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1.
PLoS One ; 16(6): e0251775, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34061871

RESUMO

OBJECTIVE: The term Idiopathic Systemic Capillary Leak Syndrome (ISCLS) refers to an uncommon condition of severe distributive shock, resulting from an abrupt shift of fluids and proteins from the intravascular to the interstitial compartment. We hypothesise that the autonomic nervous system (ANS) fails in regulating the response to hypovolemia in acute ISCLS and that ANS variables characterise the progression to the recovery. DESIGN: Prospective cohort study of patients admitted to ICU for severe ISCLS flares. SETTING: Single, referral center in Italy for ISCLS. PATIENTS: Analysis of cardiovascular signals recorded during seven severe ISCLS attacks and one prodromal period in five patients. INTERVENTIONS: ANS was studied non-invasively by means of heart rate variability (HRV) and blood pressure variability analysis, as an estimation of vagal and sympathetic modulation directed to the heart and vessels. Heart rate and systolic arterial pressure (SAP) variability were also used to assess baroreflex sensitivity. ANS variables were measured during the subsequent phases which characterise ISCLS flares, namely the acute phase, the post-acute phase, and the recovery phase. MEASUREMENTS AND MAIN RESULTS: HRV was severely depressed during the acute phase accounting for the loss of ANS modulation during massive capillary extravasation. This phase was characterised by shock and impaired baroreflex control, which allowed SAP to oscillate driven by respiratory activity. Impending shock and transition from shock to a post-acute phase were marked by change of baroreflex spectral variables. The baroreflex control was fully restored during recovery. CONCLUSIONS: ANS modulation and baroreflex control are severely impaired during the acute haemodynamic instability which characterises ISCLS crises and their progressive restoration may be a clue of improvement. ANS indices during ISCLS flares might serve as useful biomarkers, able to timely announce the transition from one phase to the subsequent one, thus helping to adapt therapy accordingly.


Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Síndrome de Vazamento Capilar/fisiopatologia , Adulto , Biomarcadores/metabolismo , Pressão Sanguínea , Feminino , Frequência Cardíaca , Humanos , Masculino , Pessoa de Meia-Idade
3.
Trop Doct ; 51(2): 246-248, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33349162

RESUMO

Idiopathic systemic capillary leak syndrome (ISCLS) is a potentially fatal disorder characterised by 'attacks' of varying intensity of hypovolemic shock in association with haemoconcentration and hypoalbuminaemia. It is a disease of exclusion, and the severity of attacks may mimic sepsis at presentation. We report a case of a lady with recurrent attacks of ISCLS with at least two life-threatening episodes, having been treated elsewhere as a case of steroid insufficiency. The diagnosis is often challenging, and treatment of an acute episode involves the judicious use of fluids and vasopressors, as required. Prophylaxis to prevent further attacks is of varied success.


Assuntos
Síndrome de Vazamento Capilar/diagnóstico , Adulto , Síndrome de Vazamento Capilar/fisiopatologia , Síndrome de Vazamento Capilar/terapia , Feminino , Humanos , Hipoalbuminemia/diagnóstico , Hipoalbuminemia/fisiopatologia , Hipoalbuminemia/prevenção & controle , Hipoalbuminemia/terapia , Imunoglobulinas Intravenosas/uso terapêutico , Diagnóstico Ausente , Recidiva , Choque/diagnóstico , Choque/fisiopatologia , Choque/prevenção & controle , Choque/terapia
5.
Am J Physiol Gastrointest Liver Physiol ; 319(5): G573-G583, 2020 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-32877220

