RESUMO
Diffuse idiopathic skeletal hyperostosis (DISH) is a common systemic disorder characterised by the ossification of the anterior longitudinal spinal ligament involving at least three contiguous vertebrae and by diffuse extraspinal enthesopathies. The condition is associated with the male sex and with advanced age; its aetiology is uncertain, but seems to be related to obesity and diabetes. The most recent studies in archaeological series demonstrated a relation between high social status and the incidence of DISH. The present study examines two cases of DISH found amongst the members of the Medici family buried in the Basilica of San Lorenzo in Florence. The skeletons of the Grand Dukes Cosimo I (1519-1574) and his son Ferdinand I (1549-1609) showed the typical features of the condition. This result is related to the obesity of the Grand Dukes, attested by the written and artistic sources, and to the protein-based alimentation demonstrated by a paleonutritional study, thus furnishing further evidence to the significance of DISH as a life style.
Assuntos
Síndrome de Hiperostose Adquirida/história , Diabetes Mellitus Tipo 2/história , Obesidade/história , Doenças da Coluna Vertebral/história , Síndrome de Hiperostose Adquirida/diagnóstico por imagem , Diabetes Mellitus Tipo 2/diagnóstico por imagem , História do Século XVI , História do Século XVII , Humanos , Itália , Ligamentos Longitudinais , Masculino , Obesidade/diagnóstico por imagem , Radiografia , Doenças da Coluna Vertebral/diagnóstico por imagemRESUMO
En este documento se revisa extensamente la literatura con respecto al síndrome SAPHO, con énfasis en los aspectos históricos, criterios de clasificación, las manifestaciones clínicas, hallazgos de laboratorio y tratamiento. Para lograr este objetivo se buscaron las referencias bibliográficas mas significativas del tema en las bases de datos disponibles
