Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 154
Filtrar
1.
Ned Tijdschr Geneeskd ; 1682024 May 14.
Artigo em Holandês | MEDLINE | ID: mdl-38747614

RESUMO

BACKGROUND: Worldwide, disease in children due to exposure to rats is increasing, also in the Netherlands. Not only the generally known pathogen Leptospira should be considered, also S. moniliformis, Yersinia pestis, Lymphocytic choriomeningitis virus, Hantavirus, Francisella tularensis and Pasteurella multocida are also known rat-associated zoonosis. CASE DESCRIPTION: An 12-year-old boy visited the pediatrician with fever, headache and nausea, followed by generalized erythema and arthritis. The boy had a pet rat. The patient's blood culture was positive for S. moniliformis. The patient was treated with antibiotics and made a full recovery. CONCLUSION: Just like many rat-associated diseases have 'rat-bite fever' caused by S. moniliformis an nonspecific clinical presentation. It is not necessary to have had a rat bite, to develop rat-bite fever. Better awareness and knowledge about rat related diseases should contribute to earlier diagnosis and treatment. Which is of great importance because of increased morbidity and mortality associated to rat related diseases.


Assuntos
Antibacterianos , Febre por Mordedura de Rato , Criança , Masculino , Humanos , Febre por Mordedura de Rato/diagnóstico , Febre por Mordedura de Rato/tratamento farmacológico , Animais , Antibacterianos/uso terapêutico , Ratos , Resultado do Tratamento , Streptobacillus/isolamento & purificação , Zoonoses/diagnóstico
2.
Inn Med (Heidelb) ; 65(5): 512-516, 2024 May.
Artigo em Alemão | MEDLINE | ID: mdl-38459199

RESUMO

BACKGROUND: Rat bite fever is a rare but potentially fatal bacterial zoonosis. The symptoms can be unspecific, but severe sepsis can be associated with involvement of different organs. CASE REPORT: A 27-year-old homeless man presented with fever, suspected meningitis, acute renal failure, unclear skin lesions as well as joint problems and muscular pain. Bite wounds were not detected. Meningitis could be excluded after lumbar puncture, and there was no evidence of endocarditis as the cause of the skin lesions. After 72 h, growth of Streptobacillus moniliformis in blood cultures was detected. Clinical symptoms were compatible with the diagnosis of rat bite fever. Calculated antibiosis with ampicillin sulbactam and doxycycline led to regression of the symptoms. CONCLUSION: Rat bite fever poses a diagnostic challenge due unspecific symptoms, diverse differential diagnostic options, and challenging microbiological detection. Patient history is of the utmost importance. Due to the rarity of the disease, this case report is intended to raise awareness.


Assuntos
Febre por Mordedura de Rato , Streptobacillus , Zoonoses , Masculino , Adulto , Febre por Mordedura de Rato/diagnóstico , Febre por Mordedura de Rato/tratamento farmacológico , Febre por Mordedura de Rato/microbiologia , Humanos , Animais , Streptobacillus/isolamento & purificação , Zoonoses/diagnóstico , Zoonoses/microbiologia , Zoonoses/transmissão , Antibacterianos/uso terapêutico , Doxiciclina/uso terapêutico , Diagnóstico Diferencial , Ratos , Sulbactam/uso terapêutico , Sulbactam/administração & dosagem , Ampicilina/uso terapêutico
3.
BMC Infect Dis ; 21(1): 479, 2021 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-34039283

RESUMO

BACKGROUND: Rat bite fever (RBF) is a rare systemic febrile illness transmitted by rats. Streptobacillus moniliformis is a pleomorphic Gram-negative bacillus which is the usual etiologic organism for rat bite fever in the United States. CASE PRESENTATION: Here we present a case of rat bite fever complicated by vertebral osteomyelitis and discitis. The patient revealed an exposure history of being bitten by pet rats. The patient's symptoms dramatically improved with a six-week course of cephalexin therapy. CONCLUSIONS: It is important to obtain a thorough zoonotic exposure history and maintain rat bite fever in the differential when considering potential causes of discitis and osteomyelitis.


