Advances in planetary sustainability.

In the 21st century, existing human societies and biodiversity on the Earth are under threat because human resource consumption is exceeding or projected to exceed some of the physical and chemical boundaries of our planet (Rockström et al., 2009). Space research and space exploration are an integral part of a sustainable development that mitigates these threats: Space science and exploration allow us to monitor environmental threats and they open up access to global communication and participation for all human societies. In addition, space exploration also promises to expand the existing limitations and planetary boundaries imposed on human development. On the other hand space exploration can also cause additional environmental problems. The best known example for the latter is the anthropogenic space debris orbiting Earth, but similar problems are likely to occur in other places, for instance on the Moon, due to scientific and commercial space exploration in the near future. Planetary sustainability is a helpful concept to address the promises and challenges posed by space exploration with respect to sustainability. This concept can be understood as a sustainable development that considers the Earth as a planet in its space environment and considers the space environment as an integral part of sustainable development, with scientific, ethical, economic, and legal ramifications. In this article we review the recent advancements in planetary sustainability. This includes the proposal that the space environment of Earth should be added as an independent goal to the existing 17 Sustainable Development Goals defined by the United Nations, considerations of the planned return of humans to the Moon in 2024, and the implications of the increase of commercial satellite networks in low Earth orbit.

COSPAR Sample Safety Assessment Framework (SSAF).

The Committee on Space Research (COSPAR) Sample Safety Assessment Framework (SSAF) has been developed by a COSPAR appointed Working Group. The objective of the sample safety assessment would be to evaluate whether samples returned from Mars could be harmful for Earth's systems (e.g., environment, biosphere, geochemical cycles). During the Working Group's deliberations, it became clear that a comprehensive assessment to predict the effects of introducing life in new environments or ecologies is difficult and practically impossible, even for terrestrial life and certainly more so for unknown extraterrestrial life. To manage expectations, the scope of the SSAF was adjusted to evaluate only whether the presence of martian life can be excluded in samples returned from Mars. If the presence of martian life cannot be excluded, a Hold & Critical Review must be established to evaluate the risk management measures and decide on the next steps. The SSAF starts from a positive hypothesis (there is martian life in the samples), which is complementary to the null-hypothesis (there is no martian life in the samples) typically used for science. Testing the positive hypothesis includes four elements: (1) Bayesian statistics, (2) subsampling strategy, (3) test sequence, and (4) decision criteria. The test sequence capability covers self-replicating and non-self-replicating biology and biologically active molecules. Most of the investigations associated with the SSAF would need to be carried out within biological containment. The SSAF is described in sufficient detail to support planning activities for a Sample Receiving Facility (SRF) and for preparing science announcements, while at the same time acknowledging that further work is required before a detailed Sample Safety Assessment Protocol (SSAP) can be developed. The three major open issues to be addressed to optimize and implement the SSAF are (1) setting a value for the level of assurance to effectively exclude the presence of martian life in the samples, (2) carrying out an analogue test program, and (3) acquiring relevant contamination knowledge from all Mars Sample Return (MSR) flight and ground elements. Although the SSAF was developed specifically for assessing samples from Mars in the context of the currently planned NASA-ESA MSR Campaign, this framework and the basic safety approach are applicable to any other Mars sample return mission concept, with minor adjustments in the execution part related to the specific nature of the samples to be returned. The SSAF is also considered a sound basis for other COSPAR Planetary Protection Category V, restricted Earth return missions beyond Mars. It is anticipated that the SSAF will be subject to future review by the various MSR stakeholders.

Availability of open data for spatial public health research.

Background: Preventive and health-promoting policies can guide (place- and space-specific) factors influencing human health, such as the physical and social environment. Required is data that can lead to a more nuanced decision-making process and identify both existing and future challenges. Along with the rise of new technologies, and thus the multiple opportunities to use and process data, new options have emerged to measure and monitor factors that affect health. Thus, in recent years, several gateways for open data (including governmental and geospatial data) have become available. At present, an increasing number of research institutions as well as (state and private) companies and citizens' initiatives are providing data. However, there is a lack of overviews covering the range of such offerings regarding health. In particular, for geographically differentiated analyses, there are challenges related to data availability at different spatial levels and the growing number of data providers. Objectives: This paper aims to provide an overview of open data resources available in the context of space and health to date. It also describes the technical and legal conditions for using open data. Results: An up-to-date summary of results including information on relevant data access and terms of use is provided along with a web visualization. All data is available for further use under an open license.

