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1.
Appl Radiat Isot ; 166: 109324, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32861973

RESUMO

Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare, malignant tumor arising in lower extremities with no effective treatment other than wide surgical resection. Here described is a case of primary CCS in the peroneal tendon of the right foot of a 54-year-old woman enrolled to undergo BNCT. The tumor mass post-BNCT disappeared totally without damage to other normal tissue, demonstrating, for the first time, the potential efficacy of BNCT in complete local control of CCS.


Assuntos
Terapia por Captura de Nêutron de Boro/métodos , Doenças do Pé/radioterapia , Sarcoma de Células Claras/radioterapia , Tendões , Biópsia por Agulha , Feminino , Doenças do Pé/diagnóstico por imagem , Doenças do Pé/patologia , Humanos , Neoplasias Pulmonares/secundário , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Planejamento da Radioterapia Assistida por Computador , Sarcoma de Células Claras/diagnóstico por imagem , Sarcoma de Células Claras/secundário , Tendões/diagnóstico por imagem , Tendões/patologia , Resultado do Tratamento
3.
Exp Clin Transplant ; 18(4): 533-535, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32552629

RESUMO

Cancer therapy-related cardiotoxicity has been presenting a major problem in cancer survivors, who constitute a growing population caused by a significant improvement in cancer therapy during the past decades. Although some listing criteria have been defined for these patients, it is still a compelling decision to list patients with a complex cancer anamnesis. We describe herein a childhood cancer survivor after a cancer anamnesis with 2 different malignancies and an end-stage heart failure following chemoradiotherapy who was successfully treated with orthotopic heart transplant.


Assuntos
Sobreviventes de Câncer , Cardiomiopatias/cirurgia , Quimiorradioterapia/efeitos adversos , Transplante de Coração , Neoplasias Renais/terapia , Lesões por Radiação/cirurgia , Sarcoma de Células Claras/terapia , Adulto , Cardiomiopatias/induzido quimicamente , Cardiomiopatias/diagnóstico , Cardiomiopatias/fisiopatologia , Cardiotoxicidade , Feminino , Humanos , Neoplasias Renais/patologia , Lesões por Radiação/diagnóstico , Lesões por Radiação/etiologia , Lesões por Radiação/fisiopatologia , Sarcoma de Células Claras/secundário , Resultado do Tratamento
5.
Am J Clin Oncol ; 41(12): 1162-1167, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-29782363

RESUMO

INTRODUCTION: The evaluation of lymph nodes and the role of groin dissection for groin sarcomas has been controversial where there have not been previous studies or guidelines published. In this study, we aim to first formulate a clinical approach in the evaluation of regional lymph nodal metastases. Second, we aim to also evaluate the role of regional lymphadenectomy in the setting of pathologically involved regional lymph nodes for groin sarcomas. MATERIALS AND METHODS: In total, 43 consecutive patients with groin sarcomas underwent treatment at the National Cancer Centre Singapore between 2002 and 2015. Univariate comparisons were performed using the log-rank test. A Cox multivariate analysis was performed for disease-specific survival to identify independent prognostic factors. RESULTS: The median disease-free survival was 18 months (range, 1 to 180 mo). The median overall survival (OS) was 28 months (range, 3 to 180 mo). In total, 28 patients underwent a groin dissection. Of the 28 patients who underwent groin dissections, 15 had negative lymph node involvement, 7 had positive lymph node involvement and 6 had lymphovascular invasion.On univariate analysis, grade (P=0.047) and clinical and/or radiological involvement (P=0.039) were significant for regional lymph nodal metastases.The 5-year OS for patients with positive lymph nodes was 31%. CONCLUSIONS: Our study suggests that the evaluation of lymph nodes via groin dissections in groin sarcomas in the Asian population should be based primarily on clinical and radiologic evidence. Regional lymph node dissection seems to confer OS benefit in patients with these high-risk tumors and can improve local control of disease.


