RESUMO
Rabbits and rats were infected intratracheally with extracellular enzyme of Streptomyces thermohygroscopicus (H9-4) by only one exposure, and lesions of the lung developed including mononuclear macrophage infiltration as well as bronchitis and vasculitis. The obvious damages in type I pneumocytes, endothelial cells of capillaries and arterioles in the lung were observed by electron microscopy. Immunofluorescent histochemistry examination revealed exudation of plasma fibronectin which might play an important role during the process of lesion repairing in lung. The experiment also confirmed that extracellular enzyme of Streptomyces thermohygroscopicus might directly damage the lung tissue. These experimental data may serve as valuable reference for studying the etiology and pathogenesis of farmer's lung disease.
Assuntos
Pulmão de Fazendeiro/induzido quimicamente , Pulmão/ultraestrutura , Streptomyces/enzimologia , Animais , Pulmão de Fazendeiro/patologia , Feminino , Fibronectinas/metabolismo , Pulmão/metabolismo , Masculino , Coelhos , Ratos , Ratos EndogâmicosRESUMO
Pesticide-induced lung fibrosis are very rare. Only the acute paraquat-fibrosis achieved clinical significance. Clinic, pathogenesis and therapy of this disease will be described in the main features. The so-called "Vineyard sprayer's lung" was observed up to now only in Portugal. This illness will be caused by longterm exposure in viniculture against "Bordeaux mixture" a solution of copper sulphate and slaked lime. Causuistries in the literature indicate that further pesticides especially organophosphates are possibly potent to induce lung-fibrosis.
