Incidence, possible risk factors and therapies for pseudopregnancy on Dutch dairy goat farms: a cross-sectional study.

Pseudopregnancy is a frequently diagnosed reproductive disorder in (dairy) goats. This cross-sectional study evaluates the incidence, possible risk factors and therapies for pseudopregnancy on Dutch dairy goat farms. Two questionnaires, one for farmers and one for veterinarians, were designed and included questions about general farm demographics, breeding management, hormonal oestrous induction, treatment, measures for reduction and stress moments in dairy goats in the period June 1, 2016-May 31, 2017. In total, 43 farmers (21.5 per cent response rate) and 27 veterinarians (22.5 per cent response rate) completed the questionnaire. The annual incidence of pseudopregnancy varied between 1 and 54 per cent per farm, with a mean annual incidence of 17 per cent (95 per cent CI 0.14 to 0.21). In this study, we found a significant association between incidence of pseudopregnancy and a higher percentage of goats with an extended lactation (p<0.0001) and between incidence of pseudopregnancy and the number of ultrasound examinations per year (p<0.0001). The recommended therapy in literature consists of two administrations of prostaglandins. This was only correctly applied by 10 per cent of the farms. On 52 per cent of the farms, an overdose was used comparing to the recommended dose in literature.

Canine pseudopregnancy: an evaluation of prevalence and current treatment protocols in the UK.

BACKGROUND: There is a dearth of literature on pseudopregnancy in the bitch, with only a few treatment-based studies published since the 1990s. Pseudopregnancy may be under-recognised in bitches and may account for a proportion of behavioural cases seen in veterinary practices including aggression. Little is known about commonly used treatments for overtly pseudopregnant bitches and it is possible that current regimes may not be prescribed for a sufficient duration to control any clinical signs including, physical and behavioural changes. To investigate current trends in diagnosis and treatment of canine pseudopregnancy, a postal survey was sent to 2000 randomly selected veterinary surgeons in UK veterinary practices. The questionnaire queried how often vets recognise cases of pseudopregnancy in spayed and entire bitches, which physical or behavioural signs are commonly recognised for diagnosis, and which management or treatment protocols are used. RESULTS: The response rate was 19.8% (397/2000). Ninety-six percent of veterinary surgeons reported seeing pseudopregnant bitches showing behavioural changes without any physical changes within the last 12 months. Of those behavioural changes, collecting and mothering objects was the most frequently reported behavioural sign (96%). Ninety-seven percent of vets had seen aggression in pseudopregnant bitches. Nevertheless, only 52% of vets routinely asked owners about behavioural changes during consultations. Forty-nine percent of respondents reported seeing pseudopregnancy in spayed bitches. The most commonly reported physical sign was enlarged mammary glands and/or milk production (89%). Treatment options varied (surgical, medical or none) and depended on duration and severity of physical and behavioural signs, owners' preference, cost, concurrent disease, drug availability and previous history. CONCLUSIONS: This is the largest epidemiological study of canine pseudopregnancy in the UK. The prevalence and severity of clinical signs in dogs with pseudopregnancy are variable and possibly under-estimated. Dogs with overt pseudopregnancy experience diverse physical and behavioural changes and information on standard treatment protocols are lacking. Although, progress on our understanding of diagnosis and treatment of pseudopregnancy in spayed and entire bitches has been made, further studies are warranted.

[Effect of bone marrow cells transplantation on the decidua formation in pseudopregnant rats].

One of the most common causes of the current pregnancy loss is the failure of the decidual reaction of endometrial cells. It is assumed that a partial source of decidual cells in endometrial tissue is bone marrow cells (BMCs). In the present work, we have studied possible effect of BMCs transplantation on the process of decidualization using the model of pseudopregnancy in rats. BMCs were flushed from the rat femurs and tibias. The obtained suspension of single BMCs was injected into one of rat uterine horns on the 5th day of pseudopregnancy. PBS without cells was injected into the contralateral horn served as the control. Rats were sacrificed on the 11th day of pseudopregnancy. Decidua formed in the experimental uterine horn showed an increase in the meso-antimezometral direction of their diameter of about 1.5-2 times as compared with a control horn. The weight of decidual tissue in the experimental horn exceeded 3 times the weight of the control one. The presence of transplanted BMCs in decidual tissue was documented by preliminary double staining of BMCs with membrane dye PKH 26 Red and nuclear dye Hoechst 33342. Histological analysis of decidua sections after transplantation revealed any alterations neither in cell differentiation nor in tissue structure. We conclude that BMCs transplantation stimulates decidualization in animals.

[Clinical signs, diagnostic approach and therapy for the so-called ovarian remnant syndrome in the bitch]. / Klinische Symptomatik, diagnostische Vorgehensweise und Therapie beim so genannten Ovarrest-Syndrom der Hündin.

The ovarian remnant syndrome arises as a consequence of incomplete ovariectomy or ovariohysterectomy. Remnant ovarian tissue which has been left mostly unintentionally in the bitch may show endocrine activity a few weeks to several years after surgery, provoking a variety of clinical signs. The majority of affected bitches return to heat, in other cases signs of pseudopregnancy and endometritis may be observed. Occasionally, bitches with unclear clinical signs are presented with the suspicion of an inactive ovarian remnant. The following article intends to place the origin of the ovarian remnant syndrome into a factual context regarding the responsibility of the veterinarian and to demonstrate a reasonable diagnostic procedure according to the respective clinical signs. In this regard, the clinical-gynaecological examination, including vaginal cytology, must receive high priority, with the addition of progesterone analysis in peripheral blood plasma or serum if required. Using these combined diagnostic tools, ovarian remnants in stages of endocrine activity (follicular and luteal phases as well as cystic or tumourous ovarian tissue) can be easily unequivocally diagnosed. The application of a GnRH-stimulation test is only reasonable in bitches in which clinical signs are missing. In this context, the usefulness of semi-quantitative LH-assays is also discussed.