Assuntos
Neoplasias Ósseas/secundário , Condrossarcoma/patologia , Virilha/patologia , Sarcoma de Células Claras/secundário , Neoplasias Cutâneas/secundário , Adulto , Neoplasias Ósseas/cirurgia , Condrossarcoma/cirurgia , Feminino , Seguimentos , Virilha/cirurgia , Humanos , Excisão de Linfonodo , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Estudos Retrospectivos , Sarcoma de Células Claras/cirurgia , Biópsia de Linfonodo Sentinela , Neoplasias Cutâneas/cirurgia , Taxa de Sobrevida
6.
Fetal Pediatr Pathol ; 37(2): 126-133, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29509095

RESUMO

INTRODUCTION: Clear cell sarcoma of the kidney (CCSK) is childhood neoplasm with its own distinctive pattern of metastasis and may appear after a disease free interval of 5 years or more. MATERIALS AND METHODS: Histopathology and immunohistochemistry were available from the radical nephrectomy and the later partial cystectomy, which was performed after a seven disease-free interval. RESULTS: The pathologic features of the primary tumor were those of a classic CCSK with a monotypic pattern of uniform rounded to ovoid tumor cells with a background network of delicate blood vessels. By contrast, the bladder recurrence had a myxoid hypocellular appearance (one of the known variant patterns of CCSK). Both tumors displayed immunopositivity for Cyclin-D1 and CD117 with a less intense reaction in the bladder metastasis. CONCLUSIONS: This case demonstrates that CCSK has the potential to metastasize after a prolonged disease-free interval and may have deceptively bland histopathologic features.


Assuntos
Neoplasias Renais/patologia , Sarcoma de Células Claras/secundário , Neoplasias da Bexiga Urinária/secundário , Criança , Pré-Escolar , Humanos , Masculino
7.
Urology ; 106: 193-195, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28438624

RESUMO

Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal malignancy after Wilms tumor. CCSK has the potential to metastasize to distant sites and was historically known as the bone metastasizing renal tumor. We report an exceedingly rare case of a bladder recurrence of CCSK. Our patient presented with gross hematuria 7 years after initial complete response. He was found to have a large sessile bladder tumor and underwent a partial cystectomy with right pelvic lymph node dissection. Final pathology was metastatic CCSK.


Assuntos
Neoplasias Renais/patologia , Sarcoma de Células Claras/secundário , Neoplasias da Bexiga Urinária/secundário , Bexiga Urinária/diagnóstico por imagem , Pré-Escolar , Cistectomia , Humanos , Masculino , Recidiva Local de Neoplasia , Sarcoma de Células Claras/diagnóstico , Sarcoma de Células Claras/cirurgia , Tomografia Computadorizada por Raios X , Bexiga Urinária/cirurgia , Neoplasias da Bexiga Urinária/diagnóstico , Neoplasias da Bexiga Urinária/cirurgia
8.
Clin Neuropathol ; 36 (2017)(1): 41-45, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27719746

RESUMO

Clear cell sarcoma (CCS) of the gastrointestinal tract presents a diagnostic challenge to the pathologist due to its morphological and immunohistochemical similarity to melanoma. It usually metastasizes to regional lymph nodes, liver, and lungs. Herein, we report the first known metastasis of a gastrointestinal CCS to the central nervous system. Cytogenetic testing showed the t(12,22) translocation corresponding to the presence of the EWS/ATF1 hybrid consistent with CCS. The literature that compares melanoma to CCS is reviewed in the context of this rare presentation to differentiate between the two diseases.
.


Assuntos
Neoplasias Encefálicas/secundário , Neoplasias do Colo/patologia , Sarcoma de Células Claras/secundário , Idoso , Biomarcadores Tumorais/análise , Evolução Fatal , Humanos , Imuno-Histoquímica , Masculino
9.
World Neurosurg ; 90: 699.e7-699.e10, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26862022

RESUMO

BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) is a rare epithelial malignant neoplasm typically arising from the minor salivary glands. Although it has been described as a benign neoplasm, there are increasing reports of malignant features and metastases to the lungs; we present the first case of biopsy-proven spinal metastases from HCCC and an overview of the literature. CASE DESCRIPTION: This is a single-patient case report in which we used immunohistochemistry and fluorescence in situ hybridization for Ewing sarcoma breakpoint region 1 translocation to confirm the diagnosis of HCCC in a spinal metastasis. The diagnosis of metastatic HCCC was confirmed on the basis of histopathology, immunohistochemistry, and fluorescence in situ hybridization studies. CONCLUSIONS: We present the first pathologically confirmed case of a spinal metastasis in HCCC. As increasing of metastatic HCCC arise, a reconsideration of HCCC as a potentially high-grade disease seems increasingly necessary as it may impact the current treatment paradigm.