RESUMO

Severe acute pancreatitis (SAP) includes persistent systemic inflammation (SIRS) and multiorgan failure (MOF). The mechanism of transition from SIRS to MOF is unclear. We developed a fluid compartment model and used clinical data to test predictions. The model includes vascular, interstitial and "third-space" compartments with variable permeability of plasma proteins at the capillaries. Consented patients from University of Pittsburgh Medical Center Presbyterian Hospital were studied. Preadmission and daily hematocrit (HCT), blood urea nitrogen (BUN), creatine (Cr), albumin (Alb), and total protein (TP) were collected, and nonalbumin plasma protein (NAPP = TP minus the Alb) was calculated. Subjects served as their own controls for trajectory analysis. Of 57 SAP subjects, 18 developed MOF (5 died), and 39 were non-MOF (0 died). Compared with preadmission levels, admission HCT increased in MOF +5.00 [25%-75% interquartile range, IQR] versus non-MOF -0.10 [-1.55, 1.40] (P < 0.002) with HCT > +3 distinguishing MOF from non-MOF (odds ratio 17.7, P = 0.014). Preadmission Alb fell faster in MOF than non-MOF (P < 0.01). By day 2, TP and NAPP dropped in MOF but not non-MOF (P < 0.001). BUN and Cr levels increased in MOF (P = 0.001), but BUN-to-Cr ratios remained constant. Pancreatic necrosis was more common in MOF (56%) than non-MOF (23%). Changing capillary permeability to allow loss of NAPP in this model predicts loss of plasma oncotic pressure and reduced vascular volume, hypotension with prerenal azotemia and acute kidney dysfunction, pancreas necrosis, and pulmonary edema from capillary leak in the lung with acute respiratory distress syndrome. Sequential biomarker analysis in humans with or without MOF is consistent with this model. This study is registered on https://clinicaltrials.gov at NCT03075605.NEW & NOTEWORTHY Acute pancreatitis is a sudden inflammatory response to pancreatic injury that may spread to systemic inflammation, multiorgan failure, and death in some patients. With the use of the predictions of a new mechanistic model, we compared patients with severe acute pancreatitis with or without multiorgan failure. All biomarkers of capillary leak and clinical features of multiorgan failure were accurately predicted. This provides a new paradigm for understanding and developing new treatments for patients with severe acute pancreatitis.


Assuntos
Permeabilidade Capilar , Insuficiência de Múltiplos Órgãos/fisiopatologia , Pancreatite/fisiopatologia , Síndrome de Resposta Inflamatória Sistêmica/fisiopatologia , Doença Aguda , Adulto , Idoso , Proteínas Sanguíneas/metabolismo , Nitrogênio da Ureia Sanguínea , Compartimentos de Líquidos Corporais , Síndrome de Vazamento Capilar/fisiopatologia , Feminino , Hematócrito , Humanos , Hipotensão/fisiopatologia , Hipovolemia/fisiopatologia , Masculino , Pessoa de Meia-Idade , Modelos Biológicos , Necrose , Albumina Sérica/metabolismo
6.
Medicine (Baltimore) ; 99(29): e21202, 2020 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-32702885

RESUMO

RATIONALE: Capillary leak syndrome is a condition that increases systemic capillary permeability and causes characteristic manifestations such as recurrent hypovolemia, systemic edema, and hemoconcentration. Acute limb compartment syndrome is a possible complication of severe capillary leak syndrome. However, timely diagnosis and prompt treatment are challenging because of atypical presentation. PATIENT CONCERNS: An 18-year-old woman with a history of clinical depression was admitted to our intensive care unit (ICU) because of metformin and vildagliptin overdose. She developed marked vasodilatory shock with recurrent severe hypovolemia and disseminated intravascular coagulation. After urgent hemodialysis and plasma exchange, she started to stabilize hemodynamically. However, her limbs became stone-hard with massive edema. Her serum creatinine kinase level increased to an extremely high level. DIAGNOSIS: Extremities were distended, and her skin developed pallor with blistering. Intramuscular pressure in both forearms and lower legs was significantly elevated. INTERVENTIONS: Decompressive fasciotomy was performed. Hemodialysis was continued because of rhabdomyolyses-induced acute kidney injury. OUTCOMES: The patient was finally able to walk by herself at the time of hospital discharge on day 109. LESSONS: The possibility of acute compartment syndrome should be considered in patients with marked capillary leakage, especially after aggressive fluid resuscitation. It is important to be aware of the compartment syndrome in an ICU setting because communication barriers often mask typical symptoms and make diagnosis difficult.


