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1.
Med Mol Morphol ; 54(3): 296-300, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33452913

RESUMO

Secretory carcinoma of the salivary glands is a relatively new disease concept, and is characterized by "morphological resemblance to mammary secretory carcinoma and ETV6-NTRK3 gene fusion." Herein we describe a confusing case and briefly discuss practical diagnostic problems. The patient was a 71-year-old Japanese man who had a tumor consistent with secretory carcinoma at the microscopic and immunohistochemical levels. Immunohistochemically, EMA and S100 protein were noted to be positive along with various cytokeratins as well as mammaglobin and pSTAT5. Moreover, vimentin was focally positive. Smooth muscle actin, p63, p40, and androgen receptor were negative. However, a search using fluorescence in situ hybridization did not reveal a definite split signal for the ETV6 gene. It is presumed that confirming the diagnosis of secretory carcinoma without genetic retrieval will be accepted as a diagnostic method, and we hope that worldwide general recognition may earlier reach "gradual acceptance."


Assuntos
Biomarcadores Tumorais/análise , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Neoplasias Parotídeas/diagnóstico , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Repressoras/análise , Idoso , Regulação Neoplásica da Expressão Gênica , Humanos , Imuno-Histoquímica , Queratinas/análise , Queratinas/genética , Masculino , Carcinoma Secretor Análogo ao Mamário/metabolismo , Carcinoma Secretor Análogo ao Mamário/patologia , Neoplasias Parotídeas/metabolismo , Neoplasias Parotídeas/patologia , Proteínas S100/análise , Proteínas S100/genética , Fator de Transcrição STAT5/análise , Fator de Transcrição STAT5/genética , Variante 6 da Proteína do Fator de Translocação ETS
2.
Clin Cancer Res ; 25(16): 5167-5176, 2019 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-31182435

RESUMO

PURPOSE: Transcription factors are commonly deregulated in cancer, and they have been widely considered as difficult to target due to their nonenzymatic mechanism of action. Altered expression levels of members of the ETS-transcription factors are often observed in many different tumors, including lymphomas. Here, we characterized two small molecules, YK-4-279 and its clinical derivative, TK-216, targeting ETS factors via blocking the protein-protein interaction with RNA helicases, for their antilymphoma activity. EXPERIMENTAL DESIGN: The study included preclinical in vitro activity screening on a large panel of cell lines, both as single agent and in combination; validation experiments on in vivo models; and transcriptome and coimmunoprecipitation experiments. RESULTS: YK-4-279 and TK-216 demonstrated an antitumor activity across several lymphoma cell lines, which we validated in vivo. We observed synergistic activity when YK-4-279 and TK-216 were combined with the BCL2 inhibitor venetoclax and with the immunomodulatory drug lenalidomide. YK-4-279 and TK-216 interfere with protein interactions of ETS family members SPIB, in activated B-cell-like type diffuse large B-cell lymphomas, and SPI1, in germinal center B-cell-type diffuse large B-cell lymphomas. CONCLUSIONS: The ETS inhibitor YK-4-279 and its clinical derivative TK-216 represent a new class of agents with in vitro and in vivo antitumor activity in lymphomas. Although their detailed mechanism of action needs to be fully defined, in DLBCL they might act by targeting subtype-specific essential transcription factors.


Assuntos
Antineoplásicos/farmacologia , Indóis/farmacologia , Inibidores de Proteínas Quinases/farmacologia , Proteínas Proto-Oncogênicas c-ets/análise , Animais , Apoptose/efeitos dos fármacos , Biomarcadores Tumorais , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Modelos Animais de Doenças , Sinergismo Farmacológico , Perfilação da Expressão Gênica , Humanos , Imuno-Histoquímica , Linfoma/tratamento farmacológico , Linfoma/genética , Linfoma/metabolismo , Linfoma/patologia , Camundongos , Prognóstico , Ligação Proteica , Transcriptoma , Ensaios Antitumorais Modelo de Xenoenxerto
3.
Blood ; 134(8): 663-667, 2019 08 22.
Artigo em Inglês | MEDLINE | ID: mdl-31248877