Assuntos
Neoplasias das Glândulas Salivares/patologia , Sarcoma de Células Claras/patologia , Sarcoma de Células Claras/secundário , Neoplasias da Coluna Vertebral/patologia , Neoplasias da Coluna Vertebral/secundário , Idoso , Diagnóstico Diferencial , Feminino , Testes Genéticos , Humanos , Neoplasias das Glândulas Salivares/genética , Sarcoma de Células Claras/genética , Neoplasias da Coluna Vertebral/genética
10.
J Dermatol ; 42(6): 621-4, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25809881

RESUMO

We report a case of clear cell sarcoma (CCS) in the left buttock in which serum neuron-specific enolase (NSE) was useful as a biomarker of CCS progression. A 40-year-old man had a subcutaneous tumor, 1.7 cm in diameter, in the left buttock. Histopathology revealed that the tumor consisted of nests of polygonal or spindle-shaped cells with abundant clear cytoplasm delineated by fibrous septa in the subcutaneous tissue. There was cellular atypia but no melanin deposits. Immunohistochemically, the tumor cells were positive for HMB-45, Melan-A, S-100 protein and NSE. Reverse transcription polymerase chain reaction demonstrated Ewing's sarcoma oncogene-activating transcription factor 1 fusion transcripts in the tumor cells. CCS was diagnosed. There was no metastasis to the lymph nodes and viscera, and the patient was treated by surgical wide resection. The serum NSE levels increased before detection of distant metastasis and further increased in parallel with the expansion of metastasis. The present case suggests that serum NSE could be used as a biochemical marker in the clinical follow up of patients with CCS.


Assuntos
Biomarcadores Tumorais/sangue , Fosfopiruvato Hidratase/sangue , Sarcoma de Células Claras/sangue , Neoplasias de Tecidos Moles/sangue , Adulto , Nádegas , Progressão da Doença , Evolução Fatal , Humanos , Masculino , Sarcoma de Células Claras/secundário , Neoplasias de Tecidos Moles/patologia
11.
Int J Surg Pathol ; 23(1): 61-7, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25145707

RESUMO

Clear cell sarcoma is a rare tumor classically associated with tendons and aponeuroses of lower extremities of young adults and has a distinctive histopathologic and molecular profile. It has been rarely described in other locations other than soft tissues, including the gastrointestinal tract. Herein we report a case of clear cell sarcoma of gastrointestinal tract arising in the ileum, which is rich in osteoclast-like giant cells with a review of the literature.


Assuntos
Íleo/patologia , Neoplasias Intestinais/patologia , Jejuno/patologia , Neoplasias Hepáticas/secundário , Sarcoma de Células Claras/secundário , Adulto , Biomarcadores Tumorais/metabolismo , Feminino , Células Gigantes/metabolismo , Células Gigantes/patologia , Humanos , Íleo/metabolismo , Íleo/cirurgia , Neoplasias Intestinais/metabolismo , Neoplasias Intestinais/cirurgia , Jejuno/metabolismo , Jejuno/cirurgia , Neoplasias Hepáticas/metabolismo , Neoplasias Hepáticas/cirurgia , Sarcoma de Células Claras/metabolismo , Sarcoma de Células Claras/cirurgia
13.
Pediatr Blood Cancer ; 61(12): 2185-90, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25175045