Assuntos
Síndrome de Vazamento Capilar/etiologia , Síndromes Compartimentais/etiologia , Inibidores da Dipeptidil Peptidase IV/toxicidade , Metformina/efeitos adversos , Adolescente , Síndrome de Vazamento Capilar/complicações , Síndrome de Vazamento Capilar/fisiopatologia , Síndromes Compartimentais/fisiopatologia , Síndromes Compartimentais/cirurgia , Descompressão Cirúrgica/métodos , Inibidores da Dipeptidil Peptidase IV/efeitos adversos , Inibidores da Dipeptidil Peptidase IV/uso terapêutico , Feminino , Hidratação/efeitos adversos , Humanos , Hipoglicemiantes/efeitos adversos , Hipoglicemiantes/uso terapêutico , Unidades de Terapia Intensiva/organização & administração , Metformina/uso terapêutico , Rabdomiólise/complicações , Vildagliptina/efeitos adversos , Vildagliptina/uso terapêutico , Vildagliptina/toxicidade
7.
Chest ; 158(6): e267-e268, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32622823

RESUMO

Systemic capillary leak syndrome is a rare disorder characterized by dysfunctional inflammatory response, endothelial dysfunction, and extravasation of fluid from the vascular space to the interstitial space leading to shock, hemoconcentration, hypoalbuminemia, and subsequent organ failure. The condition may be idiopathic or secondary to an underlying cause, which can include viral infections. Here we describe a patient with acute coronavirus disease 2019 (COVID-19) infection who presented with hemoconcentration, shock, and hypoalbuminemia. The patient subsequently developed rhabdomyolysis and compartment syndrome of all four extremities, requiring fasciotomies. This is the first reported case of systemic capillary leak syndrome associated with COVID-19 infection. This case adds to the evolving spectrum of inflammatory effects associated with this viral infection.


Assuntos
COVID-19/fisiopatologia , Síndrome de Vazamento Capilar/fisiopatologia , Síndromes Compartimentais/fisiopatologia , Hipoalbuminemia/fisiopatologia , Choque/fisiopatologia , Dor Abdominal/etiologia , Acidose Láctica/etiologia , Acidose Láctica/fisiopatologia , Acidose Láctica/terapia , Injúria Renal Aguda/etiologia , Injúria Renal Aguda/fisiopatologia , Injúria Renal Aguda/terapia , COVID-19/complicações , COVID-19/terapia , Síndrome de Vazamento Capilar/etiologia , Síndromes Compartimentais/etiologia , Síndromes Compartimentais/cirurgia , Terapia de Substituição Renal Contínua , Soluções Cristaloides/uso terapêutico , Edema/etiologia , Edema/fisiopatologia , Fasciotomia , Evolução Fatal , Hidratação , Hematócrito , Humanos , Hipoalbuminemia/etiologia , Hipoalbuminemia/terapia , Masculino , Pessoa de Meia-Idade , Respiração Artificial , Rabdomiólise/etiologia , Rabdomiólise/fisiopatologia , Choque/etiologia , Choque/terapia , Tomografia Computadorizada por Raios X , Vasoconstritores/uso terapêutico
8.
Hawaii J Health Soc Welf ; 79(6): 194-201, 2020 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-32524098

RESUMO

Engraftment syndrome (ES) has been associated with the surge of neutrophils and cytokines, which is similar to the presumed underlying pathophysiology behind acute graft-versus-host disease (aGVHD). However, there has been no meta-analysis to evaluate the association; therefore, the team attempted to verify an association between ES and aGVHD through meta-analysis. The team searched for titles of articles in MEDLINE (PubMed), the Cochrane Library, and the EMBASE database up until December 2018 that evaluated the association between ES and aGVHD and conducted a random effect meta-analysis of 8 studies involving a total of 1,945 participants to report the pooled odds ratio (OR) for association of ES and aGVHD. The team found a significantly increased odds of developing aGVHD in patients with ES with the pooled OR of 2.76 (95% confidence interval [CI]: 1.64-4.63) and an I2= 64.5%. In conclusion, patients with ES have significantly higher odds of developing aGVHD compared to patients without ES.


