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1.
PLoS One ; 15(11): e0242679, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33237923

RESUMO

PURPOSE: Ectopic Cushing Syndrome (EAS) is a rare condition responsible for about 5-20% of all Cushing syndrome cases. It increases the mortality of affected patients thus finding and removal of the ACTH-producing source allows for curing or reduction of symptoms and serum cortisol levels. The aim of this study is to present a 20-year experience in the diagnosis and clinical course of patients with EAS in a single Clinical Centre in Southern Poland as well as a comparison of clinical course and outcomes depending on the source of ectopic ACTH production-especially neuroendocrine tumors with other neoplasms. METHODS: Twenty-four patients were involved in the clinical study with EAS diagnosed at the Department of Endocrinology between years 2000 and 2018. The diagnosis of EAS was based on the clinical presentation, hypercortisolemia with high ACTH levels, high dose dexamethasone suppression test and/or corticotropin-releasing hormone tests. To find the source of ACTH various imaging studies were performed. RESULTS: Half of the patients were diagnosed with neuroendocrine tumors, whereby muscle weakness was the leading symptom. Typical cushingoid appearance was seen in merely a few patients, and weight loss was more common than weight gain. Patients with neuroendocrine tumors had significantly higher midnight cortisol levels than the rest of the group. Among patients with infections, we observed a significantly higher concentrations of cortisol 2400 levels in gastroenteropancreatic neuroendocrine tumors. Chromogranin A correlated significantly with potassium in patients with neuroendocrine tumors and there was a significant correlation between ACTH level and severity of hypokalemia. CONCLUSION: EAS is not common, but if it occurs it increases the mortality of patients; therefore, it should be taken into consideration in the case of coexistence of severe hypokalemia with hypertension and muscle weakness, especially when weight loss occurs. Because the diagnosis of gastroenteropancreatic neuroendocrine tumor worsens the prognosis-special attention should be paid to these patients.


Assuntos
Síndrome de ACTH Ectópico , Síndrome de ACTH Ectópico/sangue , Síndrome de ACTH Ectópico/diagnóstico , Síndrome de ACTH Ectópico/fisiopatologia , Adolescente , Hormônio Adrenocorticotrópico/sangue , Adulto , Idoso , Síndrome de Cushing/sangue , Síndrome de Cushing/diagnóstico , Síndrome de Cushing/fisiopatologia , Feminino , Humanos , Hidrocortisona/sangue , Hipertensão/sangue , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Hipopotassemia/sangue , Hipopotassemia/diagnóstico , Hipopotassemia/fisiopatologia , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/sangue , Debilidade Muscular/diagnóstico , Debilidade Muscular/fisiopatologia , Polônia , Estudos Retrospectivos
2.
Am J Hypertens ; 32(12): 1214-1217, 2019 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-31353410

RESUMO

BACKGROUND: New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION: We report the case of a 69-year-old man who developed severe resistant hypertension despite the use of 6 antihypertensive medications, including diuretics. He had metabolic alkalosis and hypokalemia with suppressed plasma renin activity and serum aldosterone. Concurrently, he was diagnosed with small cell neuroendocrine carcinoma of the prostate gland, a rare form of prostate cancer. Despite absence of typical Cushingoid features, investigation confirmed the diagnosis of ectopic adrenocorticotropic hormone (ACTH) syndrome from neuroendocrine prostate cancer. Because of the severity of his hypercortisolism, he underwent urgent bilateral adrenalectomy for hormonal and symptomatic control. Blood pressure improved significantly and he was dismissed with a single antihypertensive agent. Unfortunately, the patient died from his cancer 1 month later. CONCLUSION: Primary and secondary hyperaldosteronism are usually diagnosed based on measurements of aldosterone and plasma renin activity. However, if plasma renin activity and aldosterone are both low, rare causes of mineralocorticoid excess such as ectopic ACTH syndrome should be entertained.


Assuntos
Síndrome de ACTH Ectópico/etiologia , Pressão Sanguínea , Carcinoma Neuroendócrino/complicações , Síndrome de Cushing/etiologia , Hipertensão/etiologia , Neoplasias da Próstata/complicações , Síndrome de ACTH Ectópico/diagnóstico , Síndrome de ACTH Ectópico/fisiopatologia , Síndrome de ACTH Ectópico/cirurgia , Adrenalectomia , Idoso , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Carcinoma Neuroendócrino/diagnóstico , Síndrome de Cushing/diagnóstico , Síndrome de Cushing/fisiopatologia , Síndrome de Cushing/cirurgia , Resistência a Medicamentos , Evolução Fatal , Humanos , Hipertensão/diagnóstico , Hipertensão/tratamento farmacológico , Hipertensão/fisiopatologia , Masculino , Neoplasias da Próstata/diagnóstico , Resultado do Tratamento
4.
BMJ Case Rep ; 20182018 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-30115708