RESUMO

Germ line mutations in ETV6 are responsible for a familial thrombocytopenia and leukemia predisposition syndrome. Thrombocytopenia is almost completely penetrant and is usually mild. Leukemia is reported in ∼30% of carriers and is most often B-cell acute lymphoblastic leukemia. The mechanisms by which ETV6 dysfunction promotes thrombocytopenia and leukemia remain unclear. Care for individuals with ETV6-related thrombocytopenia and leukemia predisposition includes genetic counseling, treatment or prevention of excessive bleeding and surveillance for the development of hematologic malignancy.


Assuntos
Mutação em Linhagem Germinativa , Leucemia/genética , Proteínas Proto-Oncogênicas c-ets/genética , Proteínas Repressoras/genética , Trombocitopenia/genética , Medula Óssea/metabolismo , Medula Óssea/patologia , Gerenciamento Clínico , Predisposição Genética para Doença , Hemorragia/etiologia , Hemorragia/prevenção & controle , Humanos , Leucemia/complicações , Leucemia/patologia , Leucemia/terapia , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Repressoras/análise , Trombocitopenia/complicações , Trombocitopenia/patologia , Trombocitopenia/terapia , Variante 6 da Proteína do Fator de Translocação ETS
4.
Eur Rev Med Pharmacol Sci ; 21(15): 3347-3352, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28829509

RESUMO

OBJECTIVE: To investigate the clinical significance of the expression of PSMA (prostate specific membrane antigen), TERT (telomerase reverse transcriptase), and PDEF (prostate derived Ets factor) in malignant tumors of the prostate. PATIENTS AND METHODS: The study was conducted with paraffin slices from 33 specimens of malignant tumors of the prostate and 17 of normal tissue. We found high levels of PSMA, TERT, and PDEF protein by Western blot and immunofluorescence in the malignant tumor of the prostate. We also detected upregulation of PSMA, TERT, and PDEF mRNA in the malignant tumor of the prostate, suggesting complex regulation of these three genes in prostate cancer. RESULTS: Variance analysis showed statistically significant differences comparing the expression of PSMA, TERT, and PDEF in the malignant tumor of the prostate and normal tissues. The high expression of PSMA, TERT, and PDEF in the malignant tumor of the prostate suggests the important roles of these three factors in the occurrence and development of the malignant tumors of the prostate. CONCLUSIONS: PSMA, TERT, and PDEF may serve as a reference for clinical diagnosis and as potential targets for the malignant tumor of the prostate therapeutics.


Assuntos
Antígenos de Superfície/genética , Glutamato Carboxipeptidase II/genética , Neoplasias da Próstata/genética , Proteínas Proto-Oncogênicas c-ets/genética , Telomerase/genética , Antígenos de Superfície/análise , Linhagem Celular Tumoral , Glutamato Carboxipeptidase II/análise , Humanos , Masculino , Reação em Cadeia da Polimerase , Neoplasias da Próstata/patologia , Proteínas Proto-Oncogênicas c-ets/análise , RNA Mensageiro/biossíntese , RNA Mensageiro/genética , Telomerase/análise
5.
Int J Surg Pathol ; 25(2): 127-140, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27670353

RESUMO

BACKGROUND: We investigated the reliability of combined DOG1 and mammaglobin immunohistochemistry compared with ETV6 fluorescence in situ hybridization (FISH) in the assessment of salivary tumors previously diagnosed as acinic cell carcinoma (ACC). Ultrastructural features of cases reclassified as mammary analogue secretory carcinoma (MASC) were assessed by transmission electron microscopy (TEM). METHODS: Immunohistochemical (IHC) reactivity to DOG1 and mammaglobin was validated against FISH targeting the ETV6 gene in all 14 cases. RESULTS: Three cases with papillary cystic histomorphology previously diagnosed as ACC were revised to MASC. TEM features of the ETV6 rearrangement-positive MASC cases showed large numbers of secretory granules with extrusion into the intercellular spaces, well-developed endoplasmic reticulum, lipid-laden vacuoles, well-formed microvilli, and large lining cystic spaces. CONCLUSIONS: Combined DOG1 and mammaglobin immunohistochemistry is comparable to ETV6 -breakapart analysis for differentiating between papillary cystic variants of ACC and MASC.


