RESUMO
The local irritating effect of Veen 3G Inj. (glucose-added acetic acid maintenance infusion solution) was examined in male rabbits. We studied the local irritating effect of the infusion solution compared with that of Ringer's solution, 5% sulfobromophthalein sodium injection, distilled water for injection or glucose-added Ringer's solution. In the vascular irritation test, macroscopical and histopathological changes induced by the infusion solution were not observed in the vessels. Moreover, in the hemolytic test, hemolysis of rabbit erythrocyte was not observed in the mixture with the infusion solution. In the present study, no change suggesting irritation by the infusion solution was observed in the in vivo vascular irritation test using the auricular vein of rabbits or in the in vitro hemolytic test using rabbit erythrocyte. In conclusion, in clinical use the infusion solution produces extremely slight adverse effects, such as vessel pain and phlebitis on the injection site.
Assuntos
Glucose/efeitos adversos , Soluções Isotônicas/efeitos adversos , Animais , Hemólise/efeitos dos fármacos , Técnicas In Vitro , Infusões Intravenosas/efeitos adversos , Masculino , Dor/induzido quimicamente , Flebite/induzido quimicamente , Flebite/patologia , Coelhos , Solução de Ringer , Sulfobromoftaleína/efeitos adversos , Veias/efeitos dos fármacos , Veias/patologiaRESUMO
Liver function tests involving the use of Bromsulphalein can lead to hemolysis and consequent DIC. Latent forms can be detected by means of fibrinolytic degradation products and reduction in the number of leukocytes containing acid mucopolysaccharides of the heparin type, together with an increase in the total leukocyte count as a sign of stress. In comparisons between the bromsulphalein and indocyanine green tests, these parameters have sho4n that liver function tests using indocyanine green are harmless.