RESUMO

Ectopic adrenocorticotropic hormone (ACTH) secretion represents 5%-10% of cases of Cushing's syndrome (CS), and approximately 50%-60% of these arise from neuroendocrine lung tumours, including small-cell lung cancer (SCLC). We report a 42-year-old man admitted with hypertension, metabolic alkalosis and severe hypokalaemia. On physical examination, centripetal obesity with 'moon face' and 'buffalo's hump' were identified, and wheezing on left lung was heard. A markedly elevated serum cortisol, ACTH and urine free cortisol production supported the diagnosis of CS. Chest CT showed a left hilar mass with metastasis to the liver, adrenal glands and lymph nodes. Bronchoscopy identified bronchial infiltration by SCLC. Treatment with metyrapone and chemotherapy was started. Despite initial improvement, progressive clinical deterioration occurred, culminating in death 1 year after diagnosis. Ectopic ACTH secretion is uncommon but should be suspected in patients with severe hypokalaemia, hypertension and metabolic alkalosis, especially in the context of lung cancer.


Assuntos
Síndrome de ACTH Ectópico/complicações , Hormônio Adrenocorticotrópico/metabolismo , Síndrome de Cushing/complicações , Hipopotassemia/complicações , Neoplasias Pulmonares/complicações , Carcinoma de Pequenas Células do Pulmão/complicações , Síndrome de ACTH Ectópico/diagnóstico , Síndrome de ACTH Ectópico/fisiopatologia , Hormônio Adrenocorticotrópico/sangue , Adulto , Biomarcadores Tumorais/sangue , Síndrome de Cushing/diagnóstico , Evolução Fatal , Humanos , Hidrocortisona/sangue , Hidrocortisona/urina , Hipertensão/etiologia , Hipopotassemia/sangue , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/patologia , Masculino , Obesidade Abdominal/complicações , Carcinoma de Pequenas Células do Pulmão/diagnóstico , Carcinoma de Pequenas Células do Pulmão/patologia , Tomografia Computadorizada por Raios X , Imagem Corporal Total
5.
Endocr Pract ; 23(8): 907-914, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28614007

RESUMO

OBJECTIVE: Ectopic adrenocorticotropic hormone (ACTH) secretion is a less common cause of Cushing syndrome and is seen in 5 to 10% of cases with endogenous hypercortisolemia. We hereby describe our experience of patients with ectopic ACTH syndrome, who have been managed over the past 10 years at a tertiary care center in Southern India. METHODS: The inpatient and outpatient records of patients from 2006 to 2015 were retrospectively reviewed. The clinical features, clinical history, biochemical values, imaging features, including radiologic findings and positron emission tomography scans, management, details of follow-up, and outcomes, were documented. We compared the biochemical findings in these patients with 20 consecutive patients with Cushing disease (Cushing syndrome of pituitary origin). RESULTS: A total of 21 patients were studied. The median age at presentation was 34 years (range, 19 to 55 years). Seven patients had thymic carcinoid, 7 had bronchial carcinoid, 3 had lung malignancies, 2 had medullary carcinoma thyroid, 1 patient had a pancreatic neuroendocrine tumor, and 1 patient had an occult source of ACTH. The most common clinical features at presentation were muscle weakness (95%), hyperpigmentation (90%), facial puffiness (76%), easy bruising (61%), edema (57%), and striae (52%). Extensive acne was seen in a large number of patients (43%). Only 3 patients (14%) had central obesity. The median 8 am cortisol was 55.5 µg/dL (range, 3.8 to 131 µg/dL), median 8 am ACTH was 207 pg/mL (range, 31.1 to 703 pg/mL), and the median 24-hour urinary free cortisol was 2,484 µg (range, 248 to 25,438 µg). Basal cortisol and ACTH, as well as midnight cortisol and ACTH level, were markedly higher in patients with ectopic Cushing syndrome as compared to patients with Cushing disease. Twelve of 21 patients had developed life-threatening infections by follow-up. Nine patients had undergone surgical intervention to address the primary tumor. However, only 1 patient exhibited a complete cure on follow-up. CONCLUSION: In our series, ectopic Cushing syndrome was most commonly seen in association with intrathoracic tumors such as bronchial or thymic carcinoid. Hyperpigmentation and proximal myopathy were frequent, while central obesity was uncommon. Early and rapid control of hypercortisolemia was important in order to prevent life-threatening infections and metabolic complications. ABBREVIATIONS: ACTH = adrenocorticotropic hormone CT = computed tomography DOTATATE = 68Ga-DOTA-Tyr3-octreotate ECS = ectopic Cushing syndrome FDG = fluorodeoxyglucose MTC = medullary thyroid cancer NET = neuroendocrine tumor PET = positron emission tomography.


