Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 9 de 9
Filtrar
1.
BMJ Case Rep ; 12(9)2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31570350

RESUMO

We present a case of spontaneous, atraumatic splenic rupture secondary to Epstein-Barr virus (EBV) infection, in a young, female patient. Splenic rupture is a rare complication of EBV infection, but is associated with the highest mortality. Additionally, this case illustrates the diagnostic challenge in a patient presenting in atypical manner, with only left-sided pleuritic chest pain, and lacking any of the classical tonsillitis symptoms associated with EBV infection.


Assuntos
Dor no Peito/virologia , Infecções por Vírus Epstein-Barr/diagnóstico , Mononucleose Infecciosa/diagnóstico , Ruptura Espontânea/virologia , Ruptura Esplênica/virologia , Analgesia , Dor no Peito/fisiopatologia , Tratamento Conservador , Diagnóstico Diferencial , Infecções por Vírus Epstein-Barr/terapia , Feminino , Febre , Humanos , Mononucleose Infecciosa/complicações , Mononucleose Infecciosa/terapia , Ruptura Esplênica/diagnóstico por imagem , Ruptura Esplênica/terapia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Adulto Jovem
2.
Vet Microbiol ; 222: 91-97, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30080679

RESUMO

Since 2016, severe outbreaks of hepatic rupture hemorrhage syndrome (HRHS) have emerged in chickens in several Chinese provinces and caused huge economic losses to the poultry industry, but the etiological characteristics and pathogenic potential of it has remained unclear. This study sequenced the partial helicase and capsid gene of the potentially novel avian hepatitis E virus (HEV) isolated from chickens with HRHS and tested the pathogenicity of it on SPF chicks, while the appearance of clinical signs, histopathological changes, viral distribution, viremia and viral shedding were monitored for 14 days post-infection (dpi). Analysis revealed that the HRHS related avian HEV belongs to a novel genotype, and infected chicks developed the typical symptoms of HRHS. Thus, this study successfully developed an experimental infection model for studying the pathogenicity and role of the novel avian HEV in HRHS. Meanwhile, the novel avian HEV mainly existed in the liver and spleen, inducing a rapid viremia and chronic viral shedding in infected chicks, and could cause 40% mortality before 14 dpi. In conclusion, this study found the novel genotype avian HEV and confirmed its role in HRHS.


Assuntos
Genótipo , Hepatite E/veterinária , Hepatite Viral Animal/virologia , Hepevirus/genética , Hepatopatias/veterinária , Fígado/patologia , Animais , Anticorpos Antivirais/sangue , Galinhas/virologia , China/epidemiologia , Modelos Animais de Doenças , Genes Virais/genética , Hemorragia , Hepatite E/sangue , Hepatite E/virologia , Hepatite Viral Animal/sangue , Hepatite Viral Animal/epidemiologia , Hepevirus/patogenicidade , Sequenciamento de Nucleotídeos em Larga Escala , Fígado/virologia , Hepatopatias/virologia , Doenças das Aves Domésticas/virologia , Ruptura Espontânea/veterinária , Ruptura Espontânea/virologia , Viremia/patologia , Eliminação de Partículas Virais
3.
Injury ; 47(3): 531-8, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26563483