Assuntos
Discite/etiologia , Osteomielite/etiologia , Febre por Mordedura de Rato/complicações , Animais , Animais Domésticos , Antibacterianos/administração & dosagem , Mordeduras e Picadas/complicações , Cefalexina/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Febre por Mordedura de Rato/diagnóstico , Febre por Mordedura de Rato/tratamento farmacológico , Ratos , Streptobacillus/efeitos dos fármacos , Streptobacillus/isolamento & purificação , Resultado do Tratamento
4.
Diagn Microbiol Infect Dis ; 100(2): 115335, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33618204

RESUMO

Rat bite fever (RBF) caused by Streptobacillus moniliformis has been described as a diagnostic challenge. While it has a favorable prognosis with treatment, timely diagnosis is hindered by the lack of culture-free identification methods. Here we present a multiplex real-time PCR assay that detects the zoonotic Streptobacillus spp. as well as differentiate the primary causative agent of RBF, Streptobacillus moniliformis. The performance of this assay was evaluated using mock clinical specimens for blood, serum, and urine. Analytical sensitivity was determined to be 3-4 genome equivalents (GE)/µl for the zoonotic Streptobacillus spp. target, and 1-2 GE/µl for the S. moniliformis specific target. The assay correctly detected only the intended targets with no cross-reactivity identified. The pathogen was detected in all spiked matrices and not detected in the negative non-spiked specimens. This rapid diagnostic assay may permit quicker diagnosis of RBF patients.


Assuntos
Zoonoses Bacterianas/microbiologia , Febre por Mordedura de Rato/microbiologia , Reação em Cadeia da Polimerase em Tempo Real/métodos , Streptobacillus/classificação , Streptobacillus/isolamento & purificação , Animais , Clonagem Molecular , Humanos , Reprodutibilidade dos Testes , Especificidade da Espécie
5.
Pediatr Infect Dis J ; 39(12): 1131-1133, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32868746

RESUMO

Rat-bite fever caused by Streptobacillus moniliformis is a rare infection that may be fatal. An adolescent male presented with multiorgan failure, negative blood cultures and Gram-negative rods in blood smear. S. moniliformis was identified by 16S ribosomal RNA gene sequencing from the blood. He developed systemic hyperinflammatory syndrome resembling hemophagocytic lymphohistiocytosis, for which immune-globulins and steroids were added to the antibiotic regimen and he rapidly recovered.


Assuntos
Ceftriaxona/uso terapêutico , Dexametasona/uso terapêutico , Imunoglobulinas Intravenosas/uso terapêutico , Linfo-Histiocitose Hemofagocítica/patologia , Febre por Mordedura de Rato/diagnóstico , Streptobacillus/isolamento & purificação , Adolescente , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Ceftriaxona/administração & dosagem , Dexametasona/administração & dosagem , Doxiciclina/administração & dosagem , Doxiciclina/uso terapêutico , Humanos , Linfo-Histiocitose Hemofagocítica/tratamento farmacológico , Masculino , Febre por Mordedura de Rato/complicações , Febre por Mordedura de Rato/microbiologia
6.
Antonie Van Leeuwenhoek ; 113(10): 1455-1465, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32776203

RESUMO

Streptobacillus felis is a fastidious microorganism and a novel member of the potentially zoonotic bacteria causing rat bite fever. Since its description, this is the second isolation of S. felis in a diseased member of the Felidae. Interestingly, the strain from this study was isolated from a zoo held, rusty-spotted cat (Prionailurus rubiginosus), with pneumonia, thereby indicating a possible broader host range in feline species. A recent preliminary sampling of domestic cats (Felis silvestris forma catus) revealed that this microorganism is common in the oropharynx, suggesting that S. felis is a member of their normal microbiota. Due to unawareness, fastidiousness, antibiotic sensitivity and lack of diagnostics the role of S. felis as a cat and human pathogen might be under-reported as with other Streptobacillus infections. More studies are necessary to elucidate the role of S. felis in domestic cats and other Felidae in order to better estimate its zoonotic potential.


Assuntos
Felidae , Orofaringe/microbiologia , Streptobacillus/classificação , Streptobacillus/isolamento & purificação , Animais , Técnicas de Tipagem Bacteriana , Gatos , Reservatórios de Doenças , Genoma , Genômica/métodos , Fenótipo , Filogenia , Febre por Mordedura de Rato/microbiologia , Febre por Mordedura de Rato/transmissão , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz , Streptobacillus/química , Streptobacillus/genética
7.
Int J Syst Evol Microbiol ; 70(4): 2648-2656, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32209168