Assuntos
Doença Enxerto-Hospedeiro/classificação , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Disfunção Primária do Enxerto/classificação , Síndrome de Vazamento Capilar/classificação , Síndrome de Vazamento Capilar/fisiopatologia , Doença Enxerto-Hospedeiro/fisiopatologia , Transplante de Células-Tronco Hematopoéticas/métodos , Humanos , Disfunção Primária do Enxerto/fisiopatologia
10.
Clin Respir J ; 14(6): 564-570, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32056371

RESUMO

INTRODUCTION: Microalbuminuria (MA) is considered a reflection of systemic capillary leak and an early marker of acute stress reaction to the surgical insult, proportional to the severity of the initiating condition and predictive of the individual response to surgical stress. OBJECTIVES: We conducted a prospective study to assess for the variation of MA within 4 days after thoracic surgery. We correlated observed MA levels with both their respective PaO2 /FiO2 respiratory ratio and the onset of postoperative complications. METHODS: This single-centre study enrolled 255 consecutive patients having an American Society of Anaesthesiologists (ASA) score ≤ 3. The mean age was 62 years with 67% male. All patients were scheduled for elective pulmonary resection. MA was measured in urine samples as the albumin-to-creatinine ratio (A/C), prior to, at and after extubation up to 96 hours. PaO2 /FiO2 was measured at extubation and on the first postoperative day. RESULTS: Overall, preoperative A/C levels resulted normal, with a significant average increase at extubation which peaked 6 hours later (P < 0.001). Larger postoperative A/C increases were observed in patients who developed postoperative complications, compared to those without these complications (P < 0.019). Moreover, patients undergoing major open pulmonary resections had larger postoperative A/C increases, compared to those undergoing minor video-assisted thoracic surgery resections (P < 0.006). At the time of extubation, A/C was inversely related to the PaO2 /FiO2 ratio (r = -0.25; P = 0.038). Peak A/C > 61 mg/g (P = 0.0003) was associated with postoperative cardio-pulmonary complications (OR 3.85; P = 0.003). CONCLUSION: Within 6 hours after extubation, MA assessment may be a rapid and relatively inexpensive method for better predicting perioperative risk in an ASA score ≤ 3 population.


Assuntos
Albuminúria/diagnóstico , Síndrome de Vazamento Capilar/complicações , Complicações Pós-Operatórias/diagnóstico , Procedimentos Cirúrgicos Torácicos/efeitos adversos , Extubação/estatística & dados numéricos , Albuminúria/etiologia , Albuminúria/urina , Síndrome de Vazamento Capilar/fisiopatologia , Creatinina/sangue , Creatinina/urina , Diagnóstico Precoce , Procedimentos Cirúrgicos Eletivos/efeitos adversos , Procedimentos Cirúrgicos Eletivos/métodos , Feminino , Humanos , Pulmão/cirurgia , Masculino , Pessoa de Meia-Idade , Assistência Perioperatória/normas , Assistência Perioperatória/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/metabolismo , Complicações Pós-Operatórias/urina , Valor Preditivo dos Testes , Estudos Prospectivos , Medição de Risco , Cirurgia Torácica Vídeoassistida/métodos , Cirurgia Torácica Vídeoassistida/estatística & dados numéricos , Procedimentos Cirúrgicos Torácicos/estatística & dados numéricos , Procedimentos Cirúrgicos Torácicos/tendências
11.
Commun Biol ; 2: 398, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31701027

