1.
Anal Biochem
; 159(2): 358-62, 1986 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3103482
RESUMO
Tacrine (THA; 1,2,3,4-tetrahydro-9-aminoacridine) is an anticholinesterase agent which has been used clinically, most recently in the treatment of Alzheimer-type dementias. This paper describes the methodology for the isolation and quantitation of THA at therapeutic levels in serum from human subjects. Using C18 Bond Elut columns and an HPLC/fluorometry system, this assay exhibits a considerable improvement in sensitivity over previous uv methods, and allows routine testing of THA levels in serum samples of reasonable volume from human subjects.
Assuntos
Aminoacridinas/sangue , Tacrina/sangue , Animais , Cromatografia Líquida de Alta Pressão , Haplorrinos , Humanos , Monitorização Fisiológica , Espectrometria de Fluorescência , Tacrina/isolamento & purificação
2.
J Chromatogr
; 274: 388-92, 1983 May 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6874846