Plummer Vinson syndrome / Síndrome de Plummer Vinson

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Two cases with Plummer-Vinson syndrome in the 21st century.

Plummer-Vinson syndrome (PVS) is characterized by the presence of postcricoid dysphagia, iron deficiency anemia, and upper esophageal web. This syndrome is now a rare condition because of the improvement in nutritional status and increased awareness regarding iron deficiency anemia and the early diagnosis and easy treatment of this anemia or underlying causes. In this presentation, we report two middle-aged female patients with PVS and briefly review the literature.

PLUMMER VINSON SYNDROME--is it common in males?

BACKGROUND: Plummer-Vinson syndrome is characterized by a triad of dysphagia, iron deficiency anemia and esophageal web. Most of the patients are middle aged women in the fourth to seventh decade of life. OBJECTIVE: Very few cases of Plummer-Vinson syndrome affecting males have been reported. Here we report a series of male patients found to be suffering from Plummer-Vinson syndrome. METHODS: Five males presented to us with dysphagia and fatigue of various durations, from April to August, 2012. RESULTS: These patients were found to have iron deficiency anemia and esophageal web on subsequent investigations and were treated successfully with oral iron therapy. CONCLUSION: Plummer-Vinson syndrome is common in both males and females and can be successfully treated with oral iron therapy. The patients have an increased risk of developing gastrointestinal malignancies and should be thoroughly evaluated for the same.

A case of plummer-vinson syndrome associated with Crohn's disease.

Plummer-Vinson syndrome manifests as cervical dysphagia, iron deficiency anemia, an upper esophageal web, and atrophic glossitis. The cause of the esophageal web is thought to be iron deficiency anemia; however, the cause of Plummer-Vinson syndrome has not been established. Crohn's disease is usually accompanied by malnutrition and iron deficiency anemia; however, no case of concomitant Crohn's disease and Plummer-Vinson syndrome with aggravated malnutrition and anemia has been previously reported. Here, we report on a rare case of Plummer-Vinson syndrome in a Crohn's disease patient, which caused malnutrition and constipation.

Plummer-Vinson syndrome heralded by postcricoid carcinoma.

Plummer-Vinson syndrome is one of the names given to the constellation of dysphagia, iron-deficiency anemia, and esophageal webbing. Treatment consists of iron supplementation, possibly dilation, and surveillance. The syndrome is associated with an increased risk of postcricoid carcinoma, which usually presents at an advanced stage. We present a case of an early postcricoid carcinoma that led to the diagnosis of Plummer-Vinson syndrome and subsequent treatment of both conditions.

Paterson-Kelly syndrome and celiac disease--a rare combination.

Paterson-Kelly syndrome is characterized by an association of iron deficiency with dysphagia. We describe a patient with this syndrome who was later diagnosed to have celiac disease.

Celiac disease presenting as the Paterson-Brown Kelly (Plummer-Vinson) syndrome.

We describe two patients with Paterson-Brown Kelly (Plummer-Vinson) syndrome whose iron deficiency anemia was due to celiac disease. They presented with dysphagia 13 and 9 yr, respectively, before celiac disease was diagnosed. Neither had gastrointestinal symptoms suggestive of malabsorption. Celiac disease is a recognized cause of chronic iron deficiency and should be considered as an etiological factor for sideropenic dysphagia.

[Disorders caused by mutations of the thyrotropin receptor].

Since 1993, a number of mutations of the thyrotropin receptor(TSHR) gene causing human diseases have been reported; activating TSHR somatic mutations causing autonomously functioning thyroid nodules, activating TSHR germ-line mutations causing familial non-autoimmune hyperthyroidism, and inactivating TSHR germ-line mutations causing hypothyroidism due to TSH unresponsiveness. Activating TSHR mutations increase second messenger signals without stimulation of TSH or thyroid stimulating antibody, conferring autonomous growth and function upon thyroid cells. Most of activating TSHR mutations are located in the transmembrane domain of the receptor. One of most important mechanisms how these mutants activate the receptor constitutively is that inter-helical bonding(s) maintained in the silent receptor is/are disrupted by the mutations. Further investigation of activating mutations will provide insight into normal activating mechanism of the receptor.

[Double esophageal membrane in a patient with Plummer-Vinson syndrome]. / Doble membrana esofágica en paciente con síndrome de Plummer-Vinson.

A case is presented of a 27-year-old patient with Plummer-Vinson syndrome. Radiological and endoscopic study detected a double membrane in the cervical esophagus. After esophageal dilation, dysphagia remitted and the patient remains asymptomatic.

[Mucoid webs of the cervical esophagus. Apropos of 38 cases discovered during upper endoscopy at the Hôpital Principal of Dakar. Relationship to Plummer-Vinson syndrome]. / Diaphragmes muqueux de l'oesophage cervical. A propos de 38 cas découverts au cours d'endoscopies hautes à l'Hôpital Principal de Dakar. Relation avec le syndrome de Plummer-Vinson.

Thirty-eight cervical esophageal mucous diaphragms were discovered in the course of 15,000 high endoscopies carried out over the past 5 years at Dakar General Hospital. Thirty-six of the sufferers were Black Senegalese. The 29 women and 9 men had an average age of 37 years. Dysphagia was diagnosed 29 times, and anemia 22 times. Endoscopic diagnosis readily shows the mucous diaphragm at the level of, or immediately below, KILLIAN's mouth. PLUMMER-VINSON's syndrome affected 16 of these patients. Treatment consists in collapsing the mucous diaphragm by putting the endoscope through it: this happened to 30 of the patients. Endoscopic surveillance is indispensable because of the risk of cancer, but is difficult to perform.