The arrogance of teratology: A brief chronology of attitudes throughout history.

While the discipline of Teratology has existed for about 60 years, there has been a deep interest in the causes of human malformations for millennia. Absent the scientific method and acting on fervent beliefs that made sense to ancient/medieval populations, "mechanisms" were described and prognostications of future events were assigned to terata resulting in tragic (and unwarranted) sequelae. This article examines the collective beliefs and thinking within various eras in the hope of providing lessons to inform future behavior. The eugenics movement is an informative, recent example. Science of the 19th century had unraveled some of the mysteries of development and the role of genetics in determining birth outcomes. There was, however, a deep misunderstanding about the enormous amount of information that had yet to be uncovered. Based on immature science and faulty assumptions, it was suggested that "unfit" individuals be euthanized and their parents sterilized. Such "solutions" would be considered deplorable today. Surprisingly, such a reprehensible program was supported (at least in part) by many intelligent and highly regarded individuals. Today, it is imperative that we enter into the era of molecular biology and gene editing cautiously and perspicaciously. The history of teratology has elucidated our inability to understand where our new technologies and actions might take us and how unintended consequences could disrupt even our most carefully thought-out plans.

History and highlights of the teratological collection in the Museum Anatomicum of Leiden University, The Netherlands.

The anatomical collection of the Anatomical Museum of Leiden University Medical Center (historically referred to as Museum Anatomicum Academiae Lugduno-Batavae) houses and maintains more than 13,000 unique anatomical, pathological and zoological specimens, and include the oldest teratological specimens of The Netherlands. Throughout four centuries hundreds of teratological specimens were acquired by more than a dozen collectors. Due to the rich history of this vast collection, teratological specimens can be investigated in a unique retrospective sight going back almost four centuries. The entire 19th century collection was described in full detail by Eduard Sandifort (1742-1814) and his son Gerard Sandifort (1779-1848). Efforts were made to re-describe, re-diagnose and re-categorize all present human teratological specimens, and to match them with historical descriptions. In the extant collection a total of 642 human teratological specimens were identified, including exceptional conditions such as faciocranioschisis and conjoined twins discordant for cyclopia, and sirenomelia. Both father and son Sandifort differed in their opinion regarding the causative explanation of congenital anomalies. Whereas, their contemporaries Wouter Van Doeveren (1730-1783) and Andreas Bonn (1738-1817) both presented an interesting view on how congenital anomalies were perceived and explained during the 18th and 19th centuries; the golden age of descriptive teratology. Although this enormous collection is almost 400 years old, it still impresses scientists, (bio)medical students, and laymen visiting and exploring the collections of the Museum Anatomicum in Leiden, The Netherlands.

Thomas H. Shepard, M.D., pioneer in embryology and teratology.

Dr. Thomas H. Shepard died on October 3, 2016 at the age of 93. He was a major figure in the fields of teratology, embryonic and fetal pathology, and pediatrics. He was beloved by his colleagues as he was by the many students and fellows whom he taught, mentored and befriended. His contributions to teratology are extraordinary and he is greatly missed. © 2017 Wiley Periodicals, Inc.

[POETRYAND TERATOLOGY: LORENZO MASCHERONI'S "INVITO A LESBIA CIDONIA" IN ANATOMICAL PREPARATIONS]. / POESIA E TERATOLOGIA: L'INVITO A LESBIA CIDONIA DI LORENZO MASCHERONI NEI PREPARATI ANATOMICI.

In 1793 Lorenzo Mascheroni, appointed to the chair of Mathematics at the University of Pavia and well-known poet, wrote "L'invito di Dafni Orobiano a Lesbia Cidonia". In the poem he described the beauty of the University of Pavia and its wonders gathered in the scientific collections of the museums. From the beginning, one of the glass cases of the Museum for the History of the University of Pavia shows some of the preparations described in the Mascheroni's verses. In addition to some fossils, human teratological preparations are also exposed: they recall the verses of the poem dedicated to the description of "monstrous" preparations. However, after a detailed scientifc and historical research, the traditional association of the exposed anatomical preparations with the verses is questioned.

A apropriação da monstruosidade pelo saber médico / The appropriation of monstrosity by medical knowledge

O trabalho tem por objetivo descrever como o discurso em torno das deformidades é resultante de um processo, iniciado no século XIX, que deslocou o fenômeno da monstruosidade dos registros das aberrações descritas moral ou religiosamente para o campo da Biologia. A hipótese é a de que houve uma apropriação médica da monstruosidade guiada principalmente por três vetores: desenvolvimento da Teratologia como ciência; mudança das sensibilidades e o surgimento do sentimento de compaixão, estimulado em grande parte pela literatura do século XIX; e o aumento do número de pessoas deficientes, em decorrência da Primeira e da Segunda Guerras Mundiais, que levou a uma mudança na forma como as sociedades lidavam com um corpo marcado pela deformidade. Tanto a Teratologia, como a literatura foram operadores importantes no processo de conscientização sobre a humanidade dos monstros. É justamente essa transição de uma categoria social de "monstro" para a categoria social de "portador de deformidade", construída pelo saber médico, que o trabalho pretende investigar

The study aims to describe how the discourse around deformities is the result of a process that began in the nineteenth century, which shifted the phenomenon of monstrosity of records on moral aberrations morally or religiously described to the field of Biology. The hypothesis is that there was a medical appropriation of monstrosity guided by three vectors mainly: the development of Teratology as science; change of sensibilities and the emergence of the feeling of compassion, largely stimulated by the nineteenth-century literature; and increasing number of disabled people as a result of the First and Second World Wars, which led to a change in the way societies dealt with a body marked by deformity. Both Teratology, as literature were important players in the process of awareness about the humanity of monsters. It is precisely this transition from one social category of "monster" for the social category of "deformity bearer", built by the medical knowledge, this study aims to investigate

Professor David Poswillo CBE (1927-2003): Skilled oral and maxillofacial surgeon, influential scientist, teacher and adviser.