Assuntos
Síndrome de ACTH Ectópico/fisiopatologia , Síndrome de Cushing/fisiopatologia , Neoplasias/metabolismo , Síndrome de ACTH Ectópico/complicações , Síndrome de ACTH Ectópico/diagnóstico por imagem , Síndrome de ACTH Ectópico/metabolismo , Acne Vulgar/etiologia , Adulto , Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/metabolismo , Tumor Carcinoide/diagnóstico por imagem , Tumor Carcinoide/metabolismo , Carcinoma Neuroendócrino/diagnóstico por imagem , Carcinoma Neuroendócrino/metabolismo , Síndrome de Cushing/etiologia , Síndrome de Cushing/metabolismo , Edema/epidemiologia , Feminino , Humanos , Hidrocortisona/metabolismo , Hiperpigmentação/etiologia , Índia , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/metabolismo , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/etiologia , Neoplasias/diagnóstico por imagem , Tumores Neuroendócrinos/diagnóstico por imagem , Tumores Neuroendócrinos/metabolismo , Obesidade Abdominal/etiologia , Compostos Organometálicos , Neoplasias Pancreáticas/diagnóstico por imagem , Neoplasias Pancreáticas/metabolismo , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Estudos Retrospectivos , Centros de Atenção Terciária , Neoplasias do Timo/diagnóstico por imagem , Neoplasias do Timo/metabolismo , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/metabolismo , Adulto Jovem
6.
Khirurgiia (Mosk) ; (5): 21-7, 2014.
Artigo em Russo | MEDLINE | ID: mdl-24874220

RESUMO

Neuroendocrine tumors have the ability to produce the hormones and vasoactive peptides. Excess of these hormones leads to different symptoms and syndromes because of organs' injuries. Detection of ACTH origin by using of modern diagnostic methods is not always possible. Lungs and bronchi are one of the most frequent localization of ACTH-producing tumors. It is considered that carcinoids with bronchopulmonary localization like a benign tumors in the clinical course. But at the same time carcinoid tends to metastasize, so timely diagnostics and treatment improve quality of life significant and increase the life expectancy of patients. The modern state of diagnostics and surgical treatment problem of ACTH-producing tumors with bronchopulmonary localization is presented in the article. It was described the brief historical background, clinical symptoms, instrumental and biochemical methods of diagnosis. The principles of surgical treatment are presented in the article.


Assuntos
Síndrome de ACTH Ectópico , Hormônio Adrenocorticotrópico/sangue , Neoplasias Brônquicas , Neoplasias Pulmonares , Tumores Neuroendócrinos , Pneumonectomia , Síndrome de ACTH Ectópico/sangue , Síndrome de ACTH Ectópico/diagnóstico , Síndrome de ACTH Ectópico/etiologia , Síndrome de ACTH Ectópico/fisiopatologia , Síndrome de ACTH Ectópico/cirurgia , Adolescente , Adulto , Algoritmos , Neoplasias Brônquicas/sangue , Neoplasias Brônquicas/complicações , Neoplasias Brônquicas/patologia , Neoplasias Brônquicas/cirurgia , Dexametasona , Detecção Precoce de Câncer , Intervenção Médica Precoce , Feminino , Humanos , Neoplasias Pulmonares/sangue , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/métodos , Tumores Neuroendócrinos/sangue , Tumores Neuroendócrinos/complicações , Tumores Neuroendócrinos/patologia , Tumores Neuroendócrinos/cirurgia , Pneumonectomia/métodos , Pneumonectomia/psicologia , Prognóstico , Qualidade de Vida , Tomografia Computadorizada por Raios X , Resultado do Tratamento
7.
Gynecol Endocrinol ; 30(3): 192-6, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24397395

RESUMO

A 46-year-old woman with Cushing's syndrome secondary to ectopic adrenocorticotropic hormone (ACTH) secretion caused by primary ovarian mature teratoma with carcinoid components was presented in our case. The patient manifested sustained hypercortisolemia without circadian rhythm and a lack of suppression of either low-dose dexamethasone suppression test (LDDST) or high-dose dexamethasone suppression test (HDDST). There was no evidence of a pituitary mass or secretion of other hormones. After careful clinical evaluation, no other tumor masses were found. Resection of the ovarian tumors led to sharp reduction of serum ACTH and cortisol concentrations. Immunohistochemistry showed positivity in CgA, Syn, CK, NSE. To the best of our knowledge, there are rare reports of an ACTH-secreting carcinoid components located in an ovarian mature teratoma, and bilateral ovarian mature teratoma makes it rarer.