Pseudocyesis in a rural southeast Nigerian community.

CONTEXT: Pseudocyesis is uncommon and probably under reported among the African population. AIMS AND OBJECTIVES: To document the incidence and presentation of false pregnancies in a Nigerian rural population. METHODS: This involved a review of prospectively collected data on all patients who were diagnosed with pseudocyesis over a four-year period in a Mission hospital. RESULTS: Pseudocyesis occurred at a frequency of 1 in 344 pregnancies. The mean age was 33.6 years and the condition was found more commonly among poorly educated women. Amenorrhea was common among the subjects and 54% claimed they felt fetal movement. Ultrasound studies confirmed the absence of pregnancies in all cases. Management included counseling and referral to specialist clinical psychologists. CONCLUSION: Pseudocyesis is more common among the African population than in developed countries. Gynaecologists in these regions should have a high index of suspicion to diagnose this and assess the mental status of the subject and the precipitating factors.

Pseudocyesis.

Pseudocyesis - a clinical syndrome seen in non-psychotic woman, known since the time of Hippocrates. Pseudocyesis has a psychological basis in which a woman's wish for pregnancy is essential to their identity and self-esteem. Normally, pseudocyesis is seen in women who desperately want to become pregnant, especially those with longstanding infertility. Basically, the treatment of Pseudocyesis is to help these patients recognize the illness and to educate and counsel them. Here is the case of pseudocyesis in which there is no history of long standing infertility. This case is rare and liable to be missed.

A review of canine pseudocyesis.

The purpose of this article is to review the most relevant features of the physiology, clinical signs, diagnosis, treatment and prevention of canine pseudocyesis (PSC). This is a physiological syndrome, characterized by clinical signs such as: nesting, weight gain, mammary enlargement, lactation and maternal behaviour, which appears in non-pregnant bitches at the end of metaoestrus. PSC is a frequent finding in domestic dogs. Although it is generally admitted that prolactin (PRL) plays a central role in the appearance of PSC, its precise aetiophysiology is not completely understood yet. A number of clinical studies suggest that at some point of metaoestrus circulating PRL levels rise in overtly pseudopregnant bitches. Individual differences in sensitivity to PRL as well as the existence of molecular variants of canine PRL with different bioactivity versus immunoreactivity ratios may help clarify the aetiopathology of PSC. Diagnosis of PSC is based on the presence of typical clinical signs in metaoestrous non-pregnant bitches. Considering that PSC is a self limiting physiological state, mild cases usually need no treatment. Discouraging maternal behaviour and sometimes fitting Elizabethan collars to prevent licking of the mammary glands may suffice in these cases. Sex steroids (oestrogens, progestins and androgens) have been traditionally used to treat PSC but the side-effects usually outweigh the benefits of these medications. Inhibition of PRL release by ergot derivatives [bromocriptine (10-100 microg/kg per day for 10-14 days], cabergoline (5 microg/kg per day during 5-10 days), metergoline (0.2 mg/kg per day during 8-10 days) has proved to be effective for the treatment of canine PSC. Although some of these ergot derivatives present some untoward side-effects, they are transient and can usually be managed. Predisposed bitches not intended for breeding should be spayed as ovariectomy is the only permanent preventive measure.

Delusions of pregnancy in the elderly.

We present five case reports of elderly ladies with delusions of pregnancy. This symptom is discussed with reference to the cases and a review of the literature.

Tratamento homeopatico da pseudociese em cadelas / Homeopathic treatment of the pseudocyesis in bitches

Os tratamentos convencionais indicados para a pseudociese sao paliativos ou atraves de hormonios, onde se tenta corrigir o desequilibrio hormonal, observado nesta patologia. Os tratamentos paliativos nao impedem as reicidivas que geralmente sao frequentes nesta doenca. O tratamento a base de hormonio e indicado com muita cautela, pois podem provocar uma serie de efeitos colaterais geralmente graves. Por isso na maioria das vezes se opta por nao usa-los. Preventivamente aconselha-se em cadelas jovens o tratamento cirurgico, com retirada do ovario, que alem de caro e arriscado pode deixar sequelas. Com o tratamento homeopatico obtem-se bons resultados, sem efeitos colaterais ou riscos e com menor custo, sendo portanto indicado nestes casos. Durante cinco anos de rotina clinica onde utiliza-se com tratamento de eleicao os medicamentos homeopaticos, algumas cadelas foram tratadas de pseudociese. Dois casos foram selecionados e descritos. Os animais foram identificados atraves de fichas individuais contendo dados do proprietario e sua resenha. Eram anotadas a data de cada retorno, melhoras, pioras e medicamentos utilizados

Tratamento homeopatico da pseudociese em cadelas / Homeopathic treatment of false pregnancy in female dogs

Os tratamentos convencionais indicados para pseudociese sao paliativos ou hormonais. O paliativo nao impede as recidivas que geralmente sao frequentes nesta doenca. O hormonal e indicado com muita cautela, pois pode provocar uma serie de efeitos colaterais geralmente graves. Por esses motivos, na maiores das vezes se opta por nao usar esses tratamentos. Com o tratamento homeopatico obtem-se bons resultados, sem efeitos colaterais ou riscos e com menor custo. Sao descritos dois casos