Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 59
Filtrar
1.
BMJ Case Rep ; 16(4)2023 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-37185313

RESUMO

We describe a man in his 40s with a history of chronic intranasal cocaine use and C5-C7 incomplete quadriplegia complicated by neurogenic orthostatic hypotension, admitted to the intensive care unit for worsening bradycardia and hypotension requiring initiation of dopamine and an increase of his home midodrine dose. The patient experienced refractory bradycardia and hypotension with weaning of dopamine, and therefore a recommendation was made to add pseudoephedrine to his current regimen. This case describes the addition of pseudoephedrine to facilitate weaning off intravenous vasopressors within 24 hours in a patient with refractory bradycardia and hypotension secondary to autonomic dysfunction.


Assuntos
Doenças do Sistema Nervoso Autônomo , Hipotensão Ortostática , Hipotensão , Midodrina , Masculino , Humanos , Pseudoefedrina/efeitos adversos , Bradicardia/induzido quimicamente , Bradicardia/tratamento farmacológico , Dopamina/uso terapêutico , Hipotensão/induzido quimicamente , Hipotensão/tratamento farmacológico , Hipotensão/complicações , Doenças do Sistema Nervoso Autônomo/complicações , Doenças do Sistema Nervoso Autônomo/tratamento farmacológico , Hipotensão Ortostática/etiologia , Midodrina/efeitos adversos
2.
Clin Neuropharmacol ; 45(5): 145-147, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36066857

RESUMO

INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is a syndrome that is manifested by a variety of clinical findings, like headache, seizure, loss of vision and change in consciousness, and characterized by bilateral vasogenic edema, which is usually located in the posterior part of the hemispheres, but sometimes located in atypical localization. CASE PRESENTATION: A 56-year-old man with no known systemic disease with generalized tonic clonic seizure was evaluated. He had oral paracetamol + pseudoephedrine HCl for runny nose, sore throat, and headache. After the second dosage, he had a seizure while sleeping. In flair sequence of magnetic resonance imaging, bilateral cortical and subcortical hyperintensities were observed in the posterior parts of the hemispheres and the cerebellar hemispheres, which demonstrated PRES. CONCLUSION: We presented a PRES case with seizures after using 2 doses of pseudoephedrine. In addition to hypertension, several factors have been blamed, such as eclampsia-preeclampsia, some immunosuppressive and chemotherapeutic drugs, some kidney diseases. Although the patient had no known risk factors for PRES, he was diagnosed with hypertension and diabetes mellitus during follow-up.


Assuntos
Hipertensão , Síndrome da Leucoencefalopatia Posterior , Acetaminofen/uso terapêutico , Feminino , Cefaleia , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Síndrome da Leucoencefalopatia Posterior/induzido quimicamente , Síndrome da Leucoencefalopatia Posterior/diagnóstico por imagem , Gravidez , Pseudoefedrina/efeitos adversos , Convulsões/induzido quimicamente
4.
Ann Allergy Asthma Immunol ; 127(3): 342-348.e2, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34000435

RESUMO

BACKGROUND: Although it is known that oral antihistamine-pseudoephedrine combination tablets have a faster onset than intranasal corticosteroid sprays in the treatment of allergic rhinitis after the first dose, the magnitude of change has not been measured in a comparative manner. Furthermore, the sensation of sprayed liquid in the nose may lead patients to mistakenly believe that intranasal steroid sprays work instantly. OBJECTIVE: To evaluate, numerically, nasal airflow changes provided by a single dose of loratadine-pseudoephedrine tablet (LP) and fluticasone propionate nasal spray (FP) in participants experiencing allergic rhinitis symptoms, including nasal congestion. METHODS: This single-center, double-blinded, placebo-controlled, crossover study evaluated objective nasal airflow changes in patients with a documented sensitivity to ragweed pollen. Participants were randomized to receive 1 of 4 treatment sequences, and their peak nasal inspiratory flow (PNIF) was measured in a span of 4 hours after pollen exposure in an environmental exposure unit. RESULTS: Average change in PNIF was 31% with LP in the course of the study, significantly greater than with placebo and FP (12% and 15%, respectively; P < .001). Nevertheless, FP did not produce a significant change compared with its placebo. At hour one post-dose, LP had a clinically significant 31% increase in PNIF, whereas FP only yielded an 8.6% increase (P < .001). Measurable nasal airflow improvements are associated with the opening of nasal passages, allowing congested patients to breathe more freely. CONCLUSION: A single dose of LP quickly and significantly (P < .001) improved nasal airflow after ragweed pollen challenge in an environmental exposure unit. Comparatively, FP did not display this same benefit. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03443843.