RESUMO

From a phlegmon in a dog an aerobic and facultatively anaerobic, indole-, oxidase- and catalase-negative, non-motile bacterium was isolated in 2019 in Germany that stained Gram-negative and showed a pleomorphic, rod-shaped, non-spore-forming appearance. Based on the results of 16S rRNA gene sequence analyses, strain IHIT1603-19T was assigned to the genus Streptobacillus with sequence similarities of 98.6, 98.0, 97.9, 97.1 and 94.4 % to the type strains of Streptobacillus felis, Streptobacillus notomytis, Streptobacillus ratti, Streptobacillus moniliformis and Streptobacillus hongkongensis, respectively. Strain IHIT1603-19T could also clearly be differentiated from other Streptobacillus species by rpoB, groEL and recA gene, nucleotide and amino acid sequence analyses as well as by core genome phylogeny. Regarding DNA-DNA relatedness, strain IHIT1603-19T demonstrated an average nucleotide identity of 83.00 and 82.28 % compared to S. felis 131000547T and S. moniliformis DSM 12112T, respectively. Chemotaxonomic and physiological data of strain IHIT1603-19T were in congruence with other closely related members of the family Leptotrichiaceae, represented by highly similar enzyme profiles and fatty acid patterns. MALDI-TOF MS analysis also proved suitable in unequivocally discriminating strain IHIT1603-19T from all currently described taxa of the genus Streptobacillus. On the basis of these data, we propose the novel species Streptobacillus canis sp. nov. with the type strain IHIT1603-19T (=DSM 110501T=CCUG 74118T=CIP 111795T). The G+C content of the DNA of the type strain is 26.6 mol%, genome size is 1.60 Mbp.


Assuntos
Cães/microbiologia , Filogenia , Streptobacillus/classificação , Animais , Técnicas de Tipagem Bacteriana , Composição de Bases , DNA Bacteriano/genética , Ácidos Graxos/química , Genes Bacterianos , Alemanha , Hibridização de Ácido Nucleico , RNA Ribossômico 16S/genética , Análise de Sequência de DNA , Streptobacillus/isolamento & purificação
8.
BMJ Case Rep ; 13(3)2020 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-32169988

RESUMO

A 71-year-old man was admitted with confusion having been discovered on the floor of his unkempt home. Social services would later confirm that the home was infested by rats. An infection of unclear origin was suspected, and he was immediately started on broad spectrum antibiotics. He subsequently developed a swollen left knee. Two knee aspirates showed a raised white cell count but no microbiological or cytological diagnosis. Finally, samples sent for 16S rDNA PCR identified Streptobacillus monilliformis Fastidious organisms and early treatment with antibiotics can limit microbiological diagnosis through standard laboratory analysis. Newer techniques such as sequence-based testing can overcome these limitations; however, they are not widely available and require the clinician to have a high index of suspicion. Crucially, the patient continued to be treated for his clinical sepsis despite initial laboratory results being negative and conflicting specialist opinions.


Assuntos
Antibacterianos/uso terapêutico , Febre por Mordedura de Rato/tratamento farmacológico , Streptobacillus/genética , Líquido Sinovial/microbiologia , Administração Intravenosa , Idoso , Animais , Diagnóstico Diferencial , Humanos , Masculino , Reação em Cadeia da Polimerase/métodos , Febre por Mordedura de Rato/diagnóstico , Ratos , Streptobacillus/isolamento & purificação , Resultado do Tratamento
15.
Emerg Infect Dis ; 24(7): 1377-1379, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29912693

RESUMO

We report a case of rat-bite fever in a 94-year-old woman with Streptobacillus notomytis infection. We established an epidemiologic link between exposure to rats and human infection by performing nested PCRs that detected S. notomytis in the intraoral swab specimens obtained from rats captured in the patient's house.


Assuntos
Febre por Mordedura de Rato/diagnóstico , Streptobacillus/isolamento & purificação , Idoso de 80 Anos ou mais , Animais , Doenças Transmissíveis Emergentes , Diagnóstico Diferencial , Feminino , Humanos , Japão/epidemiologia , Reação em Cadeia da Polimerase , RNA Ribossômico 16S/genética , Febre por Mordedura de Rato/microbiologia , Ratos , Doenças dos Roedores/epidemiologia , Doenças dos Roedores/microbiologia , Streptobacillus/genética
16.
Unfallchirurg ; 121(9): 764-768, 2018 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-29644421

RESUMO

Rat bite fever due to Streptobacillus moniliformis induces typical but not pathognomonic clinical signs, such as local purulent wound infection followed by maculopapular exanthema, myalgia as well as purulent joint infections. Severe complications, such as osteomyelitis and endocarditis are possible. it seems that this infection is rarely diagnosed but this infection could be much more common because the final diagnostic proof is difficult to achieve. Firstly, the culture of these bacteria is critical because the bacteria are fastidious and secondly the exact differentiation of the isolates is hardly possible by standard laboratory methods. Modern techniques such as mass spectroscopy (MALDI-TOF) and molecular biology allow a precise clarification. Surgical cleansing of infection sites in combination with a rational antibiotic therapy, for example with beta-lactam antibiotics, are generally able to cure the infection if treatment is started early enough. In addition, vaccinations, for example against tetanus and rabies have to be considered in this situation as for all other bite wound infections.


