RESUMO
El síndrome de la cimitarra consiste en un retorno venoso pulmonar anómalo. En esta patología la vena pulmonar conecta con la vena cava inferior en lugar de la aurícula izquierda. Presentamos el caso de un hombre de 40 años con el diagnóstico reciente de síndrome de la cimitarra. El paciente estaba asintomático desde el punto de vista cardiológico. Tras el cauteloso estudio de cardiología y varias pruebas complementarias, entre ellas ecografías, resonancia nuclear magnética, TAC y radiología de tórax se le diagnosticó la enfermedad (AU)
Scimitar syndrome consists in an anomalous pulmonary venous return. In this pathology the pulmonary vein connects to the inferior vena cava instead of the left atrium. We present the case of a 40-year-old man with scimitar syndrome. The patient had no cardiological clinical symptoms. After a cautious cardiological study and various complementary tests -among them ecography, magnetic resonance imaging, computed tomography and chest X-ray- the diagnosis was achieved (AU)
Assuntos
Humanos , Masculino , Adulto , Síndrome de Cimitarra/genética , Síndrome de Cimitarra/patologia , Atenção Primária à Saúde , Atenção Primária à Saúde/métodos , Hemoptise/sangue , Hemoptise/patologia , Radiografia Torácica/instrumentação , Radiografia Torácica/métodos , Infecções Respiratórias/metabolismo , Infecções Respiratórias/prevenção & controle , Síndrome de Cimitarra/complicações , Síndrome de Cimitarra/metabolismo , Atenção Primária à Saúde/normas , Atenção Primária à Saúde , Hemoptise/diagnóstico , Hemoptise/metabolismo , Radiografia Torácica/tendências , Radiografia Torácica , Infecções Respiratórias/complicações , Infecções Respiratórias/diagnósticoRESUMO
Semaphorins and their receptors, neuropilins and plexins, were initially characterized as a modulator of axonal guidance during development, but are now recognized as a regulator of a wide range of developmental events including morphogenesis and angiogenesis, and activities of the immune system. Owing to the development of next-generation sequencing technologies together with other useful DNA assays, it has also become clear that semaphorin signaling plays a crucial role in many congenital diseases such as retinal degeneration and congenital heart defects. This review summarizes the recent knowledge about the relationship between a variety of congenital diseases and semaphorin signaling.