Assuntos
Antialérgicos/administração & dosagem , Fluticasona/administração & dosagem , Loratadina/administração & dosagem , Descongestionantes Nasais/administração & dosagem , Pseudoefedrina/administração & dosagem , Rinite Alérgica/tratamento farmacológico , Administração Intranasal , Adulto , Antialérgicos/efeitos adversos , Estudos Cross-Over , Método Duplo-Cego , Combinação de Medicamentos , Feminino , Fluticasona/efeitos adversos , Humanos , Loratadina/efeitos adversos , Masculino , Pessoa de Meia-Idade , Cavidade Nasal/fisiologia , Descongestionantes Nasais/efeitos adversos , Sprays Nasais , Pseudoefedrina/efeitos adversos , Fenômenos Fisiológicos Respiratórios , Rinite Alérgica/fisiopatologia , Comprimidos , Adulto Jovem
6.
Yakugaku Zasshi ; 139(11): 1417-1425, 2019.
Artigo em Japonês | MEDLINE | ID: mdl-31685738

RESUMO

Ephedra Herb is defined in the 17th edition of the Japanese Pharmacopoeia (JP) as the terrestrial stem of Ephedra sinica Stapf., Ephedra intermedia Schrenk et C.A. Meyer, or Ephedra equisetina Bunge (Ephedraceae). The stems of Ephedra Herb contain greater than 0.7% ephedrine alkaloids (ephedrine and pseudoephedrine). Despite its high effectiveness, Ephedra Herb exert several adverse effects, including palpitation, excitation, insomnia, and dysuria. Both the primary and adverse effects of Ephedra Herb have been traditionally believed to be mediated by these ephedrine alkaloids. However, our study found that several pharmacological actions of Ephedra Herb were not associated with ephedrine alkaloids. We prepared an ephedrine alkaloid-free Ephedra Herb extract (EFE) by eliminating ephedrine alkaloids from Ephedra Herb extract (EHE) using ion-exchange column chromatography. EFE exerted analgesic, anti-influenza, and anticancer activities in the same manner as EHE. Moreover, EFE did not induce adverse effects due to ephedrine alkaloids, such as excitation, insomnia, and arrhythmias, and showed no toxicity. Furthermore, we evaluated the safety of EFE in healthy volunteers. The number of adverse event cases was higher in the EHE-treated group than in the EFE-treated group, although the difference was not significant. Our evidence suggested that EFE was safer than EHE.


Assuntos
Medicamentos de Ervas Chinesas/efeitos adversos , Medicamentos de Ervas Chinesas/química , Ephedra/química , Idoso , Analgésicos , Antineoplásicos Fitogênicos , Antivirais , Cromatografia por Troca Iônica , Medicamentos de Ervas Chinesas/farmacologia , Efedrina/efeitos adversos , Efedrina/isolamento & purificação , Feminino , Humanos , Masculino , Pseudoefedrina/efeitos adversos , Pseudoefedrina/isolamento & purificação , Segurança
7.
Int J Clin Pharmacol Ther ; 56(12): 604-611, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30220290

RESUMO

OBJECTIVE: Evaluate effects of a multisymptom tablet on cold and flu symptoms within 4 hours post-administration. MATERIALS AND METHODS: This was a randomized, double-blind, placebo-controlled study in adults with cold and flu symptoms. Eligible participants with at least moderate common cold or flu symptoms and symptom onset ≤ 48 hours before screening were assigned to a single multiple-active-ingredient tablet (containing paracetamol, pseudoephedrine hydrochloride, dextromethorphan hydrobromide, and chlorpheniramine maleate) or placebo tablet. Participants rated severity of each symptom (sore throat, headache, extremity pain, nasal congestion, sneezing, runny nose, and cough) from 0 (absent) to 3 (severe) at 15 and 30 minutes and 1, 2, 3, and 4 hours post administration. The total symptom score (TSS) was calculated as the sum of the individual symptom scores (primary endpoint). Participants rated global response to treatment on a scale from 0 (ineffective) to 4 (excellent). Adverse events (AEs) were recorded throughout. RESULTS: Of 53 participants randomized, 52 received active tablet (n = 25) or placebo tablet (n = 27). Change from baseline in TSS throughout the 4-hour post-administration period was similar between groups. An efficacy criterion of 30% decrease in TSS at assessment points was not met (range, -1.91 to 8.94%). There were also no significant differences between groups in mean symptom scores for individual symptoms or global response to treatment. Four non-serious treatment-emergent adverse events occurred. CONCLUSION: In this exploratory pilot study, a multisymptom cold and flu tablet was well tolerated but did not differ from placebo tablet with regard to onset of action following a single dose.
.