Assuntos
Biomarcadores Tumorais/análise , Carcinoma de Células Acinares/diagnóstico , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Neoplasias das Glândulas Salivares/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Anoctamina-1 , Carcinoma de Células Acinares/ultraestrutura , Canais de Cloreto/análise , Canais de Cloreto/biossíntese , Feminino , Humanos , Imuno-Histoquímica , Hibridização in Situ Fluorescente , Masculino , Microscopia Eletrônica de Transmissão , Pessoa de Meia-Idade , Proteínas de Neoplasias/análise , Proteínas de Neoplasias/biossíntese , Proteínas de Fusão Oncogênica/genética , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Proto-Oncogênicas c-ets/biossíntese , Proteínas Repressoras/análise , Proteínas Repressoras/biossíntese , Neoplasias das Glândulas Salivares/ultraestrutura , Adulto Jovem , Variante 6 da Proteína do Fator de Translocação ETS
6.
J Oral Pathol Med ; 44(4): 244-51, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25040635

RESUMO

BACKGROUND: Mammary analog secretory carcinoma (MASC) of the salivary gland has been recently described according to morphological, immunohistochemical, and molecular (ETV6-NTRK3 translocation) similarities with the mammary secretory carcinoma. The most important differential diagnostic considerations of MASC are low-grade adenocarcinoma not otherwise specified (NOS), cystadenocarcinoma, and acinic cell carcinoma (AciCC). These tumors may share an overlapping morphology with MASC, and additional immunohistochemical studies are required to reinforce the diagnosis. Mammaglobin, GCDFP-15, and p63 staining have been reported in MASC. Our study was designed to check the specificity of these antibodies in MASC compared to other frequent tumors of salivary glands. METHODS: A series of 62 salivary gland tumors [10 MASCs, 5 adenocarcinomas NOS and 2 cystadenocarcinomas with MASC features and without ETV6 rearrangement, one low-grade cribriform cystadenocarcinoma (LGCCC), 9 AciCCs, 10 MECs, 10 adenoid cystic carcinomas (AdeCCs), 5 polymorphous low-grade adenocarcinomas (PLGAs), and 10 pleomorphic adenomas (PAs)] was analyzed by immunohistochemistry with mammaglobin, GCDFP-15, and p63 antibodies. RESULTS: Positivity for mammaglobin was observed in all MASCs, cystadenocarcinomas, LGCCC, and PLGAs, in some adenocarcinomas NOS, PAs, and MECs, rarely in AciCCs and never in AdeCCs. Positivity for GCDFP-15 was observed in most of the tumor types except in AdeCCs. Interestingly, cytoplasmic positivity for p63 was observed in most of MASCs and PLGAs while rarely in adenocarcinomas NOS and PAs, and never in the other tumor types. CONCLUSION: Our study revealed the usefulness of mammaglobin and p63 cytoplasmic staining to define which tumors are worth to be screened for ETV6 rearrangement.


Assuntos
Proteínas de Transporte/análise , Glicoproteínas/análise , Mamoglobina A/análise , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Neoplasias das Glândulas Salivares/química , Neoplasias das Glândulas Salivares/diagnóstico , Fatores de Transcrição/análise , Proteínas Supressoras de Tumor/análise , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/análise , Feminino , Humanos , Imuno-Histoquímica , Hibridização In Situ/métodos , Masculino , Carcinoma Secretor Análogo ao Mamário/química , Carcinoma Secretor Análogo ao Mamário/patologia , Proteínas de Membrana Transportadoras , Pessoa de Meia-Idade , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Repressoras/análise , Neoplasias das Glândulas Salivares/patologia , Adulto Jovem , Variante 6 da Proteína do Fator de Translocação ETS
7.
Urology ; 84(1): 127-31, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24824408