Assuntos
Síndrome de ACTH Ectópico/fisiopatologia , Tumor Carcinoide/fisiopatologia , Síndrome de Cushing/etiologia , Neoplasias Ovarianas/fisiopatologia , Teratoma/fisiopatologia , Síndrome de ACTH Ectópico/diagnóstico , Síndrome de ACTH Ectópico/cirurgia , Tumor Carcinoide/diagnóstico , Tumor Carcinoide/metabolismo , Tumor Carcinoide/cirurgia , Síndrome de Cushing/diagnóstico , Síndrome de Cushing/prevenção & controle , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Ovarianas/diagnóstico , Neoplasias Ovarianas/metabolismo , Neoplasias Ovarianas/cirurgia , Teratoma/diagnóstico , Teratoma/metabolismo , Teratoma/cirurgia , Resultado do Tratamento
8.
Thyroid ; 23(1): 120-3, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23140512

RESUMO

BACKGROUND: Cushing's syndrome (CS) due to ectopic adrenocorticotrophic hormone (ACTH) and/or ectopic corticotropic releasing hormone (CRH) secretion accounts for <10% of all CS. Neuroendocrine carcinomas rarely cause CS. These carcinomas have been found to secrete either ACTH or rarely CRH. Herein we report a case of neuroendocrine carcinoma originating from the thyroid as the source of ACTH-dependent CS. SUMMARY: A 30-year-old woman with features of CS presented with severe respiratory distress. Six months before that, she was diagnosed with primary hypothyroidism and started on levothyroxine (LT4) therapy. Biochemical evaluation was done, and nonsuppressed serum cortisol levels following dexamethasone with high ACTH confirmed a diagnosis of ACTH-dependent CS. Magnetic resonance imaging of the brain showed a bulky pituitary gland. Adrenal imaging showed bilateral adrenal hyperplasia. A computerized tomography scan showed a large anterior mediastinal mass arising from the neck and extending behind the transverse aortic arch. She underwent emergency thoracotomy due to rapidly progressive superior mediastinal syndrome and left vocal cord palsy. At surgery, the mass was seen originating from the thyroid and the thymus was compressed posteriorly. Near total thyroidectomy and thymectomy with removal of pericardial seedlings were done. Histopathology revealed sheets, cords, and nests of round or oval tumor cells with hyperchromatic nuclei and scant cytoplasm with local invasion and lymphovascular embolization suggestive of a neuroendocrine carcinoma arising from thyroid, staining positive for cytokeratin, synaptophysin, and chromogranin-A, and negative for calcitonin and carcinoembryonic antigen. CONCLUSIONS: Here we report a case of a neuroendocrine tumor of the thyroid causing ACTH-dependent CS. The tumor was negative for calcitonin staining, indicating that this was not a medullary carcinoma of the thyroid. Neuroendocrine carcinomas originating from the thyroid gland are very rare. A thyroid tumor of neuroendocrine origin causing ACTH-dependent CS has not been reported previously.


Assuntos
Síndrome de ACTH Ectópico/complicações , Carcinoma Neuroendócrino/complicações , Carcinoma Neuroendócrino/metabolismo , Síndrome de Cushing/etiologia , Neoplasias da Glândula Tireoide/complicações , Neoplasias da Glândula Tireoide/metabolismo , Síndrome de ACTH Ectópico/diagnóstico , Síndrome de ACTH Ectópico/fisiopatologia , Hormônio Adrenocorticotrópico/metabolismo , Adulto , Carcinoma Neuroendócrino/diagnóstico , Síndrome de Cushing/fisiopatologia , Feminino , Humanos , Neoplasias da Glândula Tireoide/diagnóstico
9.
Exp Clin Endocrinol Diabetes ; 119(9): 525-9, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22006180

RESUMO

Ectopic ACTH production causes 10% of Cushing's syndromes. The diagnostic workup is difficult, can last more than 6 months (> 50% of cases), and the underlying tumour is still frequently not located (12%). Carcinoid tumours of the appendix are frequent and are revealed in 0.3% of patients undergoing routine appendectomy. However, neuroendocrine tumours of the appendix with ACTH production are an extremely rare entity. Here we report the case of a female patient with clinically overt Cushing's syndrome due to ectopic ACTH-production from a carcinoid tumour of the appendix. During the diagnostic workup, repeated endocrine tests, multiple different imaging modalities and frequent and lengthy hospitalisations were necessary. Wrongly, even a neurosurgical pituitary exploration was performed. After 12 months from the initial admission, the tumour was finally detected by an ¹8F-fluoro-L-dihydroxyphenylalanine (¹8FDOPA PET) and an appendectomy followed by right hemicolectomy were performed. The patient recovered rapidly and the symptoms from the hypercortisolism were no more present.In this case, we discuss the multitude of problems, which may delay the diagnosis and the pitfalls, that should be avoided in order to locate the tumour and to initiate adequate therapy as early as possible. Furthermore, our case demonstrates the complexity of diagnostic procedures, which demand most of the times a multidisciplinary approach. In this setting, regular follow-ups in short time intervals and the use of novel imaging techniques can finally cut the diagnostic "Gordian knot".