Assuntos
Acetaminofen/administração & dosagem , Analgésicos não Narcóticos/administração & dosagem , Antitussígenos/administração & dosagem , Clorfeniramina/administração & dosagem , Resfriado Comum/tratamento farmacológico , Dextrometorfano/administração & dosagem , Antagonistas dos Receptores Histamínicos H1/administração & dosagem , Influenza Humana/tratamento farmacológico , Descongestionantes Nasais/administração & dosagem , Pseudoefedrina/administração & dosagem , Acetaminofen/efeitos adversos , Administração Oral , Adulto , Analgésicos não Narcóticos/efeitos adversos , Antitussígenos/efeitos adversos , China , Clorfeniramina/efeitos adversos , Resfriado Comum/diagnóstico , Resfriado Comum/virologia , Dextrometorfano/efeitos adversos , Método Duplo-Cego , Combinação de Medicamentos , Feminino , Antagonistas dos Receptores Histamínicos H1/efeitos adversos , Humanos , Influenza Humana/diagnóstico , Influenza Humana/virologia , Masculino , Pessoa de Meia-Idade , Descongestionantes Nasais/efeitos adversos , Satisfação do Paciente , Projetos Piloto , Pseudoefedrina/efeitos adversos , Indução de Remissão , Comprimidos , Fatores de Tempo , Resultado do Tratamento
9.
Apunts, Med. esport (Internet) ; 53(197): 11-18, ene.-mar. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-171426

RESUMO

The presence of adverse results in doping controls is always bad news for the sport, as it reflects the moral and ethical absence of a clean competition. Its prevalence and evolution is important to know and have criteria on the relevance of this event. Method: The results of doping controls from 2003 to 2015 at the global level, offered by the World Anti-Doping Agency on its website, have been revised. Results: The presence of adverse results of the year 2015 as last reference, reached 0.83% in Olympic sports and 2.04% in the non-Olympic ones. It remains a similar level during the last 7 years, tending to decline in the Olympics and increase in the non-Olympics. The groups of predominant substances are, in order, anabolic steroids 50.3%, stimulants 15.4% and maskers 12.5%, being the rest diverse and variable. It should be noted that many treatments with therapeutic authorisation, i.e., beta agonists (3-4%), glucocorticosteroids (6-8%) or central nervous system (3-5%), are shown as adverse results, but are therefore not doping positive and in their case punishable. Similarly, the high number of anabolic positives is the result of fraud, but also the presence of repeated samples in the follow-up study of some athletes. Conclusion: The data serve as a reference to have a more accurate criterion in reference to this field of sport (AU)


La presencia de resultados adversos en los controles de dopaje son siempre una noticia nefasta para el deporte, pues refleja la ausencia moral y ética de una competición limpia. Su prevalencia y evolución es importante para conocer y disponer de criterio sobre la relevancia de este suceso. Método: Se han revisado los resultados de los controles de dopaje del 2003 al 2015 a nivel mundial, ofrecidos por la Agencia Mundial Antidopaje en su web. Se ofrecen, además, los resultados por deportes del 2015. Resultados: La presencia de resultados adversos, tomando de referencia ese año, alcanza un 0,83% de las muestras estudiadas en los deportes olímpicos y un 2,04% en los no olímpicos. Se mantiene un nivel similar en los últimos 7 años, tendiendo a disminuir en los deportes olímpicos y aumentar en los no olímpicos. Los grupos de sustancias predominantes son, por orden, anabolizantes (50,3%), estimulantes (15,4%) y enmascarantes (12,5%), siendo el resto diverso y variable. En el total de resultados debe tenerse en cuenta que muchos tratamientos con autorización terapéutica, por ejemplo para beta-agonistas (3-4%), glucocorticoides (6-8%) o del sistema nervioso central (3-5%), se muestran como resultados adversos, pero no son por tanto dopaje positivo ni en su caso sancionables. De igual manera, el elevado número de positivos en anabolizantes son fruto del fraude pero también de la presencia de muestras repetidas en los seguimientos de estudio de algunos deportistas. Conclusión: Los datos sirven de referencia para disponer de un criterio más certero en referencia a este ámbito del deporte (AU)