RESUMO

The systemic capillary leak syndrome (SCLS, Clarkson disease) is a disorder of unknown etiology characterized by recurrent episodes of vascular leakage of proteins and fluids into peripheral tissues, resulting in whole-body edema and hypotensive shock. The pathologic mechanisms and genetic basis for SCLS remain elusive. Here we identify an inbred mouse strain, SJL, which recapitulates cardinal features of SCLS, including susceptibility to histamine- and infection-triggered vascular leak. We named this trait "Histamine hypersensitivity" (Hhs/Hhs) and mapped it to Chromosome 6. Hhs is syntenic to the genomic locus most strongly associated with SCLS in humans (3p25.3), revealing that the predisposition to develop vascular hyperpermeability has a strong genetic component conserved between humans and mice and providing a naturally occurring animal model for SCLS. Genetic analysis of Hhs may reveal orthologous candidate genes that contribute not only to SCLS, but also to normal and dysregulated mechanisms underlying vascular barrier function more generally.


Assuntos
Síndrome de Vazamento Capilar/genética , Animais , Síndrome de Vazamento Capilar/etiologia , Síndrome de Vazamento Capilar/fisiopatologia , Permeabilidade Capilar/genética , Permeabilidade Capilar/fisiologia , Mapeamento Cromossômico , Modelos Animais de Doenças , Feminino , Predisposição Genética para Doença , Estudo de Associação Genômica Ampla , Histamina/fisiologia , Humanos , Vírus da Influenza A Subtipo H3N2 , Masculino , Camundongos , Camundongos Congênicos , Camundongos Endogâmicos , Infecções por Orthomyxoviridae/complicações , Pele/irrigação sanguínea , Especificidade da Espécie , Sintenia
13.
BMC Infect Dis ; 19(1): 260, 2019 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-30876401

RESUMO

BACKGROUND: We report hereby a severe case of Hantavirus Pulmonary Syndrome" (HPS) induced by Maripa virus in French Guiana and describe the mechanism of severity of the human disease. CASE PRESENTATION: A 47-year- old patient started presenting a prodromic period with fever, dyspnea, cough and head ache. This clinical presentation was followed by a rapid respiratory, hemodynamic and renal failure leading to admission in the ICU. Biological exams revealed an increased haematocrit level with a paradoxical low protein level. Echocardiographic and hemodynamic monitoring showed a normal left ventricular function with low filling pressures, an elevated extravascular lung water index and pulmonary vascular permeability index. These findings were compatible with a capillary leak-syndrome (CLS). CONCLUSIONS: The severity of HPS caused by the virus Maripa in French Guiana can be explained by the tropism of hantavirus for the microvascular endothelial cell leading to a CLS.


Assuntos
Síndrome de Vazamento Capilar/etiologia , Síndrome de Vazamento Capilar/fisiopatologia , Síndrome Pulmonar por Hantavirus/complicações , Síndrome Pulmonar por Hantavirus/fisiopatologia , Orthohantavírus/patogenicidade , Síndrome de Vazamento Capilar/diagnóstico , Guiana Francesa , Orthohantavírus/isolamento & purificação , Síndrome Pulmonar por Hantavirus/diagnóstico , Humanos , Pessoa de Meia-Idade
14.
Obstet Gynecol ; 132(1): 179-184, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29889749