Assuntos
Síndrome de ACTH Ectópico/diagnóstico , Neoplasias do Apêndice/diagnóstico , Tumor Carcinoide/diagnóstico , Síndrome de ACTH Ectópico/fisiopatologia , Síndrome de ACTH Ectópico/cirurgia , Adulto , Neoplasias do Apêndice/metabolismo , Neoplasias do Apêndice/fisiopatologia , Neoplasias do Apêndice/terapia , Tumor Carcinoide/metabolismo , Tumor Carcinoide/fisiopatologia , Tumor Carcinoide/terapia , Terapia Combinada , Síndrome de Cushing/etiologia , Diagnóstico Tardio , Feminino , Fluordesoxiglucose F18 , Humanos , Tomografia por Emissão de Pósitrons , Compostos Radiofarmacêuticos , Resultado do Tratamento
10.
Neurosurgery ; 65(6 Suppl): E110-1; discussion E111, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19935008

RESUMO

OBJECTIVE: We aim to report a case of Kaposi sarcoma (KS) with Cushing's syndrome caused by endogenic glucocorticoid-induced immunosuppression. CLINICAL PRESENTATION: A 43-year-old woman presented with delirium, hirsutism, fatigue, and hypertension. At the time of presentation, physical findings showed a Cushingoid appearance, with moon-like facies, hirsutism, and hyperpigmentation. Laboratory findings showed the following: adrenocorticotropic hormone, 86.7 pg/mL (normal range, 0-46 pg/mL); baseline cortisol level, 50 microg/dL (normal range, 6.2-19 microg/dL); potassium, 2.2 mEq/L (normal range, 3.5-5 mEq/L); and midnight cortisol level, 33 microg/dL. Serum cortisol levels failed to suppress after low and high doses of dexamethasone; these findings confirmed the diagnosis of ectopic adrenocorticotropic hormone production. Magnetic resonance imaging revealed a 12 x 15-mm, round, hypothalamic mass lesion in the center of the median eminence. INTERVENTION: Endoscopic biopsy from the floor of the third ventricle was performed, and pathological examination of the lesion showed a diffuse adrenocorticotropic hormone-secreting adenoma. The patient developed diffuse skin lesions that were proven to be a KS by skin biopsy while she was prepared for transcranial surgery. After surgical removal of the adenoma, she became hypocortisolemic and required cortisol replacement. Within 1 month after surgery, all KS lesions disappeared spontaneously. CONCLUSION: Excessive cortisol may induce immunosuppression. KS is one of the most common malignant tumors of patients with immunosuppression. To the best of our knowledge, this is the first case of Cushing's syndrome with KS caused by endogenous glucocorticoid-induced immunosuppression.


Assuntos
Síndrome de ACTH Ectópico/imunologia , Adenoma/metabolismo , Hormônio Adrenocorticotrópico/metabolismo , Neoplasias Hipotalâmicas/metabolismo , Neoplasias Hipofisárias/metabolismo , Sarcoma de Kaposi/imunologia , Síndrome de ACTH Ectópico/patologia , Síndrome de ACTH Ectópico/fisiopatologia , Adenoma/patologia , Adenoma/cirurgia , Hormônio Adrenocorticotrópico/sangue , Adulto , Coristoma/patologia , Coristoma/fisiopatologia , Coristoma/cirurgia , Síndrome de Cushing/complicações , Síndrome de Cushing/imunologia , Síndrome de Cushing/fisiopatologia , Feminino , Humanos , Hidrocortisona/sangue , Neoplasias Hipotalâmicas/patologia , Neoplasias Hipotalâmicas/cirurgia , Hipotálamo/metabolismo , Hipotálamo/patologia , Hipotálamo/cirurgia , Tolerância Imunológica/imunologia , Hospedeiro Imunocomprometido/imunologia , Imageamento por Ressonância Magnética , Eminência Mediana/metabolismo , Eminência Mediana/patologia , Eminência Mediana/cirurgia , Procedimentos Neurocirúrgicos , Neoplasias Hipofisárias/patologia , Neoplasias Hipofisárias/cirurgia , Sarcoma de Kaposi/patologia , Sarcoma de Kaposi/fisiopatologia , Resultado do Tratamento
12.
Indian J Med Res ; 129(1): 33-41, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19287055