RESUMO

BACKGROUND: Clear cell sarcoma of the kidney (CCSK) is a rare and aggressive tumor accounting for 5% of pediatric renal tumors with an incidence of 20 patients per year in the USA. It is bone metastasizing with poor prognosis. Our aim was to show characteristics of patients in relation to improved outcome in one of the developing countries. PROCEDURE: We included all patients diagnosed as CCSK in the period between July 2007 and March 2012 at Children's Cancer Hospital, Egypt. Patients' demographics, clinical presentation, pathology, and management were reviewed. Follow up was continued until April 2013. RESULTS: Twenty-five patients were identified in the defined time interval, accounting for 7% all renal tumors diagnosed at the hospital. Mean age was 36 months. Abdominal swelling and hematuria were the most common presentations. Stages I, II, III, IV, and V represented 9 (36%), 3 (12%), 8 (32%), 3 (12%), and 2 (8%), respectively. Twenty-four patients had radical nephrectomy either upfront or after neo-adjuvant chemotherapy. Surgery was followed by adjuvant chemotherapy. Abdominal radiotherapy was given for local stages II and III. Twenty-two patients reached complete remission, while one patient had stationary disease and two patients died due to progression and relapse. Overall survival was 88.5% and event-free survival was 87.8% at 45 months. CONCLUSION: Although previous studies indicate poor prognosis of CCSK, our experience shows that those patients can be treated using extensive chemotherapy combined with proper local control.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Ósseas/terapia , Neoplasias Renais/terapia , Neoplasias Hepáticas/terapia , Neoplasias Pulmonares/terapia , Sarcoma de Células Claras/terapia , Adolescente , Neoplasias Ósseas/mortalidade , Neoplasias Ósseas/secundário , Quimioterapia Adjuvante , Criança , Pré-Escolar , Terapia Combinada , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Neoplasias Renais/mortalidade , Neoplasias Renais/patologia , Neoplasias Hepáticas/mortalidade , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/secundário , Masculino , Terapia Neoadjuvante , Estadiamento de Neoplasias , Nefrectomia , Prognóstico , Radioterapia Adjuvante , Sarcoma de Células Claras/mortalidade , Sarcoma de Células Claras/secundário , Taxa de Sobrevida
14.
J Pediatr Hematol Oncol ; 36(6): 445-50, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25050908

RESUMO

BACKGROUND: Renal tumors are one of the most common tumors in children. We aim at evaluating the characteristics and the outcome of Wilms tumor and other malignant kidney tumors in Hong Kong. PROCEDURE: Between January 1990 to December 2010, 68 patients under the age of 18 with malignant renal tumors were diagnosed and received treatment in Hong Kong. Clinical records were updated regularly. Prognostic factors and survival rate were evaluated. RESULTS: Fifty-four patients were diagnosed with Wilms tumor. The annual incidence was estimated to be 2.29 per million. The mean age was 38 months. Median follow-up was 9.2 years. The event-free survival and overall survival rate at 10 years were 85.2% and 92.6%, respectively. A pair of siblings with familial extrarenal Wilms tumor was included. Pulmonary metastasis did exhibit a significant difference in survival rate. Eight cases of clear cell sarcoma of the kidneys were reported and the survival rate was 100%. CONCLUSIONS: The clinical characteristics and outcome of the patients diagnosed Wilms tumor were comparable with other developed countries. Relatively high proportion and excellent outcome were found in clear cell sarcoma of the kidneys.


Assuntos
Neoplasias Renais/mortalidade , Neoplasias Pulmonares/mortalidade , Sarcoma de Células Claras/mortalidade , Tumor de Wilms/mortalidade , Adolescente , Criança , Pré-Escolar , Intervalo Livre de Doença , Feminino , Seguimentos , Hong Kong/epidemiologia , Humanos , Incidência , Lactente , Neoplasias Renais/patologia , Neoplasias Renais/terapia , Neoplasias Pulmonares/secundário , Neoplasias Pulmonares/terapia , Masculino , Recidiva Local de Neoplasia/mortalidade , Prognóstico , Estudos Prospectivos , Sarcoma de Células Claras/secundário , Sarcoma de Células Claras/terapia , Taxa de Sobrevida , Tumor de Wilms/patologia , Tumor de Wilms/terapia
15.
Eur J Surg Oncol ; 40(5): 505-510, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24560887