RESUMO

OBJECTIVE: To investigate the association between the length of the polymorphic trinucleotide CAG microsatellite repeats in exon 1 of the AR gene and the risk of prostate cancer containing TMPRSS2:ETS fusion genes. METHODS: This nested case-control study came from subjects enrolled in the Prostate Cancer Prevention Trial and included 195 biopsy-proven prostate cancer cases with a known TMPRSS2:ETS status and 1344 matched controls. RESULTS: There was no association between the CAG repeat length and the risk of TMPRSS2:ETS-positive (odds ratio, 0.97; 95% confidence interval, 0.91-1.04) or TMPRSS2:ETS-negative prostate cancer (odds ratio, 1.04; 95% confidence interval, 0.97-1.11) and in patients with low- or high-grade disease. CONCLUSION: Our findings suggested that AR CAG repeats are not associated with TMPRSS2:ETS formation in prostate cancer.


Assuntos
Neoplasias da Próstata/genética , Proteínas Proto-Oncogênicas c-ets/genética , Receptores Androgênicos/genética , Serina Endopeptidases/genética , Repetições de Trinucleotídeos , Estudos de Casos e Controles , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/metabolismo , Proteínas Proto-Oncogênicas c-ets/análise , Fatores de Risco , Serina Endopeptidases/análise
8.
Virchows Arch ; 458(4): 421-30, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21318373

RESUMO

The E-twenty-six (ETS) family of transcription factors is known to act as positive or negative regulators of the expression of genes that are involved in diverse biological processes, including those that control cellular proliferation, differentiation, hematopoiesis, apoptosis, metastasis, tissue remodeling, and angiogenesis. Identification of target gene promoters of normal and oncogenic transcription factors provides new insights into the regulation of genes that are involved in the control of normal cell growth and differentiation. The aim of the present investigation was to analyze the differential expression of 11 ETS (ELF-3, ESE3, ETS1, ETV3, ETV4, ETV6, NERF, PDEF, PU1, Spi-B, and Spi-C) as potential markers for prognostic of colorectal cancer. A series of paired tissue biopsies consisting of a tumor and a non-affected control sample were harvested from 28 individuals suffering from diagnosed colorectal lesions. Total RNA was isolated from the samples, and after reverse transcription, differential expression of the select ETS was carried out through real-time polymerase chain reaction. Tumor staging as determined by histopathology was carried out to correlate the degree of tumor invasiveness with the expression of the ETS genes. The results demonstrated a different quantitative profile of expression in tumors and normal tissues. ETV4 was significantly upregulated with further increase in the event of lymph node involvement. PDEF and Spi-B presented downregulation, which was more significant when lymph node involvement was present. These findings were supported by immunohistochemistry of tumoral tissues. The results suggest that select ETS may serve as potential markers of colorectal cancer invasiveness and metastasis.


Assuntos
Adenocarcinoma/metabolismo , Biomarcadores Tumorais/análise , Neoplasias Colorretais/metabolismo , Proteínas Proto-Oncogênicas c-ets/biossíntese , Adenocarcinoma/genética , Adenocarcinoma/patologia , Biomarcadores Tumorais/genética , Neoplasias Colorretais/genética , Neoplasias Colorretais/patologia , Feminino , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Humanos , Imuno-Histoquímica , Masculino , Estadiamento de Neoplasias , Prognóstico , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Proto-Oncogênicas c-ets/genética , RNA Mensageiro/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa
9.
Gene Expr Patterns ; 11(1-2): 84-92, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-20932939

RESUMO

Transcription factor families are well known to be involved in the intrinsic pathways that regulate the organogenesis, early development, and microenvironment of the thymus. However, identification of the transcription factors (TFs) involved in the late development of the thymus, particularly later than embryonic day 15.5 (E15.5), is progressing slowly. In this study, we used in situ hybridization to screen numerous expression patterns of the TFs involved in the development of the mouse thymus. More than 400 members, including unique TFs and some transcription co-factors, were tested. Among the screened TFs, 160 were found to be expressed in the thymus after E15.5, and 74 of these were expressed in restricted areas.