RESUMO

BACKGROUND & OBJECTIVE: Ectopic secretion of adrenocorticotropic hormone (ACTH) is rare, contributing to 10 per cent cases of endogenous Cushing's syndrome. We describe our experience of about two decades of patients with ectopic Cushing's syndrome (ECS) seen at a tertiary care centre from north India. METHODS: Records of patients with ECS from 1985 to 2006 were retrospectively reviewed that included the presenting manifestations, clinical symptoms and signs, biochemical investigations including plasma cortisol, ACTH and high dose dexamethasone suppression test (HDDST), imaging modalities to localize the non pituitary source of ACTH production, management and follow up of these patients. RESULTS: The study group included 12 patients (7 men) with mean (+/-SD) age at presentation 27.6 +/- 9.5 yr (range 13 to 48 yr) and the mean lag period between onset of symptoms and the diagnosis was 18.3 +/- 12.9 months with a range of 3 to 48 months. The weight loss (41.7%) followed by hyperpigmentation (25%) and infections (16.7%) were the common presenting manifestations. Cuticular atrophy (100%), hypertension (100%), bruise (92%) and proximal myopathy (83%) were the commonest signs. Plasma cortisol at 0800 h was 1267.3 +/- 483.3 nmol/l and at 2200 h was 1214.9 +/- 442.6 nmol/l indicating loss of circadian rhythm. The mean plasma ACTH was 221.1 +/- 55.9 (range 21.7 to 950 pg/ml). All but 2 patients had non-suppressibility of 0800 h plasma cortisol with HDDST. Five patients had thymic carcinoid, 3 had bronchial and one each had islet, hepatic and gut carcinoid and one had medullary thyroid carcinoma as a cause of ectopic ACTH secretion. The mean duration of follow up of these patients was 42.6 months and only two could sustain cure while remaining had either residual or recurrence. INTERPRETATION & CONCLUSION: Ectopic Cushing's syndrome is a rare disease with varied manifestations and associated with increased morbidity and mortality. It presents with clinical features quite similar to classical Cushing's. Surgery with removal of primary tumour was found to be treatment of choice.


Assuntos
Síndrome de ACTH Ectópico/complicações , Síndrome de ACTH Ectópico/fisiopatologia , Síndrome de Cushing/etiologia , Síndrome de Cushing/fisiopatologia , Síndrome de ACTH Ectópico/diagnóstico por imagem , Síndrome de ACTH Ectópico/terapia , Adolescente , Hormônio Adrenocorticotrópico/sangue , Adulto , Dexametasona , Feminino , Humanos , Hidrocortisona/sangue , Índia , Masculino , Pessoa de Meia-Idade , Radioimunoensaio , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Redução de Peso
13.
Endocrinol. nutr. (Ed. impr.) ; 55(10): 507-509, dic. 2008.
Artigo em Es | IBECS | ID: ibc-70741

RESUMO

El síndrome de Cushing por secreción ectópica de corticotropina (ACTH)es infrecuente, y la causa más frecuente es el carcinoide bronquial; sin embargo, en una proporción no despreciable de los casos (hasta un 16%)no se consigue localizar. El tratamiento del síndrome de Cushing ectópicoes la resección del tumor causal, pero en muchas ocasiones esto no es posible, bien porque no se ha localizado el tumor o bien porque éste no es resecable; en estos casos se plantea cuándo proceder a una suprarrenalectomía bilateral. Se presenta un caso de una paciente con hipercortisolismo dependiente de ACTH, en que se establece el origen ectópico de la ACTH a partir de los resultados de las pruebas complementarias (tests de supresión, cateterismo de senos petrosos y pruebas de imagen); sin embargo, ninguna de las pruebas de imagen fue capaz de localizar el origen del tumor secretor de ACTH. Por ello, después de un tiempo prudencial, se decidió proceder a suprarrenalectomía bilateral, con buena respuesta clínica (AU)


Cushing’s syndrome due to ectopicad renocorticotrophic hormone (ACTH)secretion is infrequent, the most frequent cause being bronchial carcinoid; nevertheless, in a considerable proportion of cases (up to 16%), the origin of ACTH secretion is not found. Treatment of Cushing’s syndrome due to ectopic ACTH secretion is surgical resection of the tumor. However, surgical excision is not always feasible, either because the tumor has not been located, or because it is unresectable; in these cases the question is when to carry out a bilateral adrenalectomy. We present a case of ACTH-dependent hypercortisolism, in which the ectopic origin of ACTH secretion was established from the results of complementary tests(suppression tests, petrosal sinus sampling, imaging); nevertheless, none of the imaging tests was able to identify the secreting tumor. Consequently, after a reasonable interval, a bilateral adrenalectomy was performed, with good clinical results (AU)


