RESUMO
Hemodynamic monitoring provides the basis for the optimization of cardiovascular dynamics in intensive care medicine and anesthesiology. The Journal of Clinical Monitoring and Computing (JCMC) is an ideal platform to publish research related to hemodynamic monitoring technologies, cardiovascular (patho)physiology, and hemodynamic treatment strategies. In this review, we discuss selected papers published on cardiovascular and hemodynamic monitoring in the JCMC in 2017.
Assuntos
Técnicas de Diagnóstico Cardiovascular/instrumentação , Técnicas de Diagnóstico Cardiovascular/tendências , Ecocardiografia/tendências , Técnicas de Diluição do Indicador/tendências , Monitorização Fisiológica/tendências , Publicações Periódicas como Assunto/tendências , Animais , Determinação da Pressão Arterial , Sistema Cardiovascular , Ecocardiografia/instrumentação , Hemodinâmica , Humanos , Técnicas de Diluição do Indicador/instrumentação , Monitorização Fisiológica/instrumentação , Volume SistólicoRESUMO
Hemodynamic monitoring is essential in critically ill patients. In this regard, the Journal of Clinical Monitoring and Computing (JCMC) has become an ideal platform for publishing cardiovascular and hemodynamic monitoring-related research, as reflected by an increasing number of articles related to this topic and published in the recent years. To highlight this new progress, every New Year the journal prints a descriptive review on some important papers published last year in the JCMC and related to blood, cardiovascular function and hemodynamic monitoring.
Assuntos
Técnicas de Diagnóstico Cardiovascular/instrumentação , Técnicas de Diagnóstico Cardiovascular/tendências , Ecocardiografia/tendências , Técnicas de Diluição do Indicador/tendências , Monitorização Fisiológica/tendências , Publicações Periódicas como Assunto/tendências , Animais , Ecocardiografia/instrumentação , Ecocardiografia/métodos , Hemodinâmica , Humanos , Técnicas de Diluição do Indicador/instrumentação , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodosRESUMO
Bile acid kinetics involve the measurement of pool sizes and turnover rates of individual bile acids. The technique is based on isotope dilution and was first described in the 1950s using radioactive (14)C-labelled cholic acid (CA). It took until the 1970s before stable isotopes were introduced for this purpose ((13)C, (2)H) and isotope analysis methods were developed for CA and chenodeoxycholic acid (CDCA) applying gas chromatography/electron impact mass spectrometry. Until the 1980s, the isotope enrichment measurements were performed in bile samples aspirated from the duodenum. Thereafter, methodology became available allowing measurements to be performed in blood requiring at least 2 ml serum samples. Simultaneous measurement of kinetics of metabolically dependent CA and deoxycholic acid using (13)C and (2)H labels was introduced. Until the 1990s, this technique was only possible in adult humans due to the large sample sizes. Introduction of pentafluorobenzyl bromide derivatisation and electron capture negative ion mass spectrometry (GC/ECN-MS) reduced the sample volume to 50 microl serum. This allowed isotope abundance measurement of CA in rats and in mice. However, repetitive collection of 100 microl blood samples in mice is too invasive (collection via the orbita) and exhaustive. Therefore, the method development is now focussing on enhanced sensitivity and reduction of blank effects originating from the sample preparation. The final goal is to determine CA isotope enrichments in 20 microl mouse blood obtained from the tail vein. This paper shows the feasibility of reaching this goal.