Assuntos
Regulação da Expressão Gênica no Desenvolvimento , Timo/embriologia , Timo/metabolismo , Fatores de Transcrição/análise , Fatores de Transcrição/genética , Animais , Hibridização In Situ , Camundongos , Camundongos Endogâmicos C57BL , Organogênese , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Proto-Oncogênicas c-ets/genética , Receptores Citoplasmáticos e Nucleares/análise , Receptores Citoplasmáticos e Nucleares/genética
10.
Gene ; 463(1-2): 8-17, 2010 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-20441787

RESUMO

Immunoglobulin mu-binding protein 2 (IGHMBP2/Smubp-2) is a helicase motif-containing DNA-binding protein that has been suggested to regulate various nuclear functions. Recent studies indicated that mutations in the IGHMBP2 gene are responsible for spinal muscular atrophy with respiratory distress type I (SMARD1). However, the mechanism of regulation of IGHMBP2 gene expression remains unclear. In the present study, a 2.0-kb fragment of the 5'-flanking (promoter) region of the human IGHMBP2 gene was isolated from the HL-60 genome by PCR and ligated into a luciferase (Luc) expression vector, pGL3, to generate the pSmu-Luc plasmid. Deletion analyses revealed that a 108-bp region is essential for basal promoter activity with a response to TPA in HL-60 cells. TF-SEARCH analysis showed that overlapping ets (GGAA) motifs are located upstream of the transcription start sites. Chromatin immunoprecipitation (ChIP) assay, electropheretic mobility shift assay (EMSA) and competition analyses indicated that PU.1 (Spi-1) recognizes and binds to the duplicated ets motifs in this 108-bp region. Moreover, co-transfection of the PU.1 expression plasmid and pSmu-Luc into HL-60 cells revealed that PU.1 modulates TPA-induced IGHMBP2 promoter activity. Taken together, these observations suggest that the duplicated GGAA motifs are essential for the IGHMBP2 promoter activity and its positive response to TPA in HL-60 cells.


Assuntos
Proteínas de Ligação a DNA/genética , Regiões Promotoras Genéticas , Proteínas Proto-Oncogênicas/metabolismo , Acetato de Tetradecanoilforbol/farmacologia , Transativadores/metabolismo , Fatores de Transcrição/genética , Animais , Diferenciação Celular , Fator de Transcrição de Proteínas de Ligação GA , Células HL-60 , Humanos , Camundongos , Proteínas Proto-Oncogênicas/farmacologia , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Proto-Oncogênicas c-ets/metabolismo , Transativadores/farmacologia , Sítio de Iniciação de Transcrição , Transfecção , Proteínas Elk-1 do Domínio ets
11.
Pathologe ; 30 Suppl 2: 154-7, 2009 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-19802609

RESUMO

At present the diagnosis of prostate cancer is carried out by transrectally obtained biopsy samples. The histological findings, the value for prostate-specific antigen (PSA) in the serum, and the clinical stage are the objective criteria for all subsequent therapy decisions. In over 95% of cases an acinar "usual" form of prostate cancer is diagnosed but can be very different in characteristics and differentiation. In order to correctly assess prostate cancer and to be able to select the best possible therapeutic measures resulting from the diagnosis, all information obtained from the biopsy must be used to a maximum. The demands on the optimal biopsy findings have considerably expanded in recent years. It must be able to obtain all additional biological, molecular and genetic findings from the biopsy material.