RESUMO

INTRODUCTION: Infectious mononucleosis (IM) is a common viral illness that predominantly causes sore throat, fever and cervical lymphadenopathy in adolescents and young adults. Although usually a benign, self-limiting disease, it is associated with a small risk of splenic rupture, which can be life-threatening. It is common practice therefore to advise avoiding vigorous physical activity for at least 4-6 weeks, however this is not based on controlled trials or national guidelines. We reviewed published case reports of splenic rupture occurring in the context of IM in an attempt to ascertain common factors that may predict who is at risk. METHOD: A search of MEDLINE and EMBASE databases was performed for case reports or series published between 1984 and 2014. In total, 52 articles or abstracts reported 85 cases. Data was extracted and compiled into a Microsoft Excel(®) spreadsheet. RESULTS: The average patient age was 22 years, the majority (70%) being male. The average time between onset of IM symptoms and splenic rupture was 14 days, with a range up to 8 weeks. There was a preceding history of trauma reported in only 14%. Abdominal pain was the commonest presenting complaint of splenic rupture, being present in 88%. 32% were successfully managed non-operatively, whereas 67% underwent splenectomy. Overall mortality was 9%. CONCLUSIONS AND RECOMMENDATIONS: From our data, it appears that men under 30 within 4 weeks of symptom onset are at highest risk of splenic rupture, therefore particular vigilance in this group is required. As cases have occurred up to 8 weeks after the onset of illness, we would recommend avoidance of sports, heavy lifting and vigorous activity for 8 weeks. Should the patient wish to return to high risk activities prior to this, an USS should be performed to ensure resolution of splenomegaly. The majority of cases reviewed had no preceding trauma, although previous studies have suggested this may be so minor as to go unnoticed by the patient. It is therefore prudent to warn patients about the symptoms of splenic rupture to ensure prompt presentation and minimise treatment delay rather than focusing purely on activity limitation.


Assuntos
Mononucleose Infecciosa/complicações , Ruptura Espontânea/virologia , Esplenectomia , Ruptura Esplênica/virologia , Humanos , Mononucleose Infecciosa/cirurgia , Mononucleose Infecciosa/virologia , Ruptura Espontânea/cirurgia , Ruptura Esplênica/cirurgia , Esplenomegalia
4.
BMC Res Notes ; 8: 286, 2015 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-26136216

RESUMO

BACKGROUND: Spontaneous splenic rupture is a rare but known complication of dengue fever. Previously reported cases have occurred early during the course of the disease and most cases have led to a fatal outcome. Here we report a case of spontaneous splenic rupture in a patient with dengue fever, which occurred during the recovery phase of the illness. CASE PRESENTATION: A 28-year-old Sinhalese, Sri Lankan man presented with a history of fever, myalgia and vomiting of 4 days duration. Investigations revealed a diagnosis of dengue fever with no signs of plasma leakage. He was managed in the ward as per local protocol. During the recovery phase the patient developed severe abdominal distention with circulatory failure. Radiology revealed splenic rupture with massive amounts of abdominal free fluid. The patient was resuscitated and Emergency laparotomy with splenectomy was performed. The outcome was excellent with the patient making a complete recovery. CONCLUSION: Although splenic rupture is a known complication of dengue fever it may be manifested late in the disease process. A high degree of suspicion should be maintained and patients must be monitored even during the recovery phase of dengue fever. Early diagnosis and intervention can prevent mortality.


Assuntos
Vírus da Dengue/patogenicidade , Dengue/cirurgia , Ruptura Espontânea/cirurgia , Baço/cirurgia , Adulto , Convalescença , Dengue/complicações , Dengue/patologia , Dengue/virologia , Vírus da Dengue/fisiologia , Humanos , Masculino , Ruptura Espontânea/complicações , Ruptura Espontânea/patologia , Ruptura Espontânea/virologia , Baço/patologia , Baço/virologia , Esplenectomia , Resultado do Tratamento
6.
BMJ Case Rep ; 20152015 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-25814026

RESUMO

A 27-year-old woman was admitted to the emergency department with fever and a petechial rash on suspicion of meningitis. Shortly after arriving she developed cardiac arrest. Blood work up showed severe lactate acidosis, anaemia and thrombocytopenia. A focused assessment with sonography in trauma scan showed free intraperitoneal fluid and an emergency laparotomy revealed massive bleeding from a ruptured spleen. The patient was successfully resuscitated. She proved to be infected with cytomegalovirus causing idiopathic thrombocytopenic purpura, splenomegaly and splenic rupture. She was treated for 14 days with ganciclovir and meropenem and discharged on recovery. Atraumatic splenic rupture caused by viral infection is a rare condition although well described. In the case of our patient, thrombocytopenia added to the severity of the splenic rupture. A multidisciplinary team approach was essential for the management and the eventual recovery of the patient.


