RESUMO
Antiphospholipid syndrome (APS) has been well defined in adults; however, primary nontraumatic arterial thrombosis owing to this entity is unusual in the pediatric population. The authors report a case of APS with lower extremity arterial thrombosis who had discolored feet since delivery.
Assuntos
Síndrome Antifosfolipídica/diagnóstico , Anticorpos Anticardiolipina/sangue , Anticoagulantes/uso terapêutico , Síndrome Antifosfolipídica/complicações , Síndrome Antifosfolipídica/congênito , Síndrome Antifosfolipídica/tratamento farmacológico , Síndrome Antifosfolipídica/imunologia , Arteriopatias Oclusivas/tratamento farmacológico , Arteriopatias Oclusivas/etiologia , Aspirina/uso terapêutico , Pré-Escolar , Circulação Colateral , Heparina de Baixo Peso Molecular/uso terapêutico , Humanos , Imunoglobulina G/sangue , Imunossupressores/uso terapêutico , Claudicação Intermitente/etiologia , Úlcera da Perna/etiologia , Masculino , Prednisolona/uso terapêutico , Dermatopatias Vasculares/congênito , Dermatopatias Vasculares/etiologia , Trombofilia/tratamento farmacológico , Trombofilia/etiologia , Varfarina/uso terapêuticoRESUMO
Blood coagulation protein and platelet defects are now known to account for up to ninety percent of unexplained venous thrombosis and up to seventy percent of unexplained arterial thrombotic or ischemic events. This article summarizes the common and uncommon blood protein and platelet defects which should be suspected, and searched for, in patients with such events. Defining such defects will have major impact on secondary prevention and duration of antithrombotic therapy in the afflicted patient and impact on primary prevention for identified family members in those harboring hereditary defects.