RESUMO

OBJECTIVE: To identify clinical variables associated with increased risk of composite adverse outcome in a cohort of women with puerperal group A streptococci infection. METHODS: Our prospective case registry enrolled patients between 1991 and 2017. Chart abstraction was conducted for admission demographic and clinical data in patients with culture-proven puerperal group A streptococci infection. We created a composite variable of signs of capillary leakage including pulmonary edema, pleural effusion, ascites, and abdominal distention. The composite adverse outcome included death, hysterectomy, intensive care unit admission, mechanical ventilation, and blood transfusion. Clinical characteristics were compared between those with a composite adverse outcome and those without. We fit unadjusted log-linear models with robust error variance to measure the relative risk of a composite adverse outcome associated with clinical and demographic variables among patients with group A streptococci. RESULTS: Thirty-five of 71 (49%) patients had an adverse outcome. Women who had adverse outcomes had higher admission heart rates (126±19 vs 112±22 beats per minute, P=.008) and respiratory rates (26±10 vs 20±5 breaths per minute, P=.01), lower systolic blood pressure (98±24 vs 114±19 mm Hg, P=.004), and were more likely to have signs of capillary leakage (77% vs 20%, P<.001) and symptoms of capillary leakage (dyspnea, cough, shoulder pain, abdominal bloating, and chest pain) (40% vs 17%, P=.03) compared with those without adverse outcomes. Log-linear models indicated that these clinical variables were individually associated with increased risk of a composite adverse outcome. The relative risk of an adverse outcome was 3.5 times higher among women with signs of capillary leakage (relative risk 3.67, 95% CI 1.94-6.94, P<.001). CONCLUSION: Vital sign parameters consistent with severe infection correlate with adverse outcomes in women with puerperal group A streptococci infection. Signs of capillary leakage are most strongly associated with a composite adverse outcome. These clinical characteristics, particularly signs of capillary leakage, are potentially useful to guide clinical care.


Assuntos
Síndrome de Vazamento Capilar/fisiopatologia , Infecção Puerperal/fisiopatologia , Infecções Estreptocócicas/fisiopatologia , Streptococcus pyogenes , Adulto , Pressão Sanguínea , Síndrome de Vazamento Capilar/microbiologia , Feminino , Frequência Cardíaca , Humanos , Modelos Lineares , Gravidez , Estudos Prospectivos , Infecção Puerperal/microbiologia , Sistema de Registros , Taxa Respiratória , Infecções Estreptocócicas/microbiologia , Utah
15.
An. bras. dermatol ; 92(6): 826-829, Nov.-Dec. 2017. tab
Artigo em Inglês | LILACS | ID: biblio-887130

RESUMO

Abstract: Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.


Assuntos
Humanos , Psoríase/complicações , Psoríase/patologia , Molécula 1 de Adesão Intercelular/análise , Síndrome de Vazamento Capilar/etiologia , Síndrome de Vazamento Capilar/patologia , Fator A de Crescimento do Endotélio Vascular/análise , Psoríase/fisiopatologia , Citocinas/análise , Síndrome de Vazamento Capilar/fisiopatologia
16.
Crit Care Med ; 45(7): 1216-1223, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28622216

RESUMO

OBJECTIVE: Systemic capillary-leak syndrome is a very rare cause of recurrent hypovolemic shock. Few data are available on its clinical manifestations, laboratory findings, and outcomes of those patients requiring ICU admission. This study was undertaken to describe the clinical pictures and ICU management of severe systemic capillary-leak syndrome episodes. DESIGN, SETTING, PATIENTS: This multicenter retrospective analysis concerned patients entered in the European Clarkson's disease (EurêClark) Registry and admitted to ICUs between May 1992 and February 2016. MEASUREMENTS AND MAIN RESULTS: Fifty-nine attacks occurring in 37 patients (male-to-female sex ratio, 1.05; mean ± SD age, 51 ± 11.4 yr) were included. Among 34 patients (91.9%) with monoclonal immunoglobulin G gammopathy, 20 (58.8%) had kappa light chains. ICU-admission hemoglobin and proteinemia were respectively median (interquartile range) 20.2 g/dL (17.9-22 g/dL) and 50 g/L (36.5-58.5 g/L). IV immunoglobulins were infused (IV immunoglobulin) during 15 episodes (25.4%). A compartment syndrome developed during 12 episodes (20.3%). Eleven (18.6%) in-ICU deaths occurred. Bivariable analyses (the 37 patients' last episodes) retained Sequential Organ-Failure Assessment score greater than 10 (odds ratio, 12.9 [95% CI, 1.2-140]; p = 0.04) and cumulated fluid-therapy volume greater than 10.7 L (odds ratio, 16.8 [1.6-180]; p = 0.02) as independent predictors of hospital mortality. CONCLUSIONS: We described the largest cohort of severe systemic capillary-leak syndrome flares requiring ICU admission. High-volume fluid therapy was independently associated with poorer outcomes. IV immunoglobulin use was not associated with improved survival; hence, their use should be considered prudently and needs further evaluation in future studies.


