[The clinical characteristics and immunotherapy of complicated forms of adenovirus keratoconjunctivitis]. / Klinicheskie osobenoosti i immunoterapiia oslozhnennykh form adenovirusnogo keratokon''iunktivita.

Analysis of case histories and clinical and direct immunofluorescent examinations of 72 patients enabled the authors to single out 3 forms of complicated adenovirus keratoconjunctivitis (AVKC): 1) acute grave; 2) with toxic allergic reaction to previous treatment; and 3) steroid-complicated. Recommendations on the treatment of these forms are offered. A common remedy is interferon inductor poludan and chigain obtained from human colostrum and containing secretory IgA. Poludan was administered by instillations (4-6 times a day) and periocular injections in a dose of 100 U every 1-2 days, 5-6 injections per course, chigain was administered by instillations (2-4 daily). This combined treatment was highly effective and well tolerated. Periocular injection of poludan ensured much more intensive local and even systemic interferon production than instillations alone. Mean terms of treating complicated AVKC were compatible with those in uncomplicated forms: 14.3 +/- 2.1 vs. 13.2 +/- 1.2 days, respectively. Signs of herpesvirus infection were detected in one-third of patients with steroid-complicated AVKC. For eliminating corneal opacities in AVKC patients, enzyme phonophoresis, phototherapeutic keratectomy, and (in grave cases) lamellar keratoplasty are recommended.

[Effect of different polyribonucleotide interferonogens on acute and latent viral infections in mice]. / Vliianie razlichnykh poliribonukleotidnykh interferonogenov na ostruiu i latentnuiu virusnuiu infektsiiu myshei.

Poly(G) . poly(C) and poly(I) . poly(C) complexes administered soon after the viral challenge induced a high survival rate in mice with experimental tick-borne encephalitis. The protective effect was still noted when the treatment was given 24 hours after the infection. If the therapy was conducted at the end of the incubation period, at the peak of the virus reproduction in the mouse brain, poly(I) . poly(C) intensified the infection development and increased the animal death rate, while poly(G) . poly(C) had no such effect. Poly(I) . poly(C) injected 12 hours after the peak of the virus-induced interferonogenesis led to death of 80% animals inoculated with non-pathogenous Newcastle disease virus. The action of various samples of poly(I) . poly(C) was diverse. Poly(G) . poly(C) failed to effect the outcome of latent viral infection. The death of infected mice induced by polyribonucleotide complexes was not connected with their anti-viral interferonogenous activity, but correlated with the level of their toxicity for the intact animals. The results of the study have confirmed the risk of using poly(I) . poly(C) for the therapy of viral infections, especially during their clinical manifestation, and proved the safety of application of poly(G) . poly(C) and of some other polyribonucleotide interferonogens.