RESUMO
En la última década, la expansión de cepas de bacilos gramnegativos multirresistentes ha suscitado un nuevo interés por antimicrobianos hasta ahora relegados a un segundo plano por un peor perfil de seguridad, pero que aún conservaban su actividad frente a estos microorganismos.La administración de aminoglucósidos en monodosis ha permitido minimizar sus efectos tóxicos y reintroducirlos en la práctica clínica. Por otra parte, estudios recientes han puesto en entredicho la utilidad de asociar aminoglucósidos a los (..) (AU)
The emergence of multidrug-resistant strains of gram-negative bacilli during the last decade has generated renewed interest in older antimicrobials that had been relegated to a second line because of a poorer safety profile, but that are still active against these microorganisms. Once-daily administration of aminoglycosides has limited the toxicity of these agents and enabled their reintroduction into clinical practice. Recent studies have shown no additional benefits of concomitant administration of aminoglycosides with current (..) AU)
Assuntos
Humanos , Polimixinas/farmacologia , Bactérias Gram-Negativas , Canamicina Quinase/farmacologia , Polimixinas/administração & dosagem , Polimixinas/classificação , Polimixinas/farmacocinética , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Canamicina Quinase/administração & dosagem , Canamicina Quinase/farmacocinéticaRESUMO
An antibiotic complex was isolated from culture 8-86 referred to Bacillus. The complex consisted of components 8-86A and 8-86B active against gram-negative organisms. By its physico-chemical properties such as IR and UV spectra, amino acid composition, specific rotation and fatty acid composition component 8-86B was shown to be close to polymyxin F.