Assuntos
Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Próstata/patologia , Neoplasias da Próstata/genética , Neoplasias da Próstata/patologia , Biópsia , Humanos , Interleucina-6/genética , Masculino , Invasividade Neoplásica/genética , Invasividade Neoplásica/patologia , Estadiamento de Neoplasias , Antígeno Prostático Específico/análise , Neoplasias da Próstata/terapia , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Proto-Oncogênicas c-ets/genética , Transdução de Sinais/genética , Proteína 3 Supressora da Sinalização de Citocinas , Proteínas Supressoras da Sinalização de Citocina/análise , Proteínas Supressoras da Sinalização de Citocina/genética
12.
Cancer Genet Cytogenet ; 183(1): 21-7, 2008 May.
Artigo em Inglês | MEDLINE | ID: mdl-18474293

RESUMO

The recent identification of fusion genes involving ETS family members in human prostate adenocarcinoma has confirmed the hypothesis that recurrent specific aberrations such as fusion genes may be as frequent in epithelial tumors as they are in leukemias and sarcomas. However, reciprocal translocations with fusion genes are often not detectable in carcinomas by conventional karyotyping because of additional complex chromosomal abnormalities. We retrospectively analyzed a large series of formalin-fixed, paraffin-embedded samples including 55 prostate carcinomas and 11 benign prostate tumors. We identified the fusion gene TMPRSS2-ERG by reverse-transcriptase polymerase chain reaction (RT-PCR) in 40/55 carcinomas (72%). Our study demonstrates that the detection of ETS fusion gene by RT-PCR is feasible on formalin-fixed and paraffin-embedded samples. No significant association between the presence of the fusion gene and any clinical feature, such as preoperative serum prostate-specific antigen (PSA) level (PSA>20 or PSA< or =20), pTNM stage including capsule invasion, seminal vesicle invasion, and lymph nodes metastases, or recurrence was observed in our series.


Assuntos
Adenocarcinoma/genética , Adenocarcinoma/patologia , Inclusão em Parafina , Neoplasias da Próstata/genética , Neoplasias da Próstata/patologia , Proteínas Proto-Oncogênicas c-ets/análise , Serina Endopeptidases/análise , Proteínas E1A de Adenovirus/análise , Proteínas E1A de Adenovirus/genética , Idoso , Idoso de 80 Anos ou mais , Proteínas de Ligação a DNA/análise , Proteínas de Ligação a DNA/genética , Estudos de Viabilidade , Fixadores/farmacologia , Formaldeído/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Proteínas de Fusão Oncogênica/análise , Proteínas de Fusão Oncogênica/genética , Inclusão em Parafina/métodos , Proteínas Proto-Oncogênicas/análise , Proteínas Proto-Oncogênicas/genética , Proteínas Proto-Oncogênicas c-ets/genética , Estudos Retrospectivos , Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos , Serina Endopeptidases/genética , Fatores de Transcrição/análise , Fatores de Transcrição/genética
13.
Genes Chromosomes Cancer ; 45(6): 608-11, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16552772

RESUMO

Near-tetraploidy (82-94 chromosomes) makes up fewer than 1% of childhood acute lymphoblastic leukemia (ALL) cases and has been reportedly associated with a possibly poorer prognosis compared with other ploidy groups. We analyzed 783 patients enrolled in the ALL-BFM-Austria 86, -90, -95, -99/2000 and Interfant-Austria 99 trials in order to assess its incidence, biological characteristics, and prognostic relevance. Twelve of 783 patients (1.5%) had a near-tetraploid ALL. Fluorescence in situ hybridization revealed that eight of the nine B-cell precursor (BCP) cases and none of the three T-cell ALL cases had an ETV6/RUNX1 rearrangement. After a median follow-up of 11.4 years, none of the patients has relapsed or died. Thus, near-tetraploidy appears to be a specific feature of ETV6/RUNX1+ BCP ALL cases that in turn may explain its excellent outcome.


Assuntos
Subunidade alfa 2 de Fator de Ligação ao Core/análise , Poliploidia , Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Repressoras/análise , Adolescente , Áustria , Criança , Pré-Escolar , Subunidade alfa 2 de Fator de Ligação ao Core/genética , Análise Citogenética , Humanos , Hibridização in Situ Fluorescente , Leucemia-Linfoma Linfoblástico de Células Precursoras B/patologia , Proteínas Proto-Oncogênicas c-ets/genética , Proteínas Repressoras/genética , Variante 6 da Proteína do Fator de Translocação ETS
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