RESUMO
The Yellow Nail Syndrome is a rare clinical entity, first described in 1967 by P.D. Samman and W.F. White. The triad slow-growing dystrophic yellow nails, lymphedema and chronic respiratory disorders is the typical manifestation of the disease but some variations have been described as well as associations with chylothorax, chylous ascites, intestinal lymphangiectasia, thyroid abnormalities, malignancies and immunoglobulin A (IgA) deficiency. We present a case of a 55-years-old woman that had an insidious onset of respiratory disorders and chronic sinusitis, suspected to be infectious throughout the hospitalizations, associated with therapeutically neglected autoimmune thyroiditis.
Assuntos
Síndrome das Unhas Amareladas/diagnóstico , Bronquiectasia/diagnóstico , Doença Crônica , Tosse/fisiopatologia , Diagnóstico Diferencial , Feminino , Humanos , Linfedema/diagnóstico , Pessoa de Meia-Idade , Doenças da Unha/diagnóstico , Pericardite/diagnóstico , Derrame Pleural/diagnóstico , Derrame Pleural/terapia , Sinusite/diagnóstico , Tireoidite Autoimune/diagnóstico , Tomografia Computadorizada por Raios X , Síndrome das Unhas Amareladas/fisiopatologia , Síndrome das Unhas Amareladas/terapiaRESUMO
Yellow nail syndrome (YNS) is an uncommon condition characterized by nail changes, lymphedema, in addition to pulmonary disorders and pleural effusion. Pericarditis and non-cardiac disorders can evolve with pericardial effusions including autoimmune conditions, hypothyroidism, malignancies, tuberculosis, and uremia. A 72-year-old Brazilian woman under treatment for arterial hypertension and hypothyroidism was admitted with pericarditis and pericardial effusion concomitant with yellow nail syndrome. She denied tobacco smoking, alcohol abuse, and similar disorders in her family. Clinical and complementary evaluation ruled out infectious diseases, malignancies, and autoimmune disorders as etiologic factors in this case. Hypothyroidism is a well-known cause of pericardial effusion, the vast majority in the absence of pericarditis, and has been described as an associated condition in some individuals with YNS. Case studies might contribute to better understanding of these causal or casual relationships.
Assuntos
Derrame Pericárdico/etiologia , Pericardite/etiologia , Síndrome das Unhas Amareladas/diagnóstico , Idoso , Feminino , Humanos , Hipertensão/terapia , Hipotireoidismo/etiologia , Linfedema/etiologia , Doenças da Unha/etiologia , Derrame Pleural/etiologia , Uremia/etiologia , Síndrome das Unhas Amareladas/fisiopatologiaRESUMO
A case involving a 41-year-old man with yellow nail syndrome (YNS) is reported. YNS is a rare disorder characterized by yellow, dystrophic nails, peripheral lymphedema and bronchiectasis with recurrent lower respiratory tract infections. YNS is often misdiagnosed because the syndrome is not well known. An interdisciplinary approach is required to recognize and collate the components of the syndrome accurately. Correct diagnosis is of utmost clinical importance because YNS can occur secondary to malignancies and autoimmune disorders. Hence, the diagnosis of YNS must prompt further investigation.
