from the apex during the course of periodontitis. Due to the fact that periapical disease is almost inevitably preceded by pulp disease, we shall begin by describing the causes of pulp disease and will then proceed to a discussion of the causes of periapical disease. The course of illness and classification of these pathological entities will depend on the aetiology involved. We will analyse pulp necrosis and pulp degeneration that are capable of triggering reversible apical periodontitis or irreversible apical periodontitis.

Etiología, clasificación y patogenia de la patología pulpar y periapical / Aetiology, classification and pathogenesis of pulp and periapical disease

En la actualidad, gran parte de los tratamientos que se realizan en la clínica son debidos a patologías que afectan a la pulpa y al periápice. La pulpa es un tejido ricamente vascularizado e inervado, delimitado por un entorno inextensible como es la dentina, con una circulación sanguínea terminal y con una zona de acceso circulatorio –periápice– de pequeño calibre. Todo ello, hace que la capacidad defensiva del tejido pulpar sea muy limitada ante las diversas agresiones que pueda sufrir. El tejido pulpar también puede ser afectado por una infección retrógrada (1), a partir de los canalículos secundarios, desde el ligamento periodontal o desde el ápice durante un proceso de periodontitis. Debido a que la patología periapical va casi siempre precedida de una afectación de la pulpa, describiremos en primer lugar las causas (2) de enfermedad pulpar y a continuación las causas de la patología periapical. De dicha etiología dependerá la evolución y la clasificación de estas patologías. Analizaremos la necrosis pulpar y la degeneración pulpar que pueden desencadenar una periodontitis apical reversible o una periodontitis apical irreversible (AU)

At present, the majority of the treatments that are performed in the clinic are due to disease entities involving the dental pulp and periapex. Dental pulp is a richly vascularized and innervated tissue, enclosed by surrounding tissues that are incapable of expanding, such as dentin. It has terminal blood flow and small-gauge circulatory access – the periapex. All of these characteristics severely constrain the defensive capacity of the pulp tissue when faced with the different aggressions it may be subjected to. Pulp tissue can also be affected by a retrograde infection (1), arising from the secondary canaliculi, from the periodontal ligament or from the apex during the course of periodontitis. Due to the fact that periapical disease is almost inevitably preceded by pulp disease, we shall begin by describing the causes (2) of pulp disease and will then proceed to a discussion of the causes of periapical disease. The course of illness and classification of these pathological entities will depend on the aetiology involved. We will analyse pulp necrosis and pulp degeneration that are capable of triggering reversible apical periodontitis or irreversible apical periodontitis (AU)

Periodontal-endodontic interdisciplinary treatment--a case report.

Periodontal-endodontic lesions pose a difficult diagnostic and therapeutic challenge to the dental practitioner. A careful diagnostic examination consisting of a thorough patient and dental history, comprehensive clinical examination, and use of appropriate dental radiographs is necessary to arrive at a proper diagnosis of the periodontal-endodontic lesion. Despite these measures, it is not always possible to make an accurate diagnosis, which is imperative to provide the proper therapy in the correct treatment sequence. In some instances, endodontic or periodontal therapy alone may suffice; however, in other instances, a combination of endodontic and periodontal therapy may be required to successfully treat the case. In this article, classifications of periodontal-endodontic lesions are discussed, including the appropriate treatment and correct treatment sequence for each classification. Prognosis of periodontal-endodontic lesions depends on the diagnosis, treatment, and chronicity of the lesion, as well as the duration of periodontal involvement. A clinical case is presented in which a periodontal endodontic lesion has been successfully treated with a combination of conventional endodontic therapy and regenerative periodontal surgery.

Tooth-specific risk indicators for apical periodontitis.

The present study aimed at identifying tooth-specific risk indicators for apical periodontitis (AP) and to investigate their interrelations in order to identify those teeth that would benefit from a radiographic examination. The study included 311 males and 302 females who gave written informed consent and attended a full-mouth radiographic examination. All teeth were assessed individually. AP was scored by the periapical index (PAI); other variables were root fillings, coronal fillings and crowns, pulpal posts, and caries. A conditional logistic regression analysis was used to assess the effect of tooth-specific risk indicators on the presence of apical periodontitis. The dependent variable was presence of AP versus absence of AP in the tooth. A total of 536 teeth with AP were identified. A highly increased risk for AP was seen in teeth with root fillings, particularly for technically inadequate ones. Presence of coronal fillings also increased the risk for AP, and inadequate fillings were associated with a slightly higher risk than adequate fillings. A similar pattern was seen for crowns. Teeth with caries also had an increased risk of AP, but the difference was only statistically significant for primary caries. Compared to first incisors, second incisors and canines had a significantly reduced risk, and molars, especially first maxillary molars, had a significantly increased risk for having AP.

Tobacco smoking and dental periapical condition.

The relation between smoking and apical periodontitis has been little studied to date. The aim of the present study was to investigate whether tobacco smoking might be associated with the prevalence or severity of periapical lesions. A total of 247 individuals, 81 current smokers, 63 former smokers, and 103 non-smokers participated in the study. The periapical condition was expressed as the number and percentage of radiographically detectable lesions and, in addition, as a severity index. The overall prevalence of apical periodontitis was 52% and the overall prevalence of endodontic treatment 58%. There was no significant influence of smoking on the prevalence of either apical periodontitis or endodontic treatment. The mean number (percentage) of periapical lesions per person was 1.9 (6%) in current smokers, 1.5 (4%) in former smokers, and 1.0 (3%) in non-smokers. Controlling for age, the association between smoking and periapical lesions was not statistically significant. The mean periapical severity index including all teeth, or teeth affected by periapical lesions alone, did not significantly differ between smoking groups. It is concluded that the present observations do not lend support to the assumption that tobacco smoking is associated with apical periodontitis.