Adolescent Development in Context: A Decade Review of Neighborhood and Activity Space Research.

Over the last decade, two lines of inquiry have emerged from earlier investigations of adolescent neighborhood effects. First, researchers began incorporating space-time geography to study adolescent development within activity spaces or routine activity locations and settings. Second, cultural-developmental researchers implicated neighborhood settings in cultural development, to capture neighborhood effects on competencies and processes that are salient or normative for minoritized youth. We review the decade's studies on adolescent externalizing, internalizing, academic achievement, health, and cultural development within neighborhoods and activity spaces. We offer recommendations supporting decompartmentalization of cultural-developmental and activity space scholarship to advance the science of adolescent development in context.

Immunological Aspects of Isolation and Confinement.

Beyond all doubts, the exploration of outer space is a strategically important and priority sector of the national economy, scientific and technological development of every and particular country, and of all human civilization in general. A number of stress factors, including a prolonged confinement in a limited hermetically sealed space, influence the human body in space on board the spaceship and during the orbital flight. All these factors predominantly negatively affect various functional systems of the organism, in particular, the astronaut's immunity. These ground-based experiments allow to elucidate the effect of confinement in a limited space on both the activation of the immunity and the changes of the immune status in dynamics. Also, due to simulation of one or another emergency situation, such an approach allows the estimation of the influence of an additional psychological stress on the immunity, particularly, in the context of the reserve capacity of the immune system. A sealed chamber seems a convenient site for working out the additional techniques for crew members selection, as well as the countermeasures for negative changes in the astronauts' immune status. In this review we attempted to collect information describing changes in human immunity during isolation experiments with different conditions including short- and long-term experiments in hermetically closed chambers with artificial environment and during Antarctic winter-over.

Portable Smart-Space Research Interface to Predetermine Environment Acoustics for Cochlear implant and Hearing aid users with CCi-MOBILE.

Internet of things (IoT) in healthcare, has effi-ciently accelerated medical monitoring and assessment through the real-time analysis of collected data. Hence, to support the hearing-impaired community with better calibrations to their clinical processors and hearing aids, a portable smart space interface - AURIS has been developed by the Cochlear Implant Processing Lab (CILab) at UT-Dallas. The proposed Auris interface periodically samples the acoustic space, and through a learn vs test phase, builds a Gaussian mixture model for each specific environmental locations. An effective connection is established by the Auris interface with the CRSS CCi-Mobile research platform through an android app to fine tune the con-figuration settings for cochlear implant (CI) or hearing aid (HA) users entering the room/location. Baseline objective evaluations have been performed in diverse naturalistic locations using 12 hours of audio data. The performance metrics is determined by a verified wireless communication, along with estimated acoustic environment knowledge and room classification at greater than 90% accuracy.

Science between Bioreactors and Space Research-Response to Comments by Joseph J. Bevelacqua et al. on "Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity".

We would like to thank Bevelacqua et al [...].

Beyond planetary protection: What is planetary sustainability and what are its implications for space research?

This paper presents recent developments in the interdisciplinary topic of "planetary sustainability" and discusses its potential implications for space research. The current COSPAR Planetary Protection Policy address scientific space exploration only and is primarily concerned with the issue of contamination with micro-organisms. Other impacts of human space exploration that may be detrimental to space exploration itself are not covered. The best known example is the anthropogenic space debris orbiting Earth, but similar problems will occur in other places due to scientific and commercial space exploration in the near future. One possible approach to discuss and mitigate the impact of space exploration on the environment is to consider the space environment as integral part of sustainable development. The resulting concept of "planetary sustainability" and its ethical, scientific, economic, and legal ramifications were discussed during a workshop co-sponsored by the International Space Science Institute in March 2018. In this paper, we first summarize the results of this workshop. Then we propose potential implications of this concept for space research and report reactions and suggestions by members of the space research community during the COSPAR assembly 2018.

Current status of space radiobiological studies in China.

After successfully launching two space laboratories, namely, Tiangong-1 and Tiangong-2, China has announced her next plan of constructing the Chinese Space Station (CSS) in 2022. The CSS will provide not only platforms for Chinese scientists to carry out experimental studies in outer space but also opportunities for open international cooperation. In this article, we review the development of China's manned space exploration missions and the preliminary plan for CSS. Additionally, China has initiated space radiation research decades ago with both ground-based simulation research platform and space vehicles and has made noticeable progresses in several aspects. These include studies on human health risk assessment using mammalian cell cultures and animals as models. Furthermore, there have been numerous studies on assessing the space environment in plant breeding.