Assuntos
Humanos , Masculino , Feminino , Dopagem Esportivo/métodos , Anabolizantes/análise , Esportes/normas , Estudos Longitudinais , Testosterona/análise , Pseudoefedrina/efeitos adversos , Efedrina/efeitos adversos , Cocaína/efeitos adversos , Cafeína/efeitos adversos , 3,4-Metilenodioxianfetamina/efeitos adversos
11.
Microsc Res Tech ; 81(2): 220-227, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29134721

RESUMO

Medicaments essential for alleviation of diseases may sometime adversely affect dental health by eroding the enamel, owing to their acidic nature. It is therefore highly desirable to be able to detect these effects quickly and reliably. In this study, we evaluated the erosive capacity of four most commonly prescribed respiratory disease syrup medicaments on enamel using micro-energy-dispersive X-ray fluorescence spectrometry (µ-EDXRF) and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Fifty-five enamel fragments obtained from 30 bovine teeth were treated with artificial saliva (S), acebrofilin hydrochloride (AC), ambroxol hydrochloride (AM), bromhexine hydrochloride (BR), and salbutamol sulfate (SS); by immersing in 3 mL of respective solutions for 1 min, three times a day at intervals of 1 hr, for 5 days. µ-EDXRF analysis of enamel surface did not reveal significant erosion caused by the medications. However, ATR-FTIR showed a detectable shift in the phosphate (PO4 ) antisymmetric stretching mode (ν3 ) at ∼985 cm-1 for AM, BR, and SS, indicating erosion. Multivariate statistical analysis showed that AC, AM, SS, and BR could be classified with 70%, 80%, 100%, and 100% efficiency from S (control), further highlighting the ability of ATR-FTIR to identify degree of erosion. This suggests ATR-FTIR may be used to rapidly and nondestructively investigate erosive effects of medicaments.


Assuntos
Esmalte Dentário/efeitos dos fármacos , Medicamentos sem Prescrição/efeitos adversos , Espectroscopia de Infravermelho com Transformada de Fourier , Erosão Dentária/induzido quimicamente , Antialérgicos/efeitos adversos , Bromofeniramina/efeitos adversos , Esmalte Dentário/patologia , Combinação de Medicamentos , Humanos , Loratadina/efeitos adversos , Microscopia Eletrônica de Varredura , Dente Molar/efeitos dos fármacos , Descongestionantes Nasais/efeitos adversos , Pseudoefedrina/efeitos adversos , Doenças Respiratórias/tratamento farmacológico , Espectrometria por Raios X/métodos , Propriedades de Superfície/efeitos dos fármacos
13.
J Fam Pract ; 66(6): E1-E2, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28574526

RESUMO

It is unclear. Pseudoephedrine causes an average increase of 1.2 mm Hg in systolic blood pressure (BP) in patients with controlled hypertension. However, the studies are not adequately powered to provide evidence about whether this rise in systolic BP is linked to patient-oriented outcomes (strength of recommendation: C, multiple randomized controlled trials supporting disease-oriented evidence). Significant variations in BP are defined differently among studies. In addition, we do not have data on chronic use of oral decongestants; the longest time on medication in these trials was 4 weeks.