RESUMO

INTRODUCTION: Clear cell sarcoma (CCS) of soft tissue is a rare melanocytic soft tissue sarcoma with different cytogenetic and natural history than that of melanoma. Objective of this study was to determine outcome predictors in patients treated in our Institute. This objective included the effectiveness of surgical intervention and disease progression after surgery. MATERIALS AND METHODS: Thirty-one patients were diagnosed at our institute with clear cell sarcoma through tissue pathology and immunohistochemistry. Patients received multimodality treatment (surgery, radiotherapy and chemotherapy). Five-year survival rates and prognostic predictors were determined. RESULTS: Sixteen patients were males and 15 females with a median age of 37 years (8-72-years). Twenty-eight tumors were located in extremities and 3 in the trunk area. Eight patients had metastases at their first presentation (6 local lymph nodes and 2 pulmonary metastases). Five and ten-year disease-specific survival rates were 56% and 41%. Two-year disease-specific survival rates for lymph node and pulmonary metastasis groups were 40% and 0%. All metastatic patients died within 5 years follow-up. Five and ten-year disease-specific survival rates for localized tumor cases were 72% and 53%. Male gender, less than 30-years of age, trunk tumor location and size greater than 5 cm were poor prognostic factors according to univariate analysis. Tumor location in the trunk was the only negative prognostic determinant in multivariate model. CONCLUSIONS: Although surgical treatment may be beneficial for tumors without systemic involvement, new chemotherapeutic agents and molecular targeted therapy should be implemented to improve the oncologic outcome in both early and late stage disease.


Assuntos
Antineoplásicos/uso terapêutico , Recidiva Local de Neoplasia , Radioterapia , Sarcoma de Células Claras/terapia , Neoplasias de Tecidos Moles/terapia , Adolescente , Adulto , Fatores Etários , Idoso , Criança , Terapia Combinada , Progressão da Doença , Feminino , Humanos , Neoplasias Pulmonares/secundário , Linfonodos/patologia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Sarcoma de Células Claras/mortalidade , Sarcoma de Células Claras/secundário , Fatores Sexuais , Neoplasias de Tecidos Moles/mortalidade , Neoplasias de Tecidos Moles/patologia , Resultado do Tratamento , Adulto Jovem
17.
Pathol Res Pract ; 209(12): 803-7, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23953591

RESUMO

Clear cell sarcoma is a unique tumor which has EWSR1-ATF1 or EWSR1-CREB1 fusion. Several patterns of EWSR1-ATF1 fusion are observed in clear cell sarcoma. Since type 5-7 fusions were reported recently, they are classified as type 1-7. We examined EWSR1-ATF1 and EWSR1-CREB1 fusions in a single case of clear cell sarcoma with lung metastasis in a 36-year-old Japanese man. As a result, we found only type 1 EWSR1-ATF1 fusion in the primary site, but 4 types of EWS-ATF1 fusion (type 1, 2, 5, 6) were detected in the metastatic site. These 4 types of fusion were completely identical to the recent report, but the case had the same fusion patterns in both primary and metastatic sites. In our case, increased splicing activity in the EWSR1-ATF1 fusion might be acquired at the metastatic site. There is another possibility that metastasis might develop through the increased splicing activity in the fusion.


Assuntos
Neoplasias Pulmonares/secundário , Proteínas de Fusão Oncogênica/metabolismo , Sarcoma de Células Claras/secundário , Neoplasias de Tecidos Moles/patologia , Coxa da Perna/patologia , Adulto , Humanos , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/metabolismo , Masculino , Proteínas de Fusão Oncogênica/genética , Sarcoma de Células Claras/genética , Sarcoma de Células Claras/metabolismo , Neoplasias de Tecidos Moles/genética , Neoplasias de Tecidos Moles/metabolismo
18.
Int J Obstet Anesth ; 22(3): 247-50, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23809016

