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Magnes Res ; 27(3): 113-30, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25560239

RESUMO

The renin-angiotensin system is critically involved in regulating arterial blood pressure (BP). Inappropriate angiotensin type-1 receptor activation by angiotensin-II (Ang-II) is related to increased arterial BP. Mg has a role in BP; it can affect cardiac electrical activity, myocardial contractility, and vascular tone. To evaluate the relationship between high BP induced by a high sodium (Na) diet and Mg, and other mineral balances, two experimental rat models of salt-sensitive, induced-hypertension were used: Ang-II infused and Dahl salt-sensitive (SS) rats. We found that: 1) Ang-II infusion progressively increased BP, which was accompanied by hypomagnesuria and signs of secondary hyperaldosteronism; 2) an additive effect between Ang-II and a high Na load may have an effect on strontium (Sr), zinc (Zn) and copper (Cu) balances; 3) Dahl SS rats fed a high Na diet had a slow pressor response, accompanied by altered Mg, Na, potassium (K), and phosphate (P) balances; and 4) losartan prevented BP increases induced by Ang II-NaCl, but did not modify mineral balances. In Dahl SS rats, losartan attenuated high BP and ameliorated magnesemia, Na and K balances. Mg metabolism maybe considered a possible defect in this strain of rat that may contribute to hypertension.


Assuntos
Bloqueadores do Receptor Tipo 1 de Angiotensina II/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Hipertensão/tratamento farmacológico , Losartan/uso terapêutico , Magnésio/fisiologia , Sistema Renina-Angiotensina/fisiologia , Angiotensina II/fisiologia , Angiotensina II/toxicidade , Animais , Pressão Sanguínea/fisiologia , Peso Corporal/efeitos dos fármacos , Diurese/efeitos dos fármacos , Ingestão de Líquidos/efeitos dos fármacos , Hiperaldosteronismo/etiologia , Hipertensão/etiologia , Hipertensão/genética , Hipertensão/fisiopatologia , Magnésio/sangue , Masculino , Minerais/sangue , Minerais/urina , Polidipsia/induzido quimicamente , Distribuição Aleatória , Ratos , Ratos Endogâmicos Dahl , Ratos Sprague-Dawley , Cloreto de Sódio na Dieta/efeitos adversos
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