Assuntos
Pressão Sanguínea/efeitos dos fármacos , Hipertensão/fisiopatologia , Descongestionantes Nasais/uso terapêutico , Pseudoefedrina/uso terapêutico , Humanos , Descongestionantes Nasais/efeitos adversos , Pseudoefedrina/efeitos adversos
14.
Andrology ; 5(4): 744-748, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-28380686

RESUMO

The use of pseudoephedrine, an alpha agonist, for the treatment of retrograde ejaculation is well-known, however, there is no clear consensus from the literature regarding its efficacy and treatment protocol. We evaluated the efficacy of pseudoephedrine treatment in patients with retrograde ejaculation, utilizing a yet undescribed short-period treatment protocol. Twenty men were medically treated with pseudoephedrine for retrograde ejaculation between January 2010 and May 2016 (12 with complete retrograde ejaculation and 8 with partial retrograde ejaculation). All patients had a semen analysis and post-ejaculatory urinalysis before and after treatment. The treatment protocol consisted of 60 mg of pseudoephedrine every 6 h on the day before semen analysis and two more 60 mg doses on the day of the semen analysis. Diabetes was the most common etiology for complete retrograde ejaculation (60%), whereas an idiopathic cause was the most common etiology for partial retrograde ejaculation (82%). Of the 12 complete retrograde ejaculation patients treated with pseudoephedrine prior to semen analysis, 7 (58.3%) recovered spermatozoa in the antegrade ejaculate, with a mean total sperm count of 273.5 ± 172.5 million. Of the eight patients with partial retrograde ejaculation, five (62.5%) had a ≥50% increase in the antegrade total sperm count. In this group, the mean total sperm count increased from 26.9 ± 8.5 million before treatment to 84.2 ± 24.6 million after treatment, whereas the percentage of spermatozoa in the urine declined from 43.2 ± 9% to 17 ± 10%, respectively (both p < 0.05). Overall, in men with retrograde ejaculation treated with a pseudoephedrine regimen prior to ejaculation, some improvement in seminal parameters occurred in 14 (70%) patients, with 10 patients (38.5% of all patients) achieving antegrade total sperm counts over 39 million.


Assuntos
Agonistas alfa-Adrenérgicos/administração & dosagem , Ejaculação/efeitos dos fármacos , Infertilidade Masculina/tratamento farmacológico , Pseudoefedrina/administração & dosagem , Disfunções Sexuais Fisiológicas/tratamento farmacológico , Agonistas alfa-Adrenérgicos/efeitos adversos , Adulto , Bases de Dados Factuais , Esquema de Medicação , Humanos , Infertilidade Masculina/diagnóstico , Infertilidade Masculina/fisiopatologia , Masculino , Pseudoefedrina/efeitos adversos , Estudos Retrospectivos , Disfunções Sexuais Fisiológicas/diagnóstico , Disfunções Sexuais Fisiológicas/fisiopatologia , Contagem de Espermatozoides , Motilidade dos Espermatozoides/efeitos dos fármacos , Fatores de Tempo , Resultado do Tratamento
15.
Can J Cardiol ; 33(5): 688.e1-688.e3, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28347584

RESUMO

Pseudoephedrine is a sympathomimetic α- and ß-adrenergic receptor agonist that causes vasoconstriction and reduction in edema throughout the nasal passages. Coronary vasospasm associated with pseudoephedrine has been reported in the literature. We discuss the case of a patient with new-onset atrial fibrillation receiving metoprolol for rate control on a background of pseudoephedrine use for allergic rhinitis leading to acute myocardial infarction from multivessel coronary vasospasm. This case illustrates the importance of understanding the pharmacology of potential drug-drug interactions when managing patients with acute cardiovascular syndromes.


Assuntos
Asma/tratamento farmacológico , Fibrilação Atrial/tratamento farmacológico , Vasoespasmo Coronário , Metoprolol , Infarto do Miocárdio , Nitroglicerina/administração & dosagem , Pseudoefedrina , Antiarrítmicos/administração & dosagem , Antiarrítmicos/efeitos adversos , Asma/complicações , Fibrilação Atrial/complicações , Fibrilação Atrial/diagnóstico , Broncodilatadores/administração & dosagem , Broncodilatadores/efeitos adversos , Angiografia Coronária/métodos , Vasoespasmo Coronário/induzido quimicamente , Vasoespasmo Coronário/diagnóstico por imagem , Eletrocardiografia/métodos , Feminino , Humanos , Metoprolol/administração & dosagem , Metoprolol/efeitos adversos , Pessoa de Meia-Idade , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/etiologia , Infarto do Miocárdio/fisiopatologia , Infarto do Miocárdio/terapia , Pseudoefedrina/administração & dosagem , Pseudoefedrina/efeitos adversos , Resultado do Tratamento , Vasodilatadores/administração & dosagem
16.
J Emerg Med ; 52(6): 859-862, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28341086