RESUMO

Spinal metastases occur in up to 70% of all patients with cancer. However, only 10% are symptomatic. Before considering central neuraxial blockade in patients with malignancy, a history of back pain should be excluded. Anaesthetists should be aware that intrathecal and epidural injections could cause paraplegia if metastases are impinging on the spinal cord. Failure to achieve adequate sensory anaesthesia after central neuraxial blockade or presentation with postoperative paraplegia may indicate the presence of asymptomatic vertebral canal metastases. In this report, the anaesthetic management of a patient with respiratory failure and spinal metastases from a soft tissue sarcoma, requiring caesarean section is described. Sensory anaesthesia extending above a level of imminent cord compression was achieved despite loss of cerebrospinal fluid signal on magnetic resonance imaging.


Assuntos
Anestesia Obstétrica/métodos , Raquianestesia/métodos , Cesárea/métodos , Insuficiência Respiratória/complicações , Sarcoma de Células Claras/secundário , Neoplasias da Coluna Vertebral/secundário , Adulto , Índice de Apgar , Neoplasias Ósseas/patologia , Feminino , Humanos , Recém-Nascido , Imageamento por Ressonância Magnética , Cuidados Paliativos , Gravidez , Sarcoma de Células Claras/complicações , Sarcoma de Células Claras/patologia , Neoplasias da Coluna Vertebral/complicações , Neoplasias da Coluna Vertebral/patologia
19.
Ann Oncol ; 24(5): 1400-5, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23372051

RESUMO

BACKGROUND: The role of sentinel lymph node biopsy (SLNB) in soft tissue sarcoma patients has yet to be determined. We sought to evaluate the role of SLNB in the treatment of patients with clear cell sarcoma (CCS), synovial sarcoma (SS), epithelioid sarcoma (ES) and rhabdomyosarcoma (RMS). PATIENTS AND METHODS: Sixty-two consecutive patients without history of regional lymphatic spread or evidence of distant metastases underwent SLNB. RESULTS: Positive sentinel nodes were identified in 2 out of 42 patients with SS and in 6 out of 12 patients with CCS. Only two CCS patients had further metastatic nodes in regional dissection. Both of these patients, along with another CCS patient, developed distant metastases and ultimately died of disease. The remaining three CCS patients are disease-free in follow-up. One patient with SS and another with ES developed regional lymph node metastases following a negative SLNB, while a further patient with RMS developed distant metastases followed by a local recurrence with regional metastases shortly after. CONCLUSIONS: SLNB is an important diagnostic tool for patients with CCS, who appear to have a high rate of clinically occult regional lymph node metastases at diagnosis. For SS patients, SLNB appears to be of very little relevance.


Assuntos
Metástase Linfática/diagnóstico , Rabdomiossarcoma/secundário , Sarcoma de Células Claras/secundário , Sarcoma Sinovial/secundário , Biópsia de Linfonodo Sentinela , Neoplasias de Tecidos Moles/mortalidade , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Rabdomiossarcoma/mortalidade , Sarcoma de Células Claras/mortalidade , Sarcoma Sinovial/mortalidade , Adulto Jovem
20.
Int Ophthalmol ; 33(2): 163-5, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23053771

RESUMO

To present a case of choroidal metastasis of clear cell sarcoma of the tendons and aponeuroses. Observational case report. A 63-year-old woman with multiple systemic metastasis secondary to clear cell sarcoma of the tendons and aponeuroses in her right knee presented with a 3 days history of blurred vision in her left eye. At the time of presentation, her visual acuity was 20/125 in her left eye. Fundus examination of the left eye showed three amelanotic choroidal lesions associated with subretinal fluid. The patient was diagnosed with presumed choroidal metastasis secondary to clear cell sarcoma of the tendons and aponeuroses. Clear cell sarcoma of the tendons and aponeuroses rarely metastasize to the choroid.


Assuntos
Neoplasias da Coroide/secundário , Joelho/patologia , Sarcoma de Células Claras/secundário , Neoplasias de Tecidos Moles/patologia , Tendões/patologia , Feminino , Humanos , Metástase Linfática , Pessoa de Meia-Idade
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