Assuntos
Síndrome de Vazamento Capilar/mortalidade , Síndrome de Vazamento Capilar/terapia , Imunoglobulinas Intravenosas/uso terapêutico , Unidades de Terapia Intensiva , APACHE , Adulto , Síndrome de Vazamento Capilar/tratamento farmacológico , Síndrome de Vazamento Capilar/fisiopatologia , Feminino , Hidratação/métodos , Humanos , Imunoglobulinas Intravenosas/administração & dosagem , Masculino , Pessoa de Meia-Idade , Escores de Disfunção Orgânica , Respiração Artificial/métodos , Estudos Retrospectivos
17.
Kidney Int ; 92(1): 37-46, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-28318633

RESUMO

In various human diseases, an increase in capillary permeability to proteins leads to the loss of protein-rich fluid from the intravascular to the interstitial space. Although sepsis is the disease most commonly associated with this phenomenon, many other diseases can lead to a "sepsis-like" syndrome with manifestations of diffuse pitting edema, exudative serous cavity effusions, noncardiogenic pulmonary edema, hypotension, and, in some cases, hypovolemic shock with multiple-organ failure. The term capillary leak syndrome has been used to describe this constellation of disease manifestations associated with an increased capillary permeability to proteins. Diseases other than sepsis that can result in capillary leak syndrome include the idiopathic systemic capillary leak syndrome or Clarkson's disease, engraftment syndrome, differentiation syndrome, the ovarian hyperstimulation syndrome, hemophagocytic lymphohistiocytosis, viral hemorrhagic fevers, autoimmune diseases, snakebite envenomation, and ricin poisoning. Drugs including some interleukins, some monoclonal antibodies, and gemcitabine can also cause capillary leak syndrome. Acute kidney injury is commonly seen in all of these diseases. In addition to hypotension, cytokines are likely to be important in the pathophysiology of acute kidney injury in capillary leak syndrome. Fluid management is a critical part of the treatment of capillary leak syndrome; hypovolemia and hypotension can cause organ injury, whereas capillary leakage of administered fluid can worsen organ edema leading to progressive organ injury. The purpose of this article is to discuss the diseases other than sepsis that produce capillary leak and review their collective pathophysiology and treatment.


Assuntos
Capilares/fisiopatologia , Síndrome de Vazamento Capilar/terapia , Permeabilidade Capilar , Hidratação , Substitutos do Plasma/uso terapêutico , Inibidores de Simportadores de Cloreto de Sódio e Potássio/uso terapêutico , Injúria Renal Aguda/epidemiologia , Injúria Renal Aguda/fisiopatologia , Injúria Renal Aguda/terapia , Animais , Síndrome de Vazamento Capilar/diagnóstico , Síndrome de Vazamento Capilar/epidemiologia , Síndrome de Vazamento Capilar/fisiopatologia , Diagnóstico Diferencial , Hidratação/efeitos adversos , Hemodinâmica , Humanos , Substitutos do Plasma/efeitos adversos , Derrame Pleural/epidemiologia , Derrame Pleural/fisiopatologia , Derrame Pleural/terapia , Valor Preditivo dos Testes , Fatores de Risco , Sepse/complicações , Inibidores de Simportadores de Cloreto de Sódio e Potássio/efeitos adversos , Resultado do Tratamento
18.
An Bras Dermatol ; 92(6): 826-829, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29364440

RESUMO

Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.