Assuntos
Infecções por Citomegalovirus/complicações , Infecções por Citomegalovirus/diagnóstico , Citomegalovirus/isolamento & purificação , Parada Cardíaca/etiologia , Ruptura Esplênica/cirurgia , Ruptura Esplênica/virologia , Adulto , Antivirais/administração & dosagem , Infecções por Citomegalovirus/tratamento farmacológico , Emergências , Feminino , Ganciclovir/administração & dosagem , Humanos , Meropeném , Ruptura Espontânea/cirurgia , Ruptura Espontânea/virologia , Esplenectomia/métodos , Tienamicinas/administração & dosagem , Trombocitopenia/complicações , Resultado do Tratamento
7.
Ugeskr Laeger ; 175(43): 2565-6, 2013 Oct 21.
Artigo em Dinamarquês | MEDLINE | ID: mdl-24629153

RESUMO

Non-traumatic rupture of the spleen (NRS) is a rare but serious complication to infectious mononucleosis (IM) and it is important to have in mind, when patients have IM. Although splenectomy has been advocated as the appropriate treatment for this problem, the trend goes towards conservative treatment of the haemodynamically stable patients, but because of its rarity no clear guidelines have been suggested. We present a case of a 18-year-old boy with IM who had NRS with subcapsular haematoma and was treated conservatively. He recovered completely.


Assuntos
Mononucleose Infecciosa/complicações , Ruptura Esplênica/virologia , Adolescente , Humanos , Masculino , Ruptura Espontânea/diagnóstico por imagem , Ruptura Espontânea/terapia , Ruptura Espontânea/virologia , Ruptura Esplênica/diagnóstico por imagem , Ruptura Esplênica/terapia , Esplenomegalia/diagnóstico por imagem , Esplenomegalia/terapia , Esplenomegalia/virologia , Tomografia Computadorizada por Raios X
8.
Orv Hetil ; 148(29): 1381-4, 2007 Jul 22.
Artigo em Húngaro | MEDLINE | ID: mdl-17631473

RESUMO

Splenic rupture is a rare complication of infectious mononucleosis. Although it occurs only in 0.1%-0.5% of cases, splenic rupture remains the most common fatal complication of the disease. Mononucleosis related spontaneous rupture of the spleen without any other characteristic symptoms of the disease is extremely unusual, and threatens with fatal outcome due to its rare and unexpected occurrence. The authors report the case of a 16-year-old boy who needed splenectomy following a spontaneous rupture of the spleen. Serological tests proved an acute Epstein-Barr virus infection in the background but without any signs or symptoms of infectious mononucleosis. The diagnosis and treatment of this infection related to spleen ruptures are also discussed.


Assuntos
Herpesvirus Humano 4/isolamento & purificação , Mononucleose Infecciosa/complicações , Mononucleose Infecciosa/diagnóstico , Ruptura Esplênica/cirurgia , Ruptura Esplênica/virologia , Doença Aguda , Adolescente , Anticorpos Antivirais/sangue , Herpesvirus Humano 4/imunologia , Humanos , Mononucleose Infecciosa/patologia , Masculino , Ruptura Espontânea/virologia , Esplenectomia , Ruptura Esplênica/diagnóstico por imagem , Tomografia Computadorizada por Raios X
9.
Medicina (B Aires) ; 63(1): 46-8, 2003.
Artigo em Espanhol | MEDLINE | ID: mdl-12673961

RESUMO

We present a 24 year old immunocompetent male who developed a spontaneous rupture of the spleen (SRE) during an acute cytomegalovirus (CMV) infection. The only previous clinical feature was the presence of flu-like symptoms two weeks before the SRE. The diagnosis was confirmed by the presence of IgM antibodies to CMV in the serum and a positive CMV-PCR in the splenic biopsy after splenectomy. The patient recovered completely after surgery. Spontaneous splenic rupture is an uncommon event associated with primary cytomegalovirus infection, and this is the first case reported in our country.


Assuntos
Infecções por Citomegalovirus/complicações , Ruptura Esplênica/virologia , Adulto , Anticorpos Antivirais/sangue , Citomegalovirus/imunologia , Humanos , Imunoglobulina M/sangue , Masculino , Reação em Cadeia da Polimerase , Ruptura Espontânea/virologia , Esplenectomia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...