Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents.

Reaction of piperazine with chloroacetylchloride in dry acetone yield compound 1: , which on reaction with hydrazine hydrate yielded compound 2: , which was further reacted with various substituted phenylisothiocyanates in absolute alcohol to afford compounds 3-8: i. e. 2-(carbazolylacetyl)-N-(substitutedphenyl)-hydrazinepiperazinothioamides. Compounds 3-8: on reaction with aqueous NaOH, ethanolic NaOH and conc. H2SO4 afford triazoles 9-14: , oxadiazoles 15-20: and thiadiazoles 21-26: respectively. Twenty four newly synthesized compounds were evaluated for their anticonvulsant activity and acute toxicity. The structures of these compounds were established on the basis of analytical and spectral data.