Assuntos
Síndrome de Vazamento Capilar/etiologia , Síndrome de Vazamento Capilar/patologia , Molécula 1 de Adesão Intercelular/análise , Psoríase/complicações , Psoríase/patologia , Fator A de Crescimento do Endotélio Vascular/análise , Síndrome de Vazamento Capilar/fisiopatologia , Citocinas/análise , Humanos , Psoríase/fisiopatologia
19.
J Allergy Clin Immunol ; 140(3): 663-670, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28012935

RESUMO

In 1960, Dr Bayard Clarkson described a woman experiencing sporadic recurrent episodes of shock and anasarca. Plasma from an acute attack induced a shock-like syndrome when injected into rats. The enigmatic systemic capillary leak syndrome (SCLS) named for Dr Clarkson is characterized by transient and severe but reversible hemoconcentration and hypoalbuminemia caused by leakage of fluids and macromolecules into tissues. Although less than 500 cases of SCLS have been reported in the literature since 1960, the condition is probably underdiagnosed because of a lack of awareness and a high mortality without treatment. Allergists should be vigilant of this diagnosis because its presentation can resemble more common plasma leakage syndromes, including angioedema or systemic anaphylaxis. Although the precise molecular cause of SCLS remains unknown, substantial advances over the last 5 years have increased our understanding of SCLS pathogenesis.


Assuntos
Síndrome de Vazamento Capilar , Animais , Síndrome de Vazamento Capilar/diagnóstico , Síndrome de Vazamento Capilar/epidemiologia , Síndrome de Vazamento Capilar/fisiopatologia , Síndrome de Vazamento Capilar/terapia , Humanos , Incidência , Prognóstico
20.
J Cereb Blood Flow Metab ; 37(6): 2049-2061, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27435624

RESUMO

Insult-associated blood-brain barrier leakage is strongly suggested to be a key step during epileptogenesis. In this study, we used three non-invasive translational imaging modalities, i.e. positron emission tomography, single photon emission computed tomography, and magnetic resonance imaging, to evaluate BBB leakage after an epileptogenic brain insult. Sprague-Dawley rats were scanned during early epileptogenesis initiated by status epilepticus. Positron emission tomography and single photon emission computed tomography scans were performed using the novel tracer [68Ga]DTPA or [99mTc]DTPA, respectively. Magnetic resonance imaging included T2 and post-contrast T1 sequence after infusion of Gd-DTPA, gadobutrol, or Gd-albumin. All modalities revealed increased blood-brain barrier permeability 48 h post status epilepticus, mainly in epileptogenesis-associated brain regions like hippocampus, piriform cortex, thalamus, or amygdala. In hippocampus, Gd-DTPA-enhanced T1 magnetic resonance imaging signal was increased by 199%, [68Ga]DTPA positron emission tomography by 37%, and [99mTc]DTPA single photon emission computed tomography by 56%. Imaging results were substantiated by histological detection of albumin extravasation. Comparison with quantitative positron emission tomography and single photon emission computed tomography shows that magnetic resonance imaging sequences successfully amplify the signal from a moderate amount of extravasated DTPA molecules, enabling sensitive detection of blood-brain barrier disturbance in epileptogenesis. Imaging of the disturbed blood-brain barrier will give further pathophysiologic insights, will help to stratify anti-epileptogenic treatment targeting blood-brain barrier integrity, and may serve as a prognostic biomarker.


Assuntos
Barreira Hematoencefálica/diagnóstico por imagem , Síndrome de Vazamento Capilar/diagnóstico por imagem , Permeabilidade Capilar/fisiologia , Epilepsia/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Tomografia por Emissão de Pósitrons/métodos , Animais , Barreira Hematoencefálica/fisiopatologia , Síndrome de Vazamento Capilar/etiologia , Síndrome de Vazamento Capilar/fisiopatologia , Epilepsia/complicações , Epilepsia/fisiopatologia , Feminino , Ratos Sprague-Dawley , Sensibilidade e Especificidade , Tomografia Computadorizada de Emissão de Fóton Único/métodos
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