Assuntos
Humanos , Feminino , Adulto , Hormônio Adrenocorticotrópico , Síndrome de Cushing/fisiopatologia , Síndrome de ACTH Ectópico/fisiopatologia , Doenças das Glândulas Suprarrenais/cirurgia
14.
J Endocrinol Invest ; 30(10): 828-32, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18075284

RESUMO

ACTH-dependent Cushing's syndrome is due to ACTH overproduction originating from a pituitary corticotroph adenoma (Cushing's disease) or from ectopic tumors (ectopic ACTH syndrome). Due to difficulties in the differential diagnosis between these two forms of hypercortisolism it would be important to have molecular tools able to discriminate the two conditions. It is known that proopiomelanocortin (POMC) gene transcription can originate messengers of different length. ACTHomas show the normal 1072 nucleotides (nt) transcript, whereas ectopic tumors seem to be associated with a longer mRNA form (1450 nt). In order to analyse the presence of different POMC transcripts, we extracted total RNA from peripheral lymphocytes of 10 patients with Cushing's disease, 10 with ectopic Cushing syndrome, and 20 controls as well as from pituitary tissues (2 ACTH-omas and a normal pituitary polyA+ sample). Northern blot analysis correctly revealed a 1072 nt mRNA molecule in pituitary ACTH-oma and in the normal pituitary polyA+ RNA samples, whereas neither this molecule nor other alternative transcripts were detected in blood samples from patients and controls. These data were confirmed by the more sensitive RT-PCR technique. This study further underlines the need for alternative approaches in the diagnosis of ACTH-dependent Cushing's syndrome.


Assuntos
Síndrome de ACTH Ectópico/diagnóstico , Adenoma Hipofisário Secretor de ACT/diagnóstico , Adenoma/diagnóstico , Biomarcadores Tumorais/genética , Síndrome de Cushing/diagnóstico , Pró-Opiomelanocortina/genética , Síndrome de ACTH Ectópico/complicações , Síndrome de ACTH Ectópico/fisiopatologia , Adenoma Hipofisário Secretor de ACT/complicações , Adenoma Hipofisário Secretor de ACT/fisiopatologia , Adenoma/complicações , Adenoma/fisiopatologia , Biomarcadores Tumorais/sangue , Northern Blotting , Síndrome de Cushing/etiologia , Síndrome de Cushing/fisiopatologia , Diagnóstico Diferencial , Humanos , RNA Mensageiro/sangue , Reação em Cadeia da Polimerase Via Transcriptase Reversa
17.
Nihon Rinsho ; 62(5): 951-5, 2004 May.
Artigo em Japonês | MEDLINE | ID: mdl-15148825

RESUMO

Although the clinical and biochemical discrimination of true Cushing syndrome from the Cushing phenotype is sometime difficult, four diagnostic studies are currently used: late-night serum and salivary cortisol level, urine free cortisol level, low-dose dexamethasone suppression, and the dexamethasone-CRH test. Using these tests, 90% of patients with Cushing syndrome are diagnosed. Once the diagnosis of the Cushing syndrome is firmly established, the next step is differential diagnosis of the subtype. Furthermore, the differentiation of pituitary and ectopic ACTH-dependent Cushing syndrome should be carried out using measurement of ACTH. Finally, bilateral petrosal sinus sampling for ACTH with CRH administration might be a powerful tool for a diagnosis for ectopic ACTH syndrome. A variety of benign and malignant tumors of non-pituitary tissues have been associated with the ectopic ACTH syndrome. The tumors most commonly associated with ACTH syndrome arise from neuroendocrine tissues, however, the pathogenesis of the ectopic ACTH syndrome remains unknown.


Assuntos
Síndrome de ACTH Ectópico , Síndrome de ACTH Ectópico/diagnóstico , Síndrome de ACTH Ectópico/fisiopatologia , Síndrome de ACTH Ectópico/terapia , Biomarcadores/análise , Hormônio Liberador da Corticotropina , Síndrome de Cushing , Dexametasona , Diagnóstico Diferencial , Técnicas de Diagnóstico Endócrino , Humanos , Hidrocortisona/análise
18.
Clin Endocrinol (Oxf) ; 60(3): 309-14, 2004 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15008995