Comparison between PAI and quantitative digital radiographic assessment of apical healing after endodontic treatment.

OBJECTIVE: The purpose of this study was to compare both subjective (Periapical Index, PAI) and objective (densitometric) radiographic evaluation of healing after endodontic treatment for apical periodontitis. STUDY DESIGN: Standardized radiographs of 103 teeth taken at baseline (immediately after endodontic treatment) and at 1, 4, 12, 26, and 52 weeks were evaluated. Consensus PAI scores obtained from 7 calibrated observers served as "true scores." Densitometric estimates of periapical status were obtained from digitized radiographs as the ratio of mean gray value of an area of radiolucency (AR) to an adjacent and similar-sized normal (N) area (AR/N). The selected regions of interest on baseline images were automatically superimposed on postoperative images. All estimates of change were measured with respect to baseline. The subtraction estimate was expressed as AR(S)-N(S). Linear regression was used to analyze longitudinal changes against baseline and to assess the relationship of PAI and AR/N and of change in PAI with respect to baseline and AR(S)-N(S). RESULTS: Five hundred fifty-six PAI scores were generated, with 547 AR/N values and 444 subtraction estimates. PAI, AR/N, and AR(S)-N(S) demonstrated statistical significance for change (P < or = .05) starting at 12 weeks. PAI was significantly correlated with AR/N (P < .0001), as was CHPAI with AR(S)-N(S) (P < .024). CONCLUSION: The PAI and 2 densitometric estimates (AR/N and AR(S)-N(S)) detected healing of apical periodontitis at 12 weeks after treatment. No difference could be observed among the methods.

A prognostic model for assessment of the outcome of endodontic treatment: Effect of biologic and diagnostic variables.

OBJECTIVE: Many biological variables, endodontic treatment factors, and restorative considerations have been suggested in the literature to affect the outcome of endodontic treatment. However, few attempts have been made recently to study these variables further. The purpose of this study was to identify the biologic and endodontic treatment-associated variables that are most predictive of treatment outcome for conventional endodontic therapy and to determine the magnitude of risk these variables pose on the outcome. STUDY DESIGN: The population of this historical prospective cohort study comprised a total of 200 teeth with 441 root canals. Diagnostic and treatment information was abstracted from the original patient records. An endodontic follow-up examination was conducted 4 +/- 0.5 years after obturation. Each tooth/root was analyzed according to 3 indices of periradicular status at 2 time points. The main outcome measure was the presence of apical periodontitis. The criteria used for evaluation of the outcome were modified from Strindberg. Data were subjected to univariate and multivariate analysis. Logistic regression models were fit by using various clinical measures to determine which combination of biologic and treatment-associated factors best predicted treatment outcome. RESULTS: The preoperative pulp diagnosis, the periapical diagnosis, the preoperative periapical radiolucency size, and the sex of the patients were revealed, by means of univariate analysis, to exert a significant influence on endodontic treatment outcome (P <.05). In the logistic regression model, the strongest effect on postoperative healing was the presence and magnitude of preoperative apical periodontitis. In the presence of this variable, no other factor contributed value to the prediction. The correct prediction of this model was 74.7% (P <.05). CONCLUSION: The major biologic factors influencing the outcome of endodontic treatment appear to be the extent of microbiological insult to the pulp and periapical tissue, as reflected by the periapical diagnosis and the magnitude of periapical pathosis.

Periapical status and quality of root fillings and coronal restorations in a Danish population.

AIM: The aim of this study was to investigate the quality of endodontic and coronal restorations and the association with periapical status in a Danish population. METHODOLOGY: A total of 614 randomly selected individuals (20-60+ years of age) from Aarhus County had a full-mouth radiographic examination. The quality of endodontic and coronal restorations and the periapical status of endodontically treated teeth were assessed by radiographic criteria. Root fillings were categorized as 'adequate' or 'inadequate' with regard to root filling length and lateral seal. Coronal restorations were categorized into 'adequate' and 'inadequate', defined by the absence or presence of radiographic signs of overhangs or open margins. Results were analysed statistically using the chi-squared test. RESULTS: The total number of endodontically treated teeth was 773, and 52.3% had apical periodontitis (AP). Root-filled teeth with an adequate lateral seal had a lower incidence of AP than teeth with an inadequate seal (44.3% vs. 57.8%), and teeth with an adequate root filling length were associated with a better periapical status than teeth with inadequate length of the root filling (42.0% vs. 67.6%). Similarly, adequate coronal restorations were associated with better periapical status than inadequate restorations (48.0% vs. 63.9%). When both root filling and coronal restoration quality were assessed, the incidence of AP ranged from 31.2% (optimal quality) to 78.3% (all parameters scored as inadequate). CONCLUSIONS: Inadequate root canal and coronal restorations were associated with an increased incidence of AP.

Perspectives, controversies and directives on pulpal-periodontal relationships.

While established clinical, radiographic and histologic criteria exist to explain the intimate relationship of the pulp and periodontium during pathological states, the recognition, diagnosis and treatment of this perplexing interplay remains a challenge for the practitioner. This dynamic interrelationship is investigated with a focus on simplicity and succinctness to enhance diagnostic probabilities, clarify treatment modalities and provide realistic prognoses in management.