RESUMO
Inhibition of the contractile activity of the stomach induced by psychogenic stress persisted after blockade of muscarinic and nicotinic cholinergic receptors and α2 and ß1/ß2-adrenergic receptors. Stress-induced increase in contractile activity in the proximal part of the duodenum persisted during blockade of muscarinic and nicotinic cholinergic receptors, ß1/ß2-adrenergic receptors. At the same time, blockade of the above cholinergic and adrenergic receptors eliminated the stress-induced increase in contractive activity in the distal part of the duodenum.
Assuntos
Motilidade Gastrointestinal , Animais , Refluxo Duodenogástrico/psicologia , Duodeno/fisiopatologia , Masculino , Antagonistas Muscarínicos/farmacologia , Contração Muscular , Músculo Liso/fisiopatologia , Antagonistas Nicotínicos/farmacologia , Coelhos , Estresse Psicológico/fisiopatologiaRESUMO
AIM: To investigate disorders of psychoemotional functions, humoral regulation (substance P) and duodenal motility (DM) in patients with combined refluxes for their differential correction. MATERIAL AND METHODS: A total of 60 patients with gastroesophageal and duodenogastric refluxes were examined. RESULTS: Patients with reflux disorders had more frequent and severe neurotic reactions. Humoral changes are associated with characteristics of psychoemotional regulation. The risk of subnormal levels of the substance P rises substantially in changes in the scales of anxiety, neurotic depression, hysterical reaction and autonomic disorders. Segmental duodenal motility regresses with lowering of plasmic levels of substance P. CONCLUSION: Patients with combined reflux disorders have psychoemotional disorders, abnormal humoral regulation and duodenal motility necessitating a differential approach to treatment of such patients.