RESUMO

OBJECTIVE: Several studies have demonstrated impaired GH secretion in patients with active Cushing's syndrome (CS). It has been suggested that persistence of GH deficiency, despite treatment of cortisol excess, may delay the recovery of these patients and therefore temporary treatment with GH may have some benefit. However, the time course of restoration of GH secretion after successful treatment of CS has only been investigated in a limited number of mostly paediatric reports. The aim of the present study was the evaluation of GH reserve in adult patients with CS before and after correction of cortisol excess. DESIGN AND PATIENTS: Sixteen patients (12 females, four males) with CS aged 44.7 +/- 5.05 years were recruited. These included seven patients with Cushing's disease, four patients with ectopic ACTH secretion and five patients with adrenal adenoma. All patients were evaluated before any therapeutic intervention. Twelve patients were successfully treated following appropriate surgery and these were further studied. The combined pyridostigmine/GHRH test was used to assess GH reserve in these patients. In a proportion of cases an insulin tolerance test (ITT) was also used. RESULTS: Before any therapeutic intervention, an impaired GH response to PD/GHRH was noted in all patients. Restoration of GH response at 6 months was observed in six patients (50%); at 12 months in two; at 18 months in one patient. Two of the patients with no restoration of GH response at 12 months did not accept further investigation. Only one patient did not achieve an adequate GH response even when tested 30 months following cure of CS. Restoration of GH reserve was more commonly observed in those patients in whom there was recovery of the HPA axis. There was a good correlation between peak GH levels to PD + GHRH and ITT. No statistically significant difference was revealed in IGF-I levels between pre- and post-treatment evaluation. CONCLUSIONS: Adult patients with active Cushing's syndrome demonstrate a profound suppression of stimulated GH secretion. In the majority of these patients the disruption of GH secretion is normalized within a year after successful treatment of endogenous cortisol excess.


Assuntos
Síndrome de Cushing/sangue , Síndrome de Cushing/terapia , Hormônio do Crescimento/sangue , Síndrome de ACTH Ectópico/sangue , Síndrome de ACTH Ectópico/fisiopatologia , Síndrome de ACTH Ectópico/terapia , Adenoma/sangue , Adenoma/fisiopatologia , Adenoma/terapia , Córtex Suprarrenal/fisiopatologia , Neoplasias do Córtex Suprarrenal/sangue , Neoplasias do Córtex Suprarrenal/fisiopatologia , Neoplasias do Córtex Suprarrenal/terapia , Adulto , Idoso , Inibidores da Colinesterase , Síndrome de Cushing/fisiopatologia , Feminino , Hormônio Liberador de Hormônio do Crescimento , Humanos , Insulina , Fator de Crescimento Insulin-Like I/análise , Masculino , Pessoa de Meia-Idade , Brometo de Piridostigmina , Estatísticas não Paramétricas
19.
Intern Med ; 42(9): 831-3, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-14518671

RESUMO

Paraneoplastic Cushing's syndrome caused by ectopic adrenocorticotropin production has been reported in association with a variety of malignant tumors. However, most cases of this syndrome are associated with neuroendocrine tumors such as small-cell lung cancer (SCLC), carcinoid tumors, and medullary carcinoma of the thyroid. We present a 49-year-old man who developed Cushing's syndrome associated with adenocarcinoma of the lung. He had a wide variety of clinical symptoms and comorbidity related to this syndrome during the course, and died 4 months after the diagnosis. This is a very rare case report of Cushing's syndrome associated with adenocarcinoma of the lung.


Assuntos
Síndrome de ACTH Ectópico/etiologia , Adenocarcinoma/complicações , Síndrome de Cushing/etiologia , Neoplasias Hepáticas/complicações , Neoplasias Pulmonares/complicações , Síndrome de ACTH Ectópico/fisiopatologia , Adenocarcinoma/secundário , Síndrome de Cushing/fisiopatologia , Evolução Fatal , Humanos , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias
20.
Trends Endocrinol Metab ; 12(10): 446-53, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11701343

RESUMO

11beta-Hydroxysteroid dehydrogenases (11beta HSDs) are enzymes that catalyse the interconversion of active glucocorticoids (cortisol and corticosterone) into their inactive 11-keto products (cortisone and 11-deoxycorticosterone). Two isozymes have been identified: 11beta HSD type 1 is a predominant reductase, reactivating glucocorticoids from inert metabolites, whereas 11beta HSD type 2 is a potent dehydrogenase, inactivating glucocorticoids. They play a major role in the modulation of local cortisol levels and hence access of active steroid to corticosteroid receptors. This review focuses on the clinical importance of 11beta HSDs. We describe recent research that has not only advanced our understanding of the physiological role of these enzymes, but also their role in common diseases, including primary obesity and essential hypertension. These data provide encouragement that novel therapies will arise from a fuller understanding of the 11beta HSD system.


Assuntos
Síndrome de ACTH Ectópico/fisiopatologia , Glucocorticoides/metabolismo , Hidroxiesteroide Desidrogenases/metabolismo , Obesidade/fisiopatologia , 11-beta-Hidroxiesteroide Desidrogenase Tipo 2 , 11-beta-Hidroxiesteroide Desidrogenases , Angiotensina Amida/metabolismo , Animais , Deleção de Genes , Humanos , Hidroxiesteroide Desidrogenases/deficiência , Síndrome
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