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1.
PLoS Biol ; 11(8): e1001641, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24013523

RESUMO

Paleovirology is the study of ancient viruses. The existence of a paleovirus can sometimes be detected by virtue of its accidental insertion into the germline of different animal species, which allows one to date when the virus actually existed. However, the ancient and the modern often connect, as modern viruses have unexpected origins that can be traced to ancient infections. The genomes of two species of mongooses and an egg-laying mammal called an echidna show that a virus currently present in poultry, the reticuloendotheliosis virus (REV), is actually of ancient exotic mammalian origin. REV apparently spread to poultry through a circuitous route involving the isolation of malaria parasites from a pheasant from Borneo housed at the Bronx Zoo that was contaminated with REV. Repeated passage of this virus in poultry adapted the virus to its new host. At some point, the virus got inserted into another virus, called fowlpox virus, which has spread back into the wild. Although REV may still exist somewhere in a mammalian host, its modern form links an 8 million-year-old infection of the ancestor of a mongoose to a virus that now is circulating in wild birds through malaria studies in the mid-20(th) century. These lessons of ancient and modern viruses have implications for modern human pandemics from viral reservoirs and for human interventions that may come with unintended consequences.


Assuntos
Herpestidae/virologia , Retroviridae/patogenicidade , Animais , Galinhas/virologia , Paleopatologia , Vírus da Reticuloendoteliose/patogenicidade , Tachyglossidae/virologia
2.
J Gen Virol ; 87(Pt 11): 3195-3200, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17030852

RESUMO

Papillomaviruses are a group of ubiquitous viruses that are often found in normal skin of humans, as well as a range of different vertebrates. In this study, swab samples collected from the healthy skin of 225 Australian animals from 54 species were analysed for the presence of papillomavirus DNA with the general skin papillomavirus primer pair FAP59/FAP64. A total of five putative and potential new animal papillomavirus types were identified from three different animal species. The papillomaviruses were detected in one monotreme and two marsupial species: three from koalas, and one each from an Eastern grey kangaroo and an echidna. The papillomavirus prevalence in the three species was 14 % (10/72) in koalas, 20 % (1/5) in echidnas and 4 % (1/23) in Eastern grey kangaroos. Phylogenetic analysis was performed on the putative koala papillomavirus type that could be cloned and it appears in the phylogenetic tree as a novel putative papillomavirus genus. The data extend the range of species infected by papillomaviruses to the most primitive mammals: the monotremes and the marsupials.


Assuntos
Animais Selvagens/virologia , Animais de Zoológico/virologia , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/veterinária , Pele/virologia , Animais , Austrália/epidemiologia , Primers do DNA , DNA Viral/genética , Macropodidae/virologia , Dados de Sequência Molecular , Papillomaviridae/classificação , Papillomaviridae/genética , Infecções por Papillomavirus/epidemiologia , Phascolarctidae/virologia , Filogenia , Especificidade da Espécie , Tachyglossidae/virologia
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