RESUMO
I have spent my entire professional life at Harvard Medical School, beginning as a medical student. I have enjoyed each day of a diverse career in four medical subspecialties while following the same triad of preclinical areas of investigation-cysteinyl leukotrienes, mast cells, and complement-with occasional translational opportunities. I did not envision a career with a predominant preclinical component. Such a path simply evolved because I chose instinctively at multiple junctures to follow what proved to be propitious opportunities. My commentary notes some of the highlights for each area of interest and the mentors, collaborators, and trainees whose counsel has been immensely important at particular intervals or over an extended period.
Assuntos
Alergia e Imunologia/história , Receptores de Leucotrienos/fisiologia , SRS-A/fisiologia , Androstanóis/uso terapêutico , Angioedemas Hereditários/sangue , Angioedemas Hereditários/tratamento farmacológico , Broncoconstrição/efeitos dos fármacos , Antígenos CD55/metabolismo , Ativação do Complemento/fisiologia , Via Alternativa do Complemento/fisiologia , Cromolina Sódica/uso terapêutico , Hemoglobinúria Paroxística/metabolismo , História do Século XX , História do Século XXI , Mastócitos/citologia , Mastócitos/fisiologia , Prostaglandina D2/análogos & derivados , Prostaglandina D2/urina , Receptores de Leucotrienos/história , SRS-A/história , SRS-A/farmacologia , Células-Tronco/citologia , Células-Tronco/fisiologia , Estados UnidosRESUMO
The hypothesis of 35 years ago that slowreacting substance of anaphylaxis would prove to be a pathobiologic mediator of reversible airway disease in the human has been validated. The multidisciplinary approach required to achieve this goal has been particularly prominent and consistent for the entire period in the program described in this presentation.