Assuntos
Mordeduras e Picadas/terapia , Febre por Mordedura de Rato/diagnóstico , Febre por Mordedura de Rato/terapia , Ratos , Streptobacillus/isolamento & purificação , Animais , Antibacterianos/uso terapêutico , Mordeduras e Picadas/complicações , Mordeduras e Picadas/microbiologia , Febre por Mordedura de Rato/complicações , Febre por Mordedura de Rato/microbiologia , Ratos/microbiologia
17.
J Infect Chemother ; 24(4): 302-304, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29191371

RESUMO

Rat-bite fever (RBF) is a disease that usually presents with fever, arthralgia and skin rash. Streptobacillus moniliformis was considered the main cause of RBF among the genus Streptobacillus. Although with similar clinical presentation, RBF due to Streptobacillus notomytis is unusual in humans. To the best of our knowledge, we present a case involving the first isolate of S. notomytis in humans. A 63-year-old woman was admitted to our hospital with fever, rash and polyarthritis. She recalled being bitten by a rat on her finger 5 days before presentation. Clinical manifestations were compatible with rat-bite fever (RBF) and the diagnosis was confirmed by the detection of Streptobacillus species from both blood and pustule samples. Initial polymerase chain reaction tests revealed that the organism was S. moniliformis. However, thorough genetic analysis revealed the organism to be S. notomytis. The condition was successfully treated with ampicillin.


Assuntos
Vesícula/microbiologia , Febre por Mordedura de Rato/diagnóstico , Febre por Mordedura de Rato/microbiologia , Streptobacillus/isolamento & purificação , Administração Intravenosa , Ampicilina/uso terapêutico , Animais , Antibacterianos/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , RNA Ribossômico 16S/genética , Febre por Mordedura de Rato/sangue , Febre por Mordedura de Rato/tratamento farmacológico , Ratos , Streptobacillus/genética
19.
Emerg Infect Dis ; 23(4): 719-721, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-28322713

RESUMO

We report acute tetraplegia caused by rat bite fever in a 59-year old man (snake keeper) and transmission of Streptobacillus moniliformis. We found an identical characteristic bacterial pattern in rat and human samples, which validated genotyping-based evidence for infection with the same strain, and identified diagnostic difficulties concerning infection with this microorganism.


Assuntos
Quadriplegia/etiologia , Febre por Mordedura de Rato/complicações , Streptobacillus/isolamento & purificação , Combinação Amoxicilina e Clavulanato de Potássio/uso terapêutico , Criação de Animais Domésticos , Animais , Antibacterianos/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Técnicas de Amplificação de Ácido Nucleico , Febre por Mordedura de Rato/tratamento farmacológico , Ratos , Serpentes
20.
Jpn J Infect Dis ; 70(3): 323-325, 2017 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-28003596

RESUMO

We report a case of rat bite fever, diagnosed based on positive cultures of Streptobacillus moniliformis from blood and synovial fluid. The patient was a 45-year-old man who presented with history of a rat bite and alcoholic liver cirrhosis. He had been bitten on his third finger by a rat, which was caught in a mousetrap installed in his house. Over the course of approximately 2 weeks after the bite, the patient developed fever, rash, and arthralgia. The patient was admitted to our hospital and treated with a combination of ampicillin-sulbactam, vancomycin (VAN), and minocycline (MIN) antibiotics. Initial culture findings from the Anaerobic/F resin blood culture were positive for gram-negative bacillus after overnight incubation. Thus, S. moniliformis infection was suspected, and administration of VAN and MIN was ceased. On hospital day 8, the treatment was switched to oral amoxicillin-clavulanic acid, and the patient was discharged from the hospital. Subsequently, the pathogen was also detected in synovial fluid and identified as S. moniliformis using 16S rRNA sequencing analysis.


Assuntos
Febre por Mordedura de Rato/diagnóstico , Febre por Mordedura de Rato/patologia , Streptobacillus/isolamento & purificação , Antibacterianos/uso terapêutico , Técnicas Bacteriológicas , Sangue/microbiologia , DNA Bacteriano/química , DNA Bacteriano/genética , DNA Ribossômico/química , DNA Ribossômico/genética , Humanos , Masculino , Pessoa de Meia-Idade , RNA Ribossômico 16S/genética , Febre por Mordedura de Rato/tratamento farmacológico , Febre por Mordedura de Rato/microbiologia , Análise de Sequência de DNA , Streptobacillus/classificação , Streptobacillus/genética , Líquido Sinovial/microbiologia , Resultado do Tratamento
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...