Pancytopenia in a patient given pyrimethamine and sulphamethoxidiazine during pregnancy.

This is a report of a pregnant woman who became pancytopenic in the second trimester following pyrimethamine administration. The patient recovered on steroid, antibiotics, transfusion, folic acid and folinic acid therapy, and the pregnancy was uneventful afterwards. The patient was delivered of a healthy term-infant.

Severe liver injuries due to sulfamethoxazole-trimethoprim and sulfamethoxydiazine.

Two cases of severe sulfonamide liver injury are described. In one patient, fulminant liver failure developed after two days of taking sulfamethoxazole-trimethoprim. The patient was treated with resin hemoperfusion and recovered completely. Another patient became jaundiced after using sulfamethoxydiazine for ten days. Very severe intrahepatic cholestasis developed and cleared up only after high-dose prednison treatment. Marked hyperbilirubinemia persisted for four months and aminotransferase activity had not normalized ten months after the onset of the disease.

[Varicella associated with Lyell's syndrome after administration of sulfametin]. / Varicela asociata cu un sindrom Lyell, dupa administrare de Sulfametin.

A case of chickenpox associated with Lyell syndrome, which appeared after the administration of sulfamethine, is reported. Quantitative determination of the immunoglobulins showed marked immunologic changes in the course of the syndrome. Antistaphylococcal treatment, without corticotherapy led to clinical recovery.