David Poswillo trained at Otago University Dental School, Dunedin, New Zealand (BDS) and the Royal College of Surgeons of England (FDSRCS). His great interest became the genesis and repair of cleft lip and palate and, in addition to clinical work, he undertook an experimental study of the embryology of cleft palate in pregnant rats exposed to three teratogenic agents. The microscopic work was carried out in his garden shed in Christchurch. His groundbreaking work on amniotic puncture at a critical period came to international notice and he was given the first Chair in Teratology of the Royal College of Surgeons. In experimental studies he showed that thalidomide induced focal haemorrhage in the developing embryo. Poswillo was also Consultant Oral Surgeon at Queen Victoria Hospital, East Grinstead and his skills as surgeon and teacher attracted numerous trainee surgeons. He was Professor of Oral Surgery in Adelaide and then in London. Poswillo was Chairman of two advisory committees whose lucid reports on anaesthesia, sedation and resuscitation in dentistry (Poswillo Report) and on tobacco and health were far-reaching and influential. David Poswillo had immense energy and enthusiasm and is remembered by many for his personal interest and stimulating guidance.

"Monstre". Etienne Geoffroy Saint-Hilaire and the science of monstrosity.

This article aims at analyzing the entry "Monstre", written by Etienne Geoffroy Saint-Hilaire in 1827 and included in the Dictionnaire classique d'histoire naturelle. Under Etienne Geoffroy the study of monsters brought new heuristic and theoretical approaches to the research fields of anatomy and embryology, and acquired the status of a scientific discipline having its own theoreticalfoundations and therefore its own standards for classification, seen as non-random means for revealing a groundbreaking knowledge.

Semantics of monstrosity in the ninenteenth century.

The emphasis of the normal, the human aspect and feature in monstrosities is a leitmotif that becomes prevalent in the scientific debate on teratological phenomena in the nineteenth century. The discourse highlights the organisation of the civilising process with regard to creating an antithesis between human and animality. In this respect, anthropology establishes anthropometry as a measuring and classifying instrument, hence supporting concepts of norm and abnormity in the scientific discussion. The classification approach finally translates teratological occurrences into the "human system" with the monstrosity being transformed into a subject of knowledge. Scientific discourse poses and installs the latter as living attraction for medical and anthropological examination, thus stressing boundary permeability between man and animal. Evolutionary theory finally initiates the quest for the missing link between man and ape, with congenital disorders, such as microcephaly, becoming particularly supportive of the idea of a manifesting existence of a primitive pre-human form.

Retrogressive development: transcendental anatomy and teratology in nineteenth-century Britain.

In 1855 the leading British transcendental anatomist Robert Knox proposed a theory of retrogressive development according to which the human embryo could give rise to ancestral types or races and the animal embryo to other species within the same family. Unlike monsters attributed to the older theory of arrested development, new forms produced by retrogression were neither imperfect nor equivalent to a stage in the embryo's development. Instead, Knox postulated that embryos contained all possible specific forms in potentia. Retrogressive development could account for examples of atavism or racial throwbacks, and formed part of Knox's theory of rapid (saltatory) species change. Knox's evolutionary theorizing was soon eclipsed by the better presented and more socially acceptable Darwinian gradualism, but the concept of retrogressive development remained influential in anthropology and the social sciences, and Knox's work can be seen as the scientific basis for theories of physical, mental and cultural degeneracy.

Falsehood on the move. The Aztec children and science in the second half of the 19th century.

Allegedly kidnapped from a secret city in Central America, the "Aztec children" began a showman's career in the early-1850s. They died around 1900, after being observed by countless pathologists and ethnologists from Europe and the US. Most of the literature on the "Aztec children" has emphasized racial theories, the imperial gaze, and the character of "ethnological shows", where monstrosity and ethnicity were practically synonymous. Less attention has been paid to the fact that scientists continuously insisted that the case was false, an argument that instead of debunking the myth of the "Aztec children", contributed to establishing the "Aztecs" as "a matter of fact". In examining the case of the "Aztec children", this essay aims to explore what can be called the shifting nature or elusiveness of falsehood.

Teratology in Mexico. 19th Century.

It was not until the last third of the 19th century, the period in which, according to historiography, the country definitely inserted itself into modernity, that anomalies and monstrosities had a presence in Mexico. Therefore, what I present here are four moments of teratology in Mexico, four dates in which I try to recount how teratology, which still occupied a marginal place within the main themes of national science, not only reached to cover the realm of medical discussions at the time, but also laid the foundations for new disciplines like biology and anthropology.