RESUMO

BACKGROUND: Recurrent priapism secondary to sickle cell trait in an African-American male has been reported in the literature. A common treatment for these low-flow priapism cases is aspiration and injection of the corpus cavernosum with a sympathomimetic agent. We report a rare complication not described previously in the literature of ST-elevation myocardial infarction (STEMI) and cardiogenic shock in a 29-year-old male with sickle cell trait undergoing a routine detumescence procedure. CASE REPORT: A 29-year-old African-American male with a history of sickle cell trait and recurrent low-flow/ischemic priapism presented with a painful erection for 8 h. Corporal aspiration and irrigation with phenylephrine was performed. After phenylephrine injection, the patient experienced hypertensive emergency, flash pulmonary edema, STEMI, and subsequent cardiogenic shock. He required intubation, ionotropic support, cardiac catheterization, and admission to the cardiac care unit. History taken from the patient's wife on the following day revealed that he was taking high doses of pseudoephedrine at home to treat symptoms. The patient was subsequently discharged after 3 days with normalization of ejection fraction and negative troponin. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Intracavernosal injection of phenylephrine is a common emergency department treatment utilized in management of priapism, but emergency physicians should be aware of the potential severe systemic complications resulting from this procedure. Providers should take a careful history, including over-the-counter medication use; consider comorbid medical history; standardize phenylephrine mixing instructions with pharmacy; and perform the procedure in a monitored setting with a brief observation after complete detumescence.


Assuntos
Anemia Falciforme/complicações , Priapismo/etiologia , Priapismo/fisiopatologia , Pseudoefedrina/efeitos adversos , Infarto do Miocárdio com Supradesnível do Segmento ST/etiologia , Adulto , Negro ou Afro-Americano/etnologia , Anemia Falciforme/etnologia , Serviço Hospitalar de Emergência/organização & administração , Humanos , Masculino , Pênis/fisiopatologia , Fenilefrina/administração & dosagem , Fenilefrina/farmacologia , Fenilefrina/uso terapêutico , Priapismo/terapia , Pseudoefedrina/uso terapêutico , Infarto do Miocárdio com Supradesnível do Segmento ST/fisiopatologia , Vasoconstritores/farmacologia , Vasoconstritores/uso terapêutico
18.
Health Policy ; 120(8): 875-81, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27344198

RESUMO

INTRODUCTION: The misuse of over-the-counter (OTC) drugs became a global public health concern. Although abuse with dextrometorphan (DXM), pseudoefedrine (PSD), codeine (COD) or benzydamine (BND) may lead even to psychosis, drugs containing these substances are relatively cheap and freely available. In Poland the Act on Counteracting Drug Addiction was amended in 2015, however it seems that there are still some points which could be improved. METHODS: Study was conducted between October 2014 and June 2015 using a specially designed questionnaire delivered to pharmacists from the Greater Poland region. Questionnaire consisting of 11 closed questions was distributed by direct contact and via the Internet. From over 2500 distributed questionnaires, we received 761 sheets and 680 were included. RESULTS: The misuse of OTC drugs is increasing in Poland from pharmacists point of view. The most popular substance was PSD followed by COD and DXM. The main reason of misuse of these drugs could be related to the use of Internet and free access to these medications. In respondents (58.2%) opinion OTC drugs containing analyzed substances should be moved into the prescription status. CONCLUSIONS: The misuse of OTC drugs should be considered as a very dangerous phenomenon. Although the Act on Counteracting Drug Addiction was amended in Poland in 2015, there are some facets requiring improvement. Social education may play a key role in the limitation of misuse of OTC drugs.


Assuntos
Medicamentos sem Prescrição/efeitos adversos , Medicamentos sem Prescrição/economia , Farmacêuticos/estatística & dados numéricos , Codeína/efeitos adversos , Serviços Comunitários de Farmácia/organização & administração , Humanos , Medicamentos sem Prescrição/administração & dosagem , Polônia , Papel Profissional/psicologia , Pseudoefedrina/efeitos adversos , Saúde Pública , Transtornos Relacionados ao Uso de Substâncias/prevenção & controle , Inquéritos e Questionários
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...